CN1312078A - Making process of compound sulfadiazine zinc spreader - Google Patents
Making process of compound sulfadiazine zinc spreader Download PDFInfo
- Publication number
- CN1312078A CN1312078A CN 01107197 CN01107197A CN1312078A CN 1312078 A CN1312078 A CN 1312078A CN 01107197 CN01107197 CN 01107197 CN 01107197 A CN01107197 A CN 01107197A CN 1312078 A CN1312078 A CN 1312078A
- Authority
- CN
- China
- Prior art keywords
- zinc
- sulfadiazine
- grams
- medical
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The formula of compound zinc sulfadiazine film includes (wt%) zinc sulfadiazine 0.5%-5%, silver sulfadiazine 0.2%-2.%, medical auxiliary material 1%-18%, glycerin 0-45%, medical calcium salt 0-5%, ethylparaben 0-0.08% and the rest is water. Its production process includes the following steps: adding distilled water to medical auxiliary material, adding other ingredients, uniformly stirring, boiling and using colloid mill to uniformly emulsion-grinding to obtain the invented finished product. Said invention film preparation is used for curing burn and scald, can promote wound healing and possess unique film protection action.
Description
The invention belongs to the medication preparation field, specifically is a kind of manufacture method of compound sulfadiazine zinc spreader.
In the prior art, silver sulfadiazine (SD-Ag) is the choice drug of clinical treatment burn, has stronger bacteriostasis antibiosis effect.Especially it can penetrate under the crust, and bacillus pyocyaneus and escherichia coli are had stronger inhibitory action, is the effectively medicine of treatment burn.But costing an arm and a leg of silver salt, easily oxidation, toxicity is bigger.Zinc sulfadiazine (SD-Zn) also can be used for the treatment of burn, and it not only has the effect of protecting from infection, and because zinc ion participates in the function of plurality of enzymes in the internal metabolism, can accelerate tissue repair, promotes wound healing.In addition, have in the human body 20 percent zinc concentrate on skin, and zinc is with immunity, wound healing is relevant, so burn patient zinc supplement is necessary.In the prior art, the report of the above-mentioned a kind of medicine of independent use as treatment burning, vulnerary thing arranged, but do not see the report that uses above-mentioned two kinds of medicines simultaneously.
The object of the present invention is to provide a kind of manufacture method of compound sulfadiazine zinc spreader, the liniment that obtains is used for the treatment of burn, but attenuation synergistic, promotes wound healing; film protective effect to wound surface tool uniqueness; non-stimulated to wound, with after need not wrapping, change dressings conveniently.
The objective of the invention is to realize by following technical proposals:
The manufacture method of compound sulfadiazine zinc spreader of the present invention, prescription is: zinc sulfadiazine 0.5%～5%, silver sulfadiazine 0.2%～2.5%, medical accessory 1%～18%, glycerol 0～45%, medical calcium salt 0～5%, ethylparaben or methyl parahydroxybenzoate 0～0.08%, surplus is a distilled water; Technology is: add distilled water and make it to be swelled into even pasty state in medical accessory, add all the other each components, stir post-heating and boil, weigh, deficiency then adds water and supplies weight, and colloid mill breast mill evenly is sub-packed in sealing in the container, gets product through check, packing, packing, chemical examination.
In the such scheme, medical calcium salt is: calcium gluconate, Calcium d-tartrate, calcium citrate.
In the such scheme, medical accessory is: methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, polyvinyl alcohol, sodium alginate, soluble poly vinylpyrrolidone etc.
The present invention is to be principal agent with compound sulfadiazine zinc and silver sulfadiazine, is adjuvant with the medical accessory, and ethylparaben or methyl parahydroxybenzoate are antiseptic, and glycerol is wetting agent, and medical calcium salt is viscosifier.
Used medical accessory is solvent as the substrate of liniment with water, and heating is swelled into even pasty state, and pH value is in 4～10 scope.In the medical accessory, be preferably natural seaweed acid sodium, it is a kind of natural polymer substance, but is the pharmaceutic adjuvant that coagulates amine shape high temperature sterilize for water solublity.
The present invention adds zinc sulfadiazine and silver sulfadiazine simultaneously in burn film-coating agent, through splitting the checking of experiment and clinical efficacy, proof the present invention has given full play to two kinds of medicines treatment advantage clinically, and has remarkable role in synergy and good compatibility effect.The present invention selects above-mentioned medical accessory for use, especially select for use the natural macromolecular material sodium alginate as the substrate adjuvant, the liniment water solublity that is prepared from is good, can be in the wound surface film forming, and can not only the absorptive tissue transudate, non-stimulated to wound surface, easy cleaning, good permeability can make wound surface be in the optimum humidity simultaneously, be beneficial to the growth of new cell, the protecting film that forms at wound surface can prevent extraneous pathogenic bacteria invasion; Easy to usely need not wrap up, can use aseptic water washing when changing dressings, not damage newborn cell tissue, remove or alleviate the misery that patient changes dressings from.
This liniment is used for the treatment of burn, has overcome the shortcoming of using single sulfonamide in the conventional therapy, reaches attenuation synergistic, promotes wound healing; to the film protective effect of wound surface tool uniqueness because non-stimulated to wound, with after need not to wrap up; change dressings conveniently, obtain doctor, patient's favorable comment.
The invention is further illustrated by the following examples, and the present invention is not limited only to described embodiment.
Embodiment one
Prescription is: zinc sulfadiazine 5 grams, silver sulfadiazine 2 grams, sodium alginate 180 grams, distilled water 952 grams; 3/4 of batching distilled water total amount is heated to boiling, the sodium alginate that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add components such as zinc sulfadiazine, silver sulfadiazine, stir evenly, weigh after continuing to boil half an hour, add water and supply weight, be chilled to room temperature, the colloid mill breast grinds once, and the inspection of semifinished product, packing, packing, chemical examination get product.
Embodiment two
Prescription is: zinc sulfadiazine 50 grams, silver sulfadiazine 25 grams, polyvinyl alcohol 10 grams, glycerol 450 grams, distilled water 488 grams; 3/4 of batching distilled water total amount is heated to boiling, the polyvinyl alcohol that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add components such as glycerol, sulphur peace pyrimidine zinc, silver sulfadiazine, stir evenly, weigh after continuing to boil half an hour, add water and supply weight, be chilled to room temperature, colloid mill breast mill three times, the inspection of semifinished product, packing, packing, chemical examination get product.
Embodiment three
Prescription is: zinc sulfadiazine 30 grams, silver sulfadiazine 18 grams, hydroxypropyl emthylcellulose 100 grams, glycerol 200 grams, calcium gluconate 50 grams, distilled water 610 grams; 3/4 of batching distilled water total amount is heated to boiling, the hydroxypropyl emthylcellulose that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add the components such as aqueous solution, glycerol, zinc sulfadiazine, silver sulfadiazine of calcium gluconate, stir evenly, weigh after continuing to boil half an hour, add water and supply weight, be chilled to room temperature, colloid mill breast mill three times, the inspection of semifinished product, packing, packing, chemical examination get product.
Embodiment four
Prescription is: zinc sulfadiazine 20 grams, silver sulfadiazine 12 grams, sodium carboxymethyl cellulose 100 grams, glycerol 50 grams, calcium gluconate 50 grams, ethylparaben 0.8 gram, distilled water 759.2 grams; 3/4 of batching distilled water total amount is heated to boiling, the sodium carboxymethyl cellulose that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add the components such as aqueous solution, glycerol, sulphur peace pyrimidine zinc, silver sulfadiazine of aqueous solution, the ethylparaben of calcium gluconate, stir evenly, weigh after continuing to boil half an hour, add water and supply weight, be chilled to room temperature, colloid mill breast mill secondary, the inspection of semifinished product, packing, packing, chemical examination get product.
Embodiment five
Prescription is: zinc sulfadiazine 40 grams, silver sulfadiazine 15 grams, methylcellulose 100 grams, glycerol 100 grams, Calcium d-tartrate 40 grams, ethylparaben 0.5 gram, distilled water 714.5 grams; 3/4 of batching distilled water total amount is heated to boiling, the methylcellulose that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add the components such as aqueous solution, glycerol, zinc sulfadiazine, silver sulfadiazine of aqueous solution, the ethylparaben of Calcium d-tartrate, stir evenly, continue to boil after one hour and weigh, add water and supply weight, be chilled to room temperature, colloid mill breast mill five times, the inspection of semifinished product, packing, packing, chemical examination get product.
Embodiment six
Prescription is: zinc sulfadiazine 30 grams, silver sulfadiazine 15 grams, sodium alginate 105 grams, glycerol 250 grams, calcium citrate 20 grams, methyl parahydroxybenzoate 0.2 gram, distilled water 604.8 grams; 3/4 of batching distilled water total amount is heated to boiling, the sodium alginate that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add the components such as aqueous solution, glycerol, zinc sulfadiazine, silver sulfadiazine of aqueous solution, the methyl parahydroxybenzoate of calcium citrate, stir evenly, continue to boil after two hours and weigh, add water and supply weight, be chilled to room temperature, colloid mill breast mill three times, the inspection of semifinished product, packing, packing, chemical examination get product.
Embodiment seven
Prescription is: zinc sulfadiazine 30 grams, silver sulfadiazine 15 grams, soluble poly vinylpyrrolidone 110 grams, glycerol 250 grams, calcium citrate 20 grams, methyl parahydroxybenzoate 0.2 gram, distilled water 604.8 grams; 3/4 of batching distilled water total amount is heated to boiling, the soluble poly vinylpyrrolidone that under agitation slowly adds weighing, and on boiling water bath, continue to boil molten, to even pasty state, under agitation add the components such as aqueous solution, glycerol, zinc sulfadiazine, silver sulfadiazine of aqueous solution, the methyl parahydroxybenzoate of calcium citrate, stir evenly, continue to boil after two hours and weigh, add water and supply weight, be chilled to room temperature, colloid mill breast mill three times, the inspection of semifinished product, packing, packing, chemical examination get product.
