CN1172689C - Medicine containing pittosporum glabratum lindl extract as active components for curing pulmonary tuberculosis - Google Patents

Abstract

The present invention relates to a pure natural medicinal preparation with a folk conventional medicine as the main effective ingredient, and the folk conventional medicine is named as Shanzhiling which is a pittosporum glabratum lindl plant of green branches. Each 2.5 g of extract is equivalent to 40 g of crude drugs of the original medicinal materials. The present invention can be prepared into oral preparations, such as powder, tablets and capsules. The present invention has the effects of resisting pulmonary tuberculosis, tonifying asthenia consumption, tonifying lungs and kidneys, stopping cough, clearing away heat and toxic materials, relieving inflammation and eliminating sputum, and the goals of sterilizing, inhibiting bacterium and improving immune function can be achieved. The present invention can improve the conversion rate of lymph cells and the adaptability of organisms, and has an obvious bacteriostasis effect on human tubercle bacillus and carbonic acid bacillus.

Description

The application of Pittosporum glabratum Lindl manufactured goods in all kinds of pulmonary tuberculosis medicines of preparation treatment

Technical field

The present invention be a kind of be the pure natural medical preparation that mainly contains effective constituent with the medicine of commonly using among the people.

Background technology

At present, for the treatment of all kinds pulmonary tuberculosis, be a global difficult problem, still there is not specific drug so far.Western medicine commonly used has isoniazid, streptomycin sulfate, ethambutol, rifampicin capsules, pyrrole crop amide etc., the chemicals side effect is many, because treatment time is long, clothes also are prone to drug resistance for a long time, the anti-consumptive disease of western medicine total course of treatment generally needs at least 6 months: 2 months reinforcement phases, 4 months consolidations, have in addition reached for 1～2 year, and curative effect is not obvious, and cure rate is low.Other are as rifapentine, cost an arm and a leg, toxic and side effects is big, and in addition, the above-mentioned Western medicine of informal dress has stimulation to gastrointestinal tract, causes that the pill taker feels sick, vomiting; Nervous system there is ill symptoms, produces mental excitation, muscle numbness, insomnia etc.; Polyneuritis occurs, liver function is had infringement, draw medicine lung hepatopathy, anaphylaxis dermatosis etc.

Summary of the invention

The purpose of this invention is to provide the application of a kind of Pittosporum glabratum Lindl manufactured goods in the medicine of all types of pulmonary tuberculosis of preparation treatment, it has tangible bacteriostasis to the bacillus tuberculosis typus humanus.

The Yi nationality, distributed over Yunnan, Sichuan and Guizhou, Lisu national medical material Os Gallus domesticus skin plant of commonly using among the people, have another name called the Semen Pittospori Glabrati spirit, be the Pittosporaceae plant (Pittosporum glabratum Lindl.) of QINGZHI, record " Xichang Chinese herbal medicine of writing by ground, Xichang, Sichuan Province health bureau of leather committee in January, 1972 " the 419th page.The Os Gallus domesticus skin tree root peel of stem that the present invention adopts mainly contains Os Gallus domesticus skin active ingredients such as biological alkali, soap is sweet, makes powder, tablet and capsule oral formulations based on this.

The Pittosporum glabratum Lindl manufactured goods are produced with following step: the trunk of Pittosporum glabratum Lindl plant, the outer casting skin of rhizome are scraped off, get the endosexine Rhizoma Euonymus, clean, cut into 2 cun long strip of sheet, dry, pulverize three times, be ground into coarser powder, divide three times, with thick number sieve, medium size sieve and thin dressing sieve, cross mesh sieve 80～No. 100, No. one, reuse sieve filter powder, in drying below 65 ℃ to water content 3～5%, cross a sieve series at last and get powder, per 2.5 grams of gained Pittosporum glabratum Lindl manufactured goods are equivalent to crude drug 40 gram crude drugs.

Above-mentioned Pittosporum glabratum Lindl manufactured goods, per unit dosage contain Pittosporum glabratum Lindl 2～5 grams.

Said medicine can adopt powder, tablet and capsule oral formulations when using.

The invention provides the powder that is made of single kind of medicine, be brown or micro-yellow powder preparation, the puckery hardship is directly taken.Preparation method system by pulverize, sieve, processes such as mixing, divided dose and packing.General 300 restrain into 1000 bags, can add an amount of sweetener and make pharmaceutic adjuvant.

The specific embodiment

The film-making agent: the powder through above-mentioned dry granulate adds the lubricant adjuvant, as magnesium stearate, and abundant mix homogeneously, last tablet machine is pressed into tablet.For improving mouthfeel, can place sugar coating in the coating pan.

Glue wafer: will be at last cross encapsulated the getting final product of powder that sieve series gets.

Medicine provided by the invention has anti-consumptive disease, the effect of tonify deficiency consumptive disease, and have that tonifying the lung kidney, cough-relieving are coughed, heat-clearing and toxic substances removing, the effect of antiinflammatory expectorant, reach bactericidal, improve the purpose of immunologic function.Can improve lymphocyte conversion ratio, organism adaptation ability, bacillus tuberculosis typus humanus and carbonic acid bacillus are had tangible bacteriostasis.

Medicine provided by the invention through preclinical medicine portion of unming Medical College microorganism both immunology teaching and research room to mycobacterium hominis's bacteriostatic experiment, conclusion is: Semen Pittospori Glabrati spirit extract has inhibitory action to the Bacillus tuberculosis, its MIC is 125mg/ml, is equivalent to every milliliter 2 gram crude drug.

Medicine taking convenience provided by the invention, consumption are few, free from extraneous odour, nothing are paid effect, and short treating period, curative effect are reliable rapidly, and folk prescription or share with compound recipe take medicine back and find that poison is paid effect and drug combination is avoided of produce effects, patient is all arranged does not have any bad reflection yet.Be a kind of brand-new infection, the cough suppressing medicine of anti-consumptive disease.

This medicine can effectively be treated all types of pulmonary tuberculosis, also is applicable to many sick treatments of planting such as upper respiratory tract infection inflammation, acute/chronic bronchitis, emphysema simultaneously.

Be one group of pulmonary tuberculosis case observation of curative effect table below, state of an illness weight did not wait before each routine patient of men and women took medicine in this group, and rabat shows all General Symptoms or local symptom, and human-like symptom and sign lungy is arranged in various degree, and hospital makes a definite diagnosis.All take a favorable turn or remission after taking medicine.

Intact back check one course of treatment rabat, the focus basic absorption, clinical fundamental symptoms sign disappears, row second course of therapy, focus absorbs fully, and it is normal that erythrocyte sedimentation rate recovers, and determination of tuberculosis antibody is negative, expectorant acid-fast bacilli feminine gender.

Table one

Name	The address	Sex	Age	Diagnosis	Before the treatment	Dosage	After the treatment
								Liu Zhilin	Fierce tiger	The man	43 years old	Infiltrative pulmonary tuberculosis	Noon low grade fever burglar antiperspirant, cough, cough up phlegm, rabat: the bottom right lung soaks into the focus activity.The tuberculosis antibody positive, erythrocyte sedimentation rate 79mmh.	600 grams	General Symptoms and local symptom disappear, check tuberculosis antibody feminine gender, and erythrocyte sedimentation rate 30mmh rabat, the focus basic absorption, diet still can.
Li Chengzhong	Neutralization	The man	36 years old	Infiltrative pulmonary tuberculosis	Low heat cough is coughed up phlegm, burglar's antiperspirant, pain uncomfortable in chest, rabat shows that lung soaks into focus in the right side, and unit is vaporific, the tuberculosis antibody positive, erythrocyte sedimentation rate 45mmh, leukocyte 17100mn/L	500 grams	The clinical symptoms Signs disappears, the tuberculosis antibody feminine gender, and erythrocyte sedimentation rate 26mmh, the pneumonopathy kitchen range absorbs in the rabat check left side.
								Tang Xiaolin	Yongding	The man	16 years old	Tuberculous pleuritis	Breath is had a liking in the chest pain cough, burglar's antiperspirant low grade fever, and rabat shows: the right side pleuritis, the tuberculosis antibody positive, erythrocyte sedimentation rate 55mmh, leukocyte 21000mn/L, neutral 88%.	700 grams	Treat 2 months check rabats, right side pleura focus absorbs, chest pain, cough, tachypnea disappears, diet improves, the tuberculosis antibody feminine gender, and the erythrocyte sedimentation rate hemogram is normal.
Li Jinfen	Yongding	The woman	29 years old	Infiltrative pulmonary tuberculosis	Pain uncomfortable in chest, cough is coughed up phlegm, the noon low grade fever, burglar's antiperspirant, body is become thin, menoxenia: the determination of tuberculosis antibody positive, erythrocyte sedimentation rate 87mmh, rabat shows: the bottom right lung soaks into focus, hematochrome 9.8 grams.	600 grams	Clinical oral administration Drug therapy through 40 days, symptom and sign disappears, diet is normal, body constitution is improved rabat and shown: bottom right pneumonopathy kitchen range absorbs, the tuberculosis antibody feminine gender, erythrocyte sedimentation rate 25mmh.
								Zhang Yongjie	The level land	The woman	60 years old	Cavernous pulmonary tuberculosis	Feeling of oppression and pain in the chest, cough spitting of blood expectorant, the thin rabat of heating night sweat body shows: pulmonary cavity in the right side, the tuberculosis antibody positive, erythrocyte sedimentation rate 105mmh.	900 grams	After the treatment in 2 months of taking medicine, body constitution is improved, symptom and sign is alleviated substantially, diet improves, the check rabat: the pulmonary cavity base heals entirely in the right side, it is weak positive that focus is stablized tuberculosis antibody, and erythrocyte sedimentation rate 46mmh continues to strengthen January.
Li Yongxian	Dimension	The man	47 years old	Two lung infiltrative pulmonary tuberculosis	Fever and cough is coughed up phlegm, chest pain, hot burglar's antiperspirant of noon, rabat shows: soak into focus in two lungs, cloud, the tuberculosis antibody positive, erythrocyte sedimentation rate 36mmh, blood lymphocyte 96%	600 grams	Through taking medicine February.The clinical symptoms sign, the local symptom General Symptoms is all eliminated, hole, check rabat two lungs middle part kitchen range absorbs, the determination of tuberculosis antibody feminine gender, the erythrocyte sedimentation rate hemogram is normal.
								Zhu Jiaming	Lian Chi	The man	56 years old	Tuberculous pleuritis	The chest pain cough, weak asthma, heating night sweat, rabat shows: the left side pleuritis is mixed a small amount of hydrops, the tuberculosis antibody positive, erythrocyte sedimentation rate 48mmh, hemogram is neutral high.	600 grams	2 the course of treatment medication treatment, symptom and sign disappearance check rabat shows: left pleura focus absorbs, tuberculosis is sunk the body feminine gender, erythrocyte sedimentation rate 20mmh, hemogram is normal, and food is received improvement.
Chen Jiying	Yongding	The woman	58 years old	Bottom right lung infiltrative pulmonary tuberculosis	Heating, cough is coughed up phlegm, chest pain heating at noon, night sweat, rabat shows: bottom right lung infiltrative type focus activity, cloud, the tuberculosis antibody positive, erythrocyte sedimentation rate 66mmh, hemogram is normal	600 grams	Through 2 the course of treatment medication treatment, local symptom General Symptoms sign is eliminated, the check rabat, bottom right pneumonopathy kitchen range obviously absorbs, check tuberculosis antibody feminine gender, erythrocyte sedimentation rate is normal, and food is received improvement.
								Fructus Pruni salicinae light	Yongding	The man	74 years old	The old pulmonary tuberculosis	Long-term cough is coughed up sputum with blood streaks, pain uncomfortable in chest, body is become thin, chronic facies, and rabat shows: right upper lung, the old lung soaks into focus, and tuberculosis antibody is weak positive, erythrocyte sedimentation rate 46mmh.	800 grams	Through taking medicine for 3 courses of treatment, disease body sign is improved.Diet still can, the tuberculosis antibody feminine gender, erythrocyte sedimentation rate is normally checked rabat, right upper lung focus basic absorption is continued to strengthen a course of treatment.
Li Xingfen	Fierce tiger	The woman	34 years old	Infiltrative pulmonary tuberculosis	Heating, night sweat is coughed up phlegm in cough, diet is poor, and body is thin, and night is sleeping poor, and rabat shows: upper left lung soaks into focus, the tuberculosis antibody positive, erythrocyte sedimentation rate 54mmh, hemogram height.	600 grams	The clinical medication treatment through 2 months, above-mentioned clinical manifestation is normal, and diet is normal, looks into the rabat focus and absorbs, tuberculosis antibody is turned out cloudy, and the erythrocyte sedimentation rate hemogram is normal

Claims (3)

1, the application of a kind of Pittosporum glabratum Lindl manufactured goods in the medicine of all types of pulmonary tuberculosis of preparation treatment, it is characterized in that described Pittosporum glabratum Lindl manufactured goods are made by following method: with the trunk of Pittosporum glabratum Lindl plant, the outer casting skin of rhizome scrapes off, get the endosexine Rhizoma Euonymus, clean, cut into 2 cun long strip of sheet, dry, pulverize three times, be ground into coarser powder, divide three usefulness thick number sieve, medium size sieve and fine powder sieve are crossed 80～No. 100 mesh sieves, and sieve of reuse filters, then in oven dry below 65 ℃, to water content 3～5%, to cross a sieve series at last and get powder, per 2.5 grams of gained Pittosporum glabratum Lindl manufactured goods are equivalent to crude drug 40 gram crude drugs.

2, application as claimed in claim 1 is characterized in that: the medicine of per unit dosage contains Pittosporum glabratum Lindl 2～5 grams.

3, application as claimed in claim 1 is characterized in that: described medicine is powder, tablet and capsule oral formulations.