CN1330314C - 西地碘口含片 - Google Patents
西地碘口含片 Download PDFInfo
- Publication number
- CN1330314C CN1330314C CNB2004100003896A CN200410000389A CN1330314C CN 1330314 C CN1330314 C CN 1330314C CN B2004100003896 A CNB2004100003896 A CN B2004100003896A CN 200410000389 A CN200410000389 A CN 200410000389A CN 1330314 C CN1330314 C CN 1330314C
- Authority
- CN
- China
- Prior art keywords
- ground
- brain
- west
- cydiodine
- iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 5
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 35
- 239000011630 iodine Substances 0.000 claims abstract description 35
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 20
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 11
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 11
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 6
- 239000008101 lactose Substances 0.000 claims abstract description 6
- 239000003826 tablet Substances 0.000 claims description 20
- 210000004556 brain Anatomy 0.000 claims description 11
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000007605 air drying Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000009413 insulation Methods 0.000 claims description 2
- 239000012047 saturated solution Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 51
- 239000011230 binding agent Substances 0.000 description 5
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 229950005162 benexate Drugs 0.000 description 2
- IAXUQWSLRKIRFR-SAABIXHNSA-N chembl2104696 Chemical compound C1C[C@@H](CNC(=N)N)CC[C@@H]1C(=O)OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 IAXUQWSLRKIRFR-SAABIXHNSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 208000029951 Laryngeal disease Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 208000009019 Pericoronitis Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
| 批号 | 0月碘含量(％) | 三个月碘含量(％) | |
| 实验一 | 0307052 | 103.1 | 52.6 |
| 0307062 | 104.8 | 53.9 | |
| 0307072 | 100.4 | 59.8 | |
| 实验二 | 0307051 | 106.1 | 95.4 |
| 0307061 | 104.7 | 96.0 | |
| 0307071 | 105.7 | 95.2 |
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100003896A CN1330314C (zh) | 2004-01-13 | 2004-01-13 | 西地碘口含片 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100003896A CN1330314C (zh) | 2004-01-13 | 2004-01-13 | 西地碘口含片 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1640412A CN1640412A (zh) | 2005-07-20 |
| CN1330314C true CN1330314C (zh) | 2007-08-08 |
Family
ID=34866740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100003896A Expired - Lifetime CN1330314C (zh) | 2004-01-13 | 2004-01-13 | 西地碘口含片 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1330314C (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049099A (zh) * | 1990-08-16 | 1991-02-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 复方西地碘口含片及其制备方法 |
| CN1166340A (zh) * | 1996-05-28 | 1997-12-03 | 中国人民解放军九五三三工厂 | 防治牙病药片制造工艺方法 |
| CN1203792A (zh) * | 1997-06-02 | 1999-01-06 | 张志宏 | 复方聚维酮碘口含片 |
-
2004
- 2004-01-13 CN CNB2004100003896A patent/CN1330314C/zh not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049099A (zh) * | 1990-08-16 | 1991-02-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 复方西地碘口含片及其制备方法 |
| CN1166340A (zh) * | 1996-05-28 | 1997-12-03 | 中国人民解放军九五三三工厂 | 防治牙病药片制造工艺方法 |
| CN1203792A (zh) * | 1997-06-02 | 1999-01-06 | 张志宏 | 复方聚维酮碘口含片 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1640412A (zh) | 2005-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: ZHEJIANG LISHUI ZHONGYI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHONGYI PHARMACEUTICAL INDUSTRY CO., LTD. Effective date: 20070928 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20070928 Address after: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee after: ZHEJIANG LISHUI ZHONGYI PHARMACEUTICAL Co.,Ltd. Address before: 321007 Zhejiang province Jinhua Bada big industrial zone Mount Huangshan Road No. 328 Patentee before: Zhejiang Zhongyi Pharmaceutical Co.,Ltd. |
|
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Beijing Hwellso Pharmaceutical Co.,Ltd. Assignor: Zhejiang Lishui Zhongyi Pharmaceutical Co.,Ltd. Contract fulfillment period: 2008.4.14 to 2024.1.13 Contract record no.: 2008990000071 Denomination of invention: Process for preparing buccal lozenge contg. compound sede-iodine Granted publication date: 20070808 License type: General permission Record date: 20080415 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: COMMON LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.4.14 TO 2024.1.13 Name of requester: BEIJING WALSALL PHARMACEUTICAL CO., LTD. Effective date: 20080415 |
|
| C56 | Change in the name or address of the patentee |
Owner name: ZHEJIANG ZHONGYI PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: ZHEJIANG LISHUI ZHONGYI PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee after: ZHEJIANG ZHONGYI PHARMACEUTICAL Co.,Ltd. Address before: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee before: Zhejiang Lishui Zhongyi Pharmaceutical Co.,Ltd. |
|
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee after: Zhejiang Zhongyi Pharmaceutical Co.,Ltd. Address before: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee before: ZHEJIANG ZHONGYI PHARMACEUTICAL Co.,Ltd. |
|
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee after: ZHEJIANG CHINA RESOURCES SANJIU ZHONGYI PHARMACEUTICAL CO.,LTD. Address before: No. 279 road 323000 Zhejiang Green Valley City of Lishui province Shuige Industrial Zone Patentee before: Zhejiang Zhongyi Pharmaceutical Co.,Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20070808 |
|
| CX01 | Expiry of patent term |