CN1301544A - Medicinal composition for curing arthritis and osteoarthropathy and its preparing method - Google Patents
Medicinal composition for curing arthritis and osteoarthropathy and its preparing method Download PDFInfo
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- CN1301544A CN1301544A CN99115965A CN99115965A CN1301544A CN 1301544 A CN1301544 A CN 1301544A CN 99115965 A CN99115965 A CN 99115965A CN 99115965 A CN99115965 A CN 99115965A CN 1301544 A CN1301544 A CN 1301544A
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- water
- osteoarthritis
- arthritis
- treatment
- decocts
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- 206010003246 arthritis Diseases 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 206010057178 Osteoarthropathies Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 23
- 238000011282 treatment Methods 0.000 claims description 32
- 201000008482 osteoarthritis Diseases 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000002994 raw material Substances 0.000 claims description 22
- 241001526348 Myospalax Species 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 10
- 239000000890 drug combination Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 abstract description 6
- 210000003734 kidney Anatomy 0.000 abstract description 3
- 241001145025 Saussurea involucrata Species 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 238000003809 water extraction Methods 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000002775 capsule Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 208000003947 Knee Osteoarthritis Diseases 0.000 description 3
- 230000002917 arthritic effect Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 231100001252 long-term toxicity Toxicity 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 206010018691 Granuloma Diseases 0.000 description 2
- 208000019802 Sexually transmitted disease Diseases 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- 208000009386 Experimental Arthritis Diseases 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010023215 Joint effusion Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000001307 Myosotis scorpioides Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 201000001819 hydrarthrosis Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A medicine composition is prepared with Sailonggu and Saussurea Involucrata and through crushing, water extraction and other conventional technological process. It can expel cold evil and wetness, invigorate liver and kidney so that it is used in treating arthritis and osteoarthropathy, and has high effective rate and no toxic side-effect.
Description
The present invention relates to pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis and preparation method thereof.
Osteoarthritis claims degenerative osteoarthritis again, is one of person in middle and old age's commonly encountered diseases and frequently-occurring disease, often involves positions such as knee joint and lumbar vertebra, cervical vertebra, heel.Primary disease is a principal character with the articular cartilage CCD, can form with the hyperosteogeny at synovitis, hydrarthrosis and knee joint edge.Knee osteoarthritis belongs to the arthromyodynia category in Chinese medicine, the Chinese patent medicine that is exclusively used in treatment osteoarthritis and osteoarthritis at present still belongs to seldom, along with increasing of social old people, its sickness rate is more and more higher, primary disease serious harm old people's health, therefore develop curative effect height, treatment gonarthritis safe in utilization and the Chinese patent medicine of osteoarthritis, healthy significant for the misery guarantee old people who alleviates the old people.
But the total effective rate that the object of the present invention is to provide a kind of dispelling cold and removing dampness, liver and kidney tonifying, treatment osteoarthritis and osteoarthritis reaches more than 90.33%, no side effects, treatment of arthritis safe in utilization and the pharmaceutical composition of osteoarthritis.
Another object of the present invention is to provide the preparation of drug combination method of a kind of treatment of arthritis and osteoarthritis.
Purpose of the present invention can realize by following measure:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament:
Bailey Myospalax Born 1-99% Herba Saussureae Involueratae 1-99%.
Another object of the present invention also can realize by following measure:
1. the preparation of drug combination method of a kind of treatment of arthritis and osteoarthritis comprises the steps: Herba Saussureae Involueratae is pulverized, and decocts with water twice, and the 8-12 that adds water for the first time and be raw material doubly measures, and decocts 2-4 hour; For the second time amount of water be raw material 6-10 doubly, decocted 1-2 hour, merge the water extract twice; 2. Bailey Myospalax Born is pulverized, decocted with water twice, the 8-12 that adds water for the first time and be raw material doubly measures, and decocts 8-10 hour; The 6-10 that adds for the second time water and be raw material doubly measures, and decocts 4-6 hour, merges the water extract twice; 3. after Herba Saussureae Involueratae, Bailey Myospalax Born water extract being mixed routinely preparation make medicament.
The present invention has following advantage compared to existing technology:
1, the present invention is with the cooperation of complementing each other of Herba Saussureae Involueratae, Bailey Myospalax Born, make full use of the function of its dispelling cold and removing dampness and liver and kidney tonifying, can be used for treating osteoarthritis, cold-damp resistance network, deficiency of the liver and kindey, arthralgia, swelling, joint stuffiness, meet coldly increase the weight of, disease such as soreness of the waist and knees.
2, the present invention observes through clinical 300 example treatments, and its treatment knee osteoarthritis obvious effective rate reaches more than 35.67%, and total effective rate reaches more than 90.33%; Confirm that through acute, long term toxicity test the present invention is nontoxic, have no side effect.
Toxicity test of the present invention:
1, its maximum tolerated dose is surveyed in acute toxicity test of the present invention, and the result is greater than the 100g/kg body weight, is 833 times of adult's daily dose.
2, long term toxicity test: according to 90 days long term toxicity test results of rat, the capsule in high dose group (7.5g/kg body weight) that proof the present invention makes, be equivalent to 6.25 times of clinical consumptions, do not see any toxicity, comprise general signs, outward appearance, behavior, body weight, routine blood test, hepatic and renal function, electrocardiogram, organ coefficient mensuration, pathologic finding etc. all belong to normal range.
Pharmacodynamic study of the present invention:
(1) antiinflammatory experiment
1, to the prevention experiment of rat albumen arthritis, the result shows: have and prevent arthritic effect preferably;
2, to the arthritic treatment experiment of rat formaldehyde, the result shows: PARA FORMALDEHYDE PRILLS(91,95) arthritis has the obvious treatment effect;
3, medicine separation chemistry position is to the arthritic treatment experiment of rat formaldehyde, and the result shows: the Herba Saussureae Involueratae total alkaloids has significant antiinflammatory action;
4, to the swollen outgrowth influence experiment of rat granuloma, the result shows: the granuloma hypertrophy is had certain inhibitory action;
5, to the influence experiment of mouse ear capillary permeability, the result shows: mice ear is had the obvious suppression effect.
(2) inhibitory action of adjuvant-induced arthritis
Experiment shows: the capsule that the present invention makes is to the rat assist agent arthritis primary affection, and the change of supervention sexually transmitted disease (STD) has significant inhibitory effect.
1, to the preventive effect of constitutional pathological changes: the result has significant preventive effect;
2, to the preventive effect of Secondary cases pathological changes: the result has significant preventive effect;
3, to the therapeutical effect of secondary affection: the result has the obvious treatment effect.
(3) analgesic experiment
1, to white mice electricity irritation reaction influence experiment: the result has significant analgesia role;
2, the inhibition of white mice writhing response is tested: the result has significant analgesia role.
(4) the effect experiment that mouse antibodies is generated
The special humoral immunoresponse(HI) of mice experiment showed, the be significantly improved effect of immunity of organisms of these product.
Clinical trial result of the present invention:
According to " new Chinese medicine clinical research guideline " functional characteristics, formulate clinical trial protocol, (synopsis is as follows) in conjunction with this product
(1) case is selected:
1, tcm diagnosis standard:
2, Chinese medical discrimination standard: be applicable to cold-damp resistance network, deficiency of the liver and kindey disease.
3, Western medicine diagnose standard: be applicable to that osteoarthritis is the object of observation.
4, include exclusion standard in:
(2) test method: adopt double blinding dual analog grouping contrast method and contrast method at random.
1, treatment group: 300 examples
2, matched group: 150 examples, use ZHUANGGU GUANJIE WAN.
3, the course of treatment: be 1 month, can carry out 1-2 the course of treatment.
(3) efficacy determination:
1, clinical disease changes (sxemiquantitative scoring method)
2, curative effect determinate standard: be divided into the level Four standard.
Clinical recovery: produce effects, effective, invalid.
Clinical research is summed up:
Defend the requirement that medicine is examined No. 62 file of word (1997) according to Ministry of Public Health bureau of drug administration (97) ZL-51 file and Hebei province Department of Public Health Ji, by Guang-amen Hospital, China Traditional Chinese Medicine Instl is that group leader unit, the hospital of traditional Chinese hospital, Beijing, Institute of orthopedics and traumatology, Chinese Academy for Traditional Chine, No.2 Hospital, Hebei Medical Univ. and the 3rd hospital of Hebei Medical University participate in, and from year April in October, 1997 to 1998 capsule that the present invention prepares has been carried out the clinical research work of II phase.300 examples have been finished in the clinical trial treatment, and matched group is finished 150 examples.Clinical test results: capsule for treating knee osteoarthritis obvious effective rate of the present invention is 35.67%, and total effective rate is 90.33%; Matched group obvious effective rate 22.67%, total effective rate are 76.00%; Treatment group curative effect is better than matched group, and learning by statistics to handle has significant difference.Clinical use capsule of the present invention is not seen untoward reaction, and menses, urine, the just detection of routine and the heart, liver, renal function have no adverse effects, and be safe in utilization.
The present invention also will be described in further detail in conjunction with the embodiments:
Embodiment one:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 50%, Herba Saussureae Involueratae 50%.
The preparation of drug combination method of described treatment of arthritis and osteoarthritis comprises the steps: 1. Herba Saussureae Involueratae to be pulverized, and decocts with water twice, adds 10 times of amounts that water is raw material for the first time, decocts 3 hours; For the second time amount of water is 8 times of raw material, decocts 2 hours, merges the water extract twice; 2. Bailey Myospalax Born is pulverized, decocted with water twice, add 10 times of amounts that water is raw material for the first time, decocted 9 hours; For the second time add 8 times of amounts that water is raw material, decocted 5 hours, merge the water extract twice; 3. after Herba Saussureae Involueratae, Bailey Myospalax Born water extract being mixed routinely preparation make medicament.
Embodiment two:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 2%, Herba Saussureae Involueratae 98%.
Its preparation technology and example are together.
Embodiment three:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 98%, Herba Saussureae Involueratae 2%.
Its preparation technology and example are together.
Embodiment four:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 30%, Herba Saussureae Involueratae 70%.
Its preparation technology and example are together.
Embodiment five:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 40%, Herba Saussureae Involueratae 60%.
Its preparation technology and example are together.
Embodiment six:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 70%, Herba Saussureae Involueratae 30%.
Its preparation technology and example are together.
Embodiment seven:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 60%, Herba Saussureae Involueratae 40%.
Its preparation technology and example are together.
Embodiment eight:
The pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis by comprise following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 80%, Herba Saussureae Involueratae 20%.
Its preparation technology and example are together.
Claims (3)
1, the pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis, it is characterized in that by comprise following raw materials in percentage by weight routinely formulation method make medicament:
Bailey Myospalax Born 1-99% Herba Saussureae Involueratae 1-99%.
2, the pharmaceutical composition of treatment of arthritis as claimed in claim 1 and osteoarthritis is characterized in that described medicament is meant medically any dosage form of indication.