Claims (3)
1. the manufacture method of compound sulfadiazine zinc spreader, it is characterized in that prescription is: the close pyridine zinc 0.5%～5% of sulfanilamide, silver sulfadiazine 0.2%～2.5%, medical accessory 1%～18%, glycerol 0～45%, medical calcium salt 0～5%, ethylparaben or methyl parahydroxybenzoate 0～0.08%, surplus is a distilled water; Technology is: add distilled water and make it to be swelled into even pasty state in medical accessory, add all the other each components, stir post-heating and boil, weigh, deficiency then adds water and supplies weight, and colloid mill breast mill evenly is sub-packed in sealing in the container, gets product through check, packing, packing, chemical examination.
2. the manufacture method of compound sulfadiazine zinc spreader according to claim 1 is characterized in that medical calcium salt is: calcium gluconate, Calcium d-tartrate, calcium citrate.
3. the manufacture method of compound sulfadiazine zinc spreader according to claim 1 and 2 is characterized in that described medical accessory is methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, polyvinyl alcohol, sodium alginate, solvable living polyvinylpyrrolidone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107197 CN1312078A (en) | 2001-02-28 | 2001-02-28 | Making process of compound sulfadiazine zinc spreader |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107197 CN1312078A (en) | 2001-02-28 | 2001-02-28 | Making process of compound sulfadiazine zinc spreader |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1312078A true CN1312078A (en) | 2001-09-12 |
Family
ID=4656147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01107197 Pending CN1312078A (en) | 2001-02-28 | 2001-02-28 | Making process of compound sulfadiazine zinc spreader |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1312078A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427154C (en) * | 2005-01-27 | 2008-10-22 | 天津市托福医用原子能科技有限公司 | SD-Zn irradiated biological skin and its prepn process |
| CN105854021A (en) * | 2016-05-06 | 2016-08-17 | 中国人民解放军第四军医大学 | External-use drug and preparation with analgesic and antibacterial effect and preparation method thereof |
-
2001
- 2001-02-28 CN CN 01107197 patent/CN1312078A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427154C (en) * | 2005-01-27 | 2008-10-22 | 天津市托福医用原子能科技有限公司 | SD-Zn irradiated biological skin and its prepn process |
| CN105854021A (en) * | 2016-05-06 | 2016-08-17 | 中国人民解放军第四军医大学 | External-use drug and preparation with analgesic and antibacterial effect and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100471528C (en) | Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting | |
| CN101977589B (en) | Chitosan gel for dermatological use, production method therefor and use of same | |
| CN102824308B (en) | Chitosan antibacterial filming sprayer and preparation method | |
| CN104257639B (en) | A kind of liniment for Wound treating and preparation method thereof | |
| CN104083398B (en) | A kind of medical protection flushing liquor and preparation method thereof | |
| CN104013639B (en) | A kind of compositions with skin repair function and gel thereof | |
| CN108187132A (en) | A kind of povidone iodine hydrogel antiseptic dressing and preparation method thereof | |
| CN105079858B (en) | Liquid dressing and its preparation method are repaired in a kind of wound sterilization | |
| RU2317811C1 (en) | Pharmaceutical composition for treatment of burn (variants) and method for its preparing (variants) | |
| WO2017215610A1 (en) | Efficient and safe chitosan derivative-based disinfectant and preparation method therefor | |
| CN110064070A (en) | Containing organic quaternary ammonium salt or with silane end organic quaternary ammonium salt anti-bacterial hydrogel and preparation method thereof | |
| CN114984301A (en) | Antibacterial dressing for promoting wound surface to heal without scars and preparation method thereof | |
| CN107982277B (en) | Composite antibacterial aerosol and preparation method and application thereof | |
| CN110269835A (en) | A kind of antibacterial prosthetic gel of carbomer gynaecology and preparation method thereof | |
| CN111632188A (en) | Seaweed polysaccharide composite biological matrix dressing and preparation method thereof | |
| CN105126158B (en) | Polysaccharide fiber element hemostasis isolation antibacterial repairs glue and preparation method thereof | |
| CN1312078A (en) | Making process of compound sulfadiazine zinc spreader | |
| CN102526121B (en) | Wound repair composition and preparation method and application thereof | |
| CN107595819B (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN105412977A (en) | Chitosan wound dressing | |
| CN111760067B (en) | Composition containing icodextrin and application thereof | |
| CN104721224A (en) | Gargle for relieving dry mouth and preparation method of gargle | |
| CN102349920B (en) | Sulfanilamide medicament composition for wound surface | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| KR100963611B1 (en) | Eye composition comprising alginic acid based compounds and method of preparing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |