CN1287840A - Medicine for treating gynecological chronic inflammation and preparation method thereof - Google Patents
Medicine for treating gynecological chronic inflammation and preparation method thereof Download PDFInfo
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- CN1287840A CN1287840A CN 00113671 CN00113671A CN1287840A CN 1287840 A CN1287840 A CN 1287840A CN 00113671 CN00113671 CN 00113671 CN 00113671 A CN00113671 A CN 00113671A CN 1287840 A CN1287840 A CN 1287840A
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- 239000003814 drug Substances 0.000 title claims abstract description 44
- 208000037976 chronic inflammation Diseases 0.000 title claims abstract description 19
- 230000006020 chronic inflammation Effects 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 229940079593 drug Drugs 0.000 title description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 8
- 239000008517 radix Trichosanthis Substances 0.000 claims description 8
- 241000157835 Gardenia Species 0.000 claims description 7
- 241000202807 Glycyrrhiza Species 0.000 claims description 7
- 241000405217 Viola <butterfly> Species 0.000 claims description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 244000183685 Citrus aurantium Species 0.000 abstract 1
- 235000007716 Citrus aurantium Nutrition 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000218176 Corydalis Species 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 235000013719 Houttuynia cordata Nutrition 0.000 abstract 1
- 241001071917 Lithospermum Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000612118 Samolus valerandi Species 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 241000218989 Trichosanthes Species 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
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- 239000008280 blood Substances 0.000 description 4
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- 241000233866 Fungi Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000006374 Uterine Cervicitis Diseases 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 206010008323 cervicitis Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
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- 206010057254 Connective tissue inflammation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- QBDCOUHKEVYWLO-UHFFFAOYSA-N Decanoyl acetaldehyde Chemical compound CCCCCCCCCC(=O)CC=O QBDCOUHKEVYWLO-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000004145 Endometritis Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241001430197 Mollicutes Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicament for treating gynecological chronic inflammation and a preparation method thereof. The traditional Chinese medicine is prepared from raw materials of gypsum, coptis chinensis, gardenia, bunge corydalis herb, lithospermum, red paeony root, cortex moutan, immature bitter orange, dandelion, trichosanthes root, houttuynia cordata and liquorice according to different characteristics of each traditional Chinese medicine in proportion, and is prepared into an aqua for oral administration by soaking, boiling and concentrating. The invention has unique formula and preparation method and obvious treatment effect.
Description
The present invention relates to a kind of medicine for the treatment of the female chronic inflammation disease, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
The female chronic inflammation disease comprises substantially: oophoritis, salpingitis, inflammation of pelvic connective tissue, cervicitis and vaginitis etc.By antibacterial, fungus, virus, according to female chronic inflammation diseases that pathogenic microorganism caused such as substance, mycoplasmas.At present, whole world adult women's prevalence is 85%, and teenage women's prevalence is 5～15%, is the primary gynaecopathia that influences WomanHealth.The female chronic inflammation disease will be one of key factor that causes gynecological's carcinoma if can not get timely medical treatment.
Both at home and abroad to the Drug therapy of primary disease, run into following thorny problem at present:
1. easily produce drug resistance with antibiotic;
2. antibiosis have anaphylaxis;
3. long-term heavy dose of use of antibiotic has grievous injury to liver, kidney.
Based on above reason, there are a lot of patients can only abandoning cure, develop as one pleases.
Though also some treats the Chinese patent medicine of female chronic inflammation disease, effect is not fairly obvious, and most of patient is abandoning cure also, develops as one pleases.
The object of the present invention is to provide a kind of antiinflammatory that has, repair inflammatory tissue, enhancing human body immunity reduces the female chronic inflammation disease therapeutic agent that gynecological's carcinoma takes place.
Another object of the present invention provides the preparation method of this gynecological inflammation disease therapeutic agent.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to the female chronic inflammation disease pathogenesis, with reference to modern pharmacological research achievement and the clinical practice of oneself summary of experience, from motherland's medicine treasure-house, filter out clearing away heat and cooling blood, the dampness detoxifcation, invigorating blood circulation, it is turbid to swing, the natural edible-plant and the mineral drug of mediation nutrient blood, by the theory of Chinese medical science prescription, processing preparation cleverly, make its performance antiinflammatory (comprise various antibacterials, fungus, virus, according to substance, mycoplasma, the female chronic inflammation that virus is caused etc.), repair inflammatory tissue, the effect that the prevention canceration takes place.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Gypsum Fibrosum 5～40 Rhizoma Coptidis 3～15 Fructus Gardeniaes 5～20 Herba Violaes 5～30
Radix Arnebiae (Radix Lithospermi) 5～20 Radix Paeoniae Rubra 5～20 Cortex Moutans 5～20 Fructus Aurantii Immaturuss 5～20
Pu's Herba Taraxaci 5～40 Radix Trichosanthis 5～30 Herba Houttuyniae 5～30 Radix Glycyrrhizaes 5～30
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Gypsum Fibrosum 10～35 Rhizoma Coptidis 3～10 Fructus Gardeniaes 5～15 Herba Violaes 10～30
Radix Arnebiae (Radix Lithospermi) 5～15 Radix Paeoniae Rubra 5～15 Cortex Moutans 5～15 Fructus Aurantii Immaturuss 5～15
Pu's Herba Taraxaci 10～30 Radix Trichosanthis 10～30 Herba Houttuyniae 10～30 Radix Glycyrrhizaes 5～15
The optimum weight of medicine of the present invention (part) proportioning is:
Gypsum Fibrosum 15 Rhizoma Coptidis 6 Fructus Gardeniaes 10 Herba Violaes 30
Radix Arnebiae (Radix Lithospermi) 12 Radix Paeoniae Rubra 8 Cortex Moutans 8 Radix Glycyrrhizaes 7
Pu's Herba Taraxaci 15.5 Radix Trichosanthis 20 Herba Houttuyniae 30 Fructus Aurantii Immaturuss 8
Above-mentioned each component is made medicine production method of the present invention is:
1. choose various medicaments and put in the clean vessel, add clear water and soaked 20～30 minutes;
2. heated and boiled and azeotropic are 30～60 minutes, and filtration takes concoction;
3. add clear water again, heated and boiled and azeotropic 30～60 minutes, filtration takes concoction;
4. get twice source medicine juice mixing and heating and be concentrated into 100～150 milliliters, make water preparation.
