CN1306946C

CN1306946C - Snuffle dredging capsule

Info

Publication number: CN1306946C
Application number: CNB2004100358183A
Authority: CN
Inventors: 李庆才
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-09-21
Filing date: 2004-09-21
Publication date: 2007-03-28
Anticipated expiration: 2024-09-21
Also published as: CN1605355A

Abstract

The present invention discloses a snuffle dredging capsule. Asarum, datura flower, ginseng, astragalus root, largehead atractylodes rhizome, radix sileris, raw mahuang, cassia twig, dahurian angelica, sinomenium acutum, sulfur, rhubarb, liquorice, chlortrimeton and oryzanol are used as raw materials to be prepared into a medicament of integration of traditional and western medicine through processing by a conventional method, disinfection and drying processing; the medicament comprises capsules, tablets and granules. The snuffle dredging capsule has advantages of little toxic side effect on human, wide adaptability, high curative effect, more than 80% of cure rate for treating acute and chronic rhinitis with snuffle and nose running, nasosinusitis and simple chronic tracheitis, more than 90% of effective rate, 100% of effective rate for curing wind-cold type common cold, rapid curing, no decoction, convenient taking, and functions of enhancing the organism immunity, maintaining the curative effect, preventing recurrence, etc.; the snuffle dredging capsule can treat rhinitis in various types, such as acute and chronic rhinitis, nasosinusitis, simple chronic tracheitis, wind-cold type common cold, etc.

Description

The medicine of treatment rhinitis

One, technical field

The present invention relates to medicine, particularly a kind of medicine of treatment rhinitis of the combination of Chinese and Western medicine.

Two, background technology

Acute and chronic rhinitis, sinusitis, allergic rhinitis belong to commonly encountered diseases, frequently-occurring disease, treat middle one-tenth (grass) medicine of rhinitis at present, and ubiquity (1) weak curative effect; (2) particularly Chinese herbal medicine decoction and oral liquid formulations volatilely in the decocting process fall the mass efficient composition; The high amount of drug residue is abandoned in filter again, and dosage causes the waste of Chinese herbal medicine resource greatly; (3) in the Chinese patent medicine, particularly oral liquid, the antiseptic of adding etc. have certain injury to human body; (4) because the existence of above-mentioned waste causes the rising of cost again, increase patient's financial burden.

Three, summary of the invention

The medicine that the purpose of this invention is to provide a kind of improved treatment rhinitis, it is based on traditional Chinese medical science prescription theory, with the theory of integrated Chinese and western medicine is guidance, start with from etiology and pathology and pathogenesis, the shortcoming or the deficiency that can overcome effectively or avoid existing in the prior art improve curative effect, efficiently utilize Chinese herbal medicine resource, reduce cost, alleviate patient economy burden.

The medicine of treatment rhinitis of the present invention, it is made up of following components in weight percentage:

Herba Asari 3-25 Flos Daturae 0.3-2.0 Radix Ginseng 1.5-20 Radix Astragali 6-30

Rhizoma Atractylodis Macrocephalae 3-20 Radix Saposhnikoviae 3-15 Herba Ephedrae 3-30 Ramulus Cinnamomi 3-30

Radix Angelicae Dahuricae 3-30 Radix Stephaniae Tetrandrae 3-30 sulfur 6-30 Radix Et Rhizoma Rhei 3-30

Radix Glycyrrhizae 1-12 chlorphenamine 0.06-0.24 oryzanol 0.3-1.2

The formula optimization weight proportion of preparation medicine of the present invention is (weight portion):

Herba Asari 3-20 Flos Daturae 0.3-1.5 Radix Ginseng 1.5-20 Radix Astragali 8-26

Rhizoma Atractylodis Macrocephalae 4-16 Radix Saposhnikoviae 4-12 Herba Ephedrae 4-25 Ramulus Cinnamomi 4-26

Radix Angelicae Dahuricae 4-25 prevents 4-25 sulfur 6-25 Radix Et Rhizoma Rhei 4-25

Radix Glycyrrhizae 1.5-10 chlorphenamine 0.07-0.24 oryzanol 0.4-1.0

The optimum weight of medicine of the present invention (part) proportioning is:

Herba Asari 12 Flos Daturaes 1.2 Radix Ginsengs 2 Radixs Astragali 12 Rhizoma Atractylodis Macrocephalaes 9 Radix Saposhnikoviaes 6

Herba Ephedrae 9 Ramulus Cinnamomi 9 Radixs Angelicae Dahuricae 9 Radixs Stephaniae Tetrandrae 10 sulfur 10 Radix Et Rhizoma Rhei 15

Radix Glycyrrhizae 1 chlorphenamine 0.12 oryzanol 0.6

Medicament of the present invention is capsule, tablet or electuary.

The capsule preparation method thereof of treatment rhinitis of the present invention be conventional preparation technology promptly: (1) will in (grass) medicine decoction pieces clean, remove impurity; (2) above-mentioned whole components are broken into 120 order fine powders by described mixed processing powder; (3) medicated powder that crushes is packed into cloth bag inner high voltage sterilization, oven dry; (4) above-mentioned 120 order fine powders are packed into " 0 " number capsule, every contains about medicated powder 0.4 gram, adorns one bottle for per 100.

Instructions of taking: 1.6-3.2 gram/time, day clothes 3 times, boiled water is taken after mixing it with water after meal.

The present invention has following advantage or beneficial effect compared with prior art:

1, the drug component selected for use of the present invention meets the pharmaceutical control law regulation, though as Herba Asari, Flos Daturae, sulfur is toxic herb, but the dosage of taking every day, the safe medication dosage that meets the pharmacopeia regulation, small to people's toxic and side effects, wide adaptability can be treated acute and chronic rhinitis, sinusitis, Simple form chronic tracheitis and anemofrigid cold etc.;

2, curative effect height, to based on the nasal obstruction watery nasal discharge acute and chronic rhinitis, sinusitis and Simple form chronic tracheitis cure rate up to 80%, effective percentage reaches 90%; Anemofrigid cold is cured effective percentage reach 100% and cure rapid etc.; To the empty easy catching a cold person of aversion to cold body, times of common cold significantly reduces.

3, need not decoct, taking convenience meets state food health legislation regulation.

4, have human body immunity improving power, keep curative effect, prevent the function that recurs.

It is as follows to control statistical effect through clinical examination:

(1) the treatment chronic rhinitis merges chronic sinusitis 180 example observations

Clinical data 180 routine patients are clinic case, wherein male 94 examples, women 86 examples; Age is at 13-68 between year; The course of disease 6 months-18 years; Cardinal symptom is: the long-term nasal obstruction that continues, or intermittent, property nasal obstruction alternately, and nasal mucus is many with yellow purulence tears, or with dizzy, headache, hypomnesis, insomnia, tinnitus, the inaccessible sense of in ear, rhinophonia heavily wait disease; The course of disease is long, fatiguability, the cold back of sense sx, easy concurrent ear account, deafness; The nasal sinuses tenderness; Nasal cavity is checked: mucous hyperemia takes on a red color or kermesinus nasal mucosa edema, nasal conchae hypertrophy.180 routine patients are divided into two groups at random, and 96 examples are organized in treatment, matched group 84 examples.

The self-control " nasal obstruction open capsule " of Therapeutic Method treatment group, each 4-7 grain (containing crude drug powder 1.6-2.8g approximately), every day three times, the concurrent infection person of suppurating cooperates corresponding antibiotic; The matched group each 10ML of " BIYUANSHU KOUFUYE " [Pharmaceutical Factory, Chengdu Huashen Group Corp., Ltd. produces, the accurate word Z510200208 of traditional Chinese medicines], every day three times.All took medicine 30 days for two groups.

