CN102058128A - Nutrient oral solution and preparation method thereof - Google Patents
Nutrient oral solution and preparation method thereof Download PDFInfo
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- CN102058128A CN102058128A CN200910228275XA CN200910228275A CN102058128A CN 102058128 A CN102058128 A CN 102058128A CN 200910228275X A CN200910228275X A CN 200910228275XA CN 200910228275 A CN200910228275 A CN 200910228275A CN 102058128 A CN102058128 A CN 102058128A
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Abstract
The invention discloses a formula of a Chinese medicinal oral solution and a process thereof. The oral solution is characterized by comprising the following raw materials in part by weight: 1 to 15 parts of weeping forsythia, 1 to 15 parts of almond, 3 to 29 parts of honeysuckle flower, 1 to 15 parts of astragalus, 1 to 20 parts of largehead atractylodes rhizome and 0.05 to 10 parts of codonopsis pilosula. A nutrient oral solution produced by the process is an anti-ageing medicament. In the process formula, a pure traditional Chinese medicine preparation is adopted and the process is refined and strict. A test indicates that the product is nontoxic, has no side effect and has remarkable curative effect by clinical application. In a main production method, the raw materials are soaked in low alcohol at a low temperature for multiple days, so that the aim of killing bacteria is fulfilled and active ingredients in a Chinese medicine preparation are prevented from losing.
Description
Technical field
The invention belongs to the pure field of Chinese medicines.Relate to a kind of nutrient solution, particularly a kind of nutrition oral administration and preparation method thereof.
Background technology
Be the most brilliant stage of life people in middle age, also is the stage that body falls into a decline.In life and work rhythm more and more faster today, the a middle-aged person is busy with work, looks after old man and children again in the family, often ignores rest, exercise and diet maintenance, therefore immunologic function usually is in imbalance state, is that cancer, coronary heart disease and cranial vascular disease etc. cause the dead crowd that easily sends out.The middle age early ageing, dying in youth becomes the problem of social concerns already.
The people is to old, though do not had society and family's pressure, body is obviously old and feeble.The many body hidden danger that accumulated by the middle age also begin to come out.The elderly's bone density obviously reduces, the cortex of bone attenuation, and bone toughness reduces, and easily fractures; Hypertension, cardiovascular and cerebrovascular disease, diabetes, tumour etc. become common complaint among the elderly; Forgetful, senile dementia, beard and hair bleach, alopecia, of flaccid muscles, skin kraurosis, pigmentation, the vestige in years such as senile plaque expelling occurs; Digestive function goes down, disease of digestive tract increases because smooth muscle atrophy, body of gland atrophy cause; Because the digestion power to fat reduces, synthetic hypofunction, blood fat rises, and becomes the multiple crowd of high fat of blood.
Investigation shows: with the degeneration of physical function, the elderly's mental hygiene, daily life function etc. all have a declining tendency with advancing age, and various diseases is comed one after another.Disease detection probability from middle-aged and old physical examinations of 50 years old-90 years old, this 10 big disease of coronary heart disease (ischemic), hypertension, hyperplasia of prostate, hyperlipemia, gall-bladder disease of biliary tract, cataract, cervical spondylopathy, diabetes, chronic bronchitis, chronic hepatitis and cirrhosis is having a strong impact on the elderly's daily life, and wherein the recall rate of coronary heart disease (ischemic), hypertension, 3 kinds of diseases of hyperplasia of prostate all meets or exceeds 30%.Expert advice the elderly is prevention and health care early, and carries out health exercising targetedly according to the physilogical characteristics of self.
Find that what the elderly was in sub-health state accounts for 67.2% for one at the investigation of " middle-aged and old multiple disease "; Crowd's ratio of suffering from various chronic diseases reaches more than 52%.According to another bibliographical information, along with socio-economic development, the process of aging population, chronic disease (cardiovascular disease, chronic obstructive disease of lung, malignant tumour, cerebral apoplexy, coronary heart disease, the diabetes etc.) incidence of disease is in rising trend.EPDML studies show that, Chronic Non-Communicable Diseases are the first reasons that the whole world causes death and disables.4 kinds of Chronic Non-Communicable Diseases such as hypertension, diabetes, coronary heart disease, cerebrovascular disease are just becoming the topmost disease of harm China the elderly.The harm of " slow four diseases " is serious day by day, and four kinds of diseases " jointly victimize " and especially need to cause enough attention.Hypertension is healthy " first killer " of harm the elderly, is the high risk factor that brings out important organ diseases such as the heart, brain, kidney.According to statistics, the cerebral infarction patient more than 80%, 90% cerebral hemorrhage patient have history of hypertension, and 62.9%～93.6% coronary disease patient has history of hypertension, and 40% diabetes patient suffers from hypertension simultaneously.The hemiplegia that China causes because of hypertension, dementia, plant person be up to 6,000,000 people, and the annual death toll that causes because of hypertension complication in the whole nation accounts for 41% of China's death toll up to 922.3 ten thousand people.It is reported that China's hypertension, onset diabetes rate reach 18.8% and 2.6% respectively, and the cardiovascular and cerebrovascular diseases death rate occupies first of various factors death rate ordering.The relevant expert points out that " slow four diseases " have become the healthy topmost public health problem of harm China the elderly, and scientific prevention and cure " slow four diseases " will become the vital task of healthy elder life in significant period of time from now on.
