CN1318362A - Caries preventing Magnolia Officinalis toothpaste - Google Patents
Caries preventing Magnolia Officinalis toothpaste Download PDFInfo
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- CN1318362A CN1318362A CN 01106513 CN01106513A CN1318362A CN 1318362 A CN1318362 A CN 1318362A CN 01106513 CN01106513 CN 01106513 CN 01106513 A CN01106513 A CN 01106513A CN 1318362 A CN1318362 A CN 1318362A
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- toothpaste
- magnolia officinalis
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Abstract
The caries preventing toothpaste consists of moisture maintaining agent 20-30 wt%, adhesive 1.0-1.3 wt%, sweetener 0.2-0.35 wt%, corrosion inhibitor 0.3-0.3 wt%, magnolol and/or its isomer 0.005-0.5 wt%, rubbing agent 48-52 wt%, foaming agent 1.8-2.5 wt% and essence 1.0-1.4 wt% and water the rest. It has the functions of preventing caries and eliminating halitosis and no side effect.
Description
The invention belongs to Chinese medicinal toothpaste, be specifically related to anticariogenic middle web toothpaste.
Dental caries is human modal frequently-occurring disease, and external dental caries sickness rate reaches 90%, and the sickness rate of China's dental caries is generally at 40-60%.The expert has carried out a large amount of research and discussion to this both at home and abroad, generally acknowledges that dental caries is by antibacterial in the oral cavity and specific ecological conditions--bacterial plaque is caused.Particularly several product acid streptococcis wherein have blood group streptococcus, Streptococcus mutans, absurd fantastic streptococcus and streptococcus mitis.EPDML studies have shown that: the relation of Streptococcus mutans and dental caries is the closest, thinks that promptly Streptococcus mutans is the main pathogenic bacterium of dental caries morbidity.
Prevent and treat the generally employing mechanical removal method of dental caries at present, promptly brush teeth and dental floss removing bacterial plaque with toothbrush.Brush teeth with fluoride dental cream and to prevent and treat dental caries public use already.But modern medicine finds by the microdetermination technological means, and at high fluorine with do not lack the fluorine area to the fluoride dental cream user, by the microanalysis discovery to its hair, its fluorine average more not user has significant difference.Therefore, the use to fluoride should adopt a cautious attitude need according to the various places different condition.
Purpose of the present invention is that the toothpaste of function ingredients is to the effect that prevents and treats dental caries and its content in toothpaste is provided seeking with the Chinese medicine Cortex Magnoliae Officinalis extract.
Cortex Magnoliae Officinalis be China comparatively precious with Chinese crude drug, the chain timbers orchid.The Cortex Magnoliae Officinalis bark contains magnolol, tetrahydromagnolol, iso-agnolol, honokiol, volatilization wet goods composition.Cortex Magnoliae Officinalis has functions such as warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, the disease that disappears, and can control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia disease disease such as do not disappear.How Cortex Magnoliae Officinalis extract is used for toothpaste is prevented and treated dental caries and is not had document open at present as yet.
Toothpaste is a kind of compositions of being made up of plurality of raw materials, and it requires mastic to keep relative stability in considerable time, and the content of controlling the tooth agent will guarantee that it is effective.Dried up or inefficacy does not appear dividing in person's mastic.Therefore, the inventor proposes following scheme: preventing decayed tooth Cortex Magnoliae Officinalis toothpaste controls tooth agent magnolol by the toothpaste wetting agent 20-70% toothpaste adhesive 0.8-1.3% toothpaste sweeting agent 0.2-0.35% toothpaste corrosion inhibiter 0-0.9% of percentage by weight and/or magnolol isomer 0.005-0.5% toothpaste abrasives 18-52% toothpaste foaming agent 1.8-2.5% essence 1.0-1.4% toothpaste antiseptic 0-0.1% surplus is that water is formed.Except that component was controlled tooth agent magnolol and/or magnolol isomer, other component proposed with upperseat concept in this programme, because of other component is that present technique field those of ordinary skill can not realized by creative work.Check above mixture result to prove, indexs such as mastic viscosity, pH value, cold-resistant, foam all are up to state standards.Be placed on the toothpaste of depositing in 50 ℃ of calorstats after one month, the mastic result is normal, and no abnormal phenomenon takes place.See Table one.
Table one preventing decayed tooth Cortex Magnoliae Officinalis toothpaste detects data
| Inspection item | Standard | The result |
| PH value | 5-10 | ?8.43 |
| Viscosity at ambient temperature (mm) | ≥9 | ?18 |
| Heat-resisting viscosity (mm) | ≥9 | ?18 |
| Room temperature is squeezed cream pressure (the mm/ mercury column is poor) | ≤300 | ?120 |
| The cold-resistant cream pressure (the mm/ mercury column is poor) that squeezes | ≤350 | ?140 |
| Foam volume (mm) | ≥60 | ?150 |
| Mastic stability | By test |
Accompanying drawing preventing decayed tooth Cortex Magnoliae Officinalis toothpaste technological process of production figure
Embodiment 1:
The production technology of preventing decayed tooth Cortex Magnoliae Officinalis toothpaste is the production method of existing toothpaste.See accompanying drawing, do not elaborate at this.
In order to prove the bacteriostasis of Cortex Magnoliae Officinalis toothpaste, we have made the Cortex Magnoliae Officinalis toothpaste of different content, and blank toothpaste sees Table two to the big small test of oral microorganism antibacterial circle diameter (mm):
The blank toothpaste of table two different content Cortex Magnoliae Officinalis toothpaste is to oral microorganism antibacterial circle diameter (mm) size
| Strain | C1 | ?D1 | ?B1 | ?E1 | ?F1 | Blank toothpaste |
| Atc110556 | 18 | ?12 | ?15.5 | ?13.5 | ?12 | ?11.5 |
| Streptococcus mutans (C) | 26 | ?30 | ?31 | ?29 | ?28 | ?14 |
| Streptococcus mutans (B) | 19 | ?20 | ?16 | ?24 | ?23 | ?10 |
| Streptococcus mutans (E) | 20 | ?18.5 | ?23 | ?26 | ?23 | ?13 |
| Streptococcus mutans (F) | 24 | ?26 | ?28 | ?27 | ?27 | ?14 |
Annotate: antibacterial circle diameter 15mm is above to be extremely sensitive, and 10-14mm is a medium sensitivity, and 8mm is following to be low responsive.
Above Cortex Magnoliae Officinalis toothpaste basis weight percentage component is as follows: the toothpaste wetting agent adopts glycerol or sorbitol 20% toothpaste adhesive to adopt sodium carboxymethyl cellulose 1.2% toothpaste sweeting agent to adopt glucide 03% toothpaste corrosion inhibiter to adopt Chile saltpeter or waterglass 0.3% toothpaste abrasives to adopt calcite or aluminum hydride 50% toothpaste foaming agent to adopt sodium lauryl sulfate 2.3% essence 1.2%; The above-mentioned Cortex Magnoliae Officinalis toothpaste that contains basis weight percentage component selects magnolol honokiol isomer honokiol percentage by weight to be respectively: the C1--0.005% surplus is a pure water; The D1--0.03% surplus is a pure water; The B1--0.06% surplus is a pure water; The E1--0.09% surplus is a pure water; The F1--0.5% surplus is a pure water.
Can illustrate that from above table the magnolol and the magnolol isomer honokiol that contain weight fraction 0.005%--0.5% in the toothpaste have the function of obvious inhibition Streptococcus mutans.Here preferably magnolol and magnolol isomer honokiol percentage by weight 0.01%--0.1%.
In order to determine the anti-caries effect of Cortex Magnoliae Officinalis toothpaste, select 179 4-6 year child at four essentially identical kindergartens, be divided into two groups to test, use Cortex Magnoliae Officinalis toothpaste for one group, use blank toothpaste for one group.On inspection, these children caries all between 0-4, are learned by statistics and are handled P70.05 no significant difference before experiment.After 12 months, remake the dental caries check, calculate each children caries increased numbers, result such as table three:
Table three
| The dental caries increased numbers | Cortex Magnoliae Officinalis toothpaste | Blank toothpaste |
| ????0 | ????65 | ????42 |
| ????1 | ????18 | ????30 |
| ????2 | ?????5 | ????20 |
| ????3 | ?????1 | ?????5 |
| ????4 | ?????0 | ?????3 |
| ????5 | ?????0 | ?????1 |
| Add up to | ????89 | ???101 |
From last table as seen, observation group's children caries increased numbers is 0.348, matched group be 1.009 each, learn check by statistics, matched group is to be higher than test group (P＜0.01) significantly.This shows that Cortex Magnoliae Officinalis toothpaste has certain anti-caries, mothproof effect.
Embodiment 2:
Make transparent Cortex Magnoliae Officinalis toothpaste, its percentage by weight is composed as follows: glycerol and sorbitol 60-70% sodium carboxymethyl cellulose 0.8-1% glucide 0.2-0.3% sodium lauryl sulfate 1.8-2.5% essence 0.8-1.2% silica 1 8-28% magnolol and honokiol 0.05-0.1% surplus are pure water.
Embodiment 3:
Make high-grade Cortex Magnoliae Officinalis toothpaste, its percentage by weight is composed as follows: glycerol and sorbitol 20-30% sodium carboxymethyl cellulose 0.8-1% glucide 0.2-0.3% sodium lauryl sulfate 1.8-2.5% essence 0.8-1.2% calcium hydrogen phosphate 44-48% sodium benzoate 0.05-0.08% magnolol and honokiol 0.05-0.1% surplus are pure water.
Claims (10)
1, a kind of caries preventing Magnolia Officinalis toothpaste, it controls tooth agent magnolol by the toothpaste wetting agent 20-70% toothpaste adhesive 0.8-1.3% toothpaste sweeting agent 0.2-0.35% toothpaste corrosion inhibiter 0-0.9% of percentage by weight and/or magnolol isomer 0.005-0.5% toothpaste abrasives 18-52% toothpaste foaming agent 1.8-2.5% essence 1.0-1.4% toothpaste antiseptic 0-0.1% surplus is that water is formed.
2, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that selecting magnolol honokiol isomer honokiol, percentage by weight 0.01-0.1%.
3, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that the toothpaste wetting agent adopts glycerol or and/or sorbitol.
4, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that the toothpaste adhesive adopts sodium carboxymethyl cellulose.
5, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that the toothpaste corrosion inhibiter adopts waterglass or Chile saltpeter, weight percent content 0.3-0.9%.
6, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that toothpaste abrasives adopts calcite or aluminium hydroxide, weight percent content 48-52%
7, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that the toothpaste foaming agent adopts sodium lauryl sulfate.
8, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that toothpaste abrasives adopts calcium hydrogen phosphate, weight percent content 44-48%.
9, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that toothpaste abrasives adopts silicon dioxide, weight percent content 18-28%.
10, caries preventing Magnolia Officinalis toothpaste according to claim 1 is characterized in that the toothpaste antiseptic adopts sodium benzoate weight percent content 0.05-0.1%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011065133A CN1173689C (en) | 2001-02-28 | 2001-02-28 | Caries preventing Magnolia Officinalis toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011065133A CN1173689C (en) | 2001-02-28 | 2001-02-28 | Caries preventing Magnolia Officinalis toothpaste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1318362A true CN1318362A (en) | 2001-10-24 |
| CN1173689C CN1173689C (en) | 2004-11-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011065133A Expired - Fee Related CN1173689C (en) | 2001-02-28 | 2001-02-28 | Caries preventing Magnolia Officinalis toothpaste |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012015408A1 (en) * | 2010-07-29 | 2012-02-02 | Colgate-Palmolive Company | Phosphate free oral care compositions based on magnolia antibacterial agent |
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| CN109260130A (en) * | 2018-10-26 | 2019-01-25 | 纳诺神蜂（福建）个人护理用品有限公司 | A kind of children's mothproof toothpaste and preparation method thereof |
| CN114588059A (en) * | 2022-03-25 | 2022-06-07 | 湖南有美生物科技有限公司 | Preparation method and application of oral cavity mothproof paste |
-
2001
- 2001-02-28 CN CNB011065133A patent/CN1173689C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| WO2012015408A1 (en) * | 2010-07-29 | 2012-02-02 | Colgate-Palmolive Company | Phosphate free oral care compositions based on magnolia antibacterial agent |
| CN103153270A (en) * | 2010-07-29 | 2013-06-12 | 高露洁-棕榄公司 | Phosphate free oral care compositions based on magnolia antibacterial agent |
| RU2533220C2 (en) * | 2010-07-29 | 2014-11-20 | Колгейт-Палмолив Компани | Phosphate-free oral care compositions with antibacterial agent of magnolia |
| US9125860B2 (en) | 2010-07-29 | 2015-09-08 | Colgate-Palmolive Company | Phosphate free oral care compositions based on magnolia antibacterial agent |
| CN103153270B (en) * | 2010-07-29 | 2016-09-07 | 高露洁-棕榄公司 | The most phosphatic oral care composition of based on Drymotaenium miyoshianum (Mak.) Mak. antibacterial |
| CN109260130A (en) * | 2018-10-26 | 2019-01-25 | 纳诺神蜂（福建）个人护理用品有限公司 | A kind of children's mothproof toothpaste and preparation method thereof |
| CN114588059A (en) * | 2022-03-25 | 2022-06-07 | 湖南有美生物科技有限公司 | Preparation method and application of oral cavity mothproof paste |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1173689C (en) | 2004-11-03 |
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