CN1089851A - Control cold spray and preparation method thereof - Google Patents
Control cold spray and preparation method thereof Download PDFInfo
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- CN1089851A CN1089851A CN 93100926 CN93100926A CN1089851A CN 1089851 A CN1089851 A CN 1089851A CN 93100926 CN93100926 CN 93100926 CN 93100926 A CN93100926 A CN 93100926A CN 1089851 A CN1089851 A CN 1089851A
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Abstract
The present invention relates to a kind of control cold spray and preparation method thereof, the various composition ratios of described medicine are: Ephedra sinica, Radix Bupleuri, Radix Saposhnikoviae, Oleum menthae, Flos Lonicerae, Radix Isatidis, Fructus Forsythiae, Calculus Bovis, berberine, Moschus, the Radix Astragali, ribavirin, chlorphenamine.This control cold spray has effects such as antiviral, analgesic, antiallergic, antiinflammatory, can be used for preventing and treating influenza, common cold, popularity encephalitis B, mumps can play preventive effect, allergic rhinitis, acute hypertrophic rhinitis, acute pharyngitis also there are certain curative effect, particularly suitable to infant, old person.
Description
The present invention relates to the anti-class medicine that cures cold, particularly a kind of control cold spray and preparation method thereof.
At present, mostly the various anti-class medicine of selling on the market that cures cold is to send out back oral medication class medicine in disease, and this class medicine all is the purposes that reach the treatment disease by the absorption of intestinal.
The object of the present invention is to provide a kind of control cold spray that just can reach prevention, treatment flu by direct spraying nasal cavity, oral cavity and preparation method thereof.
Purpose of the present invention can adopt following measure to realize:
The various composition ratios of control cold spray of the present invention are: Ephedra sinica 250-300g; Radix Bupleuri 150-200g, Radix Saposhnikoviae 25-50g, Oleum menthae 1-5ml; Flos Lonicerae 25-50g Radix Isatidis 150-200g; Fructus Forsythiae 25-50g, Calculus Bovis 5-10g, berberine 1-2g; Moschus 0.1-5g; Radix Astragali 25-100g, ribavirin 3-5g, chlorphenamine 5-10g.
The various composition ratios of medicine of the present invention are preferably: Ephedra sinica 300g, Radix Bupleuri 150g, Radix Saposhnikoviae 25g, Oleum menthae 1ml, Flos Lonicerae 25g Radix Isatidis 150g, Fructus Forsythiae 25g, Calculus Bovis 10g, berberine 2g, Moschus 0.1-5g, Radix Astragali 50g, ribavirin 5g, chlorphenamine 10g.
The preparation method of control cold spray of the present invention is as follows:
A, get the water (weight) that Ephedra sinica, Radix Bupleuri, Radix Saposhnikoviae, Flos Lonicerae, Fructus Forsythiae four Chinese medicine add 6 times and soaked 8 hours, distillate is got in high temperature distillation;
B, get the water (weight) that Radix Isatidis, the Radix Astragali add 6 times and soaked 8 hours, after the decoction filtering, be condensed into paste, (volume) ethanol content of placing 5 times again be handle in 70% the ethanol filter after, reclaim alcohol, add distilled water (ethanol volume 1/5), tween 80 (ethanol volume 1.5 ‰) and dissolve filtration;
C, Calculus Bovis is dissolved in (weight) ethanol content of 10 times is in 70% the ethanol, adds 1: 1 distilled water (weight) again after reclaiming ethanol;
D, ribavirin, chlorphenamine are dissolved in the distilled water of 7 times (weight), get filtrate;
E, Moschus is dissolved in the normal saline of 20 times (weight), after 24 hours, gets filtrate;
F, Oleum menthae is placed the ethanol content of 4 times (volumes) is that 70% ethanol fully dissolves it;
G, elder generation mix above a, b, c, d solution and add the berberine stirring, make its dissolving after-filtration, add e, f solution again, after the rapid mixing, behind the high temperature sterilize, can divide in the aerosol bottle of packing into.