Recently, the World Health Organization announces that China's cerebral apoplexy (be commonly called as apoplexy, comprise hemorrhagic cerebral hemorrhage, ischemic cerebral thrombus or cerebral embolism) incidence of disease is 2,50/,100,000, occupies the second place of the world.The incidence of disease of cerebral apoplexy increases with advancing age, but in recent years, the morbidity of cerebral apoplexy has the trend of rejuvenation.Stroke onset is anxious, disables, death rate height, and people especially suffer from the elderly of cardiovascular and cerebrovascular disease, must enhance your vigilance to it.Cranial vascular disease has become the elderly's the important cause of the death now, and wherein half is sudden death.So relevant expert suggestion, the elderly must active treatment causes the source disease of apoplexy, as hypertension, high fat of blood, hyperglycaemia, heart disease etc.
Summary of the invention
The object of the present invention is to provide a kind of pure Chinese medicine auxotype anti-fatigue nutrient oral liquid that does not contain any chemical composition.
Technical scheme of the present invention: a kind of nutrition oral administration is characterized in that by the capsule of weeping forsythia, almond, honeysuckle, the bighead atractylodes rhizome, the Radix Astragali and Radix Codonopsis and aseptic deionized water formulated.
Nutrition oral administration of the present invention is characterized in that raw materials used parts by weight are: capsule of weeping forsythia 1-15, almond 1-15, honeysuckle 3-29, Radix Astragali 1-15, bighead atractylodes rhizome 1-20, Radix Codonopsis 0.05-10.
The method of nutrition oral administration of the present invention is characterized in that carrying out the following step according to above-mentioned various medicinal material proportionings:
The capsule of weeping forsythia, almond, honeysuckle, bighead atractylodes rhizome medicinal material after the washing impurity elimination, are soaked, and water extracts, and merges extract, filters, is concentrated into medicinal extract shape extract, refrigerates standby;
With Radix Astragali section, pulverizing back alcohol extracting, be concentrated into medicinal extract shape extract;
Above-mentioned two step gained medicinal extract are merged, with the aseptic deionized water dilution of the 40-80% that is equivalent to total medicinal material weight, the centrifugal post precipitation that goes, clear liquid adds the 0.05-10% Radix Codonopsis that is equivalent to total medicinal material weight;
In clear liquid, add aseptic deionized water 0.8-1.5 times again to total medicinal material weight, refrigerate 24 hours, filter, obtain clear and bright filtrate, in the aseptic bottle of packing into, every 10ml of loading amount.
Radix Astragali alcohol extracting of the present invention was adopted 30-85% medicinal alcohol cold soaking 24 hours, and the ethanol consumption is 3-6 a times of astragalus weight, and centrifugal branch removes slag, and the clear liquid decompression concentrates removes ethanol to medicinal extract shape extract.
Nutrition oral administration of the present invention, according to Chinese medicine data record and clinical practice as can be known monarch drug in a prescription be: almond, honeysuckle.Ministerial drug, adjutant: the bighead atractylodes rhizome and the Radix Astragali.
Almond: Xin Gan and temperature is promoting blood circulation wherein, the cold row stasis of blood of loosing, active ingredient: effects such as cassia oil, cinnaldehydrum: remove smooth muscle spasm; Antibiotic, antiviral; Diuresis; Antiallergy
Honeysuckle: clearing damp and promoting diuresis, strengthening the spleen and replenishing qi is calmed the nerves, active ingredient: honeysuckle triterpene etc., diuresis; Antibiotic; Antitumor; Calm raising immunity.
Ministerial drug, adjutant: the bighead atractylodes rhizome and Radix Astragali cooling blood to dissipate stasis, the relieving spasm to stop pain of regulating the flow of vital energy, active ingredient: its arduous trembling with fear such as Paeonol, promoting blood circulation and removing blood stasis, note of the ancient Chinese dissipating bind that disappears, the clear stagnant heat of holding concurrently.Has antibacterial action; Calm, bring down a fever; Step-down; Reduce capillary permeability, suppress platelet aggregation; Antihistamine.
The sweet tepor of the Radix Astragali, pair cell immunity and humoral immunity all have facilitation, can strengthen and engulf systemic-function, promote lymphocyte transformation, and inducing interferon generates.
Almond Xin Ganwen of the present invention goes into the heart, lung, urinary bladder channel, can declare logical heart-yang, the logical bladder of temperature, the hot stasis of blood of loosing to stagnate.Honeysuckle is sweet light, goes into the heart, spleen, urinary bladder channel, the energy invigorating spleen and nourishing heart, and capable water eliminates the phlegm.The disappear merit of note of the ancient Chinese of the flavor medicine capable water that activates yang of building together, stagnation resolvation is characterized in that eliminating evil the following stasis of blood is not just being hindered to consolidate, and row water is impairment of yin not, and negative and positive are taken into account, and qi and blood is also transferred, multisystem, multiregion ground regulation and control bodily fuctions, but focus on promoting blood circulation and removing blood stasis, Huan Xiao Disorder piece.Little dose, slow agent for the treatment syndrome of blood stasis.So can take for a long time by the course of treatment on the one hand, can be widely used in treatment syndrome of blood stasis disease on the other hand.
Nutrition oral administration of the present invention is fruit and the rhizome that adopts medicine, the dual-purpose medicinal material capsule of weeping forsythia of food, almond, honeysuckle, the bighead atractylodes rhizome and the Radix Astragali, forms through the scientific method refining refinement, does not contain synthetic, artificial color, artificial sweetening agent and alcohol.Have strong physique, strengthen body's immunity, can improve the body ability to work, enhance metabolism the normal person, eliminate fatigue, prolong aging, protecting liver and detoxication, strengthen cytoactive:, help to strengthen endurance, muscle power and operating efficiency to sportsman and heavy worker; To children, can improve the amino acid of people's bulk-growth necessity, have aid digestionly, improve a poor appetite; Can quicken rehabilitation to the weak and sick latter, strengthen immunity of organisms and function of detoxification, should make the health drink of chronic disease (as chronic hepatitis, cardiovascular and cerebrovascular disease) and chemotherapy (as cancer chemotherapy) person supplemental treatment.Therefore nutrition oral administration of the present invention goes for different crowds, and particularly ring has taking of diabetic.
Further specify good effect of the present invention below by elaboration to the animal experiment study of nutrition oral administration of the present invention:
One. improve body excitability and metabolic function-amobarbital sleep experiments
Totally 42 of mouse body weight 18-22g are divided into three groups, 14 every group, first group is the blank group, only gives physiological saline 0.4ml/20g body weight, and second group is low dose group, this product 0.25ml/20g body weight is irritated stomach and is taken, and the 3rd group is high dose group, this product 0.50ml/20g body weight, the filling stomach is taken, and each is organized in irritating stomach and took lumbar injection amobarbital 30mg/ μ g back 30 minutes, the length of one's sleep of every mouse, the result carries out statistical disposition in writing down every group.The results are shown in Table 1.
From table 1 result as seen, the dosage of this product 0.25 and 0.5ml/20g all can significantly shorten amobarbital length of one's sleep, compare low dose group P＜0.05 with control group, high dose group P＜0.01 shows that this product can significantly improve the excitability of body and quicken the metabolism of amobarbital.
Table 1 mouse amobarbital sleep experiments result
| Group | Number of animals (only) | Dosage＜ml/20g) | The length of one's sleep min | Rate of change % |
| Blank | 14 | 0 | 76±14 | 0 |
| Low dosage | 14 | 0.25 | 62±19 * | -18.4 |
| High dose | 14 | 0.50 | 45±15 ** | -40.8 |
* compare P＜0.05, * * P＜0.01 with control group
Two. build up health and endurance-swimming test
30 of mouse (body weight 20-22g) are divided into three groups, 10 every group.First group of blank, irritate stomach and take physiological saline 0.4ml/20g body weight, second group of nutrition oral administration 0.25ml/20g body weight, the 3rd group gavages nutrition oral administration 0.5ml/20g body weight, each is organized mouse and took back 30 minutes in irritating stomach, drop into water temperature and be in 20 ℃ the pond, write down swimming time (the sink to the bottom the time first time) data of every animal and carry out statistical disposition.Experimental result is as shown in table 2.The result shows: nutrition oral administration energy significant prolongation mouse swimming time, the effect that building up health is arranged and improve endurance.
The influence of table 2 pair mouse swimming test
| Group | Number of animals (only) | Dosage (m1/20g) | Swimming time min | Rate of change % |
| Blank | 10 | 0 | 182±43 | 0 |
| Low dosage | 10 | 0.25 | 242±67 * | +32.9 |
| High dose | 10 | 0.50 | 239±62 ** | +31.3 |
* compare P＜0.05, * * P＜0.01 with control group
The protecting liver and detoxication experiment
30 of normal mouses (body weight 20-22g) are divided into three groups, 10 every group.First group of blank irritated stomach every day and taken physiological saline once, continuous 7 days, second group is the pathology control group, irritate stomach hepatotoxicity wind agitation compound pyrimidine (SBM) three times, first and third day dosage is 200mg/kg, and dosage was 100mg/kg in the 6th day, the 3rd group is the treatment group, except that gavage SBM three times by the second prescription case, gavage the extract of nutrition oral administration every day, be equivalent to raw material 15g/kg, once a day, continuous 7 days.In the 8th day, three groups of mouse were all handled, and serum paddy third Cyklokapren (SGPT) is measured in blood sampling.
The results are shown in Table 4.
Above-mentioned experiment triplicate.From the visible this product of experimental result the hepatic injury that chemical substance causes there is therapeutic action, take this product continuously, can prevent that liver glycogen from reducing, increase total serum protein and albumin, reduce the serum Cyklokapren, promote liver cell regeneration, improve the toxic dose of hepatic injury material, serum paddy third Cyklokapren (SGPT) is significantly descended, reduce to normal level.
The influence of table 4 pair Mouse Liver function
△ and normal control group be P＜0.05 relatively, and * and pathology control group be P＜0.05 relatively
With Hepatoxic substance SBM half lethal dose (LD
50) be index, observe the variation of nutrition oral administration to the LD50 of SBM.The LD of the single usefulness of SBM
50Mouse is 1033mg/kg (LD
50) when a component thing of SBM and Qi stilbene benefit health drink share, SBM was at the LD of mouse
50Be 1193mg/kg, make the dosage of SBM increase by 15.3%.The constituent of proof nutrition oral administration has protective effect to death due to the Hepatoxic substance.
Toxicity test
This product does not show any toxic reaction to the oral 100ml/kg of mouse.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
Embodiment 1
(1) prescription consumption:
Capsule of weeping forsythia 500g, almond 500g, honeysuckle 500g, Radix Astragali 500g, bighead atractylodes rhizome 500g, Radix Codonopsis 50g.
(2) method for making:
By above-mentioned charge ratio just the capsule of weeping forsythia, almond, honeysuckle, bighead atractylodes rhizome medicinal material after the washing impurity elimination, add 30L, the immersion of 18L deionized water respectively, extract twice, twice filtrate merges, and is evaporated to proportion and is 1.25 medicinal extract, puts cold (below 4 ℃), 95% medicinal alcohol that adds the soup doubling dose, stir evenly and put low temperature (4 ℃-10 ℃) 24 hours, remove by filter sediment, filtrate decompression concentrates removes ethanol to medicinal extract shape extract.
2. the section of the 1000g Radix Astragali, pulverizing were added 8L 70% medicinal alcohol cold soaking 48 hours, centrifugal branch removes slag, and the clear liquid decompression concentrates, and removes ethanol to medicinal extract shape extract.
3. above-mentioned two step gained medicinal extract are merged, stir, add the aseptic deionized water dilution of 3.2L, (being that the 4000g medicinal material is made about 3200ml), refrigerate 24 hours, the centrifugal precipitation of going, final clear liquid adds Radix Codonopsis 50g, refrigeration is filtered, obtain clear and bright filtrate, in clear liquid, add aseptic deionized water again to 4000ml, pack in the aseptic bottle every 10ml of loading amount into.
