AU2002353240B2 - Triazolo-quinolin derivatives useful as adenosine receptor ligands - Google Patents

Triazolo-quinolin derivatives useful as adenosine receptor ligands Download PDF

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Publication number
AU2002353240B2
AU2002353240B2 AU2002353240A AU2002353240A AU2002353240B2 AU 2002353240 B2 AU2002353240 B2 AU 2002353240B2 AU 2002353240 A AU2002353240 A AU 2002353240A AU 2002353240 A AU2002353240 A AU 2002353240A AU 2002353240 B2 AU2002353240 B2 AU 2002353240B2
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compounds
general formula
solvates
salts
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AU2002353240A1 (en
Inventor
Peter Aranyi
Laszlo Balazs
Sandor Batori
Judit Bence
Kinga Boer
Felix Hajdu
Zoltan Kapui
Endre Mikus
Tibor Szabo
Lajos T. Nagy
Geza Timari
Katalin Urban-Szabo
Erzsebet Walcz
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Sanofi Aventis France
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Sanofi Aventis France
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/04—Antipruritics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
AU2002353240A 2001-12-21 2002-12-17 Triazolo-quinolin derivatives useful as adenosine receptor ligands Ceased AU2002353240B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP0105407 2001-12-21
HU0105407A HUP0105407A3 (en) 2001-12-21 2001-12-21 Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
PCT/HU2002/000143 WO2003053968A1 (en) 2001-12-21 2002-12-17 Triazolo-quinolin derivatives useful as adenosine receptor ligands

Publications (2)

Publication Number Publication Date
AU2002353240A1 AU2002353240A1 (en) 2003-07-09
AU2002353240B2 true AU2002353240B2 (en) 2008-06-19

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AU2002353240A Ceased AU2002353240B2 (en) 2001-12-21 2002-12-17 Triazolo-quinolin derivatives useful as adenosine receptor ligands

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US (2) US7365089B2 (enExample)
EP (1) EP1456204A1 (enExample)
JP (2) JP4724366B2 (enExample)
KR (1) KR100934796B1 (enExample)
CN (1) CN1307175C (enExample)
AU (1) AU2002353240B2 (enExample)
BR (1) BR0215276A (enExample)
CA (1) CA2470064C (enExample)
EA (1) EA007066B1 (enExample)
HR (1) HRP20040672A2 (enExample)
HU (2) HUP0105407A3 (enExample)
IL (2) IL162444A0 (enExample)
IS (1) IS7318A (enExample)
MA (1) MA27094A1 (enExample)
MX (1) MXPA04006113A (enExample)
NO (1) NO329757B1 (enExample)
NZ (1) NZ534016A (enExample)
PL (1) PL370747A1 (enExample)
RS (1) RS56004A (enExample)
TN (1) TNSN04106A1 (enExample)
UA (1) UA79955C2 (enExample)
WO (1) WO2003053968A1 (enExample)
ZA (1) ZA200404802B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0203976A3 (en) 2002-11-15 2004-08-30 Sanofi Aventis Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
HUP0400812A2 (en) * 2004-04-19 2006-02-28 Sanofi Aventis Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them
JP2008504294A (ja) * 2004-06-25 2008-02-14 アムジエン・インコーポレーテツド サイトカイン介在疾患および他の疾患の治療において有用な縮合トリアゾールおよびインダゾール
CN102702312A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdvyigsk、制备和应用
CN102702314A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdfyigsr、制备和应用
CN102702313A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdvyigsr、制备和应用
CN102702315A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdsyigsk、制备和应用
CN102702316A (zh) * 2006-11-30 2012-10-03 首都医科大学 具有靶向抗血栓活性的rgdfyigsk、制备和应用
HUP0700395A2 (en) * 2007-06-07 2009-03-02 Sanofi Aventis Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
DE102007061763A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
BR122021012629B1 (pt) 2013-02-01 2022-06-07 Wellstat Therapeutics Corporation Compostos de amina, composição compreendendo os referidos compostos e usos dos mesmos
CN108358927B (zh) * 2018-01-26 2020-09-01 郑州大学 1,4-二取代1,2,3-三氮唑核苷类似物及其制备方法和应用
BR112023011284A2 (pt) 2020-12-09 2024-02-06 Wellstat Therapeutics Corp Composto de imidazoquinolina com atividade anti-inflamatória, antifúngica, antiparasítica e antineoplásica
CN119302957B (zh) * 2023-07-14 2025-11-21 同济大学 三唑并喹啉衍生物在制备预防或治疗疟疾的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5101028A (en) * 1989-08-12 1992-03-31 Basf Aktiengesellschaft (1,2,4)triazolo[2,3-a]pyridines

Family Cites Families (10)

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DE280110C (enExample)
DE280109C (enExample)
GB1479759A (en) * 1974-11-23 1977-07-13 Lepetit Spa Heterocyclic fused derivatives of indole and quinoline
DD280110A1 (de) * 1989-02-22 1990-06-27 Univ Berlin Humboldt Verfahren zur herstellung von 1.2.4-triazolo/1.5-a/-pyridin-8-carbonitrilen
DD280109A1 (de) * 1989-02-22 1990-06-27 Univ Berlin Humboldt Verfahren zur herstellung substituierter 1.2.4-triazolo/1.5-a/-pyridine
JP4431638B2 (ja) * 1996-01-29 2010-03-17 アメリカ合衆国 ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途
US5780481A (en) * 1996-08-08 1998-07-14 Merck & Co., Inc. Method for inhibiting activation of the human A3 adenosine receptor to treat asthma
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5101028A (en) * 1989-08-12 1992-03-31 Basf Aktiengesellschaft (1,2,4)triazolo[2,3-a]pyridines

Also Published As

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HRP20040672A2 (en) 2005-08-31
NO20043119L (no) 2004-07-20
ZA200404802B (en) 2005-08-29
US20050124648A1 (en) 2005-06-09
HUP0105407A2 (hu) 2003-10-28
CN1606556A (zh) 2005-04-13
BR0215276A (pt) 2004-12-14
IS7318A (is) 2004-06-16
EP1456204A1 (en) 2004-09-15
KR100934796B1 (ko) 2009-12-31
US20080146604A1 (en) 2008-06-19
US7365089B2 (en) 2008-04-29
EA007066B1 (ru) 2006-06-30
NO329757B1 (no) 2010-12-13
JP2011042653A (ja) 2011-03-03
HUP0105407A3 (en) 2004-04-28
EA200400848A1 (ru) 2004-12-30
US7713992B2 (en) 2010-05-11
AU2002353240A1 (en) 2003-07-09
IL162444A (en) 2010-04-29
WO2003053968A1 (en) 2003-07-03
HUP0402282A3 (en) 2007-12-28
TNSN04106A1 (en) 2006-06-01
HUP0402282A2 (hu) 2005-02-28
NZ534016A (en) 2005-04-29
HUP0105407D0 (en) 2003-02-28
CA2470064A1 (en) 2003-07-03
JP2005518384A (ja) 2005-06-23
JP4724366B2 (ja) 2011-07-13
KR20040072671A (ko) 2004-08-18
CN1307175C (zh) 2007-03-28
RS56004A (sr) 2006-10-27
IL162444A0 (en) 2005-11-20
PL370747A1 (en) 2005-05-30
MA27094A1 (fr) 2004-12-20
MXPA04006113A (es) 2005-06-08
UA79955C2 (en) 2007-08-10
CA2470064C (en) 2010-01-26

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