CN1582753A - Yak marrow powder health care product and its making method - Google Patents
Yak marrow powder health care product and its making method Download PDFInfo
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- CN1582753A CN1582753A CNA2004100427535A CN200410042753A CN1582753A CN 1582753 A CN1582753 A CN 1582753A CN A2004100427535 A CNA2004100427535 A CN A2004100427535A CN 200410042753 A CN200410042753 A CN 200410042753A CN 1582753 A CN1582753 A CN 1582753A
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- bovis grunniens
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- semen nelumbinis
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A health-care food rich in peptides, amino acids and nutrients for promoting absorption to Ca and P, regulating microecological balance and immunity, and delaying senility is prepared from the extract of yak's bone marrow, tuckahoe, lotus seed and flax oil.
Description
Technical field
The present invention relates to a kind of nutrient and healthcare products, specifically a kind of have mend bone and fill out marrow, the Medulla Bovis grunniens powder health product of raise immunity the invention still further relates to the preparation method of these health product.
Background technology
Yak is Qinghai-Tibet distinctive poultry kind, lives in the snowy region plateau of free of contamination height above sea level more than 3000 meters, owing to live in for a long time in high and cold, the anoxic environment, makes yak more be rich in nutritions such as hemoglobin, aminoacid than other domestic animal.So be the many of health product with Medulla Bovis grunniens bone meal at present, still, the exploitation kind is few, function singleness.
Summary of the invention
The objective of the invention is to enrich Medulla Bovis grunniens powder health care kind provides a kind of and has the bone of benefit and fill out marrow, the Medulla Bovis grunniens powder health product of raise immunity.
Another purpose of the present invention provides the preparation method of these Medulla Bovis grunniens powder health product.
Medulla Bovis grunniens powder health product of the present invention are made up of the activated feedstock of following weight portion proportioning: 10～20 parts of Medulla Bovis grunniens extracts, 4～8 parts in Poria, 4～8 parts of Semen Nelumbinis extracts, 60～80 parts of oleum linis.
Medulla Bovis grunniens powder health product preferred version of the present invention is made up of the activated feedstock of following weight portion proportioning: 12～18 parts of Medulla Bovis grunniens extracts, 5～7 parts in Poria, 5～7 parts of Semen Nelumbinis extracts, 65～75 parts of oleum linis.
Medulla Bovis grunniens powder health product preferred plan of the present invention is made up of the activated feedstock of following weight portion proportioning: 16 parts of Medulla Bovis grunniens extracts, 6 parts in Poria, 6 parts of Semen Nelumbinis extracts, 72 parts of oleum linis.
Medulla Bovis grunniens powder health product preparation method of the present invention comprises following step:
(1) preparation of Medulla Bovis grunniens extract: 1. choose the epiphysis end of irregular Os Bovis grunniens and long bone and 2 years with interior teenage yak long bone, the muscle fat tissue that removal is adhered to, clean standby, 2. it is standby pretreated bone to be crushed to half centimetre big small offence colloid mill pulverizing back in bone cutter, 3. the pulp of getting pulverizing utilizes flavor protease to carry out enzymolysis, centrifuging and taking supernatant ultrafiltration collection molecular weight is that the following little peptide of 3000d is standby behind the enzymolysis, 4. the aforesaid liquid spray drying is promptly got the Medulla Bovis grunniens extract;
(2) processing of Poria: get the above granularity fine powder of dry micronizing to 300 order of Poria crude drug;
(3) preparation of Semen Nelumbinis extract: through supersound extraction or boiling water lixiviate, centrifugal water extract is got the supernatant spray drying and is promptly got Semen Nelumbinis extract with Semen Nelumbinis;
(4) with marrow extract, Poria, Semen Nelumbinis extract and oleum lini, mix stirring by said ratio, homogenate makes active ingredient compositions of the present invention;
(5) the aforesaid active principles in combination thing can be processed into soft capsule with the soft capsule process equipment.
Medulla Bovis grunniens powder health product of the present invention also can with can be made into various dosage forms, as oral liquid etc.
Refining the forming of key component Medulla Bovis grunniens extract of the present invention utilization modern biotechnology, the multiple nutritional components that has effectively kept Medulla Bovis grunniens and full bone contain rich in protein, phosphorus matter, mineral and vitamin A, B1, B2, D, etc. nutrient.Medulla Bovis grunniens powder is rich in the following little peptide of molecular weight 3000d, and these little peptide dissolubility height, dissolution velocity is fast and avoided the coacervation in the course of dissolution, especially what deserves to be mentioned is, the little peptide of part can absorb with complete form, directly be the body utilization.Collagen protein is the main matter in the soft tissue of joint, and is simultaneously closely related with the human body bone density, and an amount of replenishing can effectively be protected joint, prevention of osteoporosis, simultaneously can the skin nutrition hair, fingernail, have the effect of beauty treatment.Poria is the Polyporaceae plant, contains abundant polysaccharide class nutrient, is good dietary fiber and high-energy food.Semen Nelumbinis are function and the delaying senility functions with spleen reinforcing antidiarrheal, supplementing the kidney to control the nocturnal, tranquilizing by nourishing the heart.Main functional component alpha-linolenic acid in the Semen Lini oil, its extremely uneven being present in the green plants is a kind of primary raw material of omega-3 unsaturated fatty acid class, human body can not self synthesize, and can only absorb from nature.After the absorption, suppressed the synthetic of the interior extra-low density apolipoprotein B of body, and synthesized, increased the removing of extra-low density apolipoprotein, Chylomicron and cholesterol, had complete effect for reducing fat by the synthetic extra-low density apolipoprotein that reduces of retardance liver fat acid.Above-mentioned four kinds of components cooperate, and have realized having complementary functions and give full play to synergistic function between the component.
Medulla Bovis grunniens powder health product of the present invention eat evidence through animal function test and crowd: have following advantage:
(1) acute toxicity test and subacute toxicity test explanation, Medulla Bovis grunniens powder health product of the present invention are without any side effects, meet the requirement and the development trend of health product.
(2) this product can promote the absorption of human body to calcium, phosphorus, regulates the human body microecological balance, and commonly encountered diseases such as control senile osteoporosis, hyperosteogeny and arthritis also play the effect of balanced nutritious, raise immunity, life lengthening.
(3) this product is to be suitable for need replenish the calcium crowd's natural tonic of each age.
The specific embodiment
Embodiment 1:
(1) preparation of marrow extract: 1. choose the epiphysis end of irregular Os Bovis grunniens and long bone and 2 years with interior teenage yak long bone, the muscle fat tissue that removal is adhered to, clean standby, 2. it is standby pretreated bone to be crushed to half centimetre big small offence colloid mill pulverizing back in bone cutter, 3. the pulp of getting pulverizing utilizes the flavor protease of letter Bioprocessors Corp. of Novi production to carry out enzymolysis, enzyme concentration is 1～4%, the control temperature is at 50 ℃～55 ℃, pH is 8 left and right sides enzymolysis 4～6 hours, centrifuging and taking supernatant ultrafiltration collection molecular weight is that the following little peptide of 3000d is standby behind the enzymolysis, 4. the aforesaid liquid spray drying is promptly got Medulla Bovis grunniens powder;
(2) processing of Poria: get the dry superfine powder of Poria crude drug and be broken into 300 purpose Poria fine powders;
(3) preparation of Semen Nelumbinis extract: through supersound extraction, extracting temperature is 60 ℃ with Semen Nelumbinis, and extraction time is 30min, and ultrasonic frequency is 20khz, and centrifugal water extract is got the dry spray-dried powdered of supernatant and promptly got Semen Nelumbinis extract;
(4) with marrow extract 1.6kg, Poria 0.6kg, Semen Nelumbinis extract 0.6kg, oleum lini 7.2kg mixes stirring, and homogenate makes active ingredient compositions 10kg of the present invention.
Embodiment 2:
With marrow extract 1.8kg, Poria 0.6kg, Semen Nelumbinis extract 0.6kg, oleum lini 7.0kg mixes stirring, and homogenate makes active ingredient compositions 10kg of the present invention, is processed into soft capsule with the soft capsule process equipment.
Test 1: toxicity test:
Acute toxicity test: the Medulla Bovis grunniens powder health product active ingredient compositions with embodiment 1 preparation is given mouse stomach, and maximum dosage reaches 40g/kg, four gastric infusions within a day, and accumulated dose reaches 60g/kg, and all not being found to mice has any untoward reaction.
Subacute toxicity test: 48 of rats selecting body weight 50-60g for use, male and female half and half, be divided into four groups at random, the administration group is with the Medulla Bovis grunniens powder health product active ingredient compositions 100mg/kg of embodiment 1 preparation, 200mg/kg and 400mg/kg, irritate stomach respectively once every day, matched group is drunk identical normal saline, after the administration 100 days, the result shows that administration group and the every detection index of matched group all belong to normally, there was no significant difference relatively between group, pathologic finding administration treated animal internal organs and organize the pathological change of not seeing drug-induced.
Acute toxicity test and subacute toxicity test explanation, Medulla Bovis grunniens powder health product of the present invention are without any side effects.
Test 2: the Medulla Bovis grunniens powder health product are tested the prevention and treatment of osteoporosis effect
Select 50 of male rats for use, be divided into 5 groups at random: the normal saline matched group, model group (retinoic acid 70mg/kg) gavages, every day 1 time, totally 2 weeks), the Medulla Bovis grunniens powder health product group of embodiment 1 preparation (1.25,2.5,3 dosage groups of 5.0g/kg, gavage).The test group animal bushing beyond the region of objective existence of taking medicine gavages 2 weeks of retinoic acid simultaneously, withdraw retinoic acid after, continue 4 weeks of administration.Get the femoral head position and measure bone Ca, P content with plasma light quantity instrument.
Table 1 Medulla Bovis grunniens powder health product are to the influence of Ca, P content in the osteoporosis rat model femur
| Group | Dosage (g/kg) | ??Ca(％) | ??P(％) |
| Matched group | ????- | ??22.59±0.44 | ??9.21±0.19 |
| Model group | ????- | ??18.44±1.26 *** | ??7.59±1.00 *** |
| Test group | ????1.25 | ??21.62±0.98 ΔΔΔ | ??9.11±0.36 ΔΔ |
| ????2.5 | ??22.18±0.92 ΔΔΔ | ??9.16±0.30 ΔΔΔ | |
| ????5.0 | ??22.20±0.75 ΔΔΔ | ??9.45±0.33 ΔΔΔ |
Test shows: the model group rat is compared with normal rats, degrees of osteoporotic occurs, and Ca, P content significantly reduce in the femur femur.The Medulla Bovis grunniens powder health product can make tentative osteoporosis rat femur Ca, P content apparently higher than model group (P＜0.01), can promote the pathological changes bone density to recover.
Claims (5)
1, a kind of Medulla Bovis grunniens powder health product is characterized in that it is made up of the activated feedstock of following weight portion proportioning: 10～20 parts of Medulla Bovis grunniens extracts, 4～8 parts in Poria, 4～8 parts of Semen Nelumbinis extracts, 60～80 parts of oleum linis.
2, Medulla Bovis grunniens powder health product according to claim 1, wherein the weight portion proportioning of each activated feedstock is: 12～18 parts of Medulla Bovis grunniens extracts, 5～7 parts in Poria, 5～7 parts of Semen Nelumbinis extracts, 65～75 parts of oleum linis.
3, Medulla Bovis grunniens powder health product according to claim 1, wherein the weight portion proportioning of each activated feedstock is: 16 parts of Medulla Bovis grunniens extracts, 6 parts in Poria, 6 parts of Semen Nelumbinis extracts, 72 parts of oleum linis.
4, according to claim 1,2 or 3 described Medulla Bovis grunniens powder health product, the dosage form that it is characterized in that it is a soft capsule.
5, the preparation method of Medulla Bovis grunniens powder health product according to claim 4: it is characterized in that: comprise following step:
(1) preparation of Medulla Bovis grunniens extract: 1. choose the epiphysis end of irregular Os Bovis grunniens and long bone and 2 years with interior teenage yak long bone, the muscle fat tissue that removal is adhered to, clean standby, 2. it is standby through colloid mill pulverizing back pretreated bone to be crushed to half centimetre of size in bone cutter, 3. the pulp of getting pulverizing utilizes flavor protease to carry out enzymolysis, centrifuging and taking supernatant ultrafiltration collection molecular weight is that the following little peptide of 3000d is standby behind the enzymolysis, 4. the aforesaid liquid spray drying is promptly got Medulla Bovis grunniens powder;
(2) processing of Poria: get the above fine powder of dry micronizing to 300 order of Poria crude drug;
(3) preparation of Semen Nelumbinis extract: through supersound extraction or boiling water lixiviate, centrifugal water extract is got the supernatant spray drying and is promptly got Semen Nelumbinis extract with Semen Nelumbinis.
(4) with marrow extract, Poria, Semen Nelumbinis extract and oleum lini, mix stirring by said ratio, homogenate makes active ingredient compositions of the present invention.
(5) the aforesaid active principles in combination thing is processed into soft capsule with the soft capsule process equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100427535A CN1319471C (en) | 2004-05-26 | 2004-05-26 | Yak marrow powder health care product and its making method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100427535A CN1319471C (en) | 2004-05-26 | 2004-05-26 | Yak marrow powder health care product and its making method |
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| Publication Number | Publication Date |
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| CN1582753A true CN1582753A (en) | 2005-02-23 |
| CN1319471C CN1319471C (en) | 2007-06-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100427535A Expired - Fee Related CN1319471C (en) | 2004-05-26 | 2004-05-26 | Yak marrow powder health care product and its making method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102657332A (en) * | 2012-05-08 | 2012-09-12 | 祁宝红 | Preparation method for successively producing yak bone marrow oil and ultramicro polypeptide bone calcium powder once |
| CN103719868A (en) * | 2013-06-27 | 2014-04-16 | 广州维思贝生物科技有限公司 | Breakfast nutrition flour rich in omega-3 polyunsaturated fatty acids and preparing method thereof |
| CN103750330A (en) * | 2014-02-18 | 2014-04-30 | 安国市金木生物科技有限公司 | Oral composition comprising bovine bone marrow powder and preparation method of oral composition |
| CN105166957A (en) * | 2015-07-30 | 2015-12-23 | 王之宝 | Bovine bone marrow powder production process and application thereof |
| CN108185407A (en) * | 2017-12-28 | 2018-06-22 | 王清秀 | The method for promoting glossy ganoderma powder absorption rate and obtained ganoderma lucidum sheep marrow peptide compound powder and application |
| CN114946975A (en) * | 2022-04-12 | 2022-08-30 | 王连声 | Health tea containing yak bone marrow powder and preparation process thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1063031C (en) * | 1998-08-11 | 2001-03-14 | 北京长寿保健品有限公司 | Nutritious health-care product for delaying senility and producing method therefor |
| CN1259384A (en) * | 1999-01-06 | 2000-07-12 | 哈尔滨红太阳实业有限公司 | Bone strengthening powder made of yak marrow and its processing method |
| CN1244425A (en) * | 1999-07-30 | 2000-02-16 | 冶明忠 | Health food of yak marrow powder and its production process |
| CN1313091A (en) * | 2000-03-13 | 2001-09-19 | 哈尔滨红太阳保健品有限公司 | Bone strengthening capsules of Biyang yak bone marrow |
| CN1356115A (en) * | 2001-01-11 | 2002-07-03 | 李方瑞 | Instant particles made of cordyceps and yak for making bone stronger |
| CN1231146C (en) * | 2001-04-08 | 2005-12-14 | 内蒙古草原兴发股份有限公司 | Process for preparing polypeptide bone powder |
| CN1146667C (en) * | 2001-05-24 | 2004-04-21 | 谢启安 | Process for extracting amino acid polypeptide with animal bone marrow and tissue |
-
2004
- 2004-05-26 CN CNB2004100427535A patent/CN1319471C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657332A (en) * | 2012-05-08 | 2012-09-12 | 祁宝红 | Preparation method for successively producing yak bone marrow oil and ultramicro polypeptide bone calcium powder once |
| CN103719868A (en) * | 2013-06-27 | 2014-04-16 | 广州维思贝生物科技有限公司 | Breakfast nutrition flour rich in omega-3 polyunsaturated fatty acids and preparing method thereof |
| CN103750330A (en) * | 2014-02-18 | 2014-04-30 | 安国市金木生物科技有限公司 | Oral composition comprising bovine bone marrow powder and preparation method of oral composition |
| CN103750330B (en) * | 2014-02-18 | 2015-02-25 | 安国同源堂生物科技有限公司 | Oral composition comprising bovine bone marrow powder and preparation method of oral composition |
| CN105166957A (en) * | 2015-07-30 | 2015-12-23 | 王之宝 | Bovine bone marrow powder production process and application thereof |
| CN108185407A (en) * | 2017-12-28 | 2018-06-22 | 王清秀 | The method for promoting glossy ganoderma powder absorption rate and obtained ganoderma lucidum sheep marrow peptide compound powder and application |
| CN114946975A (en) * | 2022-04-12 | 2022-08-30 | 王连声 | Health tea containing yak bone marrow powder and preparation process thereof |
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| CN1319471C (en) | 2007-06-06 |
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