CN1319556C - Oral Chinese-medicine preparation for treating neuropathic pain - Google Patents
Oral Chinese-medicine preparation for treating neuropathic pain Download PDFInfo
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- CN1319556C CN1319556C CNB2005100227088A CN200510022708A CN1319556C CN 1319556 C CN1319556 C CN 1319556C CN B2005100227088 A CNB2005100227088 A CN B2005100227088A CN 200510022708 A CN200510022708 A CN 200510022708A CN 1319556 C CN1319556 C CN 1319556C
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Abstract
The present invention relates to an oral Chinese medicine preparation for treating neuropathic pain. The raw material of the present invention comprises 140 to 180 shares of prepared sichuan aconite roots, 140 to 180 shares of prepared wild aconite roots, 160 to 200 shares of orientvine stems, 160 to 200 shares of pawpaws, 100 to 140 shares of pubescent angelica roots, 100 to 140 shares of angelica roots, 100 to 140 shares of safflowers and 100 to 140 shares of pilose asiabell roots. The present invention is a pure Chinese medicine preparation and has the effects of supporting the healthy energy, nourishing blood, benefiting qi, expelling wind, alleviating pain and promoting blood circulation to remove meridian obstructions. The present invention has significant curative effects on various neuropathic pains, such as neuropathic pain, sciatica, trigeminal neuralgia, pain in legs and waists, wind dampness arthralgia, etc. and has the advantages of convenient clinical application, favorable absorption, high safety, reliability, fast symptom removal and relieve, and no toxic and side effect.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine for the treatment of neuropathic pain, be specifically related to a kind of oral Chinese medicine preparation for the treatment of neuropathic pain.
Background technology
Neuropathic pain is a kind of commonly encountered diseases, and it comprises nervous headache, sciatica, trigeminal neuralgia, lumbago and skelalgia and rheumatic arthritis etc.At present, the oral drugs of some neuralgia of treatment of Shi Yonging clinically, its curative effect is not obvious, and toxic and side effects is bigger, uses also to be restricted.
Summary of the invention
The objective of the invention is for overcoming disadvantages of background technology, and a kind of oral Chinese medicine preparation of treatment neuropathic pain of evident in efficacy, safe without toxic side effect is provided.
The present invention realizes by the following technical solutions: make that medical material in the raw material of this oral Chinese medicine preparation is formed and weight portion is:
160～200 parts of 140～180 parts of Caulis Sinomeniis of 140～180 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
100～140 parts of 100～140 parts of Radix Angelicae Sinensis of 160～200 parts of Radix Angelicae Pubescentiss of Fructus Chaenomelis
100～140 parts of 100～140 parts of Radix Codonopsis of Flos Carthami.
Described oral Chinese medicine preparation is capsule, tablet, pill, electuary, granule, unguentum or oral solutions.
Radix Aconiti Preparata and Radix Aconiti Kusnezoffii Preparata among the side of the present invention, hot, bitter, hot, be aided with Caulis Sinomenii, Fructus Chaenomelis and Radix Angelicae Pubescentis, five nature,taste and actions are close, are used in combination the back and strengthen the efficacy of a drug mutually, on drug effect, play mutually promote, complementary effect.The present invention can not produce toxic and side effects to human body through pharmacology, pharmacodynamics, chemical kinetics, toxicologic zoopery and clinical checking repeatedly, and has the effect of strengthening the body resistance, invigorating qi and benefiting blood, wind-expelling pain-stopping, relaxing muscles and tendons and activating QI and blood in the collateral.
Advantage of the present invention is: the present invention is a pure Chinese medicinal preparation, effect with strengthening the body resistance, blood yiqi, wind-expelling pain-stopping, promoting blood circulation to remove obstruction in the collateral, to treating various neuropathic pains, diseases such as, lumbago and skelalgia logical as neuropathic pain, sciatica, nervi trigeminus, rheumatic arthralgia are evident in efficacy, clinical practice is convenient, and good absorbing is safe and reliable, transference cure is alleviated fast, has no side effect.
The specific embodiment
Embodiment 1
Make that medical material in the raw material of this embodiment is formed and weight is:
Radix Aconiti Preparata 160 is restrained Radix Aconiti Kusnezoffii 160 gram Caulis Sinomeniis 180 grams
Fructus Chaenomelis 180 gram Radix Angelicae Pubescentiss 120 gram Radix Angelicae Sinensis 120 grams
Flos Carthami 120 gram Radix Codonopsis 120 grams.
The preparation technology of present embodiment is: earlier above-mentioned eight flavor medical materials are made only, it is an amount of to get Radix Angelicae Sinensis then, pulverizes 100 mesh sieves, collects 1/3 recipe quantity fine powder, standby; Get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Radix Angelicae Pubescentis and add 85% alcohol reflux 3 times, add 5 times of amounts for the first time and refluxed 1.5 hours; Adding 4 times of amounts for the third time refluxed 1.5 hours; Merge three times filtrate, abandon medicinal residues, decompression recycling ethanol, solution decompression are concentrated into the clear paste that relative density is 1.33-1.36 (60 ℃), and 65 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, and fine powder is standby; Decoct with water 2 times after getting Fructus Chaenomelis, 2/3 recipe quantity Radix Angelicae Sinensis, Flos Carthami, Radix Codonopsis mixing again, add 10 times of water gagings for the first time and decocted 1.0 hours; Adding for the second time 10 times of water gagings decocted 1.0 hours; Merge filtrate twice, abandon medicinal residues, it is 1.33-1.36 (60 ℃) that filtrate decompression is concentrated into relative density, in 60 ℃ of drying under reduced pressure, pulverize and be screened into 80 order fine powders, mix with 1/3 recipe quantity Radix Angelicae Sinensis fine powder, alcohol extraction fine powder, with an amount of ethanol system soft material, 20 mesh sieve system granules, dry below 50 ℃, 16 mesh sieve granulate are packed No. 2 capsules into promptly, every 0.20 gram.
Embodiment 2
Make that medical material in the raw material of this embodiment is formed and weight is:
Radix Aconiti Preparata 140 is restrained Radix Aconiti Kusnezoffii 140 gram Caulis Sinomeniis 160 grams
Fructus Chaenomelis 160 gram Radix Angelicae Pubescentiss 140 gram Radix Angelicae Sinensis 140 grams
Flos Carthami 140 gram Radix Codonopsis 140 grams.
Its preparation technology: earlier above-mentioned eight flavor medical materials are made only, it is an amount of to get Radix Angelicae Sinensis then, pulverizes 100 mesh sieves, collects 1/3 recipe quantity fine powder, standby; Get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Radix Angelicae Pubescentis and add 85% alcohol reflux 3 times, add 5 times of amounts for the first time and refluxed 1.5 hours; Adding 4 times of amounts for the third time refluxed 1.5 hours; Merge three times filtrate, abandon medicinal residues, decompression recycling ethanol, solution decompression are concentrated into the clear paste that relative density is 1.33-1.36 (60 ℃), and 65 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, and fine powder is standby; Decoct with water 2 times after getting Fructus Chaenomelis, 2/3 recipe quantity Radix Angelicae Sinensis, Flos Carthami, Radix Codonopsis mixing again, add 10 times of water gagings for the first time and decocted 1.0 hours; Adding for the second time 10 times of water gagings decocted 1.0 hours; Merge filtrate twice, abandon medicinal residues, it is 1.33-1.36 (60 ℃) that filtrate decompression is concentrated into relative density, in 60 ℃ of drying under reduced pressure, pulverize and be screened into 80 order fine powders, mix with 1/3 recipe quantity Radix Angelicae Sinensis fine powder, alcohol extraction fine powder, with an amount of ethanol system soft material, 20 mesh sieve system granules, dry below 50 ℃, 16 mesh sieve granulate are packed No. 2 capsules into promptly, every 0.20 gram.
Embodiment 3
Make that medical material in the raw material of this embodiment is formed and weight is:
Radix Aconiti Preparata 180 is restrained Radix Aconiti Kusnezoffii 180 gram Caulis Sinomeniis 200 grams
Fructus Chaenomelis 200 gram Radix Angelicae Pubescentiss 100 gram Radix Angelicae Sinensis 100 grams
Flos Carthami 100 gram Radix Codonopsis 100 grams.
Its preparation technology: earlier above-mentioned eight flavor medical materials are made only, it is an amount of to get Radix Angelicae Sinensis then, pulverizes 100 mesh sieves, collects 1/3 recipe quantity fine powder, standby; Get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Caulis Sinomenii, Radix Angelicae Pubescentis and add 85% alcohol reflux 3 times, add 5 times of amounts for the first time and refluxed 1.5 hours; Adding 4 times of amounts for the third time refluxed 1.5 hours; Merge three times filtrate, abandon medicinal residues, decompression recycling ethanol, solution decompression are concentrated into the clear paste that relative density is 1.33-1.36 (60 ℃), and 65 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, and fine powder is standby; Decoct with water 2 times after getting Fructus Chaenomelis, 2/3 recipe quantity Radix Angelicae Sinensis, Flos Carthami, Radix Codonopsis mixing again, add 10 times of water gagings for the first time and decocted 1.0 hours; Adding for the second time 10 times of water gagings decocted 1.0 hours; Merge filtrate twice, abandon medicinal residues, it is 1.33-1.36 (60 ℃) that filtrate decompression is concentrated into relative density, in 60 ℃ of drying under reduced pressure, pulverize and be screened into 80 order fine powders, mix with 1/3 recipe quantity Radix Angelicae Sinensis fine powder, alcohol extraction fine powder, with an amount of ethanol system soft material, 20 mesh sieve system granules, dry below 50 ℃, 16 mesh sieve granulate are packed No. 2 capsules into promptly, every 0.20 gram.
Embodiment 4
Make that medical material in the raw material of this embodiment is formed and weight is:
Radix Aconiti Preparata 150 is restrained Radix Aconiti Kusnezoffii 150 gram Caulis Sinomeniis 170 grams
Fructus Chaenomelis 170 gram Radix Angelicae Pubescentiss 130 gram Radix Angelicae Sinensis 130 grams
Flos Carthami 130 gram Radix Codonopsis 130 grams.
Its preparation technology is with embodiment 1.
Embodiment 5
Make that medical material in the raw material of this embodiment is formed and weight is:
Radix Aconiti Preparata 170 is restrained Radix Aconiti Kusnezoffii 170 gram Caulis Sinomeniis 190 grams
Fructus Chaenomelis 190 gram Radix Angelicae Pubescentiss 110 gram Radix Angelicae Sinensis 110 grams
Flos Carthami 110 gram Radix Codonopsis 110 grams.
Its preparation technology is with embodiment 1.
The present invention is that 60 gram whites are antitheft bottled, liner Cotton Gossypii, 0.2g/ grain, 60/bottle; Its usage and dosage is: oral, one time 2～3, every day 3 times, children's is cut down according to the circumstance.
The present invention passes through animal acute toxicity experiment, irritate stomach 1 time in 1 day for mice with Cmax maximum volume of the present invention, observed 7 days continuously, animal does not see death, recording its maximum tolerated dose is 34.8g/kg (being equivalent to the 174g/kg crude drug), be equivalent to 773 times of clinical daily dose, show that the present invention does not have obvious acute toxicity.
The present invention's " refreshing Tongning capsule of Chinese medicine " carries out clinical trial to 354 routine clinical patients, total effective rate 94.6%, and wherein clinical recovery effective percentage+obvious effective rate is 85.0%; Treatment nervous headache 150 examples, total effective rate 96.7%, recovery from illness effective percentage+obvious effective rate is 85.0%; Treatment trigeminal neuralgia 46 examples, total effective rate 93.5%, recovery from illness effective percentage+obvious effective rate is 82.6%; Treatment sciatica 96 examples, total effective rate 95.8%, recovery from illness effective percentage+obvious effective rate is 88.5%; Treatment rheumatic arthritis 62 examples, total effective rate 88.8%, recovery from illness effective percentage+obvious effective rate is 69.4%.
Claims (3)
1, a kind of oral Chinese medicine preparation for the treatment of neuropathic pain is characterized in that making that medical material in the raw material of this medicine is formed and weight portion is:
160～200 parts of 140～180 parts of Caulis Sinomeniis of 140～180 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
100～140 parts of 100～140 parts of Radix Angelicae Sinensis of 160～200 parts of Radix Angelicae Pubescentiss of Fructus Chaenomelis
100～140 parts of 100～140 parts of Radix Codonopsis of Flos Carthami.
2, a kind of oral Chinese medicine preparation for the treatment of neuropathic pain according to claim 1 is characterized in that making that medical material in the raw material of this medicine is formed and weight portion is:
180 parts of 180 portions of Fructus Chaenomeliss of 160 parts of Caulis Sinomeniis of 160 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
120 parts of 120 parts of Radix Codonopsis of 120 parts of Flos Carthamis of 120 parts of Radix Angelicae Sinensis of Radix Angelicae Pubescentis.
3, a kind of oral Chinese medicine preparation for the treatment of neuropathic pain according to claim 1 and 2 is characterized in that described oral Chinese medicine preparation is capsule, tablet, pill, electuary, granule, unguentum or oral solutions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100227088A CN1319556C (en) | 2005-12-23 | 2005-12-23 | Oral Chinese-medicine preparation for treating neuropathic pain |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100227088A CN1319556C (en) | 2005-12-23 | 2005-12-23 | Oral Chinese-medicine preparation for treating neuropathic pain |
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| Publication Number | Publication Date |
|---|---|
| CN1813966A CN1813966A (en) | 2006-08-09 |
| CN1319556C true CN1319556C (en) | 2007-06-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100227088A Expired - Fee Related CN1319556C (en) | 2005-12-23 | 2005-12-23 | Oral Chinese-medicine preparation for treating neuropathic pain |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349692B (en) * | 2013-05-13 | 2015-04-01 | 中国人民解放军第三七一医院 | Traditional Chinese medicine preparation for treating migraine and trigeminal neuralgia |
| CN103432418B (en) * | 2013-09-06 | 2015-10-28 | 大连民族学院 | Chinese medicine composition of a kind of gout pain relieving and its production and use |
| CN104984264A (en) * | 2015-08-06 | 2015-10-21 | 吴倩颖 | Traditional Chinese medicine composition for treating cervical vertebra pain and preparing method of traditional Chinese medicine composition |
| CN107625833A (en) * | 2017-09-29 | 2018-01-26 | 南京仙草堂生物科技有限公司 | A kind of preparation method for the rheumatic plaster for treating Post lumbar surgery lumbago |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN1480522A (en) * | 2003-08-06 | 2004-03-10 | 蔡玉堂 | Medicinal wine compsn and its prepn. method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN1480522A (en) * | 2003-08-06 | 2004-03-10 | 蔡玉堂 | Medicinal wine compsn and its prepn. method |
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| Publication number | Publication date |
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| CN1813966A (en) | 2006-08-09 |
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Granted publication date: 20070606 Termination date: 20161223 |