CN1331992A - Chinese herbal medicine for treating hypertension - Google Patents

Abstract

The Chinese herbal medicine for treating hypertension is prepared with gingko leaf, Radix Puerariae, Astragalus membranaceus, Radix Acanthopanacis Senticosi, Radix Polygoni Multiflori and other eight kinds of Chinese medicinal materials. Clinical application shows that the said medicine has long-time and stable curative effect and a cure rate to simple hypertension over 85%.

Description

A kind of Chinese herb medicine for the treatment of hypertension

The present invention relates to a kind of medicine for the treatment of hypertension, specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.

Simple property hypertension refers to that the clinical case screening gets rid of isolated systolic hypertension, the hyperpietic with complication, Woman climacteric hypertension and have patient's (overweight, pathoglycemia, dyslipidemia) of correlative factor except that the blood pressure lowering treatment with blood pressure, also do not have direct active drug at this hypertension treatment at present.

Therefore, the object of the present invention is to provide a kind of hypertension treatment agent that can treat simple property hypertension and complication effect.

Solution of the present invention is based on motherland's medical science to hypertension and pathogenetic understanding of complication and Therapeutic Principle, achieves with reference to modern pharmacological research; From motherland's medicine treasure-house, select nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, the natural plant crude drugs of the body resistance strengthening and constitution consolidating, by theory of Chinese medical science prescription microcirculation improvement attach most importance to and to internal and external environment lifting want the hormonal system of regulating action and the relative equilibrium between the associated metabolic, to reach the normal terminal point index of blood pressure natural stability.

Medicine of the present invention is made by following component: (consumption is weight percentage) Folium Ginkgo, Radix Puerariae each 12-22,

The Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli each 6-10

Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Angelicae Sinensis each 4-8

Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Ramulus Uncariae Cum Uncis, structure Fructus Lycii each 3-5

Folium Ginkgo: Folium Ginkgo has stronger antioxidant radical damage and lipid-peroxidation effect, and albuminuria forms to preventing, the change and the glomerular injury of renal hemodynamics have important function.

Radix Puerariae: cool in nature, control stiffness of the nape, migraine, pharmacological research shows to have coronary artery dilator and cerebrovascular effect, improves blood viscosity, reduce vascular resistance, microcirculation improvement has β-receptor blocking agent effect, the unusual cerebral blood flow of hypertensive patient is changed, and can reduce the plasma renin effect.

The Radix Astragali: slightly warm in nature; dual regulation and neuropeptide to blood pressure; feritin-angiotensin-aldosterone system; aspects such as kallikrein-kinin system are relevant; enhancing antibody and raise immunity reagentia are arranged; the metabolic effect of the cell physiological of enhancing is arranged, red blood cell deformation is had protective effect, can promote nucleic acid metabolism to remove free radical and lipoid peroxidization resistant.

Radix Et Caulis Acanthopanacis Senticosi: tangible anti-stress effect is arranged, can change the pathological process of body to stress, the energy enhancing body has endocrine regulation dysfunction effect to the opposing and the adaptive capacity of nonspecific stimulation.

Radix Polygoni Multiflori Preparata: slightly warm in nature, nourishing the liver and kidney, tangible promotion cellular immunization is arranged and regulate the body fluid immunization, have and suppress moving film speckle formation and lipidosis, prevent that arteriosclerosis from the effect of development taking place, improve neuroendocrine function and make it to be more than normally to keep and to regulate the organism physiology biochemical mechanism, the removing of superoxides in the acceleration bodies, reduce the generation of lipid peroxide, the adjusting lipid is arranged, protein effect and the dual regulation of blood glucose, blood pressure.

Herb Gynostemmae Pentaphylli: cold in nature, body blood fat, blood glucose, protein metabolism are had regulating action; the effect that increases cellular immunization and humoral immune function is arranged; and, can suppress the impaired interior blood vessel skin of thrombosis protection, each bar approach of the atherosis formation of interruption artery to the hormonal system regulating action.To cerebrovascular, nervous system has regulating action preferably.

Radix Salviae Miltiorrhizae: cold nature, blood circulation promoting and blood stasis dispelling, Radix Salviae Miltiorrhizae can significantly increase the blood capillary netting index, quicken little blood flow, promote the regeneration of diseased region myocardial cell, can suppress the formation of lipid peroxidation effectively and obviously improve erythrocyte deformability, by regulating the generation and the release of vaso-active substance, the expansion arteriole, Radix Salviae Miltiorrhizae can increase the prostacyclin of blood vessel dilating in the blood plasma, nitric oxide production concentration, reduce the concentration of pressor thromboxane A2 and Endothelin, the humoral immunization of adjusting and immunization of cell are arranged, the deposition antigen antibody complex is had the promotion Absorption.

Herba Epimedii; Warm in nature; the kidney invigorating; body's immunity there is dual regulation; the effect that improves hemodynamic and hemorheology is arranged, and can promote proteinic synthesizing, regulate cellular metabolism and certain maincenter depression effect; the protection cell exempts from free radical damage; the Herba Epimedii polysaccharide can obviously promote immunocompetence, and good promotion cardiovascular and cerebrovascular vessel activity is arranged again, and it is unusual obviously to improve the blood lipoprotein.

Radix Angelicae Sinensis: warm in nature, have the arteriosclerosis effect, and should be relevant with its oxidation and removing free radicals, blood fat reducing and anticoagulant equivalence, can prevent and treat tubulointerstitial injury and glomerular sclerosis effectively.

Rhizoma Chuanxiong: warm in nature, promoting flow of QI and blood, Rhizoma Chuanxiong can improve soft brain meninges microcirculation, and chronic microcirculation disturbance is had obvious opsonic action, and the glomerule of alleviating pathological changes is arranged, suppressing crescent formation and glomerule fibrosis has certain effect, and expansion peripheral blood vessel and antithrombotic effect are arranged.

Fructus Schisandrae Chinensis: nourishing kidney.An amount of Fructus Schisandrae Chinensis can promote its neural activity normalization, may be relevant to the dual regulation of blood pressure with its " adaptogen " sample effect, and to the immunologic function dual regulation, Wheat Protein, enhancing body is to the defence capability equivalent force of nonspecific stimulation.

Ramulus Uncariae Cum Uncis: cool in nature, refrigerant suppressing the hyperactive liver cures mainly dizziness, dizzy, the blood pressure lowering characteristics be effect slowly and lasting, balance and significantly, Ramulus Uncariae Cum Uncis blood pressure lowering mechanism relates to nerve centre, and different links such as neuroganglion, peripheral nerve, heart and peripheral blood vessel can suppress collagen-induced thromboxane A2 and generate.

Fructus Lycii: property is flat, nourishing the kidney for subduing the hyperactivity of liver-YANG, treating the liver kidney yin lose, have a dizzy spell, and lycium barbarum polysaccharide is not only immunostimulant, and still immunoregulation effect is arranged, and the effect that has atherosclerosis to form.

Medicine of the present invention is treated simple property hypertension 100 examples from clinical use in 93 years, effective 85 examples, and invalid 15 examples, effective percentage reaches 85%.Long-term observation result shows; Blood pressure is steady in a long-term normal behind the part patient treatment, and it is clear and definite that the hypertension complication left ventricular hypertrophy recovers, and the relevant clinical performance is uncomfortable in chest, chest pain, headache, dizzy elimination ideal.From establishing criterion of therapeutical effect: simple property hypertension, promptly clinical without have the hyperpietic of obvious correlative factor to get rid of with hypertension as: overweight or complication etc.The pathology damage of this group case still is in the recessive progress stage, PD is generally within 3-5 years, main treatment target for this therapy, 1, the characteristics because of individual patients basic blood pressure, age and disease progression have nothing in common with each other, so differ greatly the course of treatment, general 1-3 months, show promptly that blood pressure obviously descends or near normal.2, the blood pressure drops process is persistence and alleviates, its process even can extend to stopped treatment after 1-2 years.3, cure back blood pressure level ideal (average is the 122.8/775.5 millimetres of mercury), even can return to premorbid blood pressure level.4, effective and invalid the two differentiation obviously.Case Xu certain, the women, 65 years old, hypertension 4 years, sometimes dizzy, dim eyesight, blood pressure 170/102 millimetres of mercury was taken medicine of the present invention two months continuously when went to a doctor in June, 96, stopped treatment blood pressure so far is still normal, reaches later annual mediodespidine average and is respectively 132/82,128/80,122/76,124/76 millimetres of mercury in 97 years.