Embodiment 2
(1) prescription consumption:
Capsule of weeping forsythia 800g, almond 800g, honeysuckle 800g, Radix Astragali 800g, bighead atractylodes rhizome 800g, Radix Codonopsis 80g
(2). method for making:
By above-mentioned charge ratio just the capsule of weeping forsythia, almond, honeysuckle, bighead atractylodes rhizome medicinal material after the washing impurity elimination, add 30L, the immersion of 18L deionized water respectively, extract twice, twice filtrate merges, and is evaporated to proportion and is 1.3 medicinal extract, puts cold (below 4 ℃), 75% medicinal alcohol that adds the soup doubling dose, stir evenly and put low temperature (4 ℃-10 ℃) 24 hours, remove by filter sediment, filtrate decompression concentrates removes ethanol to medicinal extract shape extract.
2. the section of the 1000g Radix Astragali, pulverizing were added 20L 70% medicinal alcohol cold soaking 48 hours, centrifugal branch removes slag, and the clear liquid decompression concentrates, and removes ethanol to medicinal extract shape extract.
3. above-mentioned two step gained medicinal extract are merged, stir, add the aseptic deionized water dilution of 5.2L, (being that the 5000g medicinal material is made about 3200ml), refrigerate 24 hours, the centrifugal precipitation of going, final clear liquid adds Radix Codonopsis 50g, refrigeration is filtered, obtain clear and bright filtrate, in clear liquid, add aseptic deionized water again to 4000ml, pack in the aseptic bottle every 10ml of loading amount into.
Embodiment 3
Prescription consumption: capsule of weeping forsythia 180g, almond 180g, honeysuckle 180g, Radix Astragali 180g, bighead atractylodes rhizome 180g, Radix Codonopsis 20g.Method for making is with embodiment 1.
Claims (4)
1. a nutrition oral administration is characterized in that by the capsule of weeping forsythia, almond, honeysuckle, the bighead atractylodes rhizome, the Radix Astragali and Radix Codonopsis and aseptic deionized water formulated.
2. nutrition oral administration according to claim 1 is characterized in that raw materials used parts by weight are: capsule of weeping forsythia 1-15, almond 1-15, honeysuckle 3-29, Radix Astragali 1-15, bighead atractylodes rhizome 1-20, Radix Codonopsis 0.05-10.
3. method for preparing claim 1,2 described nutrition oral administrations is characterized in that carrying out the following step according to above-mentioned various medicinal material proportionings:
(1) with the capsule of weeping forsythia, almond, honeysuckle, bighead atractylodes rhizome medicinal material after the washing impurity elimination, soak, water extracts, and merges extract, filters, is concentrated into medicinal extract shape extract, refrigerates standby;
(2) with Radix Astragali section, pulverizing back alcohol extracting, be concentrated into medicinal extract shape extract;
(3) above-mentioned two step gained medicinal extract are merged, with the aseptic deionized water dilution of the 40-80% that is equivalent to total medicinal material weight, the centrifugal post precipitation that goes, clear liquid adds the 0.05-10% Radix Codonopsis that is equivalent to total medicinal material weight;
(4) in clear liquid, add aseptic deionized water 0.8-1.5 times again to total medicinal material weight, refrigerate 24 hours, filter, obtain clear and bright filtrate, in the aseptic bottle of packing into, every 10ml of loading amount.
4. the preparation method of nutrition oral administration according to claim 3, it is characterized in that described Radix Astragali alcohol extracting, adopted 30-85% medicinal alcohol cold soaking 24 hours, the ethanol consumption is 3-6 a times of astragalus weight, centrifugal branch removes slag, and the clear liquid decompression concentrates removes ethanol to medicinal extract shape extract.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995332A (en) * | 2016-05-24 | 2016-10-12 | 南宁圣特生物科技有限公司 | Double flower drink and preparation method thereof |
| CN107485020A (en) * | 2017-08-18 | 2017-12-19 | 武汉华士特工业生物技术开发有限公司 | A kind of oral liquid with whitening function and preparation method thereof |
| CN112691591A (en) * | 2021-01-09 | 2021-04-23 | 黑龙江仁合堂药业有限责任公司 | Five-dimensional amino acid oral liquid and production device thereof |
-
2009
- 2009-11-16 CN CN200910228275XA patent/CN102058128A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995332A (en) * | 2016-05-24 | 2016-10-12 | 南宁圣特生物科技有限公司 | Double flower drink and preparation method thereof |
| CN107485020A (en) * | 2017-08-18 | 2017-12-19 | 武汉华士特工业生物技术开发有限公司 | A kind of oral liquid with whitening function and preparation method thereof |
| CN112691591A (en) * | 2021-01-09 | 2021-04-23 | 黑龙江仁合堂药业有限责任公司 | Five-dimensional amino acid oral liquid and production device thereof |
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Application publication date: 20110518 |