CN1319471C - Yak marrow powder health care product and its making method - Google Patents
Yak marrow powder health care product and its making method Download PDFInfo
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- CN1319471C CN1319471C CNB2004100427535A CN200410042753A CN1319471C CN 1319471 C CN1319471 C CN 1319471C CN B2004100427535 A CNB2004100427535 A CN B2004100427535A CN 200410042753 A CN200410042753 A CN 200410042753A CN 1319471 C CN1319471 C CN 1319471C
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Abstract
The present invention discloses a yak marrow powder health care product which has the functions of nourishing bones, complementing marrow, and enhancing immune ability. The yak marrow powder health care product is prepared by the raw materials of marrow extract, poria, lotus seed extract and flax oil. The present invention contains rich peptides, amino acid and a plurality of kinds of nutrient components, has a better nutrient health care effect on a human body, can promote calcium and phosphorus absorption for the human body, has the advantages of human body micro-ecological balance regulation, immune function enhancement, life extension and no any side effect, and is suitable for all people to complement the calcium.
Description
Technical field
The present invention relates to a kind of nutrient and healthcare products, specifically a kind of have mend bone and fill out marrow, strengthen the yak marrow powder health products of immunologic function, the invention still further relates to the preparation method of these health products.
Background technology
Yak is Qinghai-Tibet distinctive poultry kind, lives in the snowy region plateau of free of contamination height above sea level more than 3000 meters, owing to live in for a long time in high and cold, the anoxic environment, makes yak more be rich in nutritions such as hemoglobin, amino acid than other livestock.So be the many of health products with yak marrow bone meal at present, still, the exploitation kind is few, function singleness.
Summary of the invention
The objective of the invention is to enrich yak marrow powder health care kind provides a kind of and has the bone of benefit and fill out marrow, strengthens the yak marrow powder health products of immunologic function.
Another purpose of the present invention provides the preparation method of these yak marrow powder health products.
Yak marrow powder health products of the present invention are made up of the activated feedstock of following weight portion proportioning: 10～20 parts of yak marrow extracts, 4～8 parts in Poria cocos, 4～8 parts of Semen Nelumbinis extracts, 60～80 parts of linseed oil.
Yak marrow powder health products preferred version of the present invention is made up of the activated feedstock of following weight portion proportioning: 12～18 parts of yak marrow extracts, 5～7 parts in Poria cocos, 5～7 parts of Semen Nelumbinis extracts, 65～75 parts of linseed oil.
Yak marrow powder health products preferred plan of the present invention is made up of the activated feedstock of following weight portion proportioning: 16 parts of yak marrow extracts, 6 parts in Poria cocos, 6 parts of Semen Nelumbinis extracts, 72 parts of linseed oil.
Yak marrow powder health products preparation method of the present invention comprises following step:
(1) preparation of yak marrow extract: 1. choose the epiphysis end of irregular Yak Bone and long bone and 2 years with interior teenage yak long bone, the muscle fat tissue that removal is adhered to, clean standby, 2. it is standby pretreated bone to be crushed to half centimetre big small offence colloid mill pulverizing back in bone cutter, 3. the pulp of getting pulverizing utilizes flavor protease to carry out enzymolysis, centrifuging and taking supernatant ultrafiltration collection molecular weight is that the following little peptide of 3000d is standby behind the enzymolysis, 4. the aforesaid liquid spray-drying is promptly got the yak marrow extract;
(2) processing of Poria cocos: get the above granularity fine powder of dry ultramicro grinding to 300 order of Poria cocos;
(3) preparation of Semen Nelumbinis extract: through ultrasonic extraction or boiling water lixiviate, centrifugal water extract is got the supernatant spray-drying and is promptly got Semen Nelumbinis extract with lotus seeds;
(4) with marrow extract, Poria cocos, Semen Nelumbinis extract and linseed oil, mix stirring by said ratio, homogenate makes active ingredient compositions of the present invention;
(5) the aforesaid active principles in combination thing can be processed into soft capsule with the soft capsule process equipment.
Yak marrow powder health products of the present invention also can with can be made into various formulations, as oral liquid etc.
