CN1320900C - Bone erosion renewel pill - Google Patents
Bone erosion renewel pill Download PDFInfo
- Publication number
- CN1320900C CN1320900C CNB2005100174822A CN200510017482A CN1320900C CN 1320900 C CN1320900 C CN 1320900C CN B2005100174822 A CNB2005100174822 A CN B2005100174822A CN 200510017482 A CN200510017482 A CN 200510017482A CN 1320900 C CN1320900 C CN 1320900C
- Authority
- CN
- China
- Prior art keywords
- shares
- root
- radix
- pill
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000006187 pill Substances 0.000 title claims abstract description 13
- 206010051728 Bone erosion Diseases 0.000 title abstract description 3
- 239000009636 Huang Qi Substances 0.000 claims abstract description 6
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 6
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 208000007875 Femur Head Necrosis Diseases 0.000 claims description 12
- 206010031264 Osteonecrosis Diseases 0.000 claims description 8
- 241000756943 Codonopsis Species 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 5
- 241000283956 Manis Species 0.000 claims description 5
- 241001057584 Myrrha Species 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 abstract description 21
- 239000008280 blood Substances 0.000 abstract description 21
- 230000017531 blood circulation Effects 0.000 abstract description 17
- 230000001737 promoting effect Effects 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 210000004185 liver Anatomy 0.000 abstract description 7
- 210000003734 kidney Anatomy 0.000 abstract description 6
- 230000008030 elimination Effects 0.000 abstract description 2
- 238000003379 elimination reaction Methods 0.000 abstract description 2
- 230000002787 reinforcement Effects 0.000 abstract description 2
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 abstract 1
- 241000427159 Achyranthes Species 0.000 abstract 1
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 240000000425 Chaenomeles speciosa Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241000208688 Eucommia Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 241000283966 Pholidota <mammal> Species 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000001338 necrotic effect Effects 0.000 abstract 1
- 244000132619 red sage Species 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 39
- 229940079593 drug Drugs 0.000 description 17
- 210000003128 head Anatomy 0.000 description 12
- 239000000843 powder Substances 0.000 description 12
- 210000000988 bone and bone Anatomy 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 210000003205 muscle Anatomy 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 210000001624 hip Anatomy 0.000 description 3
- 210000004394 hip joint Anatomy 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000037273 Pathologic Processes Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940121657 clinical drug Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 238000003305 oral gavage Methods 0.000 description 2
- 230000009054 pathological process Effects 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- -1 sieve Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010002027 Amyotrophy Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000034657 Convalescence Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 241001446509 Psoralea Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 208000037873 arthrodesis Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000011981 development test Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007119 pathological manifestation Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001612 separation test Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001694 thigh bone Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Abstract
The present invention relates to a bone erosion regeneration pill which is characterized in that the pill is prepared from the following raw materials of the proportion by weight: 89 to 93 shares of angelica, 86 to 90 shares of danshen root, 72 to 76 shares of eucommia bark, 74 to 80 shares of slenderstyle acanthopanax bark, 76 to 80 shares of common floweringquince fruit, 60 to 65 shares of pangolin scale, 74 to 78 shares of himalayan teasel root, 58 to 64 of safflower, 59 to 64 shares of suberect spatholobus stem, 60 to 65 shares of notoginseng, 58 to 64 shares of myrrh, 60 to 65 shares of pilose asiabell root, 60 to 64 shares of largehead atractylodesrhizome, 60 to 65 shares of membranous milkvetch root and 58 to 63 shares of twotooth achyranthes root. The present invention has the functions of promoting blood circulation for removing blood stasis, tonifying the liver and the kidneys, benefiting qi, nourishing the blood, reinforcement and elimination in combination, and treating both manifestation and root of diseases, and mainly improves the stagnation of blood stasis of necrotic femoral heads.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine, relate to a kind of pill (bone erosion renewel pill) that is used for the treatment of osteonecrosis, ischemic necrosis of femoral head specifically.
Background technology
Ischemic necrosis of femoral head is meant because the different causes of disease causes capital disturbance of blood circulation, makes femoral head that the pathological process of part or completeness ischemia take place.This patient is more common in 30-50 year, and has half to involve bilateral femoral head.Motherland's medical science is thought, ischemic necrosis of femoral head belongs to " osteomyelitis " category, its main pathogenesis is that caused by liver and kidney deficiency, qi depression to blood stasis, bone lose and moisten fosterly, or hindered by violence, or the infection excessive QI, or sexual strain, or the natural endowment deficiency, its clinical manifestation is symptoms such as the hip arthralgia, limping, function limitation, lower limb muscles atrophy, until the forfeiture self care ability, its course of disease is long, disability rate is high, brings huge misery to the patient.
Femur head necrosis has become current orthopaedics commonly encountered diseases, also is one of world's orthopaedics three big difficult and complicated illness.Owing to after the collapse of the femoral head distortion, often cause the hip joint handicap, therefore more and more be subjected to the attention of medical circle.At present, the comparatively popular method of western medical treatment primary disease mainly is an operative treatment, and be broadly divided into following two classes: (1) improves the femoral head blood supply: implement synovectomy, core decompression art, vessel pedicle ilium transplantation, vascular bundle implantation; (2) improve the mortar head and contain, improve the femoral head at weight loading position: as distinguishing osteotomy, shelf operation of hip joint between the femoral head rotor.Other is also being accepted by people gradually as artificial femoral head replacement, replacement of total hip, arthrodesis etc.Above-mentioned various operation all is to reach different curative effects by different means, and clinical manifestation is that the patient is movable better, ambulation in early days, and the hospital stays is shorter.But postoperative is prone to complication such as collapse of the femoral head, the loosening dislocation of artificial thigh bone, cervical region fracture and infection, and is difficult to remedy.Therefore, the patient has doubt more before the art, even can suffer that the patient refuses.
Modern medicine is thought: femur head necrosis is the downright bad caused pathological process of active component (osteocyte, medullary cell and adipose cell) of bone, but up to the present still can not determine the definite reason that causes primary disease.General think relevant with the wound of hip joint, some drugs (as adrenocortical hormone), multiple disease, chronic alcoholism etc. more.The common pathological manifestations of femur head necrosis is the unusual of the femoral head disturbance of blood circulation that caused by a variety of causes and joint stress.Motherland's medical science extensive knowledge and profound scholarship, aboundresources, people-oriented, utilizes motherland's traditional medicine, adopts the non-operative treatment ischemic necrosis of femoral head, and expense is lower, and no pain, and treating both the principal and secondary aspects of a disease has caused the great attention of medical circle in recent years, and has obtained gratifying achievement.Clinical pharmacology studies show that: Chinese medicine is applicable to the overall process of primary disease treatment, and its effect comprises the blood circulation that improves bone, and blood flow increasing reduces intra-osteal pressure, and anticoagulant alleviates the osteonecrosis degree, promotes effects such as osteonecrosis reparation.Current research finds that also Chinese medicine also has the angiogenic growth of promotion and the effect of protection circulation.
Summary of the invention
Purpose of the present invention provides a kind of just on the basis of above-mentioned Chinese medicine research be the pill that is used to be used for the treatment of osteonecrosis, ischemic necrosis of femoral head of the rule of treatment with blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, reinforcing the kidney to strengthen the bone.
Purpose of the present invention can realize by following measure:
Raw materials of effective components is formed and weight portion is: Radix Angelicae Sinensis 89-93 part, Radix Salviae Miltiorrhizae 86-90 part, Cortex Eucommiae 72-76 part in the pill that is used for the treatment of osteonecrosis, ischemic necrosis of femoral head of the present invention, Cortex Acanthopancis 74-80 part, Fructus Chaenomelis 76-80 part, Squama Manis 60-65 part, Radix Dipsaci 74-78 part, Flos Carthami 58-64 part, Caulis Spatholobi 59-64 part, Radix Notoginseng 60-65 part, Myrrha 58-64 part, Radix Codonopsis 60-65 part, Rhizoma Atractylodis Macrocephalae 60-64 part, Radix Astragali 60-65 part, Radix Achyranthis Bidentatae 58-63 part.
Prescription analysis of the present invention is as follows:
Radix Angelicae Sinensis, sweet, hot, bitter, warm, go into the liver heart, spleen channel, having enriches blood invigorates blood circulation, the effect of pain relieving, " book on Chinese herbal medicine through hundred kinds of records " day: " Radix Angelicae Sinensis is hot fragrant and moisten, and perfume (or spice) is then gone into spleen, and profit is then enriched blood, thus the branch of burnt ying-qi in penetrating, and be the panacea of nourishing YIN "; Radix Salviae Miltiorrhizae, bitter, warm, go into the conscience warp, the promoting blood circulation and breaking stagnation pain relieving is the key medicine of blood circulation promoting and blood stasis dispelling; Above-mentioned two medicine blood circulation promoting and blood stasis dispelling, promoting blood circulation improves the confession of femoral head blood in order to dispel the blood stasis at warp, is monarch drug altogether.The Cortex Eucommiae, sweet, little suffering, temperature, invigorating the liver and kidney, the nourishing muscle and tendon bone is moistened in bone and muscle strengthening; Cortex Acanthopancis, wind-damp dispelling, strengthening bone and muscle, blood circulation promoting and blood stasis dispelling; Fructus Chaenomelis, Radix Dipsaci, invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating are ministerial drug altogether.Squama Manis is gone into liver stomach warp, and the meridian dredging is controlled insensitive impediment; Flos Carthami, blood circulation promoting and blood stasis dispelling; Caulis Spatholobi, bitter in the mouth, sweet, property is sliding, goes into the heart, spleen two warps, but relaxing muscles and tendons to promote blood circulation; Radix Notoginseng, sweet, bitter, warm, large intestine channel, it is diffusing stagnant to have QI invigorating, blood circulation promoting and blood stasis dispelling, the effect of clots absorbing pain relieving; Myrrha, bitter, flat, the dissipating blood stasis analgesic therapy, " property of medicine book on Chinese herbal medicine " said: " all golden cuttves are hindered, beat that damage is got injured by a fall, fallen off a horse, bones and muscles pain, must abdomen blood stasis person, and should grind mashed, hot wine and be taken after mixing with liquid "; Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, air making-up and spleen enlivening, with the source of helping life, above-mentioned all medicines are adjuvant drug altogether.Radix Achyranthis Bidentatae " it is descending to draw all medicines " is a messenger drug.
Take a broad view of full side, blood circulation promoting and blood stasis dispelling focuses on and improves downright bad femoral head stagnation of blood stasis, but adjusting and reinforcing liver and kidney arranged, benefiting qi and nourishing blood, reinforcement and elimination in combination, treating both the principal and the secondary aspects of a disease at the same time.
Clinical drug of the present invention is observed and is tested as follows:
Clinical observation: 100 examples are as the object of observation.
Clinical manifestation: local red and swollen, twinge, painful have the place of deciding, becoming severe at night, complexion is dark, and hair quality is dark red, deep pulse, tcm diagnosis is a qi stagnation and blood stasis type.Western medicine diagnose is a local pain, or radiated pain; Waist is to strong lateral bending song: " 4 " word is levied (+); The pelvis separation test positive; Amyotrophy; X-ray film, CT sheet show the clinical manifestation of fracture, osteonecrosis.
The present invention is according to conditions of patients, the medicine that cooperates Psoralea pill, bone impediment convalescence capsule and the treatment Avascular Necrosis Of Femur Head of selecting the separate case application for use, clinical efficacy shows: obey each 6 grams patient's day three times, taking 480 days (80 days is a course of treatment) tracing observation statistics total effective rates continuously is 94%.With state of an illness weight branch: I phases 18 row, effective percentage 100%; II phases 39 example, effective percentage 96%; III phases 31 example, effective percentage 93.5%; IV phases 12 example, effective percentage 75%.
Great new medicine science and technology development test result is as follows through Henan for the drug effect of medicine of the present invention, acute toxicity test:
Acute toxicity test: with medicine of the present invention be equivalent to clinical medicine 133 extraordinarily pure water be mixed with suspension, give mouse stomach, a continuous week observes, outward appearance, action activity, the mental status, diet, drinking-water, feces, fur, the colour of skin, breathing are all normal, the no abnormal secretions in nose, eye and oral cavity, acute toxic reaction and death do not appear, healthy survival.
Long term toxicity test: with medicine of the present invention be equivalent to clinical medicine 50～30 extraordinarily pure water be mixed with suspension, give rat oral gavage, 3 months test periods (clinical 1 month) observe, the figure does not have pathology and changes, and slowness toxicity do not occur and changes.
The test of pesticide effectiveness: be mice, rat paw, ears, blood capillary, the administration respectively of two axil otch, cause inflammation, pain and swelling etc., with clinical drug dosage of the present invention 10～20 extraordinarily pure water be mixed with suspension, give rat oral gavage, with be equivalent to the clinical application amount 12.5～25 extraordinarily pure water be mixed with suspension, give mouse stomach, observed, and proved that medicine of the present invention had tangible detumescence, antiinflammatory, analgesic activity in continuous 7 days.