Other various types of hypertension, the patients with hypertension that correlative factor is promptly arranged, as isolated systolic hypertension, overweight, dyslipidemia, pathoglycemia, Woman climacteric, hypertension complication, generally after treatment 3 months, part patient can have tangible stratum character blood pressure drops, reduces to normal person naturally but still find no blood pressure thereafter.

The improvement of pathology damage can recover normally fully as left ventricular hypertrophy, is that main shower does not almost have specific therapeutical with kidney injury.

Case: Min, male, 59 years old, overweight has family's medical history, tells and suffers from hypertension so far in 82 years, hypertension was in hospital in 97 years, had made a definite diagnosis hypertensive heart disease, coronary heart disease, old myocardial infarction etc., blood pressure 220/120 millimetres of mercury when go to a doctor in March, 2000, left ventricular hypertrophy, the myocardial blood flow deficiency, urine protein is found in urine examination +++the positive, with medicine of the present invention is main treatment four months, through repeatedly check, it is normal that above disease is recovered, the controlling of blood pressure ideal.

Clinical drug of the present invention uses the result to show that following advantage is arranged: this compatibility is proper, meet the Chinese traditional treatment rule, 1-3 months courses of treatment, patient's blood pressure drops is still obvious behind the stopped treatment, and lasting stability, to simple property hyperpietic's effective percentage more than 85%, at normal level, hypertension, left ventricular hypertrophy are had clear and definite good restitution, and treatment rate is more than 85%.

The invention will be further described below in conjunction with embodiment:

Embodiment 1

Take by weighing raw material (kilogram) by following proportioning

Folium Ginkgo, Radix Puerariae each 22, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli each 6, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Angelicae Sinensis each 4, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Ramulus Uncariae Cum Uncis, Fructus Lycii each 5.

Embodiment 2

Take by weighing raw material (kilogram) by following proportioning

Folium Ginkgo, Radix Puerariae each 12, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli each 10, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Angelicae Sinensis each 8, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Ramulus Uncariae Cum Uncis, Fructus Lycii each 3.

Embodiment 3

Take by weighing raw material (kilogram) by following proportioning

Folium Ginkgo, Radix Puerariae each 17, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli each 8, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Angelicae Sinensis each 6, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Ramulus Uncariae Cum Uncis, structure Fructus Lycii each 4.

With the foregoing description 1,2,3 make capsule by following technology respectively, choose the high-quality medical material, remove impurity, with Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Fructus Schisandrae Chinensis powder is broken into coarse grain, soak with clear water and to boil after rising, be incubated three hours, with Folium Ginkgo, the Herba Epimedii chopping is standby, Radix Puerariae is concocted and is removed powder, the Radix Astragali, Herb Gynostemmae Pentaphylli, Radix Angelicae Sinensis, Fructus Lycii adds medicine-feeding and soaked 24 hours, adopts Technology in Pressing to get its dense medicine juice, adding boiling water then again soaked 2 hours, repress squeezes medicine juice, and repeat 3-4 times front and back, treat that medicine juice is exhausted substantially till, all medicine juice leave standstill filtration, with the water proof concentration pan moisture content is all evaporated, form semisolid below 10 ℃ in room temperature, in the filled capsules, standby through ultraviolet disinfection, patient's every day, 12-16 branch secondaries were oral.

Claims (2)

1, a kind of Chinese herb medicine for the treatment of hypertension is characterized in that: it is the medicament of being made by the following weight proportion raw material;

Folium Ginkgo, Radix Puerariae each 12-22,

The Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli each 6-10

Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Angelicae Sinensis each 4-8

Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Ramulus Uncariae Cum Uncis, structure Fructus Lycii each 3-5

2, a kind of Chinese herb medicine for the treatment of hypertension according to claim 1, it is characterized in that: described medicament is a capsule.