CN1299643A - Beauty method for making skin white - Google Patents
Beauty method for making skin white Download PDFInfo
- Publication number
- CN1299643A CN1299643A CN 00130494 CN00130494A CN1299643A CN 1299643 A CN1299643 A CN 1299643A CN 00130494 CN00130494 CN 00130494 CN 00130494 A CN00130494 A CN 00130494A CN 1299643 A CN1299643 A CN 1299643A
- Authority
- CN
- China
- Prior art keywords
- skin
- corn seed
- cell
- melanin
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
In a cosmetic method for lightening the skin or minimizing the pigmentation level, the corn seed extracts are used as active components.
Description
The present invention is directed to the beauty method that makes whiteness of skin with the corn seed extract.
People wish that whiteness of skin has two kinds of situations: some consumer wishes that the natural colour of skin of oneself is more shallow, and also some people wishes to eliminate skin speckle or aging speckle, perhaps makes it become shallow as far as possible at least.
The human colour of skin determined by melanin, melanin by mainly between the cell of epidermis basis, be referred to as the biopolymer pigment of melanocytic special arborescent cell manufacturing.Biochemical process makes to be worked by the enzyme that is referred to as tryrosinase and causes that melanin produces, and this tryrosinase starts a succession of biosynthesis reaction.The biosynthetic accurate mechanism of melanin is very complicated process.Though the basic law that melanin produces is by Gene Handling, environmental factors is to its synthetic very important function that also plays.Being exposed to sunlight or other ultraviolet rays also can stimulate melanocyte to produce more melanin, and this is referred to as " tanned " reaction.Melanic generation is also owing to aging, conceived or use control fertility tablet etc. causes that the hormone fluctuation increases.
The normal pegmentation calmness of skin surface should be uniform.Partial, too much pigment can occur, and so painted system is referred to as hyperpigmentation.Hyperpigmentation is accompanied by melanin and produces increase.Human hyperpigmentation can comprise as freckle, dyschromasia or dermatosis such as pigmentation after aging freckle, chloasma hepaticum, melasma, brown macules or senile plaque, Exposure to Sunlight pigmentation, the inflammation.Hyperpigmentation is also because friction, burn, injured, insect bite, dermatitis, and other the skin fritter that similarly makes is caught the damage of pigment.
From the beauty treatment angle, people wish that usually normal pigmentation skin becomes fair and clear, perhaps make hyperpigmentation zone and normal skin zone blending on every side.
Therefore, prior art has been developed and has been attempted the method and composition that skin shoaled or discolor.Since allergy, zest, irreversible influence, deficient in stability and other preparation defective, and lack foreseeable result, and these products usually are very disadvantageous.
Barnet Product Corp. sells a kind of commodity " Solabia VegetalFilatov " by name, is used for corn seed extractive composition facial and the body care beauty treatment.Barnet reports that this extract can improve fibroblast proliferation and hepatocellular oxygen expenditure in the body.It is unexpected that the melanin of corn seed extract suppresses activity, and does not see from Barnet supplier's document and introduced.
The present invention relates to be applied in skin, make the beauty method of whiteness of skin with the corn seed extract in the suitable carrier of improving looks.
Except as otherwise noted, all consumptions are all in final composition weight.
So-called herein " making whiteness of skin " means and the skin natural colour is shoaled and/or removes hyperpigmentation, or makes it to reduce to minimum.
The inventive method comprises the corn seed extract.This extract prepares then filtration purification according to the Filatov extraction conditions in 120 ℃ in pressure cooker.This extract can be buied from BarnetProducts Corp..
With composition weight meter, the content of corn seed extract in the present composition is 0.01-20%, preferred 0.1-10%, override 1-5%.
The used skin care compositions and methods of the present invention also comprises the carrier that beauty treatment is suitable, and described carrier is that inert, common content is the highest, and its effect is to carry active matter or effective ingredient.
Vehicles other than water can comprise liquid or solid-state emollient, solvent, wetting agent, thickening agent and powder.Particularly preferred nonaqueous carrier is polydimethylsiloxane and/or poly dimethyl phenyl siloxane.Siloxanes of the present invention can be range of viscosities 10-10, the siloxanes of 000,000 centistoke (25 ℃).Especially wish it is the mixture of low viscosity and high-viscosity silicone.Described siloxanes can be General Electric Co. Limited's commodity Vicasil, SE by name and the siloxanes of SF and 200 and 550 series of products of DowCorning company.The content of siloxanes is 5-95% in the present composition, preferred 25-90%.In composition total weight, the amount of carrier can be the about 99wt% of about 2-, and preferably about 50-is about 99%, most preferably from about 80-99%.
According to the present invention,, has the water of 60wt% at least in vehicle weight.The present composition is oil-in-water emulsions preferably.Optionally the skin-friendly material of Jia Ruing and the beauty treatment additive
Can contain all kinds active component in the cosmetic composition of the present invention.Active matter is defined as the reagent of the skin-friendly except that emollient and other improve the composition of compositions physical property.Generally comprise crease-resistant chemical compound and sunscreen, be not limited to these certainly.
Sunscreen comprises and generally is used to intercept ultraviolet material, for example titanium dioxide, PABA derivant, cinnamate and salicylate.Octyl methoxycinnamate and 2-hydroxyl-4-methoxyl group-benzophenone (also being oxybenzene ketone) for example, this two chemical compound is commercially available with Parsol MCX and benzophenone-3 trade name respectively.The accurate amount of used sunscreen in the emulsion, the degree of the ultraviolet rays that can intercept according to need changes.
Other functional components in the cosmetic composition of the present invention is a thickening agent.Thickening agent accounts for the 0.1-20% of composition weight usually, preferred 0.5-10%.The example of thickening agent is the commercially available Acusol772 Acusol771 material of commodity Carbopol (B.F.Goodrich company) by name.Xanthan gum, carrageenin, gelatin, natural gum such as POLY-karaya, pectin and locust bean gum are also available.
In some cases, the function of thickening agent also can be reached by materials such as siloxanes or emollient.For example surpass esters such as the siloxane glue of 10 centistokes and tristerin dual-use function is just arranged.
The powder thing can mix in the cosmetic composition of the present invention, for example comprise Chalk, Pulvis Talci, bleaching earth, Kaolin, starch, terre verte, chemical modification Magnesiumaluminumsilicate, organic modification montmonrillonite, aluminium hydrosilicate, fumed silica, aluminum starch succinic acid octene ester, and their mixture.
Other less important additive also can mix in the cosmetic composition of the present invention, and these compositions can comprise coloring agent, opacifier and spice.These compositions can account for 0.001% to nearly 20% of composition weight.The application of compositions
Compositions of the present invention is mainly as the product that is applied to application on human skin outward, specifically as skin whitener.
During use, from appropriate containers or applicator, with the small number of groups compound, for example 1-100ml is applied in and exposes on the skin, and if desired, and then with hands or finger, perhaps a kind of suitable device applies it and opens and/or rub in the skin.
According to the inventive method,, realize effect with the active component skin whitening by being coated with the corn seed extract outward.
Below specific embodiment further specify the present invention, but the present invention has more than and is limited to these.
Embodiment 1
Use the B16 cell, promptly the Mus melanoma cell series is estimated the ability that the corn seed extract suppresses the melanin generation.
The B16 cell available from ATCC (Rockville, MD.).The B16 cell is merged in the Asia is inoculated on the 96 hole microdroplet flat boards with the density of 5000 cells/well, and with it at 37 ℃, 5%CO
2Under the condition, overnight incubation in containing 10% hyclone, 1% penicillin/streptomycin, no phenol red DMEM (LifeTechnologies NY).Replace these culture medium with the fresh culture that contains these inorganic agents after 24 hours.With cell insulation 72 hours, the plain appearance of this moment of visible black color in the control treatment sample.To contain melanic culture medium then and transfer on 96 orifice plates of cleaning, and use the microplate spectrophotometer, read absorbance and quantitative analysis in the 530nm place from each hole.
In order to guarantee the melanin inhibitory action, by dimethyl diaminophenazine chloride dyestuff absorptionmetric determination cell survival rate not simply owing to cell killing occurs.After removing culture medium, the pre-warm culture medium that 200 μ l is contained 25 μ g/ml dimethyl diaminophenazine chloride dyestuffs adds in each hole, and incubation 3 hours.Wash the cell secondary with PBS, add 100 μ l, 50 H
2O: 49 ethanol: 1 acetic acid solution extracts dyestuff, jolting 20 minutes gently under room temperature then.Carry out the dyestuff quantitative analysis with 530nm place absorbance reading.Have only survivaling cell to be expected absorbing dye, and absorbance just directly is directly proportional with the survivaling cell number of handling.
Each time processing is expressed as the percentage average of untreated control sample all with 4 duplicate reading calculating mean values.Use Student ' s t-test to determine statistical significance.
When keeping cell survival rate,, be expected to obtain low melanin content for handling cell.
The corn seed extract is available from Barnet Products Corp., NJ.
Gained is the result conclude in the table 1.
Table 1
* compared significant difference with not testing active matter, p＜0.05
| Corn seed extract g/l | Melanin | Cell survival rate | ||
| To percentage rate in the same old way | Standard deviation | To percentage rate in the same old way | Standard deviation | |
| ????0 | ????100 | ????8.4 | ????100 | ????3.2 |
| ????0.04 | ????98.9 | ????8.7 | ????105 | ????7.8 |
| ????0.2 | ????97.8 | ????12.6 | ????101 | ????9.4 |
| ????1 | ????92.4 | ????6.3 | ????104 | ????9.6 |
| ????2 | ????69.6 * | ????8.4 | ????104 | ????4.9 |
| ????3 | ????64.1 * | ????3.1 | ????102 | ????3.8 |
| ????4 | ????0 * | ????0.1 | ????91.4 | ????12.8 |
| ????5 | ????0 * | ????0.9 | ????78.5 | ????13.7 |
| ????6 | ????0 * | ????0.008 | ????77.4 | ????20.6 |
| ????7 | ????0 * | ????0.2 | ????48.4 | ????24.8 |
As finding out from table 1 gained result, the corn seed extract of concentration range 2-4g/l can provide required activity, and keeps cell survival rate.