Control cold spray of the present invention has effects such as antiviral, analgesic, antiallergic, antiinflammatory, can be used for preventing and treating influenza, common cold, popularity encephalitis B, mumps can play preventive effect, allergic rhinitis, acute hypertrophic rhinitis, acute pharyngitis also there are certain curative effect, particularly suitable to infant, old person.
Below with reference to embodiment the present invention is done with detailed description, but do not limit the present invention.
Embodiment 1:
A, get Ephedra sinica 300g, Radix Bupleuri 150g, Radix Saposhnikoviae 25g, Flos Lonicerae 25g, Fructus Forsythiae 25g four Chinese medicine adds water 3150ml, soaks 8 hours, high temperature distillation is distilled to 400ml;
B, get Radix Isatidis 150g, Radix Astragali 50g adds water 1200ml, soaks 8 hours, after the decoction filtering, is condensed into paste, the ethanol content of placing 1500ml again be handle in 70% the ethanol filter after, reclaim alcohol, add distilled water 300ml, tween 80 2ml and dissolve filtration;
C, Calculus Bovis 10g is dissolved in the 100ml ethanol content is in 70% the ethanol, reclaim ethanol after, add distilled water 100ml again;
D, ribavirin 5g, chlorphenamine 10g are dissolved in the distilled water of 100ml, get filtrate;
E, Moschus 5g is dissolved in the normal saline of 100ml, after 24 hours, gets filtrate;
F, Mentholum 1ml is placed the ethanol content of 4ml is that 70% ethanol fully dissolves it;
G, elder generation mix above a, b, c, d solution and add berberine 2g stirring, make its dissolving after-filtration, add e, f solution again, after the rapid mixing, behind the high temperature sterilize, can divide in the aerosol bottle of packing into.
Embodiment 2:
A, get Ephedra sinica 250g, Radix Bupleuri 200g, Radix Saposhnikoviae 35g, Flos Lonicerae 30g, Fructus Forsythiae 40g four Chinese medicine adds water 3330ml, soaks 8 hours, high temperature distillation is distilled to 400ml;
B, get Radix Isatidis 170g, Radix Astragali 30g adds water 1200ml, soaks 8 hours, after the decoction filtering, is condensed into paste, the ethanol content of placing 1500ml again be handle in 70% the ethanol filter after, reclaim alcohol, add distilled water 300ml, tween 80 2ml and dissolve filtration;
C, Calculus Bovis 8g is dissolved in the 100ml ethanol content is in 70% the ethanol, adds distilled water 100ml again after reclaiming ethanol;
D, ribavirin 4g, chlorphenamine 9g are dissolved in the distilled water of 100ml, get filtrate;
E, Moschus 4g is dissolved in the normal saline of 100ml, after 24 hours, gets filtrate;
F, Oleum menthae 1.5ml is placed the ethanol content of 6ml is that 70% ethanol fully dissolves it;
G, elder generation mix above a, b, c, d solution and add berberine 2g stirring, make its dissolving after-filtration, add e, f solution again, after the rapid mixing, behind the high temperature sterilize, can divide in the aerosol bottle of packing into.
Claims (3)
1, the present invention relates to the anti-class medicine that cures cold, particularly a kind of control cold spray is characterized in that: the various composition ratios of described medicine are: Ephedra sinica 250--300g; Radix Bupleuri 150--200g, Radix Saposhnikoviae 25--50g, Oleum menthae 1--5ml; Flos Lonicerae 25--50g, Radix Isatidis 150--200g, Fructus Forsythiae 25--50g; Calculus Bovis 5--10g; berberine 1--2g, Moschus 0.1--5g, Radix Astragali 25--100g; ribavirin 3--5g, chlorphenamine 5--10g.
2, control cold spray according to claim 1 is characterized in that: the various composition ratios of described medicine are preferably: Ephedra sinica 300g, Radix Bupleuri 150g; Radix Saposhnikoviae 25g; Oleum menthae 1ml, Flos Lonicerae 25g Radix Isatidis 150g, Fructus Forsythiae 25g; Calculus Bovis 10g; berberine 2g, Moschus 0.1-5g, Radix Astragali 50g; ribavirin 5g, chlorphenamine 10g.
3, the preparation method of control cold spray according to claim 1 is characterized in that:
A, get the water (weight) that Ephedra sinica, Radix Bupleuri, Radix Saposhnikoviae, Flos Lonicerae, Fructus Forsythiae four Chinese medicine add 6 times and soaked 8 hours, distillate is got in high temperature distillation;
B, get the water (weight) that Radix Isatidis, the Radix Astragali add 6 times and soaked 8 hours, after the decoction filtering, be condensed into paste, (volume) ethanol content of placing 5 times again be handle in 70% the ethanol filter after, reclaim alcohol, add distilled water (ethanol volume 1/5), tween 80 (ethanol volume 1.5 ‰) and dissolve filtration;
C, Calculus Bovis is dissolved in (weight) ethanol content of 10 times is in 70% the ethanol, adds 1: 1 distilled water (weight) again after reclaiming ethanol;
D, ribavirin, chlorphenamine are dissolved in the distilled water of 7 times (weight), get filtrate;
E, Moschus is dissolved in the normal saline of 20 times (weight), after 24 hours, gets filtrate;
F, Oleum menthae is placed the ethanol content of 4 times (volumes) is that 70% ethanol fully dissolves it;
G, elder generation mix above a, b, c, d solution and add the berberine stirring, make its dissolving after-filtration, add e, f solution again, after the rapid mixing, behind the high temperature sterilize, can divide in the aerosol bottle of packing into.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100926 CN1089851A (en) | 1993-01-20 | 1993-01-20 | Control cold spray and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100926 CN1089851A (en) | 1993-01-20 | 1993-01-20 | Control cold spray and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1089851A true CN1089851A (en) | 1994-07-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93100926 Pending CN1089851A (en) | 1993-01-20 | 1993-01-20 | Control cold spray and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1089851A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306946C (en) * | 2004-09-21 | 2007-03-28 | 李庆才 | Snuffle dredging capsule |
| CN103977080A (en) * | 2014-05-29 | 2014-08-13 | 高广忠 | Traditional Chinese medicinal drops for treating rhinitis and preparation method thereof |
| CN106109593A (en) * | 2016-08-11 | 2016-11-16 | 洛阳名力科技开发有限公司 | A kind of prevention and the medicinal liquid for the treatment of respiratory tract disease |
| WO2018073549A1 (en) * | 2016-10-21 | 2018-04-26 | Universite Claude Bernard Lyon 1 | Antiviral compositions for the treatment of infections linked to coronaviruses |
-
1993
- 1993-01-20 CN CN 93100926 patent/CN1089851A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306946C (en) * | 2004-09-21 | 2007-03-28 | 李庆才 | Snuffle dredging capsule |
| CN103977080A (en) * | 2014-05-29 | 2014-08-13 | 高广忠 | Traditional Chinese medicinal drops for treating rhinitis and preparation method thereof |
| CN103977080B (en) * | 2014-05-29 | 2016-04-27 | 高广忠 | A kind of Chinese medicine dropping for the treatment of rhinitis and preparation method thereof |
| CN106109593A (en) * | 2016-08-11 | 2016-11-16 | 洛阳名力科技开发有限公司 | A kind of prevention and the medicinal liquid for the treatment of respiratory tract disease |
| WO2018073549A1 (en) * | 2016-10-21 | 2018-04-26 | Universite Claude Bernard Lyon 1 | Antiviral compositions for the treatment of infections linked to coronaviruses |
| FR3057773A1 (en) * | 2016-10-21 | 2018-04-27 | Universite Claude Bernard Lyon 1 | NOVEL ANTIVIRAL COMPOSITIONS FOR THE TREATMENT OF CORONAVIRUS-RELATED INFECTIONS |
| RU2753534C2 (en) * | 2016-10-21 | 2021-08-17 | Юниверсите Клод Бернар Лион 1 | Antiviral compositions for the treatment of coronavirus-related infections |
| US11510896B2 (en) | 2016-10-21 | 2022-11-29 | Universite Claude Bernard Lyon 1 | Antiviral compositions for the treatment of infections linked to coronaviruses |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |