CN1321498A - Medicine for curing acne and sore - Google Patents

Abstract

A Chinese medicine for curing comedo and dark sore is made up by using (by weight portion) 2-10 portions of ginseng, 8-15 portions of mulberry root bark, 8-15 portions of dried/fresh rehmannia, 10-18 portions of scutellaria root, 15-25 portions of licorice, 24-36 portions of rhubarb and 7-15 portions of pearl, and can be made into various dosage forms according to the conventional Chinese medicine preparation process. Said invented medicine can be used for oral medication, also can be used for external application; if the said medicine is taken in, it possesses the functions of clearing away heat, removing toxic material, supplementing vacuity, transforming stasis, regulating gastrointestinal function, fortifying spleen and coursing liver; if the said medicine is used for external application, it possesses the actions of nourishing skin and face, inhibiting growth of pathogenic bacteria, stopping pain and promoting growth of new tissues.

Description

A kind of medicine for the treatment of acne and sore

The present invention relates to field of medicaments, specifically provide a kind of medicine of the treatment acne and sore of making by Chinese medicine medicines.

Pimples, the formal name used at school acne, be commonly called as acne, clinical symptoms is the hair follicle pimple, and color is red on every side, being extruded with grain of rice sample white fat bolt discharges, deal with improperly and can cause the top that pimple takes place, form abscess, cyst shape skin sore, uncomfortable, get angry red and swollen pustule shape skin sore also also takes place, as a kind of beauty treatment disease, perplexing people for a long time, the conscious pruritus of patient, pain, this course of disease is touching, often down here, the new continuous secondary of rash, ulceration recovery from illness back is the chromogenesis calmness easily, or forms the cicatrix of a plurality of sinus tracts and depression, corse sweat pore, severe patient are the Pericarpium Citri tangerinae face.For this disease, more existing in the market medicines, external is as " acne are clean ", for oral administration as " PAIDU YANGYAN JIAONANG " etc., these medicines have contains chemical constituent, and toxic side effect is easily irritated, the mostly produce effects of pure Chinese medicinal preparation is slow, easily repeatedly, need take for a long time after the drug withdrawal; Treating residual cicatrix in addition roughly adopts the mill pico farad and fills and leads up method, this dual mode all needs the doctor with superb medical skill to operate, expense costliness, and mill skin art infringement normal skin, easily allergy and chromogenesis precipitation, if medical skill of poor quality more can cause melanosis, be difficult to eliminate again, can not produce above-mentioned consequence though fill and lead up art, living cells of inserting and elastin are not somas, slowly absorbed the back cicatrix and still can be revealed, do not reached the purpose of thorough radical cure.

Purpose of the present invention is intended to overcome above-mentioned defective, utilize the traditional traditional Chinese medical science theory of visceral outward manifestation of China, set about from the conditioning human-body viscera function, selected Chinese medicine medicines, provide a kind of can be inside and outside with fast, difficult repeatedly with, produce effects, as can thoroughly to effect a radical cure acne and sore medicine with the back.

The objective of the invention is to be achieved through the following technical solutions, a kind of medicine for the treatment of the skin sore acne, it is by (by weight) Radix Ginseng 2-10 part, Cortex Mori 8-15 part, Radix Rehmanniae 8-15 part, Radix Scutellariae 10-18 part, Radix Glycyrrhizae 15-25 part, Radix Et Rhizoma Rhei 24-36 part, the medicament that Margarita 7-15 part is made according to the conventional preparation technology of Chinese medicine.

The preferred version of each set of dispense ratio is among the present invention, (by weight) Radix Ginseng 3-8 part, Cortex Mori 9-12 part, Radix Rehmanniae 9-12 part, Radix Scutellariae 12-16 part, Radix Glycyrrhizae 18-23 part, Radix Et Rhizoma Rhei 27-32 part, Margarita 8-12 part.

The best preferred version of each set of dispense ratio is among the present invention, 5 parts of (by weight) Radix Ginsengs, 10 parts of Cortex Mori, 10 parts in the Radix Rehmanniae, 15 parts of Radix Scutellariaes, 20 parts in Radix Glycyrrhizae, 30 parts of Radix Et Rhizoma Rhei, 10 parts of Margaritas.

Chinese medicine is thought, though cosmetic problem betides body surface, witness is in a certain part of skin, but human body is a complete unified system, skin problem is inevitable to have certain relation with visceral dysfunction, " element ask the most pure virginity will discuss greatly " order: " all sufferings skin ulcers all belong to the heart "." surgery opens profound bright skin infection constipation opinion " said: " skin infection generally, all by the five internal organs discord, six internal organs are stopped up stagnant, then make passages through which vital energy circulates obstructed and here give birth to ".So no matter be that depression of liver-QI, the lung-heat epidemic disease stasis of blood, damp-heat in the spleen and stomach fire-toxin or the intestines and stomach steam " wet, the heat " that causes damp and hot accumulateing, all can reach in face and cause acne, skin sore, the selected all functions of tool accent taste, removing pathogenic heat from blood and toxic substance from the body, clearing away heat and eliminating dampness purging FU-organs of Chinese medicine of respectively distinguishing the flavor of of the present invention, its pharmacological property is:

Radix Ginseng, property is sweet, warm, returns spleen, lung meridian, invigorating primordial QI, strengthening spleen and lung, the beneficial blood that promotes the production of body fluid cure mainly diseases such as deficiency of spleen-QI and stomach-QI, change source deficiency, blood deficiency and yellow complexion, and record " main five kinds of strain and seven kinds of impairment; deficient thin and weak ... tonifying five ZANG-organs six internal organs is kept god among the guarantor " is big tonic in " property of medicine book on Chinese herbal medicine ".

Cortex Mori, the property sweet, cold, return lung, the effect that eliminating pathogen from the lung for relieving asthma, line water detumescence are arranged, can be used to treat lung-fire pent-up, QI rising in reverse order do not fall due to lung-heat and lung qi stop up disease real, insufficiency of the spleen leading to overabundance of dampness, do the animal experiment with rabbit, decoct is irritated stomach (2g/kg), and voided volume and oxide thereof all have significantly in 6 hours increases.

The Radix Rehmanniae has another name called Radix Rehmanniae, and property is sweet, bitter, cold, GUIXIN, liver, kidney channel have the only effect of heat of clearing away heat-fire, removing heat from blood, because of it has the diffusing power of row concurrently, hemostasis does not have the fraud of staying the stasis of blood, can be used for treating diseases such as the heat in blood poison is contained, the macule purple is black, record in " herbal classic " " the main folding fallen exhausted muscle, damaging the spleen and stomach; by arthralgia due to stagnation of blood; fill out bone marrow, longue meat " experimental results show that the extract of Radix Rehmanniae has inhibitory action to dermatophytes.

Radix Scutellariae, property hardship, cold is returned lung, stomach, gallbladder, intestinal warp, and the effect of heat clearing and damp drying, eliminating fire and detoxication is arranged, with Cortex Mori with controlling lung-fire, can control pathogenic fire,toxin and furuncles with Radix Rehmanniae compatibility, " herbal classic " note " main all hot jaundice, intestinal is warded off and is let out dysentery ... the malignant boil cellulitis is lost acute scleritis "; " book on Chinese herbal medicine just " state " fire of the clear part of the body cavity above the diaphragm housing the heart and lungs of withered person, the expectorant promoting the circulation of QI ... treat pulmonary fistula, acute mastitis carbuncle on the back, the heat of flesh table of dispelling especially is so control macule ".Do the in-vitro antibacterial test with Radix Scutellariae, be broad-spectrum antibacterial action, the skin pathogenicity fungus is had inhibitory action, zoopery shows can suppress anaphylaxis edema and inflammatory reaction, reduces vascular permeability.

Radix Glycyrrhizae, property is sweet, flat, and GUIXIN, lung, spleen channel have the QI invigorating invigorating middle warmer, and the effect of detoxifcation pain relieving can be used for treating multiple deficiency of vital energy disease, and " herbal classic " says " long muscles, times strength, incised wound is swollen, detoxifies for main vital organs of the human body cold and heat pathogen, hard muscles and bones ".Modern study shows that Radix Glycyrrhizae not only can suppress pathogen growth, and ulcer surface is had significant protective effect.

Radix Et Rhizoma Rhei, property hardship, cold is returned spleen, stomach, intestinal warp, and having purges heat relieves inflammation or internal heat, the effect of removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, be used for the treatment of that fire-toxin is flourishing, qi stagnation hemagglutination and send out the disease of furuncle carbuncle, record in " property of medicine book on Chinese herbal medicine " " logical woman is through waiting, and diuretic is swollen; paste hot toxic swelling, the time disease dysphoria with smothery sensation, erosion pus ".Experimental results show that Radix Et Rhizoma Rhei extract can suppress nucleic acid and the protein synthesis of antibacterial.

Margarita is generally acknowledged cosmetic good merchantable brand, and Orally taken and externally all can, the property sweet, become, cold, GUIXIN, Liver Channel, the treatment skin ulcer of can detoxifying again can promoting tissue regeneration and ulcer healing, can be used for treating the skin infection diseases such as not holding back, rot to swell and ache of bursting for a long time, " Kaibao Bencao " says " relieving palpitation removes skin cataracta film ", and " book on Chinese herbal medicine converges and says " says " poison unhitches; change malignant boil, receives the internal ulceration junk ".Experiment shows that Margarita also has anti-allergic effects.

The present invention is according to Chinese Chinese medicine theory, long-pending clinical practice for many years, according to the principle of curing the disease and to effect a permanent cure, from heat-clearing and toxic substances removing, tonify deficiency blood stasis dispelling staff, selected Chinese medicine medicines, regulating gastointestinal, spleen invigorating soothing liver-QI, make the whole body internal organs be in normal running status, the interior stagnation of QI fire-toxin of reason body is not attacked in body surface and is caused acne and sore; Moreover, according to the reason of the treatment by oral administration of medicines of Chinese medicine is that reason, the treatment by oral administration of medicines medicine of external treatment is external treatment medicine scheduling theory, the present invention can be inside and outside with using, outer time spent medicine is by the infiltration and the Absorption of facial point skin, messenger drug is along with the through sick institute of meridians blood vessels, utilize the reason of the described blood stasis dispelling erosion of the property of medicine of respectively distinguishing the flavor of pus, pain relieving granulation promoting and suppress the effect that pathogenic bacteria grows, reach the effect that detumescence and promoting granulation removes trace; Medicine of the present invention can improve the blood of human body circulation, quicken metabolism, outside interior supporting, inside and outside rule together, make skin obtain best maintenance, reach delicate, slick skin care effect, and this product component is less, compatibility is reasonable, and is without any side effects, is a kind of medicine of comparatively ideal treatment acne and sore.

Provide specific embodiment below, be used for further specifying enforcement of the present invention and application.

Embodiment 1, gets Radix Ginseng 20g, Cortex Mori 80g, Radix Rehmanniae 80g, Radix Scutellariae 100g, Radix Glycyrrhizae 150g, Radix Et Rhizoma Rhei 240g, Margarita 70g, above-mentioned Chinese crude drug washes, remove impurity, pulverize, cross dusting cover, mix, produce extracting solution according to the conventional processing technology of Chinese medicine, make water preparation, pack by the 150ml/ bottle and get final product.

Embodiment 2, get Radix Ginseng 100g, Cortex Mori 150g, Radix Rehmanniae 150g, Radix Scutellariae 180g, Radix Glycyrrhizae 250g, Radix Et Rhizoma Rhei 360g, Margarita 150g washes, and removes impurity, pulverize, cross dusting cover, mixing is made powder according to the conventional processing technology of Chinese medicine, packs by 6g/ to get final product.

Embodiment 3, get Radix Ginseng 30g, Cortex Mori 90g, Radix Rehmanniae 90g.Radix Scutellariae 120g, Radix Glycyrrhizae 180g, Radix Et Rhizoma Rhei 270g, Margarita 80g, above-mentioned Chinese crude drug washes, remove impurity, pulverize, cross dusting cover, mix, according to the conventional processing technology of Chinese medicine, add the honeyed pill that an amount of drug excipient (as Mel) is made heavily about 10g, or the sublimed preparation of 0.1-0.3g, packing gets final product.

Embodiment 4, get Radix Ginseng 80g, Cortex Mori 120g, Radix Rehmanniae 120g, Radix Scutellariae 160g, Radix Glycyrrhizae 230g, Radix Et Rhizoma Rhei 320g, Margarita 120g cleans, and removes impurity, pulverize, cross dusting cover, mix, make granular powder according to the conventional processing technology of Chinese medicine then, be made into capsulation by the 0.3g/ grain and get final product.

Embodiment 5, get Radix Ginseng 50g, Cortex Mori 100g, Radix Rehmanniae 100g, Radix Scutellariae 150g, Radix Glycyrrhizae 200g, Radix Et Rhizoma Rhei 300g, Margarita 100g, above-mentioned Chinese crude drug washes, and removes impurity, pulverize, cross dusting cover, mixing is made water preparation according to the conventional processing technology of Chinese medicine then, packs by the 100ml/ bottle to get final product.

Toxicity and anaphylaxis experiment:

1, toxicity test:

Select 10 of the white mice (each 5 of male and female) of body weight 18-22g; get powder medicine 10g of the present invention; adding distil water is made concentrated solution 15ml; every white mice gives concentrated solution 0.25ml filling stomach, twice of every day (5 hours at interval), observed 10 days; all healthy existence of white mice; do not have any toxicity, anatomic observation hemogram, liver function, each organs and tissues form compare zero difference with common matched group.

This medicine, is equivalent to clinical adult and estimates more than 100 times of consumption at 16500mg/kg the oral maximum tolerated dose of white mice, experimental results show that the present invention is nontoxic, without any side effects.

2, anaphylaxis experiment:

Select 10 of the white rabbit (each 5 of male and female) of 1-2kg, family's rabbit back unhairing is exposed exocuticle, unhairing scope 3cm * 3cm gets water preparation medicine 20ml of the present invention, spreads upon on the exocuticle of rabbit, keep smearing again once after 12 hours, observed 10 days, the allergic experiment of reforming a time after 10 days is at interval observed after twice experiment, do not find erythema on the exocuticle, rabbit appetite, breathing, the colour of skin all do not have any unusual.

Experiment showed, that the reflection of the present invention's skin of outer time spent is normal, no sensitization phenomenon.

Clinical observation material of the present invention is provided below:

1, physical data: use this product to treat several thousand routine patients for many years, stochastic sampling 1752 examples, women's 1438 examples wherein, male's 314 examples, 25.7 years old mean age, minimum 14 years old, maximum 35 years old, site of disease was in the majority with face, mostly show as facial easily fecula thorn, skin sore redness (weight person grows in flakes), corse sweat pore, the individual patient local skin improperly is black speck for Pericarpium Citri tangerinae shape and color because of pushing.

2, administrated method: use this product oral, pill 1-2 every day ball, powder 2-3 every day bag, other dosage forms are increase and decrease as one feels fit, and 10 days is a course of treatment; Use the direct external application of water preparation of this product, every day at initial stage, each once changed into once a day after redness disappears and takes off sooner or later, cooperated massage better during wiping, grew up because of the massage Ethylene, can fill up pothole as quickly as possible, the desalination cicatrix, and external 15 days was a course of treatment.

Diet is not avoided during the medication, but if few food is hot, the thing of raw meat, curative effect is more remarkable.

3, observation of curative effect standard:

Cure: after treatment, original acne or skin sore absorb fully, and the blood stasis point of leaving over because of acne (pigmentation) absorbs wholly or in part, and skin is level and smooth, no longer include newborn acne herpes and occur, and no recidivist cures in 3 months through following up a case by regular visits to.

Produce effects: after treatment, original acne absorbs fully, and red and swollen skin sore disappears and takes off, and the blood stasis point of leaving over (pigmentation) absorbs not exclusively, and the corse sweat pore phenomenon has improvement greatly, and the skin trend is level and smooth, no longer includes newborn skin sore herpes and occurs.

Effectively: after treatment for several times, original acne pimple begins to soften, absorb, the skin sore detumescence, skin is smooth gradually, bleach, and newborn acne quantity significantly reduces or no longer includes newborn skin sore and occurs, and the women can continue to first menstrual phase of treatment back and arrive, outburst person is not taken place, for effectively.

Invalid: after 2-5 the course of treatment, original acne pimple does not see and absorbs or absorb relatively poor that detumescence slowly, and have newborn acne, skin sore to occur simultaneously, or after treatment effectively, before women's menstruation first, still have large tracts of land acne pimple outburst phenomenon to occur, and the erubescence person is for invalid.

4, result:

Therapeutic outcome shows that Most patients uses this product after a course of treatment tangible sensation to be arranged promptly, and acne diminish and are difficult for taking place head infection and become the pustule sample, and skin sore takes off red detumescence in the short time; After adhering to using three courses of treatment, symptom the lighter can cure fully, the skin smooth delicacy, residual pigment spot also disappears and takes off no shadow, do not recur, the heavier person of symptom, acne and sore is most of to disappear, residual mottle color desalination, the pore convergence attenuates, and the peripheral outline of dark cicatrix thickens, and the degree of depth shoals, after this part patient treated two to three courses of treatment again, cure rate can reach 95%; After individual patient was used, the skin sore detumescence slowly had new acne growth, adheres to using three courses of treatment, and facial sick place just has improvement slightly, and it is invalid to think.

Data shows that this medicine is interior with roughly suitable with the length course of treatment of external, can treat according to individual's skin and the difference of disease weight, but inside and outside dual-purpose effect is remarkable.

The data statistics result: 1752 examples of sampling, wherein cure 1587 examples (accounting for 90.58%), produce effects 104 examples (accounting for 5.94%), effective 45 examples (accounting for 2.57%), invalid 16 examples (accounting for 0.91%), total effective rate reaches 99%.

