CN1307175C - 用作腺苷受体配体的三唑并喹啉衍生物 - Google Patents

用作腺苷受体配体的三唑并喹啉衍生物 Download PDF

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CN1307175C
CN1307175C CNB028256468A CN02825646A CN1307175C CN 1307175 C CN1307175 C CN 1307175C CN B028256468 A CNB028256468 A CN B028256468A CN 02825646 A CN02825646 A CN 02825646A CN 1307175 C CN1307175 C CN 1307175C
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branched
straight
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compound
hydrogen atom
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Chinese (zh)
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CN1606556A (zh
Inventor
P·阿兰伊
L·巴拉兹
S·巴托里
J·本斯
K·博尔
F·哈杰都
Z·卡普
E·米库斯
T·萨伯
L·特纳吉
G·蒂马里
K·厄班－萨伯
E·瓦尔茨
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Sanofi Aventis France
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Sanofi Synthelabo SA
Sanofi Aventis France
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
CNB028256468A 2001-12-21 2002-12-17 用作腺苷受体配体的三唑并喹啉衍生物 Expired - Fee Related CN1307175C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0105407 2001-12-21
HU0105407A HUP0105407A3 (en) 2001-12-21 2001-12-21 Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates

Publications (2)

Publication Number Publication Date
CN1606556A CN1606556A (zh) 2005-04-13
CN1307175C true CN1307175C (zh) 2007-03-28

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CNB028256468A Expired - Fee Related CN1307175C (zh) 2001-12-21 2002-12-17 用作腺苷受体配体的三唑并喹啉衍生物

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US (2) US7365089B2 (enExample)
EP (1) EP1456204A1 (enExample)
JP (2) JP4724366B2 (enExample)
KR (1) KR100934796B1 (enExample)
CN (1) CN1307175C (enExample)
AU (1) AU2002353240B2 (enExample)
BR (1) BR0215276A (enExample)
CA (1) CA2470064C (enExample)
EA (1) EA007066B1 (enExample)
HR (1) HRP20040672A2 (enExample)
HU (2) HUP0105407A3 (enExample)
IL (2) IL162444A0 (enExample)
IS (1) IS7318A (enExample)
MA (1) MA27094A1 (enExample)
MX (1) MXPA04006113A (enExample)
NO (1) NO329757B1 (enExample)
NZ (1) NZ534016A (enExample)
PL (1) PL370747A1 (enExample)
RS (1) RS56004A (enExample)
TN (1) TNSN04106A1 (enExample)
UA (1) UA79955C2 (enExample)
WO (1) WO2003053968A1 (enExample)
ZA (1) ZA200404802B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0203976A3 (en) 2002-11-15 2004-08-30 Sanofi Aventis Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
HUP0400812A2 (en) * 2004-04-19 2006-02-28 Sanofi Aventis Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them
JP2008504294A (ja) * 2004-06-25 2008-02-14 アムジエン・インコーポレーテツド サイトカイン介在疾患および他の疾患の治療において有用な縮合トリアゾールおよびインダゾール
CN102702312A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdvyigsk、制备和应用
CN102702314A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdfyigsr、制备和应用
CN102702313A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdvyigsr、制备和应用
CN102702315A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdsyigsk、制备和应用
CN102702316A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdfyigsk、制备和应用
HUP0700395A2 (en) * 2007-06-07 2009-03-02 Sanofi Aventis Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
DE102007061763A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
BR122021012629B1 (pt) 2013-02-01 2022-06-07 Wellstat Therapeutics Corporation Compostos de amina, composição compreendendo os referidos compostos e usos dos mesmos
CN108358927B (zh) * 2018-01-26 2020-09-01 郑州大学 1,4-二取代1,2,3-三氮唑核苷类似物及其制备方法和应用
BR112023011284A2 (pt) 2020-12-09 2024-02-06 Wellstat Therapeutics Corp Composto de imidazoquinolina com atividade anti-inflamatória, antifúngica, antiparasítica e antineoplásica
CN119302957B (zh) * 2023-07-14 2025-11-21 同济大学 三唑并喹啉衍生物在制备预防或治疗疟疾的药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD280110A1 (de) * 1989-02-22 1990-06-27 Univ Berlin Humboldt Verfahren zur herstellung von 1.2.4-triazolo/1.5-a/-pyridin-8-carbonitrilen
DD280109A1 (de) * 1989-02-22 1990-06-27 Univ Berlin Humboldt Verfahren zur herstellung substituierter 1.2.4-triazolo/1.5-a/-pyridine
US5101028A (en) * 1989-08-12 1992-03-31 Basf Aktiengesellschaft (1,2,4)triazolo[2,3-a]pyridines

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DE280110C (enExample)
DE280109C (enExample)
GB1479759A (en) * 1974-11-23 1977-07-13 Lepetit Spa Heterocyclic fused derivatives of indole and quinoline
JP4431638B2 (ja) * 1996-01-29 2010-03-17 アメリカ合衆国 ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途
US5780481A (en) * 1996-08-08 1998-07-14 Merck & Co., Inc. Method for inhibiting activation of the human A3 adenosine receptor to treat asthma
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD280110A1 (de) * 1989-02-22 1990-06-27 Univ Berlin Humboldt Verfahren zur herstellung von 1.2.4-triazolo/1.5-a/-pyridin-8-carbonitrilen
DD280109A1 (de) * 1989-02-22 1990-06-27 Univ Berlin Humboldt Verfahren zur herstellung substituierter 1.2.4-triazolo/1.5-a/-pyridine
US5101028A (en) * 1989-08-12 1992-03-31 Basf Aktiengesellschaft (1,2,4)triazolo[2,3-a]pyridines

Non-Patent Citations (4)

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Title
1 2 4triazoles potts k t et al,j org chem,Vol.31 No.1 260.5 1966 *
7-phenyl 1 2 4 triazolo 1 5 a pyrimidines-selby thomas p et al,acs symposium seri es synth chem agrochem iii,Vol.504 No.91.102 1992 *
n alky lation and electrophilic brown roger f c et al,australian journal of chemistry,Vol.47 No.6 1994 *
the py rolytic rearrangement of brown roger f c et al,australian journal of chemistry,Vol.47 No.6 1994 *

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HRP20040672A2 (en) 2005-08-31
NO20043119L (no) 2004-07-20
ZA200404802B (en) 2005-08-29
US20050124648A1 (en) 2005-06-09
HUP0105407A2 (hu) 2003-10-28
CN1606556A (zh) 2005-04-13
BR0215276A (pt) 2004-12-14
IS7318A (is) 2004-06-16
AU2002353240B2 (en) 2008-06-19
EP1456204A1 (en) 2004-09-15
KR100934796B1 (ko) 2009-12-31
US20080146604A1 (en) 2008-06-19
US7365089B2 (en) 2008-04-29
EA007066B1 (ru) 2006-06-30
NO329757B1 (no) 2010-12-13
JP2011042653A (ja) 2011-03-03
HUP0105407A3 (en) 2004-04-28
EA200400848A1 (ru) 2004-12-30
US7713992B2 (en) 2010-05-11
AU2002353240A1 (en) 2003-07-09
IL162444A (en) 2010-04-29
WO2003053968A1 (en) 2003-07-03
HUP0402282A3 (en) 2007-12-28
TNSN04106A1 (en) 2006-06-01
HUP0402282A2 (hu) 2005-02-28
NZ534016A (en) 2005-04-29
HUP0105407D0 (en) 2003-02-28
CA2470064A1 (en) 2003-07-03
JP2005518384A (ja) 2005-06-23
JP4724366B2 (ja) 2011-07-13
KR20040072671A (ko) 2004-08-18
RS56004A (sr) 2006-10-27
IL162444A0 (en) 2005-11-20
PL370747A1 (en) 2005-05-30
MA27094A1 (fr) 2004-12-20
MXPA04006113A (es) 2005-06-08
UA79955C2 (en) 2007-08-10
CA2470064C (en) 2010-01-26

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