CN1315498C - 一种小儿热速清泡腾片及其制备方法 - Google Patents
一种小儿热速清泡腾片及其制备方法 Download PDFInfo
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- CN1315498C CN1315498C CNB2005100987230A CN200510098723A CN1315498C CN 1315498 C CN1315498 C CN 1315498C CN B2005100987230 A CNB2005100987230 A CN B2005100987230A CN 200510098723 A CN200510098723 A CN 200510098723A CN 1315498 C CN1315498 C CN 1315498C
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- infantile fever
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 21
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
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- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 4
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019202 steviosides Nutrition 0.000 claims description 4
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
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- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 4
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
配方号 | 药粉(g) | 酸种类(g) | 碱种类(g) | 结果 |
123456 | 757575757575 | 酒石酸87.5己二酸87.5丁二酸87.5苹果酸87.5富马酸87.5柠檬酸87.5 | 碳酸氢钠87.5碳酸氢钠87.5碳酸氢钠87.5碳酸氢钠87.5碳酸氢钠87.5碳酸氢钠87.5 | 制粒、压片、泡腾均好泡腾太慢,效果不好吸潮,无法制粒吸潮,无法制粒较好,泡腾慢结块,无法制粒 |
序号 | 药粉占片重比例 | 泡腾剂占片重比例 | 酸占泡腾剂比例 | 泡腾效果 | 崩解时间 |
12345678910111213141516 | 1/31/31/31/31/21/21/21/23/53/53/53/52/32/32/32/3 | 2/32/32/32/31/21/21/21/22/52/52/52/51/31/31/31/3 | 40%45%50%55%40%45%50%55%40%45%50%55%40%45%50%55% | ++++++++++++++++++++++++++++±±±± | 1分29秒1分35秒1分46秒1分52秒4分35秒4分39秒超出限时超出限时超出限时超出限时超出限时超出限时超出限时超出限时超出限时超出限时 |
序号 | 药粉(g) | 酸(g) | 碱(g) | 崩解时间 | 泡腾后药液评价 |
12 | 0.750.75 | 0.650.75 | 0.850.75 | 1分53秒1分52秒 | 药液中有少量絮状物,口感差。药液澄清,口感好。 |
34 | 0.750.75 | 0.790.83 | 0.710.67 | 2分25秒2分40秒 | 药液有少量絮状物,口感较好。药液中有少量絮状物,口感差。 |
样品 | 外观性状 | 泡腾时间 |
试验前试验后 | 黄褐色片剂黄褐色片剂 | 1分55秒1分42秒 |
Claims (3)
Priority Applications (1)
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CNB2005100987230A CN1315498C (zh) | 2005-09-07 | 2005-09-07 | 一种小儿热速清泡腾片及其制备方法 |
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CNB2005100987230A CN1315498C (zh) | 2005-09-07 | 2005-09-07 | 一种小儿热速清泡腾片及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN1733028A CN1733028A (zh) | 2006-02-15 |
CN1315498C true CN1315498C (zh) | 2007-05-16 |
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CNB2005100987230A Active CN1315498C (zh) | 2005-09-07 | 2005-09-07 | 一种小儿热速清泡腾片及其制备方法 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101085055B (zh) * | 2007-06-26 | 2010-06-02 | 黑龙江省珍宝岛制药有限公司 | 一种清热解毒、泻火利咽的中药组合物糖浆剂及其制备方法 |
CN103110705A (zh) * | 2012-12-17 | 2013-05-22 | 青岛中科润美润滑材料技术有限公司 | 一种治疗小儿风寒感冒的中药组合物及其制备方法 |
CN104274537A (zh) * | 2013-07-02 | 2015-01-14 | 天津药物研究院 | 一种中药组合物及其制备方法和用途 |
CN114767533A (zh) * | 2022-04-08 | 2022-07-22 | 江西倍肯药业有限公司 | 一种基于小儿热速清颗粒的醇沉工艺过程控制方法 |
CN115181609A (zh) * | 2022-08-23 | 2022-10-14 | 江西倍肯药业有限公司 | 一种小儿热速清颗粒用挥发油的提取方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1364581A (zh) * | 2001-01-16 | 2002-08-21 | 杨孟君 | 纳米小儿热速清制剂药物及其制备方法 |
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2005
- 2005-09-07 CN CNB2005100987230A patent/CN1315498C/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1364581A (zh) * | 2001-01-16 | 2002-08-21 | 杨孟君 | 纳米小儿热速清制剂药物及其制备方法 |
Non-Patent Citations (1)
Title |
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化学工业出版社 2000年版药典一部 2000 * |
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Effective date of registration: 20161223 Address after: Beijing city Changping District town Beiqijia Hongfu building room 1009 Patentee after: BEIJING INCREASE PHARMACEUTICAL INSTITUTE CO., LTD. Address before: 519040 Guangdong city of Zhuhai province Jinwan District Sanzao Town Airport Road No. 288 building four floor F area B Patentee before: Zhuhai Bao Derun Health Technology Co., Ltd. |
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Effective date of registration: 20170630 Address after: Beijing city Changping District town Beiqijia Hongfu building room 1009 Patentee after: Beijing Kerui innovative drug research Co. Ltd. Address before: Beijing city Changping District town Beiqijia Hongfu building room 1009 Patentee before: BEIJING INCREASE PHARMACEUTICAL INSTITUTE CO., LTD. |