Be the model case reference below:

1, in * *, woman, 26 years old, the white collar worker of overseas-funded enterprise, the readme adolescence rises and begins long acne, and is constant, after working, for keeping tender good image, the raw meat of dare not having a meat diet, but effect is bad, and because of work strain, making up, it is frequent to change the makeup, the existing part of facial acne plays pustule, and skin sore takes place frequently, and worries endlessly, adopt medicine of the present invention to treat, oral administration and externally was observed after 10 days, the pustule head peeling of having formed a scab, skin sore is red and swollen to disappear, and newborn acne reduces, and treats after 15 days again and observes, pustule and skin sore impression all disappear, only Sheng minority acne is withered and here is diminished, and skin smooth is delicate, and conscious god cools down refreshing, the he or she adheres to after treatment in 10 days again, cure fully, also remain dormant before and after the menstrual phase, follow the tracks of to follow up a case by regular visits to and do not recur in three months.

2, Miss Huang, 20 years old, on the occasion of adolescence, facial acne is the large tracts of land fulminant, irascible temperament, often extruding carelessly, when coming inquiring, whole Blushing, many places pustule skin sore, according to her state of an illness, at first adopted the internal treatment during treatment, advise its secondary to take this medicine every day on time, especially morning suitable (medicine) being taken before meal usefulness, avoid pungent food, clear water washes one's face, need not any soap and cosmetics, observe the flush sx after the course of treatment, the readme free movement of the bowels, refreshing skin care is light, increases external application for curing to it then, massages 1 hour at every turn, after the course of treatment (15 days), pustule all incrustation comes off, and skin sore only stays red impression, after two courses of treatment of ruling together inside and outside again, see its face, recovered original delicate skin, residual cicatrix soft edge, the patient has carried out the external application massage treatment of a course of treatment again, because the effect of medicine adds that the young skin growth metabolism is very fast, cure fully, skin is ruddy pale, smooth and flexible.This patient symptom is heavier, from inquiring to cure only used five the course of treatment about two wheat harvesting periods time, therapeutic effect is very satisfied.

3, Tan *, the man, 22 years old, whole face " youth beautiful pimple pox " also had red pox growth on the neck, use this product oral medicine, and the back that washes one's face every night is outer wipes water aqua type medicine of the present invention, obviously took effect after 20 days." pimple pox " reduces, and redness disappears and takes off, treat 30 days again after, facial skin ulcer bleb disappears substantially, the cicatrix soft edge is extremely smooth.Follow the tracks of and followed up a case by regular visits in two months, except that the excessive initiation minority skin sore of once drinking, not recurrence again.

4, Ms Zhang, the woman, 33 years old, the middle level leader of business unit, the work dinner party is many, it is vexatious to get angry, and causes often long on the face skin sore, scorching hot, pain, add crowded at an early age acne and stay a lot of cicatrixes, facial coarse lackluster, to its this medicine for oral administration, twice of every day, morning, (medicine) being taken before meal was used, advise its every day the court of finding time to do cleaning skin, this liquid medicine of external application agent massage nursing then, the patient adheres to having treated after two months, sees its people again, skin sore all disappears and takes off, the cicatrix desalination, skin is ruddy level and smooth, laughs to say to seem young 10 years old.

Claims (4)

1, a kind of medicine for the treatment of acne and sore, it is made up of following component, comprises (by weight) Radix Ginseng 2-10 part, Cortex Mori 8-15 part, Radix Rehmanniae 8-15 part, Radix Scutellariae 10-18 part, Radix Glycyrrhizae 15-25 part, Radix Et Rhizoma Rhei 24-36 part, Margarita 7-15 part.

2, according to the described a kind of medicine for the treatment of acne and sore of claim 1, it is characterized in that, each component contain the most (by weight) Radix Ginseng 3-8 part, Cortex Mori 9-12 part, Radix Rehmanniae 9-12 part, Radix Scutellariae 12-16 part, Radix Glycyrrhizae 18-23 part, Radix Et Rhizoma Rhei 27-32 part, Margarita 8-12 part.

According to the described a kind of medicine for the treatment of acne and sore of claim 1, it is characterized in that 3, each components contents is 5 parts of (by weight) Radix Ginsengs, 10 parts of Cortex Mori, 10 parts in the Radix Rehmanniae, 15 parts of Radix Scutellariaes, 20 parts in Radix Glycyrrhizae, 30 parts of Radix Et Rhizoma Rhei, 10 parts of Margaritas.

According to claim 1 or 2 or 3 described a kind of medicines for the treatment of acne and sore, it is characterized in that 4, described medicine is any pharmaceutical formulation of making according to the conventional preparation technology of Chinese medicine.