The specific embodiment
The present invention does with detailed description below with reference to embodiment:
Embodiment 1:
Present embodiment adopts following proportioning and processing step to realize:
Divide two groups of processing levigations with ten Six-element medicines.
First group: get Radix Angelicae Sinensis 89g by weight, Cortex Eucommiae 76g, Cortex Acanthopancis 76g, Fructus Chaenomelis 80g, Squama Manis 60g, Flos Carthami 60g, Radix Notoginseng 60g, Myrrha 64g, Rhizoma Atractylodis Macrocephalae 60g, Radix Astragali 64g pulverize with pulverizer and are ground into fine powder, sieve, drug powder after will pulverizing afterwards carries out sterilization treatment with 100 ℃ of steam, its time was controlled between 25～40 minutes, make antibacterial by 10000-100000/g reduce to 500/below the g, mycete by 1000-1500/g reduce to 100/below the g, drug powder seal storage after the sterilization treatment, standby;
Second group: get Radix Salviae Miltiorrhizae 86g by weight, Radix Dipsaci 74g, Caulis Spatholobi 64g, Radix Codonopsis 62g, medicines such as Radix Achyranthis Bidentatae 62g decoct with water, and amount of water is 8-12 a times of said medicine gross weight, decoct 3～5 times, each 70～90 minutes, afterwards decoction liquor is concentrated into relative density 1.20～1.40%; After this, first group of drug powder added mixing in the concentrated solution, oven dry, crushed after being dried become fine powder standby;
With above-mentioned two groups of fine powder facing-ups, sieve, fully mix after, add pure water and make the watered pill, irregular parts such as dispersion, distortion are removed in oven dry, coating is patent medicine after the polishing.
Embodiment 2:
Present embodiment adopts following proportioning and processing step to realize:
Divide two groups of processing levigations with ten Six-element medicines.
First group: get Radix Angelicae Sinensis 93g by weight, Cortex Eucommiae 74g, Cortex Acanthopancis 80g, Fructus Chaenomelis 76g, Squama Manis 64g, Flos Carthami 64g, Radix Notoginseng 65g, Myrrha 58g, Rhizoma Atractylodis Macrocephalae 63g, Radix Astragali 60g pulverize with pulverizer and are ground into fine powder, sieve, drug powder after will pulverizing afterwards carries out sterilization treatment with 100 ℃ of steam, its time was controlled between 25～40 minutes, make antibacterial by 10000-100000/g reduce to 500/below the g, mycete by 1000-1500/g reduce to 100/below the g, drug powder seal storage after the sterilization treatment, standby;
Second group: get Radix Salviae Miltiorrhizae 90g by weight, Radix Dipsaci 76g, Caulis Spatholobi 59g, Radix Codonopsis 64g, medicines such as Radix Achyranthis Bidentatae 60g decoct with water, and amount of water is 8-12 a times of said medicine gross weight, decoct 3～5 times, each 70～90 minutes, afterwards decoction liquor is concentrated into relative density 1.20～1.40%; After this, first group of drug powder added mixing in the concentrated solution, oven dry, crushed after being dried become fine powder standby;
With above-mentioned two groups of fine powder facing-ups, sieve, fully mix after, add pure water and make the watered pill, irregular parts such as dispersion, distortion are removed in oven dry, coating is patent medicine after the polishing.
Claims (1)
1, a kind of pill that is used for the treatment of osteonecrosis, ischemic necrosis of femoral head is characterized in that: raw materials of effective components composition and weight portion thereof are in this pill: Radix Angelicae Sinensis 89-93 part, Radix Salviae Miltiorrhizae 86-90 part, Cortex Eucommiae 72-76 part, Cortex Acanthopancis 74-80 part, Fructus Chaenomelis 76-80 part, Squama Manis 60-65 part, Radix Dipsaci 74-78 part, Flos Carthami 58-64 part, Caulis Spatholobi 59-64 part, Radix Notoginseng 60-65 part, Myrrha 58-64 part, Radix Codonopsis 60-65 part, Rhizoma Atractylodis Macrocephalae 60-64 part, Radix Astragali 60-65 part, Radix Achyranthis Bidentatae 58-63 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100174822A CN1320900C (en) | 2005-04-01 | 2005-04-01 | Bone erosion renewel pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100174822A CN1320900C (en) | 2005-04-01 | 2005-04-01 | Bone erosion renewel pill |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1686217A CN1686217A (en) | 2005-10-26 |
| CN1320900C true CN1320900C (en) | 2007-06-13 |
Family
ID=35304259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100174822A Expired - Fee Related CN1320900C (en) | 2005-04-01 | 2005-04-01 | Bone erosion renewel pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1320900C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188672A (en) * | 2010-03-09 | 2011-09-21 | 王贻涛 | Plaster capable of treating pain from shoulders, neck, waist and legs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105245A (en) * | 1993-06-10 | 1995-07-19 | 王进东 | Ronggukang capsule for curing bone disease |
| CN1404863A (en) * | 2002-10-25 | 2003-03-26 | 郭永昌 | Medicine for treating ischemic necrosis of head of femur and preparation method thereof |
| CN1410112A (en) * | 2002-11-20 | 2003-04-16 | 郭永昌 | Fuyuan plaster for promoting blood circulation |
-
2005
- 2005-04-01 CN CNB2005100174822A patent/CN1320900C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105245A (en) * | 1993-06-10 | 1995-07-19 | 王进东 | Ronggukang capsule for curing bone disease |
| CN1404863A (en) * | 2002-10-25 | 2003-03-26 | 郭永昌 | Medicine for treating ischemic necrosis of head of femur and preparation method thereof |
| CN1410112A (en) * | 2002-11-20 | 2003-04-16 | 郭永昌 | Fuyuan plaster for promoting blood circulation |
Non-Patent Citations (1)
| Title |
|---|
| 骨复生胶囊治疗早期激素性股骨头缺血坏死的临床研究 李毅 等，山东中医药大学学报，第28卷第1期 2004 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1686217A (en) | 2005-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101015651A (en) | Medicine for treating protrusion of lumbar intervertebral disc | |
| CN101138623A (en) | Medicament for preventing and treating deficiency of the kidney essence | |
| CN104688932A (en) | Traditional Chinese medicine preparation for postmenopausal osteoporosis and preparation method | |
| CN112494606A (en) | Traditional Chinese medicine composition for treating arthralgia, myalgia and rheumatic pain and preparation method and application thereof | |
| CN103599404A (en) | Traditional Chinese medicinal decoction for treating cervical spondylosis | |
| CN1320900C (en) | Bone erosion renewel pill | |
| CN1270741C (en) | Psoralea pill | |
| CN107617081B (en) | Traditional Chinese medicine composition for treating alopecia and preparation method thereof | |
| CN101337044B (en) | External preparation for mammary gland disease and preparation method thereof | |
| CN101284059A (en) | Chinese medicinal materials preparation for reinforcing the spleen and kidney and curing the chronic nephritis | |
| CN1318080C (en) | Medicine used for treating osteonecrosis, femur ischemic osteonecrosis | |
| CN112755134B (en) | Plaster for treating hyperosteogeny and preparation method thereof | |
| CN1613471A (en) | Preparation of compound pseudo-ginseng drop pellets for treating traumatologic disease | |
| CN102028810B (en) | Traditional Chinese medicine for treating lumbar intervertebral disc protrusion | |
| CN101810825B (en) | Medicament for treating femoral head necrosis and preparation method thereof | |
| CN105535802A (en) | Traditional Chinese medicine preparation for treating habitual abortion and preparation method of traditional Chinese medicine preparation | |
| CN104840814A (en) | Traditional Chinese medicine combination for treating senile femoral head necrosis | |
| CN1183918C (en) | Medicine for curing protrution of intervetebral disc and its preparing method | |
| CN104645244A (en) | Traditional Chinese medicine composition for treating atherosclerosis | |
| CN113577152A (en) | Pharmaceutical composition and application thereof in preparation of nutritional muscle product | |
| CN104397284A (en) | Kidney tonifying and bone strengthening eleutherococcus senticosus health tea and preparation method thereof | |
| CN113730525A (en) | Traditional Chinese medicine composition for treating postmenopausal osteoporosis and application thereof | |
| CN116077573A (en) | Traditional Chinese medicine for dredging channels and collaterals and preparation method thereof | |
| CN103007236A (en) | Chinese medicinal composition for treating ankylosing spondylitis | |
| CN111840441A (en) | A Chinese medicinal powder for treating hernia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070613 |