An important feature of the present invention is a medicament antiinflammatory superior performance, the clinical experiment comparing result, and medicament of the present invention is on treatment gynecological inflammation disease, and drug effect is 2.8 times of Cefamezin.
Embodiment:
Take by weighing raw material (kilogram) by following proportioning
Pu's Herba Taraxaci 50 Radix Trichosanthis 55 Herba Houttuyniae 50 Gypsum Fibrosum 60
Radix Arnebiae (Radix Lithospermi) 12.5 Radix Paeoniae Rubra 15 Cortex Moutans 15 Rhizoma Coptidis 12.5
Herba Violae 45 Radix Glycyrrhizaes 15 Fructus Aurantii Immaturuss 20 Fructus Gardeniaes 15
Production method is as follows:
Raw material is put in the vessel, and it is an amount of to add clear water, soaks 30 minutes, be placed on the slow fire and heat, seethe with excitement and took out that the source medicine juice is some for the first time in 40 minutes, add water again and boil in right amount and abandon the medicine short, bristly hair or beard after 40 minutes and get source medicine juice for the second time, twice medicine juice mixed the back concentrate and obtain oral drink liquid.
Prescription strictness of the present invention, scientific and reasonable: Gypsum Fibrosum, Rhizoma Coptidis clearing away heat-fire, dampness swing the turbid monarch drug that is, Fructus Gardeniae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan clearing away heat and cooling blood, mediation nutrient blood is ministerial drug; Pu's Herba Taraxaci, Radix Trichosanthis, Herba Houttuyniae, Fructus Aurantii Immaturus heat-clearing and toxic substances removing, regulating QI to relieve pain are adjuvant drug; The Radix Glycyrrhizae spleen invigorating is set upright, and coordinating the actions of various ingredients in a prescription is a messenger drug.
According to pharmacological research and clinical report: 1. the contained main component berberine of Rhizoma Coptidis, not only can kill bacteria and fungus, and short cancer material capable of blocking is to the effect of potential cancerous tumor cell, thus obtain the anti-cancer effect, so precancerous lesion can be taken for a long time.2. one of contained main component of Herba Houttuyniae houttuynine sodium bisulfite not only has broad-spectrum antiseptic and antifungal and antiviral effect, and can improve body nonspecific immunity power.3. the pharmacology of other drug is had a broad spectrum antiphlogistic effect, the part medicine can be regulated blood vessel and cell permeability and effects such as the pituitary hormone of adjusting and adrenocortical hormone are arranged, thereby reach antiinflammatory, antiallergic, reparation inflammatory tissue, the effect of enhancing human body immunity power.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1. to select natural Chinese traditional medicines be raw material in the present invention, and each component meets the pharmaceutical control law regulation. Utilize the Chinese medicine of respectively distinguishing the flavor of Comprehensive function treatment female chronic inflammation disease, no chemical addition agent, nontoxic to human body.
2. the present invention need not patient reprocess, and is namely sick instant, taking convenience. The rule that meet national regulations Fixed.
3. the lighter's short-term can be cured, and severe patient also can be taken the midium or long term, and particularly long-term taking has anti-canceration And increase the effect of the strong immunity of organisms of Queensland.
4. to serious virus in patients with cervicitis, the outer lotion of the traditional Chinese medical science can be share, good effect can be received.
Instructions of taking: 50 milliliters/day, day takes one after each meal 3 times. Clinical test results such as subordinate list.
Medicament of the present invention has carried out the result for the treatment of observation to 421 routine female chronic inflammation diseases clinically, knot Fruit is: ovary, salpingitis 99 examples, cure 58 examples, and produce effects 32 examples, 9 examples take a turn for the better; Cervicitis 79 examples are controlled More 39 examples, produce effects 30 examples, 10 examples take a turn for the better; Connective tissue inflammation of pelvic cavity 57 examples are cured 26 examples, produce effects 24 examples, 7 examples take a turn for the better; Bartholinitis 8 examples are cured 8 examples; Endometritis 83 examples are cured 42 examples, produce effects 28 Example, 13 examples take a turn for the better; Vaginitis 62 examples are cured 35 examples, produce effects 21 examples, and 6 examples take a turn for the better; Inflammatory fallopian tubal stalk Hinder 7 examples, cure 5 examples, invalid 2 examples obtain clinical cure 239 examples (accounting for 56.77%), and produce effects 135 examples (account for 32.06%), 45 examples that take a turn for the better (accounting for 10.68%), invalid 2 examples (accounting for 0.47%), total effective rate 99.52%. The disinfecting anti inflammatory drink is to the observation of curative effect list Fu of 421 routine gynaecological imflammation diseases
Claims (6)
1, a kind of medicine for the treatment of female chronic inflammation is characterized in that it is the medicament of being made by following materials of weight proportions
Gypsum Fibrosum 5～40 Rhizoma Coptidis 3～15 Fructus Gardeniaes 5～20 Herba Violaes 5～30
Radix Arnebiae (Radix Lithospermi) 5～20 Radix Paeoniae Rubra 5～20 Cortex Moutans 5～20 Fructus Aurantii Immaturuss 5～20
Pu's Herba Taraxaci 5～40 Radix Trichosanthis 5～30 Herba Houttuyniae 5～30 Radix Glycyrrhizaes 5～30
2, the medicine of treatment female chronic inflammation according to claim 1, wherein the weight proportion of each raw material is
Gypsum Fibrosum 10～35 Rhizoma Coptidis 3～10 Fructus Gardeniaes 5～15 Herba Violaes 10～30
Radix Arnebiae (Radix Lithospermi) 5～15 Radix Paeoniae Rubra 5～15 Cortex Moutans 5～15 Fructus Aurantii Immaturuss 5～15
Pu's Herba Taraxaci 10～30 Radix Trichosanthis 10～30 Herba Houttuyniae 10～30 Radix Glycyrrhizaes 5～15
3, the medicine of treatment female chronic inflammation according to claim 1, wherein the weight proportion of each raw material is
Gypsum Fibrosum 15 Rhizoma Coptidis 6 Fructus Gardeniaes 10 Herba Violaes 30
Radix Arnebiae (Radix Lithospermi) 12 Radix Paeoniae Rubra 8 Cortex Moutans 8 Radix Glycyrrhizaes 7
Pu's Herba Taraxaci 15.5 Radix Trichosanthis 20 Herba Houttuyniae 30 Fructus Aurantii Immaturuss 8
4,, it is characterized in that said medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1,2 or 3 described treatment female chronic inflammations
5, the medicine of described treatment female chronic inflammation according to claim 4 is characterized in that said medicament is a water preparation.
6, the preparation method of described treatment female chronic inflammation medicine according to claim 5 is characterized in that choosing earlier various medicaments and puts in the vessel, adds clear water and soaks 20～30 minutes; Heated and boiled and azeotropic are 30～60 minutes then, and filtration takes concoction; Add clear water again, heated and boiled and azeotropic 30～60 minutes, filtration takes concoction; Get twice source medicine juice mixing and heating and be concentrated into 100～150 milliliters, make water preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00113671 CN1287840A (en) | 2000-09-05 | 2000-09-05 | Medicine for treating gynecological chronic inflammation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00113671 CN1287840A (en) | 2000-09-05 | 2000-09-05 | Medicine for treating gynecological chronic inflammation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1287840A true CN1287840A (en) | 2001-03-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00113671 Pending CN1287840A (en) | 2000-09-05 | 2000-09-05 | Medicine for treating gynecological chronic inflammation and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1287840A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124945B (en) * | 2007-09-27 | 2010-05-19 | 天津农学院 | Special-purpose traditional Chinese medicinal composition for fresh water fish infectious diseases |
| CN103623241A (en) * | 2013-11-05 | 2014-03-12 | 蒋树玲 | Traditional Chinese medicine preparation for treating senile vaginitis |
| US8795742B2 (en) | 2006-01-20 | 2014-08-05 | Livzon Pharmaceutical Group Inc. | Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof |
-
2000
- 2000-09-05 CN CN 00113671 patent/CN1287840A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8795742B2 (en) | 2006-01-20 | 2014-08-05 | Livzon Pharmaceutical Group Inc. | Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof |
| US9265805B2 (en) | 2006-01-20 | 2016-02-23 | Livzon Pharmaceutical Group Inc. | Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof |
| CN101124945B (en) * | 2007-09-27 | 2010-05-19 | 天津农学院 | Special-purpose traditional Chinese medicinal composition for fresh water fish infectious diseases |
| CN103623241A (en) * | 2013-11-05 | 2014-03-12 | 蒋树玲 | Traditional Chinese medicine preparation for treating senile vaginitis |
| CN103623241B (en) * | 2013-11-05 | 2016-02-17 | 蒋树玲 | A kind of Chinese medicine preparation for the treatment of senile vaginitis |
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