3,1. the preparation of drug combination method of described treatment of arthritis of a kind of claim 1 and osteoarthritis is characterized in that comprising the steps: Herba Saussureae Involueratae is pulverized, and decocts with water twice, and the 8-12 that adds water for the first time and be raw material doubly measures, and decocts 2-4 hour; For the second time amount of water be raw material 6-10 doubly, decocted 1-2 hour, merge the water extract twice; 2. Bailey Myospalax Born is pulverized, decocted with water twice, the 3-12 that adds water for the first time and be raw material doubly measures, and decocts 8-10 hour; The 6-10 that adds for the second time water and be raw material doubly measures, and decocts 4-6 hour, merges the water extract twice; 3. after Herba Saussureae Involueratae, Bailey Myospalax Born water extract being mixed routinely preparation make medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115965A CN1105570C (en) | 1999-12-30 | 1999-12-30 | Medicinal composition for curing arthritis and osteoarthropathy and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115965A CN1105570C (en) | 1999-12-30 | 1999-12-30 | Medicinal composition for curing arthritis and osteoarthropathy and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1301544A true CN1301544A (en) | 2001-07-04 |
| CN1105570C CN1105570C (en) | 2003-04-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99115965A Expired - Lifetime CN1105570C (en) | 1999-12-30 | 1999-12-30 | Medicinal composition for curing arthritis and osteoarthropathy and its preparing method |
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| Country | Link |
|---|---|
| CN (1) | CN1105570C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028325A (en) * | 2007-04-24 | 2007-09-05 | 杨文龙 | Medicinal composition containing sailonggu, and its preparation and quality control |
| CN101716217B (en) * | 2009-12-02 | 2012-05-23 | 中国科学院西北高原生物研究所 | Medical composition containing rhododendron anthopogonoide oil and application thereof |
| CN104277091A (en) * | 2014-09-17 | 2015-01-14 | 正源堂（天津滨海新区）生物科技有限公司 | Method for extracting 7-beta-hydroxyl cholesterol from osteon myospalacem baileyi |
| CN104857089A (en) * | 2015-05-21 | 2015-08-26 | 河南黑马动物药业有限公司 | Liquid medicine for treating rheumatism and rheumatoid arthritis and preparation method of liquid medicine |
| CN105055449A (en) * | 2015-07-27 | 2015-11-18 | 中国科学院西北高原生物研究所 | Sailong bone extract with activities of resisting inflammation and easing pain as well as preparation method and Chinese herbal preparation |
| CN115300539A (en) * | 2022-08-16 | 2022-11-08 | 西安今正制药有限公司 | Compound sialon capsule, its preparation method and application in rheumatism bone disease |
-
1999
- 1999-12-30 CN CN99115965A patent/CN1105570C/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028325A (en) * | 2007-04-24 | 2007-09-05 | 杨文龙 | Medicinal composition containing sailonggu, and its preparation and quality control |
| CN101028325B (en) * | 2007-04-24 | 2013-05-29 | 杨文龙 | Medicinal composition containing sailonggu, and its preparation and quality detection method |
| CN101716217B (en) * | 2009-12-02 | 2012-05-23 | 中国科学院西北高原生物研究所 | Medical composition containing rhododendron anthopogonoide oil and application thereof |
| CN104277091A (en) * | 2014-09-17 | 2015-01-14 | 正源堂（天津滨海新区）生物科技有限公司 | Method for extracting 7-beta-hydroxyl cholesterol from osteon myospalacem baileyi |
| CN104857089A (en) * | 2015-05-21 | 2015-08-26 | 河南黑马动物药业有限公司 | Liquid medicine for treating rheumatism and rheumatoid arthritis and preparation method of liquid medicine |
| CN104857089B (en) * | 2015-05-21 | 2018-04-06 | 许昌市天源生物科技股份有限公司 | A kind of decoction for treating rheumatism and rheumatoid arthritis and preparation method thereof |
| CN105055449A (en) * | 2015-07-27 | 2015-11-18 | 中国科学院西北高原生物研究所 | Sailong bone extract with activities of resisting inflammation and easing pain as well as preparation method and Chinese herbal preparation |
| CN105055449B (en) * | 2015-07-27 | 2019-08-09 | 中国科学院西北高原生物研究所 | A kind of Sailongbone extracts with anti-inflammatory and antalgic activity, preparation method and Chinese materia medica preparation |
| CN115300539A (en) * | 2022-08-16 | 2022-11-08 | 西安今正制药有限公司 | Compound sialon capsule, its preparation method and application in rheumatism bone disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1105570C (en) | 2003-04-16 |
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