Embodiment 2
Make the used skin care compositions of whiteness of skin below the preparation:
| Composition | ????WT％ |
| Stearic acid | ????17.90 |
| Spermol | ????0.53 |
| (Dow 200,350c) for dimethyl siloxane | ????0.50 |
| Propyl p-hydroxybenzoate | ????0.10 |
| The corn seed extract | ????3.00 |
| Water | ????74.53 |
| Glycerol | ????1.00 |
| ?EDTA | ????0.04 |
| Methyl parahydroxybenzoate | ????0.20 |
| ?KOH.22％ | ????2.20 |
| Total amount | ????100.00 |
Should clear and definite the present invention herein to the description of particular form with illustrate just as representative.Comprise the variation of those contents that proposed in (but being not limited to) this description, can make, and do not depart from clear disclosed engineering philosophy with the form of specific embodiments.Therefore should be with reference to following appended claims, to determine complete scope of the present invention.
Claims (1)
1. make whiteness of skin or make hyperpigmentation reduce to minimum beauty method, this method comprises that the compositions that will contain the corn seed extract in the suitable carrier of beauty treatment is applied on the skin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15971099P | 1999-10-15 | 1999-10-15 | |
| US60/159710 | 1999-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1299643A true CN1299643A (en) | 2001-06-20 |
Family
ID=22573681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00130494 Pending CN1299643A (en) | 1999-10-15 | 2000-10-13 | Beauty method for making skin white |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN1299643A (en) |
| BR (1) | BR0004829A (en) |
| ID (1) | ID27628A (en) |
| ZA (1) | ZA200005221B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550815A (en) * | 2017-09-18 | 2018-01-09 | 上海家化联合股份有限公司 | A kind of maize seed extract and its application in skin preparations for extenal use |
-
2000
- 2000-09-28 ZA ZA200005221A patent/ZA200005221B/en unknown
- 2000-10-12 ID IDP20000883A patent/ID27628A/en unknown
- 2000-10-13 BR BR0004829A patent/BR0004829A/en not_active Application Discontinuation
- 2000-10-13 CN CN 00130494 patent/CN1299643A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550815A (en) * | 2017-09-18 | 2018-01-09 | 上海家化联合股份有限公司 | A kind of maize seed extract and its application in skin preparations for extenal use |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200005221B (en) | 2002-03-28 |
| BR0004829A (en) | 2001-05-22 |
| ID27628A (en) | 2001-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69329764T2 (en) | NEW COSMETIC PREPARATION | |
| KR100486442B1 (en) | Natural Look Cosmetic Compositions | |
| EP0949902B1 (en) | Cosmetic preparation with a peptide addition | |
| EP0908175B1 (en) | Stable topical composition containing a solid elastomeric organopolysiloxane and spherical particles | |
| DE69305578T2 (en) | PRODUCT BASED ON COLORED MINERAL PARTICLES CONTAINING A MELANINE PIGMENT, ITS PRODUCTION PROCESS AND ITS USE IN COSMETICS | |
| CN108714110A (en) | A kind of formula and purposes of whitening spot-removing compound | |
| CN111358745B (en) | Whitening, firming and moisturizing cream and preparation method thereof | |
| CN109549863A (en) | A kind of lightening compositions and preparation method thereof | |
| DE69600165T2 (en) | Carrier and composition containing this carrier and a stabilized cosmetic or dermatological active ingredient | |
| CN111671685A (en) | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof | |
| CN110090167A (en) | Biological polyoses and its application for ultraviolet injury repair | |
| US8545859B2 (en) | Use of acrylates copolymer as waterproofing agent in personal care applications | |
| CN112932990A (en) | Anti-aging composition and preparation method and application thereof | |
| DE60036401T2 (en) | COSMETIC AGENTS CONTAINING ANIS EXTRACT AND RETINOIDS | |
| JP3908126B2 (en) | Epidermal keratinization normalizing agent and skin external preparation containing the same | |
| CN108852969B (en) | Anti-wrinkle anti-aging whitening mask and preparation method thereof | |
| FR2965483A1 (en) | COSMETIC USE OF A TROPAEOLUM MAJUS EXTRACT AS AN ACTIVE INGREDIENT TO PROMOTE OXYGENATION OF SKIN TISSUE | |
| JP2009196915A (en) | Composition for cosmetic | |
| CN111904915A (en) | Whitening and freckle removing composition and preparation method and application thereof | |
| CN109646389B (en) | Flavobacterium fermentation extract and application thereof in cosmetics | |
| CN1299643A (en) | Beauty method for making skin white | |
| JPS6124512A (en) | Overcoating for lipstick | |
| KR20110073935A (en) | Cosmetic compositions containing adipic acid neophentyl glicol crosspolymer suspension solution for covering the skin pores | |
| CN115700114A (en) | Anti-aging composition, application thereof and eye cream containing composition | |
| EP1800653A1 (en) | Cosmetic, esp. silicon-free composition comprising PPG-3 Benzyl ether myristate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |