CN1298716A - Medicine containing pittosporum glabratum lindl extract as active components for curing pulmonary tuberculosis - Google Patents

Abstract

A medicine for treating tuberculosis is ma pure natural medicinal preparation made up from an extract of pittosporum glabratum lindl, which is made into powder, tablet or capsule for taking orally, and it possesses the functions of antituberculosis, tonify lung and kidney, relieving cough, clearing away heat and toxic materials, relieving inflammation and reducing phlegm, etc..

Description

A kind of medicine for the treatment of all types of pulmonary tuberculosis with the Os Gallus domesticus peel extract as active ingredient

The present invention be a kind of be the pure natural medical preparation that mainly contains effective constituent with the medicine of commonly using among the people.

At present, for the treatment of all kinds pulmonary tuberculosis, be a global difficult problem, still there is not specific drug so far.Western medicine commonly used has isoniazid, streptomycin sulfate, ethambutol, rifampicin capsules, pyrrole crop amide etc., the chemicals side effect is many, because treatment time is long, clothes also are prone to drug resistance for a long time, the anti-consumptive disease of western medicine total course of treatment generally needs at least 6 months: 2 months reinforcement phases, 4 months consolidations, have in addition reached for 1～2 year, and curative effect is not obvious, and cure rate is low.Other are as rifapentine, cost an arm and a leg, toxic and side effects is big, and in addition, the above-mentioned Western medicine of informal dress has stimulation to gastrointestinal tract, causes that the pill taker feels sick, vomiting; Nervous system there is ill symptoms, produces mental excitation, muscle numbness, insomnia etc.; Polyneuritis occurs, liver function is had infringement, draw medicine lung hepatopathy, anaphylaxis dermatosis etc.

The purpose of this invention is to provide and a kind ofly treat the medicine of all types of pulmonary tuberculosis with the Os Gallus domesticus peel extract as active ingredient, it has tangible bacteriostasis to the bacillus tuberculosis typus humanus.

The Yi nationality, distributed over Yunnan, Sichuan and Guizhou, Lisu national medical material Os Gallus domesticus skin plant of commonly using among the people, have another name called the Semen Pittospori Glabrati spirit, be the Pittosporaceae plant (Pittosporum glabratum Lindl.) of QINGZHI, record " Xichang Chinese herbal medicine of writing by ground, Xichang, Sichuan Province health bureau of leather committee in January, 1972 " the 419th page.The Os Gallus domesticus skin tree root peel of stem that the present invention adopts mainly contains Os Gallus domesticus skin active ingredient compositions such as biological alkali, soap is sweet, makes powder, tablet and capsule oral formulations based on this.

The Os Gallus domesticus peel extract is produced with following step: the trunk of Os Gallus domesticus skin plant, the outer casting skin of rhizome are scraped off, get the endosexine Rhizoma Euonymus, clean, cut into 2 cun long strip of sheet, dry, pulverize three times, be ground into coarser powder, divide three times, with thick number sieve, medium size sieve and thin dressing sieve, cross mesh sieve 80～No. 100, No. one, reuse sieve filter powder, in drying below 65 ℃ to water content 3～5%, cross a sieve series at last and get powder, per 2.5 grams of gained Os Gallus domesticus peel extract are equivalent to crude drug 40 gram crude drugs.

More than one Os Gallus domesticus peel extract of stating are treated the medicine of all types of pulmonary tuberculosis as active ingredient, and its per unit dosage contains Os Gallus domesticus peel extract 2～5 grams.

The invention provides the powder that is made of single kind of medicine, be brown or micro-yellow powder preparation, the puckery hardship is directly taken.Preparation method system by pulverize, sieve, processes such as mixing, divided dose and packing.General 300 restrain into 1000 bags, can add an amount of sweetener and make pharmaceutic adjuvant.

The film-making agent: the powder through above-mentioned dry granulate adds the lubricant adjuvant, as magnesium stearate, and abundant mix homogeneously, last tablet machine is pressed into tablet.For improving mouthfeel, can place sugar coating in the coating pan.

Glue wafer: will be at last cross encapsulated the getting final product of powder that sieve series gets.

Oral drugs provided by the invention have anti-consumptive disease, the effect of tonify deficiency consumptive disease, and have that tonifying the lung kidney, cough-relieving are coughed, heat-clearing and toxic substances removing, the effect of antiinflammatory expectorant, reach bactericidal, improve the purpose of immunologic function.Can improve lymphocyte conversion ratio, organism adaptation ability, bacillus tuberculosis typus humanus and carbonic acid bacillus are had tangible bacteriostasis.

Medicine provided by the invention through preclinical medicine portion of unming Medical College microorganism both immunology teaching and research room to mycobacterium hominis's bacteriostatic experiment, conclusion is: Semen Pittospori Glabrati spirit extract has inhibitory action to the Bacillus tuberculosis, its MIC is 125mg/ml, is equivalent to every milliliter 2 gram crude drug.

Medicine taking convenience provided by the invention, consumption are few, free from extraneous odour, nothing are paid effect, and short treating period, curative effect are reliable rapidly, and folk prescription or share with compound recipe take medicine back and find that poison is paid effect and drug combination is avoided of produce effects, patient is all arranged does not have any bad reflection yet.Be a kind of brand-new infection, the cough suppressing medicine of anti-consumptive disease.

This medicine can effectively be treated all types of pulmonary tuberculosis, also is applicable to many sick treatments of planting such as upper respiratory tract infection inflammation, acute/chronic bronchitis, emphysema simultaneously.

Be one group of pulmonary tuberculosis case observation of curative effect table below, state of an illness weight did not wait before each routine patient of men and women took medicine in this group, and rabat shows all General Symptoms or local symptom, and human-like symptom and sign lungy is arranged in various degree, and hospital makes a definite diagnosis.All take a favorable turn or remission after taking medicine.

Intact back check one course of treatment rabat, the focus basic absorption, clinical fundamental symptoms sign disappears, row second course of therapy, focus absorbs fully, and it is normal that erythrocyte sedimentation rate recovers, and determination of tuberculosis antibody is negative, expectorant acid-fast bacilli feminine gender.

Table one

Claims (3)

1, a kind of Os Gallus domesticus peel extract is characterized in that: the trunk of Os Gallus domesticus skin plant, the outer casting skin of rhizome are scraped off, get the endosexine Rhizoma Euonymus, clean, cut into 2 cun long strip of sheet, dry, pulverize three times, be ground into coarser powder, divide thick number sieve of three usefulness, medium size sieve and fine powder sieve, cross 80～No. 100 mesh sieves, sieve of reuse filters, then in oven dry below 65 ℃, to water content 3～5%, to cross a sieve series at last and get powder, per 2.5 grams of gained Os Gallus domesticus peel extract are equivalent to crude drug 40 gram crude drugs.

2, a kind ofly treat the medicine of all types of pulmonary tuberculosis as active ingredient with the described Os Gallus domesticus peel extract of claim 1, its feature in: per unit dosage contains Os Gallus domesticus peel extract 2～5 grams.

3, the medicine of all types of pulmonary tuberculosis of a kind of treatment as claimed in claim 2, its feature in: it is powder, tablet and the capsule oral formulations that contains the active ingredient of Os Gallus domesticus skin.