The recovery from illness of treatment standard: symptom all disappears, and the nasal cavity inspection is normal; Produce effects: nasal obstruction, watery nasal discharge transference cure, or obviously alleviate, nasal cavity inspection sign is obviously improved; Effectively: nasal obstruction watery nasal discharge sx, local sign is improved; Invalid: symptom and sign does not have obvious improvement.

Two groups of patient's cure rates of therapeutic outcome treatment group 82.3%, matched group compares P＜0.01 for 51.1%, two group; Two groups of total effective rate treatment groups 97.9%, matched group compares P＜0.01 for 51.1%, two group.See the following form:

Two groups of patient clinical data Comparative Examples (%)

Group	n	Recovery from illness	Produce effects	Effectively	Invalid	Effectively total
Group	n	Recovery from illness	Produce effects	Effectively	Invalid	Effectively total	The treatment group	96	79(82.3)	10(10.4)	5(5.2)	2(2.1)	94(97.9)
Matched group	84	43(51.1)	16(19)	11(13.1)	14(16.7)	70(83.3)	The treatment group	96	79(82.3)	10(10.4)	5(5.2)	2(2.1)	94(97.9)

(2) treatment acute rhinitis 210 examples are observed

Clinical data 210 routine patients are clinic case, wherein male 106 examples, women 104 examples; Age is at 13-68 between year; Showing effect repeatedly with repeated cold is characteristics, course of disease 1-5; Cardinal symptom is: intermittent or property nasal obstruction alternately, and nasal secretion increases, rhinorrhea or thin nasal discharge, headache, night, nasal obstruction increased the weight of, and rhinophonia is heavy, or diseases such as tinnitus, the sense of in ear obturation are arranged; The course of disease is long, tired, the cold back of sense sx, easy concurrent bulge of the ear, deafness; Nasal cavity is checked: the nasal mucosa congestion and edema, nasal secretion is many.Above case all meets the diagnostic criteria of acute rhinitis.210 routine patients are divided into two groups at random, and 105 examples are organized in treatment, matched group 105 examples.

Therapeutic Method treatment group " is treated the capsule of rhinitis " with self-control, each 4-7 grain (containing crude drug powder 1.6-2.8g approximately), and every day three times, concurrent infection rhinorrhea person cooperates corresponding antibiotic; The matched group each 10ML of " BIYUANSHU KOUFUYE " [Pharmaceutical Factory, Chengdu Huashen Group Corp., Ltd. produces, the accurate word Z510200208 of traditional Chinese medicines], every day three times.All took medicine 15 days for two groups.

The criterion of therapeutical effect recovery from illness: symptom all disappears, and the nasal cavity inspection is normal; Produce effects: nasal obstruction, watery nasal discharge transference cure, or obviously alleviate, nasal cavity inspection sign is obviously improved; Effectively: nasal obstruction watery nasal discharge sx, local sign is improved; Invalid: symptom and sign does not have obvious improvement.

Two groups of patient's cure rates of therapeutic outcome treatment group 84.8%, matched group compares P＜0.01 for 60%, two group; Two groups of total effective rate treatment groups 98%, matched group compares P＜0.01 for 84.8%, two group.See the following form:

Two groups of patient clinical data Comparative Examples (%)

Five, the specific embodiment

The capsule of treatment rhinitis of the present invention, it is made by the following weight proportion raw material:

Herba Asari 3-25 Flos Daturae 0.3-2.0 Radix Ginseng 1.5-20 Radix Astragali 6-30

Radix Glycyrrhizae 1-12 chlorphenamine 0.06-0.24 oryzanol 0.3-1.2.

Herba Asari 3-20 Flos Daturae 0.3-1.5 Radix Ginseng 1.5-20 Radix Astragali 8-26

Radix Angelicae Dahuricae 4-25 Radix Stephaniae Tetrandrae 4-25 sulfur 6-25 Radix Et Rhizoma Rhei 4-25

Radix Glycyrrhizae 1.5-10 chlorphenamine 0.07-0.24 oryzanol 0.4-1.0.

Radix Glycyrrhizae 1 chlorphenamine 0.1 2 oryzanol 0.6.

The medicine of treatment rhinitis of the present invention takes by weighing raw material (kilogram) by following proportioning:

Specific embodiment one

Herba Asari 3 Flos Daturaes 0.3 Radix Ginseng 1.5 Radixs Astragali 6 Rhizoma Atractylodis Macrocephalaes 3 Radix Saposhnikoviaes 3

Herba Ephedrae 3 Ramulus Cinnamomi 3 Radixs Angelicae Dahuricae 3 Radixs Stephaniae Tetrandrae 3 sulfur 6 Radix Et Rhizoma Rhei 3

Radix Glycyrrhizae 1 chlorphenamine 0.06 oryzanol 0.3.

Specific embodiment two

Herba Asari 25 Flos Daturaes 2 Radix Ginsengs 20 Radixs Astragali 30 Rhizoma Atractylodis Macrocephalaes 20 Radix Saposhnikoviaes 15

Herba Ephedrae 30 Ramulus Cinnamomi 30 Radixs Angelicae Dahuricae 30 Radix Stephaniae Tetrandrae 30 sulfur 30 Radix Et Rhizoma Rhei 30

Radix Glycyrrhizae 12 chlorphenamines 0.24 oryzanol 1.2.

Specific embodiment three

Herba Ephedrae 9 Ramulus Cinnamomi 9 Radixs Angelicae Dahuricae 9 Radix Stephaniae Tetrandrae 10 sulfur 10 Radix Et Rhizoma Rhei 15

Radix Glycyrrhizae 1 chlorphenamine 0.12 oryzanol 0.6.

The mode of production is as follows:

Decoction pieces is cleaned, remove impurity, the cool solarization or oven dry; Above-mentioned whole components are broken into 120 order fine powders by described mixed processing powder, medicated powder is adorned " 0 " number capsule of packing into after the cloth bag inner high voltage is sterilized, dried, every contains about medicated powder 0.4 gram, adorns one bottle for per 100.Or make tablet, every contains medicated powder amount 0.3-0.5 gram, per 100 one bottle on chip.

Claims

1, a kind of medicine for the treatment of rhinitis is characterized in that it is made up of following components in weight percentage:

Radix Glycyrrhizae 1 chlorphenamine 0.06 oryzanol 0.3.

2, a kind of medicine for the treatment of rhinitis is characterized in that it is made up of following components in weight percentage:

Herba Ephedrae 30 Ramulus Cinnamomi 30 Radixs Angelicae Dahuricae 30 Radixs Stephaniae Tetrandrae 30 sulfur 30 Radix Et Rhizoma Rhei 30

Radix Glycyrrhizae 12 chlorphenamines 0.24 oryzanol 1.2.

3, a kind of medicine for the treatment of rhinitis is characterized in that it is made up of following components in weight percentage:

Herba Asari 12 Flos Daturaes 1.2 Radix Ginsengs 2 Radixs Astragali 12 Rhizoma Atractylodis Macrocephalaes 9

Radix Saposhnikoviae 6 Herba Ephedrae 9 Ramulus Cinnamomi 9 Radixs Angelicae Dahuricae 9 Radixs Stephaniae Tetrandrae 10

Sulfur 10 Radix Et Rhizoma Rhei 15 Radix Glycyrrhizaes 1 chlorphenamine 0.12 oryzanol 0.6.

4,, it is characterized in that it is a capsule according to the medicine of claim 1 or 2 or 3 described treatment rhinitis.

5,, it is characterized in that it is tablet or electuary according to the medicine of claim 1 or 2 or 3 described treatment rhinitis.