CN1315557C - 键合相光聚合溶胶-凝胶柱和相关的方法 - Google Patents

键合相光聚合溶胶-凝胶柱和相关的方法 Download PDF

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Publication number
CN1315557C
CN1315557C CNB02818548XA CN02818548A CN1315557C CN 1315557 C CN1315557 C CN 1315557C CN B02818548X A CNB02818548X A CN B02818548XA CN 02818548 A CN02818548 A CN 02818548A CN 1315557 C CN1315557 C CN 1315557C
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column
solution
separation
introducing
porous
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Chinese (zh)
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CN1556729A (zh
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R·N·扎雷
M·T·杜莱
J·P·奎里诺
B·D·贝内特
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Leland Stanford Junior University
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Leland Stanford Junior University
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Priority claimed from US09/929,275 external-priority patent/US6866785B2/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282Porous sorbents
    • B01J20/285Porous sorbents based on polymers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26Synthetic macromolecular compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042Shaped bodies; Monolithic structures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/287Non-polar phases; Reversed phases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/288Polar phases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/29Chiral phases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54Sorbents specially adapted for analytical or investigative chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/80Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J2220/82Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/80Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J2220/84Capillaries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/50Conditioning of the sorbent material or stationary liquid
    • G01N30/52Physical parameters
    • G01N2030/524Physical parameters structural properties
    • G01N2030/528Monolithic sorbent material

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CNB02818548XA 2001-08-13 2002-08-13 键合相光聚合溶胶-凝胶柱和相关的方法 Expired - Lifetime CN1315557C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/929,275 US6866785B2 (en) 2001-08-13 2001-08-13 Photopolymerized sol-gel column and associated methods
US09/929,275 2001-08-13
US09/978,515 2001-10-15
US09/978,515 US6884346B2 (en) 2001-08-13 2001-10-15 Bonded phase photopolymerized sol-gel column and associated methods

Publications (2)

Publication Number Publication Date
CN1556729A CN1556729A (zh) 2004-12-22
CN1315557C true CN1315557C (zh) 2007-05-16

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Country Link
EP (1) EP1418997B1 (https=)
JP (1) JP4295095B2 (https=)
CN (1) CN1315557C (https=)
WO (1) WO2003015891A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050127002A1 (en) * 2003-12-12 2005-06-16 Zare Richard N. Immobilized-enzyme microreactor devices for characterization of biomolecular analytes and associated methods
US20070014699A1 (en) * 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
US8721384B2 (en) 2009-09-25 2014-05-13 Innovation First, Inc. Display case for vibration powered device
US8905813B2 (en) 2009-09-25 2014-12-09 Innovation First, Inc. Vibration powered toy
US8882558B2 (en) 2009-09-25 2014-11-11 Innovation First, Inc. Habitat for vibration powered device
US8834226B2 (en) 2009-09-25 2014-09-16 Innovation First, Inc. Vibration powered toy
US9017136B2 (en) 2009-09-25 2015-04-28 Innovation First, Inc. Vibration powered toy
US11478720B2 (en) 2009-09-25 2022-10-25 Innovation First, Inc. Vibration powered toy
US9050541B2 (en) 2009-09-25 2015-06-09 Innovation First, Inc. Moving attachments for a vibration powered toy
GB2490665B (en) * 2011-05-06 2017-01-04 Genetic Microdevices Ltd Device and method for applying an electric field
CN103182188B (zh) 2011-12-30 2016-10-19 创首公司 振动驱动的攀爬机器人
EP2859053B1 (en) 2012-06-08 2019-12-25 University Of Houston Self-cleaning coatings and methods for making same
USD698395S1 (en) 2012-09-20 2014-01-28 Innovation First, Inc. Toy figure
US9694388B2 (en) 2013-05-14 2017-07-04 University Of Houston System Waterproof coating with nanoscopic/microscopic features and methods of making same
CN103293268B (zh) * 2013-06-18 2016-03-23 南京金域医学检验所有限公司 一种人尿氢化可的松的检测方法
US9129785B2 (en) 2013-08-01 2015-09-08 The Board Of Trustees Of The Leland Stanford Junior University Metal organic polymer matrices and systems for chemical and biochemical mass spectrometry and methods of use thereof
CN109569026B (zh) * 2018-01-11 2021-12-03 南开大学 制备多孔框架材料为基质的色谱固定相用于手性分离
CN108760871B (zh) * 2018-06-11 2021-01-19 上海大学 细胞亲和力检测出样装置及其在细胞亲和力测定中的应用
CN110200743B (zh) * 2019-05-28 2021-07-30 广州新诚生物科技有限公司 一种自固定示踪泪点塞及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135627A (en) * 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
CN1236892A (zh) * 1998-05-28 1999-12-01 中国人民解放军军事医学科学院放射医学研究所 交联聚丙烯酰胺类涂层毛细管柱辐照制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
JP2893104B2 (ja) * 1994-03-14 1999-05-17 直弘 曽我 有機官能基の結合した無機系多孔質体の製造方法
JP4080565B2 (ja) * 1996-04-26 2008-04-23 大日本インキ化学工業株式会社 多孔質体の製造方法および多孔質体
US6207098B1 (en) * 1996-12-26 2001-03-27 Merck Patent Gmbh Method for producing porous inorganic materials
US6136187A (en) * 1997-12-09 2000-10-24 The Board Of Trustees Of The Leland Stanford Junior University Separation column containing porous matrix and method of packing column
JP3979612B2 (ja) * 1998-06-15 2007-09-19 財団法人川村理化学研究所 センサー及びその製造方法
US6210570B1 (en) * 1998-08-21 2001-04-03 Agilent Technologies, Inc. Monolithic silica column
EP1157270A1 (en) * 1999-02-03 2001-11-28 Aclara BioSciences, Inc. Multichannel control in microfluidics
JP2003520962A (ja) * 2000-01-18 2003-07-08 アドビオン バイオサイエンシーズ インコーポレーティッド 分離媒体、複式電気噴霧ノズルシステム、および方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135627A (en) * 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
CN1236892A (zh) * 1998-05-28 1999-12-01 中国人民解放军军事医学科学院放射医学研究所 交联聚丙烯酰胺类涂层毛细管柱辐照制备方法

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Publication number Publication date
CN1556729A (zh) 2004-12-22
JP4295095B2 (ja) 2009-07-15
JP2004538482A (ja) 2004-12-24
EP1418997B1 (en) 2010-04-28
WO2003015891A1 (en) 2003-02-27
EP1418997A1 (en) 2004-05-19
EP1418997A4 (en) 2005-01-26

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