Refining the forming of key component yak marrow extract of the present invention utilization modern biotechnology, the multiple nutritional components that has effectively kept yak marrow and full bone contain rich in protein, phosphorus matter, mineral matter and vitamin A, B1, B2, D, etc. nutrient.Yak marrow powder is rich in the following little peptide of molecular weight 3000d, and these little peptide solubility height, dissolution velocity is fast and avoided the coacervation in the course of dissolution, especially what deserves to be mentioned is, the little peptide of part can absorb with complete form, directly be the body utilization.Collagen is the main matter in the soft tissue of joint, and is simultaneously closely related with the human body bone density, and an amount of replenishing can effectively be protected joint, prevention of osteoporosis, simultaneously can the skin nutrition hair, nail, have the effect of beauty treatment.Poria cocos is the Polyporaceae plant, contains abundant glycan class nutrient, is good dietary fiber and high-energy food.Lotus seeds are function and the delaying senility functions with tonifying spleen antidiarrheal, supplementing the kidney to control the nocturnal, mental-tranquilization.Main functional component alpha-linolenic acid in the linseed oil, its extremely uneven being present in the green plants is a kind of primary raw material of omega-3 unsaturated fatty acid class, human body can not self synthesize, and can only absorb from nature.After the absorption, suppressed the synthetic of the interior extra-low density apolipoprotein B of body, and synthesized, increased the removing of extra-low density apolipoprotein, chylomicron and cholesterol, had complete effect for reducing fat by the synthetic extra-low density apolipoprotein that reduces of retardance liver fat acid.Above-mentioned four kinds of components cooperate, and have realized having complementary functions and give full play to synergistic function between the component.
Yak marrow powder health products of the present invention eat evidence through animal function test and crowd: have following advantage:
(1) acute toxicity test and subacute toxicity test explanation, yak marrow powder health products of the present invention are without any side effects, meet the requirement and the development trend of health products.
(2) this product can promote the absorption of human body to calcium, phosphorus, regulates the human body microecological balance, and common diseases such as control senile osteoporosis, osteoproliferation and arthritis also play effect balanced nutritious, that strengthen immunologic function, promote longevity.
(3) this product is to be suitable for need replenish the calcium crowd's natural tonic of each age.
The specific embodiment
Embodiment 1:
(1) preparation of marrow extract: 1. choose the epiphysis end of irregular Yak Bone and long bone and 2 years with interior teenage yak long bone, the muscle fat tissue that removal is adhered to, clean standby, 2. it is standby pretreated bone to be crushed to half centimetre big small offence colloid mill pulverizing back in bone cutter, 3. the pulp of getting pulverizing utilizes the flavor protease of letter Bioprocessors Corp. of Novi production to carry out enzymolysis, enzyme concentration is 1～4%, the control temperature is at 50 ℃～55 ℃, pH is 8 left and right sides enzymolysis 4～6 hours, centrifuging and taking supernatant ultrafiltration collection molecular weight is that the following little peptide of 3000d is standby behind the enzymolysis, 4. the aforesaid liquid spray-drying is promptly got yak marrow powder;
(2) processing of Poria cocos: get the dry ultramicro grinding of Poria cocos and become 300 purpose Poria cocos fine powders;
(3) preparation of Semen Nelumbinis extract: through ultrasonic extraction, extracting temperature is 60 ℃ with lotus seeds, and extraction time is 30min, and ultrasonic frequency is 20khz, and centrifugal water extract is got the dry spray-dried powdered of supernatant and promptly got Semen Nelumbinis extract;
(4) with marrow extract 1.6kg, Poria cocos 0.6kg, Semen Nelumbinis extract 0.6kg, linseed oil 7.2kg mixes stirring, and homogenate makes active ingredient compositions 10kg of the present invention.
Embodiment 2:
With marrow extract 1.8kg, Poria cocos 0.6kg, Semen Nelumbinis extract 0.6kg, linseed oil 7.0kg mixes stirring, and homogenate makes active ingredient compositions 10kg of the present invention, is processed into soft capsule with the soft capsule process equipment.
Test 1: toxicity test:
Acute toxicity test: the yak marrow powder health products active ingredient compositions with embodiment 1 preparation is given mouse stomach, and maximum dosage reaches 40g/kg, four gastric infusions within a day, and accumulated dose reaches 60g/kg, and all not being found to mouse has any bad reaction.
Subacute toxicity test: 48 of rats selecting body weight 50-60g for use, male and female half and half, be divided into four groups at random, the administration group is with the yak marrow powder health products active ingredient compositions 100mg/kg of embodiment 1 preparation, 200mg/kg and 400mg/kg, irritate stomach respectively once every day, control group is drunk identical physiological saline, after the administration 100 days, the result shows that administration group and the every detection index of control group all belong to normally, there was no significant difference relatively between group, pathologic finding administration treated animal internal organs and organize the pathological change of not seeing drug-induced.
Acute toxicity test and subacute toxicity test explanation, yak marrow powder health products of the present invention are without any side effects.
Test 2: the yak marrow powder health products are tested the prevention and treatment of osteoporosis effect
Select 50 of male rats for use, be divided into 5 groups at random: the physiological saline control group, model group (vitamin A acid 70mg/kg) gavages, every day 1 time, totally 2 weeks), the yak marrow powder health products group of embodiment 1 preparation (1.25,2.5,3 dosage groups of 5.0g/kg, gavage).The test group animal bushing beyond the region of objective existence of taking medicine gavages 2 weeks of vitamin A acid simultaneously, withdraw vitamin A acid after, continue 4 weeks of administration.Get the femoral head position and measure bone Ca, P content with plasma light quantity instrument.
Table 1 yak marrow powder health products are to the influence of Ca, P content in the osteoporosis rat model femur
| Group | Dosage (g/kg) | Ca(％) | P(％) |
| Control group | - | 22.59±0.44 | 9.21±0.19 |
| Model group | - | 18.44±1.26 *** | 7.59±1.00 *** |
| Test group | 1.25 | 21.62±0.98 ΔΔΔ | 9.11±0.36 ΔΔ |
| 2.5 | 22.18±0.92 ΔΔΔ | 9.16±0.30 ΔΔΔ | |
| 5.0 | 22.20±0.75 ΔΔΔ | 9.45±0.33 ΔΔΔ |
Test shows: the model group rat is compared with normal rats, degrees of osteoporotic occurs, and Ca, P content significantly reduce in the femur femur.The yak marrow powder health products can make tentative osteoporosis rat femur Ca, P content apparently higher than model group (P＜0.01), can promote the pathology bone density to recover.
Claims (5)
1, a kind of yak marrow powder health products is characterized in that it is made up of the activated feedstock of following weight portion proportioning: 10～20 parts of yak marrow extracts, 4～8 parts in Poria cocos, 4～8 parts of Semen Nelumbinis extracts, 60～80 parts of linseed oil.
2, yak marrow powder health products according to claim 1, wherein the weight portion proportioning of each activated feedstock is: 12～18 parts of yak marrow extracts, 5～7 parts in Poria cocos, 5～7 parts of Semen Nelumbinis extracts, 65～75 parts of linseed oil.
3, yak marrow powder health products according to claim 1, wherein the weight portion proportioning of each activated feedstock is: 16 parts of yak marrow extracts, 6 parts in Poria cocos, 6 parts of Semen Nelumbinis extracts, 72 parts of linseed oil.
4, according to claim 1,2 or 3 described yak marrow powder health products, the formulation that it is characterized in that it is a soft capsule.
5, the preparation method of yak marrow powder health products according to claim 4: it is characterized in that: comprise following step:
(1) preparation of yak marrow extract: 1. choose the epiphysis end of irregular Yak Bone and long bone and 2 years with interior teenage yak long bone, the muscle fat tissue that removal is adhered to, clean standby, 2. it is standby through colloid mill pulverizing back pretreated bone to be crushed to half centimetre of size in bone cutter, 3. the pulp of getting pulverizing utilizes flavor protease to carry out enzymolysis, centrifuging and taking supernatant ultrafiltration collection molecular weight is that the following little peptide of 3000d is standby behind the enzymolysis, 4. the aforesaid liquid spray-drying is promptly got yak marrow powder;
(2) processing of Poria cocos: get the above fine powder of dry ultramicro grinding to 300 order of Poria cocos;
(3) preparation of Semen Nelumbinis extract: through ultrasonic extraction or boiling water lixiviate, centrifugal water extract is got the supernatant spray-drying and is promptly got Semen Nelumbinis extract with lotus seeds.
(4) with marrow extract, Poria cocos, Semen Nelumbinis extract and linseed oil, mix stirring by said ratio, homogenate makes active ingredient compositions of the present invention.
(5) the aforesaid active principles in combination thing is processed into soft capsule with the soft capsule process equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100427535A CN1319471C (en) | 2004-05-26 | 2004-05-26 | Yak marrow powder health care product and its making method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100427535A CN1319471C (en) | 2004-05-26 | 2004-05-26 | Yak marrow powder health care product and its making method |
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| CN1582753A CN1582753A (en) | 2005-02-23 |
| CN1319471C true CN1319471C (en) | 2007-06-06 |
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| CNB2004100427535A Expired - Fee Related CN1319471C (en) | 2004-05-26 | 2004-05-26 | Yak marrow powder health care product and its making method |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657332B (en) * | 2012-05-08 | 2013-07-31 | 祁宝红 | Preparation method for successively producing yak bone marrow oil and ultramicro polypeptide bone calcium powder once |
| CN103719868A (en) * | 2013-06-27 | 2014-04-16 | 广州维思贝生物科技有限公司 | Breakfast nutrition flour rich in omega-3 polyunsaturated fatty acids and preparing method thereof |
| CN103750330B (en) * | 2014-02-18 | 2015-02-25 | 安国同源堂生物科技有限公司 | Oral composition comprising bovine bone marrow powder and preparation method of oral composition |
| CN105166957A (en) * | 2015-07-30 | 2015-12-23 | 王之宝 | Bovine bone marrow powder production process and application thereof |
| CN108185407A (en) * | 2017-12-28 | 2018-06-22 | 王清秀 | The method for promoting glossy ganoderma powder absorption rate and obtained ganoderma lucidum sheep marrow peptide compound powder and application |
| CN114946975A (en) * | 2022-04-12 | 2022-08-30 | 王连声 | Health tea containing yak bone marrow powder and preparation process thereof |
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| CN1209297A (en) * | 1998-08-11 | 1999-03-03 | 北京长寿保健品有限公司 | Nutritious health-care product for delaying senility and producing method therefor |
| CN1244425A (en) * | 1999-07-30 | 2000-02-16 | 冶明忠 | Health food of yak marrow powder and its production process |
| CN1259384A (en) * | 1999-01-06 | 2000-07-12 | 哈尔滨红太阳实业有限公司 | Bone strengthening powder made of yak marrow and its processing method |
| CN1313091A (en) * | 2000-03-13 | 2001-09-19 | 哈尔滨红太阳保健品有限公司 | Bone strengthening capsules of Biyang yak bone marrow |
| CN1327069A (en) * | 2001-05-24 | 2001-12-19 | 谢启安 | Process for extracting amino acid polypeptide with animal bone marrow and tissue |
| CN1334037A (en) * | 2001-04-08 | 2002-02-06 | 内蒙古草原兴发股份有限公司 | Process for preparing polypeptide bone powder |
| CN1356115A (en) * | 2001-01-11 | 2002-07-03 | 李方瑞 | Instant particles made of cordyceps and yak for making bone stronger |
-
2004
- 2004-05-26 CN CNB2004100427535A patent/CN1319471C/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209297A (en) * | 1998-08-11 | 1999-03-03 | 北京长寿保健品有限公司 | Nutritious health-care product for delaying senility and producing method therefor |
| CN1259384A (en) * | 1999-01-06 | 2000-07-12 | 哈尔滨红太阳实业有限公司 | Bone strengthening powder made of yak marrow and its processing method |
| CN1244425A (en) * | 1999-07-30 | 2000-02-16 | 冶明忠 | Health food of yak marrow powder and its production process |
| CN1313091A (en) * | 2000-03-13 | 2001-09-19 | 哈尔滨红太阳保健品有限公司 | Bone strengthening capsules of Biyang yak bone marrow |
| CN1356115A (en) * | 2001-01-11 | 2002-07-03 | 李方瑞 | Instant particles made of cordyceps and yak for making bone stronger |
| CN1334037A (en) * | 2001-04-08 | 2002-02-06 | 内蒙古草原兴发股份有限公司 | Process for preparing polypeptide bone powder |
| CN1327069A (en) * | 2001-05-24 | 2001-12-19 | 谢启安 | Process for extracting amino acid polypeptide with animal bone marrow and tissue |
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Effective date of registration: 20080104 Address after: Room 11, building 331, Xiangyang District, Ping Zhen Town, Yuanbaoshan District, the Inner Mongolia Autonomous Region, Chifeng Patentee after: Lv Yongli Address before: The Inner Mongolia Autonomous Region Chifeng City Yuanbaoshan District Economic Development Zone Building of Caoyuanxingfa Patentee before: Caoyuan-Xingfa Co., Ltd., Inner Mongolian Autonomous Region |
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Correction item: Address of the patentee Correct: Room 11, building 331, Xiangyang District, Ping Zhen Town, Yuanbaoshan District, the Inner Mongolia Autonomous Region, Chifeng False: 331, building 11, Xiangyang District, Ping Town, Yuanbaoshan District, the Inner Mongolia Autonomous Region, Chifeng Number: 6 Page: 1316 Volume: 24 |
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