CN1316187A - Water-soluble sulfa disinfectants for agriculture and its preparing process - Google Patents
Water-soluble sulfa disinfectants for agriculture and its preparing process Download PDFInfo
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- CN1316187A CN1316187A CN 00104893 CN00104893A CN1316187A CN 1316187 A CN1316187 A CN 1316187A CN 00104893 CN00104893 CN 00104893 CN 00104893 A CN00104893 A CN 00104893A CN 1316187 A CN1316187 A CN 1316187A
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- water
- sulfa
- soluble
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- disinfectants
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Abstract
A water-soluble sulfa disinfectant for agricultural purpose is prepared from sulfa chemicals by dissolving the chemicals in the aqueous alkali solution, adding inorganic acid, to neutrolize excess alkali in the solution, thus a watet soluble salt in formed, genurally sulfa sodium (potassium) salt, some accessary in gradients are added to the sulfa salt such as, penetrant, wetting agent and filler. Its advantages include without use orgauic solvent low cost, no environmental pollution and high effect on preventing and eliminating rice blast.
Description
The present invention relates to agriculture chemicals fungicide, also relate to sulfonamides compound.
People know that rice blast is to endanger one of heavier main disease in the paddy growth, and it occurs in paddy rice from seedling to each period of earing, grain is in the milk.No matter which morbidity in period all can bring adverse consequences to the output of paddy rice.20th century, successively there is the agricultural chemicals of some control rice blast on agricultural, to use, as " tricyclazole ", " Isoprothiolane ", " S-1901 ", " rabcide ", " probenazole ", " Hinosan " or the like, wherein, " tricyclazole " hangs down with its good drug efficacy and price and is used widely.Yet above-mentioned these agricultural chemicals comprise " tricyclazole ", only can rise for rice blast and suppress and prevention effect, and the agricultural chemicals that really can be used for the treatment of rice blast but is blank basically.And owing to use the time limit of these agricultural chemicals long, some plant of paddy rice have produced pesticide resistance, cause its control efficiency to descend year by year.At present, still there is not the better agricultural chemicals listing of treatment rice blast.Though Bayer Pesticide Co., Ltd., Japan has pointed out " multiple known sulfamide compound useful as fungicides; be particularly suitable for preventing and treating rice blast " (seeing Chinese patent application No. 94119442.6), but the multiple sulfamide compound that this Co., Ltd. is enumerated is all water insoluble, they to be applied in the agricultural and go, must adopt organic solvent to dissolve this compounds.This just must bring sulfonamides pesticide cost height, have pollution, crop to be difficult for absorption or the like shortcoming to environment.Although sulfamide compound has similar structure and chemical property to sulfa drugs, yet there is not sulfonamides compound to make the report of water soluble pesticide up to now as yet.
The object of the present invention is to provide a kind of water-soluble sulfa disinfectants for agriculture and its manufacture method is provided.
The inventor finds that sulfonamides compound not only can be used for human body and makes anti-inflammation drugs, and rice blast is had fabulous curative effect through research.It is a lot of to can be used as the sulfonamides compound of preventing and treating rice blast, can think that the compound that meets following general formula can be as the raw material of water-soluble sulfa disinfectants for agriculture;
R-SO
2-NH-R′ (1)
Wherein R is a following groups:
NH
2 
NH
2-CH
2
R ' is a following groups:
Belonging to the sulfamido material that this class can be used for making water-soluble bactericide agricultural chemicals has:
Sulphoamidine:
Sulphadiazine (or sodium sulfadiazine):
Water-soluble sulfa disinfectants for agriculture provided by the invention, the salt that is dissolvable in water water of the sulfanilamide (SN) of making after exactly sulfa drugs being processed is generally sodium (potassium) salt of sulfanilamide (SN).
The method for making of this water-soluble sulfa disinfectants for agriculture is that sulfanilamide (SN) is dissolved in the aqueous solution of alkali, add in the inorganic acid and excessive alkali, and interpolation is necessary in the salt of sulfanilamide (SN) auxiliary agent and inserts makes.
The alkali that can be used to dissolve sulfanilamide (SN) comprises sodium hydroxide, potassium hydroxide, ammonium hydroxide, slaked lime, aluminium hydroxide, sodium carbonate, guanidine carbonate, potash, sodium bicarbonate, saleratus, carbonic hydroammonium etc.Be easy to get and economic angle from raw material, best with sodium carbonate certainly.Use sodium carbonate can make the sodium salt of the fabulous sulfanilamide (SN) of dissolubility.
In order to make this agricultural chemicals play bactericidal action well, be necessary to add some auxiliary agents---deep and thorough dose, wetting agent etc., help the wax coat of medicine infiltration plant epidermis, bleeding agent commonly used has water-soluble azone, and wetting agent commonly used is a Nekal BX; In addition, for packing, convenient transportation, also will add inserts in the salt of sulfanilamide (SN), inserts is used white carbon black usually.
The amount that bleeding agent adds is 1%～10% of a sulfonamide amount; The amount that wetting agent adds is 2%～16% of a sulfonamide amount; Inserts then calculates and amount interpolation on demand with the mass fraction of the contained bactericide active ingredient of finished product.
Water-soluble sulfa disinfectants for agriculture provided by the invention has been avoided the formulations such as wetting powder, granule, missible oil, colloidal suspending agent of bactericide on the common market to need the shortcoming of multiple auxiliary agent or solvent, thereby has been reduced cost; Simultaneously, because need not be, have avoided solvent to the pollution of environment with to the threat of producers' health such as benzene,toluene,xylene, acetone and other organic solvent; It is the agricultural chemicals that a class has economic benefit, social benefit and environmental benefit concurrently.This bactericide can suppress and treat rice blast effectively.
Embodiment: take by weighing sulfamethoxazole 5kg, sodium sulphite 5kg, sodium bicarbonate 50kg, wetting agent BX0.4kg, water-soluble azone 0.25kg, and prepare enough white carbon blacks.Successively respectively sulfamethoxazole and sodium bicarbonate are poured in the reaction pot, stir and 50～80 ℃ under be dissolved in water.Molten intact back slowly adds sodium sulphite, stirs half an hour; When treating that temperature drops to 30 ℃, under agitation drip dilute sulfuric acid, clear liquid occurs until the upper strata.Leach clear liquid, add water-soluble azone, wetting agent BX and stirring.Weighing afterwards, the addition that pro rata is calculated the white carbon black of inserts is 41kg, add white carbon black by this amount, then with this mixture oven dry, abrasive dust and pulverizing according to a conventional method again, sieve out right rail, promptly obtain 100kg active ingredient percentage composition and be 5% agriculture chemicals fungicide product, this product trade name is " No. one, Great Wall ".
Claims (5)
1 by meeting following general formula
R-SO
2-NH-R′
Wherein R is a following groups:
NH
2 
NH
2-CH
2 
R ' is a following groups:
The water-soluble sulfa disinfectants for agriculture that makes of sulfonamides compound, it is characterized in that it is the salt that is dissolvable in water water of the sulfanilamide (SN) made after will sulfa drugs processing, is generally sodium (potassium) salt of sulfanilamide (SN).
The method for making of 2 water-soluble sulfa disinfectants for agriculture as claimed in claim 1 is characterized in that it is that sulfanilamide (SN) is dissolved in the aqueous solution of alkali, add in the inorganic acid and excessive alkali, and interpolation is necessary in the salt of sulfanilamide (SN) auxiliary agent and inserts makes.
The method for making of 3 water-soluble sulfa disinfectants for agriculture as claimed in claim 2, the alkali that it is characterized in that can be used to dissolving sulfanilamide (SN) comprises sodium hydroxide, potassium hydroxide, ammonium hydroxide, slaked lime, aluminium hydroxide, sodium carbonate, guanidine carbonate, potash, sodium bicarbonate, saleratus, carbonic hydroammonium etc.
The method for making of 4 water-soluble sulfa disinfectants for agriculture as claimed in claim 2 is characterized in that the auxiliary agent of using always has the water-soluble azone of bleeding agent, wetting agent Nekal BX; Inserts commonly used is white carbon black.
5 method for makings as claim 2 or 4 described water-soluble sulfa disinfectants for agriculture, the addition that it is characterized in that bleeding agent is 1%～10% of a sulfonamide amount; The addition of wetting agent is 2%～16% of a sulfonamide amount.Inserts is then measured interpolation on demand with the mass fraction of the contained bactericide active ingredient of finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00104893 CN1316187A (en) | 2000-04-03 | 2000-04-03 | Water-soluble sulfa disinfectants for agriculture and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00104893 CN1316187A (en) | 2000-04-03 | 2000-04-03 | Water-soluble sulfa disinfectants for agriculture and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1316187A true CN1316187A (en) | 2001-10-10 |
Family
ID=4577452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00104893 Pending CN1316187A (en) | 2000-04-03 | 2000-04-03 | Water-soluble sulfa disinfectants for agriculture and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1316187A (en) |
-
2000
- 2000-04-03 CN CN 00104893 patent/CN1316187A/en active Pending
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |