CN1306950C - Long acting potent kidney-invigorating and Yang-strengthening medicine and method for preparing same - Google Patents

Abstract

The present invention provides a kidney tonification and yang strengthening medicine with long and strong effect and a preparation method thereof. The present invention uses snake penises as the main medicine and silky ants, oysters, common curculigo rhizomes, cassia bark, barbary wolfberry fruit and Chinese yam as auxiliary medicines; the snake penises, the silky ants, the oysters and the common curculigo rhizomes are extracted by ethanol, and the rest components are extracted by water; after respective extract of the components is concentrated and dried, flavoring agents, excipients, solvent, etc. are added, and then preparations in pharmacy are prepared. The kidney tonification and yang strengthening medicine has the effects of yin nourishing, kidney tonification, Qi and essence benefiting and yang strengthening, and can enhance sexual desire and pleasant sexual sensation; the duration time is long, the pause time is short, and the sexual actions are not made at the cost of body loss.

Description

A kind of kidney-nourishing yang-strengthening medicine and preparation method thereof

(1) technical field:

The present invention relates to kidney invigorating and YANG supporting medicine field, contain kidney invigorating and YANG supporting medicine of Penis et testis Serpentis and preparation method thereof specifically.

(2) background technology:

In the medicine of kidney invigorating and YANG supporting, particularly Chinese herbal medicine there be much the medicine of kidney invigorating and YANG supporting, its basic function is roughly the same, and the curative effect of the kidney invigorating, QI invigorating, YIN nourishing, tonifying YANG, controlling nocturnal emission with astringent drugs is all arranged, though reasonable recipe, dialectical executing controlled, and right effect is very not remarkable.

(3) summary of the invention:

The purpose of this invention is to provide a kind of kidney invigorating and YANG supporting medicine, this medicine has the effect of building body concurrently, can strengthen physical ability.

The present invention also provides the preparation method of this kidney-nourishing yang-strengthening medicine of preparation.

Technical scheme of the present invention is, is principal agent with the Penis et testis Serpentis, and accessory drugs is Formica fusca, Concha Ostreae, Rhizoma Curculiginis, Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae.

The composition by weight of above-mentioned component is:

Penis et testis Serpentis 20～90, Formica fusca 20～90, Concha Ostreae 30～80, Rhizoma Curculiginis 40～80, Fructus Lycii 40～80, Cortex Cinnamomi 40～80, Rhizoma Dioscoreae 40～80.

The preferable composition by weight of the present invention is: Penis et testis Serpentis 50～70, and Formica fusca 30～50, Concha Ostreae 40～60, Rhizoma Curculiginis 60～80, Fructus Lycii 50～70, Cortex Cinnamomi 40～60, Rhizoma Dioscoreae 60～80,

In order to reach better effect, Penis et testis Serpentis adopts different Penis et testis Serpentis and/or Agkistrodon halys whip, is the best with different Penis et testis Serpentis again wherein.

Preparation method of the present invention comprises:

A, get Penis et testis Serpentis 20～90, Formica fusca 20～90, Concha Ostreae 30～80, Rhizoma Curculiginis 40～80, put in the extraction pot, 40%～95% ethanol with 6～10 times of weight extracts each 1～3 hour 2～3 times under 60～100 ℃ temperature;

After the extracting solution of b, a merges, concentrate drying;

C, get Cortex Cinnamomi 40～80, Fructus Lycii 40～80, Rhizoma Dioscoreae 40～80, put in the extraction pot,, under 80～100 ℃ temperature, extract 2～3 times each 1～3 hour with the water of 6～10 times of weight;

After the extracting solution of d, c merges, concentrate drying;

E, get the dry thing of b and d gained, add flavoring agent, excipient, solvent, make the dosage form on the pharmaceutics.

For making extraction effect better, concentration of ethanol is 70%～80% in the preparation process.Temperature during extraction is controlled to be: alcohol extraction is 80～90 ℃, and it is 90～100 ℃ that water is carried.

The present invention is used as medicine with Penis et testis Serpentis according to the theory of " dirty with dirty benefit, as to ask mutually with device " on the traditional Chinese medical science, thereby reaches long-acting potent purpose.

The thing of Serpentis and Zhiyin, and Penis et testis Serpentis is the thing of Zhiyang, the function of the YIN nourishing and YANG strengthening of Penis et testis Serpentis, non-Penis et testis Tigris, Testis Et penis Bovis seu Bubali, Penis et testis sus domestica, Penis et testis canitis are comparable.Particularly different Serpentis---be the different Serpentis of the open country of originating in the Yongzhou mentioned among the Liu Zongyuan " person of catching snakes says ", its Sex apparatus has special part, and male Serpentis has two penises, and every breeding season, one time mating time is 6～8 hours, and what have reaches twenties hours.Post-coitum of female Serpentis, the hatching snakelet that can lay eggs in continuous 3 years, unique in regnum animale.

The present invention quotes the classics according to the principle that a traditional Chinese medical science the monarch and his subjects left side makes, and is equipped with some typical Chinese herbal medicine commonly used again, to reduce toxic and side effects, strengthens effect.Formica fusca can strong physique, but Concha Ostreae tonification healthy energy, the Fructus Lycii the kidney invigorating and essence nourishing has sun in the moon, and YIN nourishing and unlikely the moon declines is supporing yang and can make postcoital protrusion, Cortex Cinnamomi complement sun, Rhizoma Curculiginis the kidney warming sun strengthening bone and muscle cures mainly the sexual impotence cold sperm, and the Rhizoma Dioscoreae benefit of reinforcing the kidney is smart.Rhizoma Dioscoreae, Fructus Lycii can be controlled first YANG deficiency, the sun loss of fecundity (Jing-Yue Complete Works Yougui Wan, the kidney-Yang-Reinforcing Bolus) that declines in allocating Cortex Cinnamomi into.And Cortex Cinnamomi to be Rhizoma Curculiginis bring into play use when supporing yang warm smart treatment fire declines not from thing.

Kidney invigorating and YANG supporting medicine YIN nourishing of the present invention, the kidney invigorating, QI invigorating, benefit are smart, warm smart, and and solid Yang-strengthening effect strengthens physical ability with building body to be brought into play, are not to be cost as some medicine that just increases libido with consumption essence and blood gas.Thereby Yang invigorating medicine of the present invention has following numerous excellent characteristics: (1) increases libido and voluptus; (2) longer duration; (3) intermittent time is short; (4) medicine has no side effect to health, does not also produce dependency; (5) the performance function is not a cost with the health consume; (6) building body strengthens physical ability.

The maximum excellent characteristics of preparation method of the present invention are respectively different medical materials to be extracted active ingredient in a different manner, can obtain active ingredient as much as possible like this, make full use of medicine resource, can also improve the purity of active ingredient, remove a large amount of useless or even impurity toxic effect, guaranteed drug quality, made also that following process becomes simply, workload reduces.

By gained medicine of the present invention, can make granule on the pharmaceutics, solution, capsule, tablet, syrup, oral liquid etc.For the convenience on taking, preferably make in the every gram medicine of capsule and contain crude drug 0.33g, the 0.4g that at every turn takes medicine is equivalent to crude drug 0.132g.

(4) specific embodiment:

The following examples can elaborate the present invention, but content of the present invention has more than and is limited to embodiment.

Embodiment 1

Dried Penis et testis Serpentis, Formica fusca, Concha Ostreae, Rhizoma Curculiginis are smashed to pieces respectively, take by weighing dried Penis et testis Serpentis particle 60g, Formica fusca particle 40g, Concha Ostreae particle 50g, Rhizoma Curculiginis particle 70g put into round bottom glass extraction flask together, add 1760g concentration and be 75% ethanol, extracted 2 hours during 80 ℃ of water-baths.Cooling, inclining extracting solution.Add 1760g concentration again in the bottle and be 75% ethanol, extracted 2 hours during 80 ℃ of water-baths.Cooling, inclining extracting solution.Repeat again to extract once.The material slag is poured out, and filters 80 ℃ of hot ethanol washery slag secondaries with a small amount of 75%.After extracting solution of each time and washing liquid merged, being concentrated into volume under vacuum was 200ml.Be spray dried to solid extract then.Getting weight is 67.2g.

Embodiment 2

Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae (dry) are smashed to pieces respectively, taken by weighing Cortex Cinnamomi particle 50g, Fructus Lycii particle 60g, Rhizoma Dioscoreae particle 70g places round bottom glass extraction flask, adds 1440g water, extracts 2 hours when 95 ℃ of bath temperatures.Cooling, inclining extracting solution.In bottle, add 1440g water again, extracted 2 hours during 95 ℃ of water-baths.Cooling, inclining extracting solution.Repeat again to extract once.The material slag is poured out, and filters, with a small amount of 95 ℃ of hot water washery slag secondaries.After extracting solution of each time and washing liquid merged, being concentrated into volume under vacuum was 180ml.Be spray dried to solid extract then.Getting weight is 53.8g.

Embodiment 3

Press the step of embodiment 1, use 75% ethanol instead 45% ethanol, finally obtain dried solid extract 63.6g.

Embodiment 4

Press the step of embodiment 1, use 75% ethanol instead 95% ethanol, finally obtain dried solid extract 68.8g.

Embodiment 5

Press the step of embodiment 1, bath temperature is set at 60 ℃, finally obtain dried solid extract 66.4g.

Embodiment 6

Press the step of embodiment 1, bath temperature is set at 90 ℃, finally obtain dried solid extract 67.1g.

Embodiment 7

Get the dried solid extract 6.7g of embodiment 1 gained, get the dried solid extract 5.4g of embodiment 2 gained, xylitol 50g, mannitol 57.9g gets the 120g granule through mixing, granulation, airpillow-dry.

Embodiment 8

Get the dried solid extract 6.7g of embodiment 1 gained, get embodiment 2 gained drying solid extractum 5.4g, xylitol 30g, mannitol 28.9g, starch 45g gets the 116g granule through mixing, granulation, airpillow-dry.By every 0.2g, incapsulate, become capsule.

Claims (6)

1, a kind of kidney-nourishing yang-strengthening medicine is characterized in that: principal agent is a Penis et testis Serpentis, and accessory drugs is Formica fusca, Concha Ostreae, Rhizoma Curculiginis, Cortex Cinnamomi, Fructus Lycii, Rhizoma Dioscoreae, and raw material consumption composition by weight is:

Penis et testis Serpentis 20～90, Formica fusca 20～90, Concha Ostreae 30～80, Rhizoma Curculiginis 40～80, Fructus Lycii 40～80, Cortex Cinnamomi 40～80, Rhizoma Dioscoreae 40～80.

2,, it is characterized in that prescription is according to the kidney-nourishing yang-strengthening medicine of claim 1:

Penis et testis Serpentis 50～70, Formica fusca 30～50, Concha Ostreae 40～60, Rhizoma Curculiginis 60～80, Fructus Lycii 50～70, Cortex Cinnamomi 40～60, Rhizoma Dioscoreae 60～80,

Each component is composition by weight.

3,, it is characterized in that Penis et testis Serpentis is different Penis et testis Serpentis and/or Agkistrodon halys whip according to the kidney-nourishing yang-strengthening medicine of claim 1 or 2.

4, the preparation method of the described kidney-nourishing yang-strengthening medicine of claim 1 comprises:

A, get Penis et testis Serpentis 20～90, Formica fusca 20～90, Concha Ostreae 30～80, Rhizoma Curculiginis 40～80, put in the extraction pot, 40%～95% ethanol with 6～10 times of weight extracts each 1～3 hour 2～3 times under 60～100 ℃ temperature;

After the extracting solution of b, a merges, concentrate drying;

C, get Cortex Cinnamomi 40～80, Fructus Lycii 40～80, Rhizoma Dioscoreae 40～80, put in the extraction pot,, under 80～100 ℃ temperature, extract 2～3 times each 1～3 hour with the water of 6～10 times of weight;

After the extracting solution of d, c merges, concentrate drying;

E, get the dry thing of b and d gained, add flavoring agent, excipient, solvent, make the dosage form on the pharmaceutics.

5, the preparation method of medea according to claim 4 is characterized in that concentration of ethanol is 70%～80%.

6, the preparation method of medea according to claim 4, the extraction temperature that it is characterized in that a is 80～90 ℃, the extraction temperature of c is 90～100 ℃.