CN1284487C - Beverage capable of lowering and preventing high blood sugar - Google Patents
Beverage capable of lowering and preventing high blood sugar Download PDFInfo
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- CN1284487C CN1284487C CN200410009037.7A CN200410009037A CN1284487C CN 1284487 C CN1284487 C CN 1284487C CN 200410009037 A CN200410009037 A CN 200410009037A CN 1284487 C CN1284487 C CN 1284487C
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- Medicines Containing Plant Substances (AREA)
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Abstract
The present invention relates to a beverage for decreasing and preventing hyperglycemia, which comprises the natural functionality ingredients of birch down extract, kudzu vine root isoflavone, ginsenoside, etc., and the ingredients have the same medicine and edible sources. The beverage can adjust and decrease blood sugar, promote diabetic patients' recovery and decrease diabetic patients' medicine dosage, and the beverage can prevent hyperglycemia for healthy people.
Description
Technical field:
The present invention relates to a kind of beverage that reduces and prevent hyperglycaemia, particularly relate to the hypoglycemic drink that contains natural function compositions such as CHAGA extract.
Background technology:
The incidence of disease of countries in the world diabetes increases year by year.Show that according to World Health Organization's interrelated data global diabetic surpasses 100,000,000, about 2,000 ten thousand people of China diabetic, diabetic's rehabilitation medical has become one of important content of China's medicine and health work.The morbidity of hyperglycaemia and diabetes has congenital heredity and the multiple reason of acquired disposition, but one of the main reasons, be in recent years in Chinese's meals, energy, protein and the adipose-derived obvious variation that taken place, bean food reduces, pure energy food, animal fat increase, this (Chinese medical epidemiology magazine 1998 that all impels the generation of diabetes in rising trend; 19 (6): 361).
Existing on the market at present various beverage products contain a certain amount of sugar more, and high sugar beverage is accompanied by high-fat food, and the blood sugar level that makes more people is in high critical condition, are actually to be in invisible diabetic disease states, as easy as rolling off a log initiation diabetes.Even sugar-free beverage does not have yet and reduces and the effect of prevention hyperglycaemia.Therefore, be badly in need of having a kind of new beverage that can reduce and prevent hyperglycaemia and promote recovery of melituria on the dining table.
16-17 is since century, Eastern Europe, Russia, Poland, Finland etc. are among the people to be CHAGA (Inonotus obliquus with regard to extensively utilizing the precious medicinal fungi of a kind of Chaga of crying, its formal name used at school is: Phaeoporus obliquus (Pers.:Fr.) J.Schroet. is in foreign language datum, its formal name used at school often occurs with Inonotus obliquus or Fuscoporia obliqua, its another name also has Black birch tuchwood, Malalon mushroon) prevent and treat as diabetes.It is said that the smart powder of Inonotus obliquus that the Muscovite Suo Molesiji of bearing (Komsomlski) drugmaker produces reaches 93% to the cure rate of diabetes.But use the effect of CHAGA extract reduction hyperglycaemia slow merely through clinical observation, need long-term (the 3-6 month) take just and produce effect.In addition, therefore Inonotus obliquus refined powder producing process complexity, cost height cost an arm and a leg.
The root of kudzu vine is the root of Papilionaceae (or claiming pulse family) Pueraria lobota platymiscium.Modern pharmacological research shows that isoflavonoids such as Puerarin, Puerarin xyloside, Genistein, daidzin, daidzein are the effective constituents that mainly contains of the root of kudzu vine, has to promote cardiovascular and cerebrovascular blood flow, reducing blood lipid, different physiological roles such as hypoglycemic.
Genseng belongs to the medicine-food two-purpose product of Ministry of Public Health's approval, has research to think that genseng has corrective action to blood sugar level, plays certain function of health care to the diabetic.But can only play health-care recovery, improve the effect of diabetic's quality of life.And use genseng merely, cost an arm and a leg, the medicine source is also deficient year by year.
The hypoglycemic drink that also useful in the market Chinese medicine is made, but its prescription complexity, much more general more than 3-8 flavor herbal medicine, with its decoct water carry concentrate after, the several times of reinjecting water, can becomes beverage.This class beverage is owing to be that numerical digit herbal medicine mixings decocting extracts, and plurality of active ingredients mixes and is easy to generate chemical reaction and precipitates, and final remaining active ingredient is indeterminate, and its concentration also is difficult to reach or keeps treating necessary concentration.In addition, its mouthfeel as beverage had not both met the beverage production standard, can not satisfy the needs of people's taste.
Summary of the invention:
The objective of the invention is to develop a kind of beverage, when having meal, drink and promptly can play the effect that reduces or stabilize hyperglycaemia with medicine food homologous raw materials.
Contain the CHAGA water extract in the beverage of the present invention.Because CHAGA has slow and stable blood sugar reducing function, can reach purpose of the present invention.
Described CHAGA water extract is meant and adopts water logging bubble CHAGA or decoct extract, (soak: get it and soak supernatant, the residual solid material is soaked in water again, get supernatant.This process concentrates the merging of each time water extract then repeatedly, can control its concentration according to the volume after concentrating, and is that every 125g CHAGA raw material obtains the 1L water extract as embodiments of the invention; Decoct extract; Divide to add an amount of water boiling and extraction three times, then the merging of each time decoction liquor is concentrated, can control its concentration according to the volume after concentrating, described CHAGA water extract proterties is brown clear liquid.
Extraction process is:
(1) CHAGA is soaked in water 2～4, gets supernatant;
(2) the solid dregs of a decoction were soaked in water 3～5 again, get supernatant;
(3) again the solid dregs of a decoction were soaked in water 2～4, get supernatant;
(4) merge above-mentioned three times and soak supernatant, filter, concentrate.
In the above-mentioned beverage that contains the CHAGA water extract, can also add kudzuvine root isoflavone, perhaps add panaxoside, also can add kudzuvine root isoflavone, two kinds of compositions of panaxoside simultaneously.
Described kudzuvine root isoflavone is the commercially available prod, comprises the kudzuvine root isoflavone extract concentrated solution of kudzuvine root isoflavone powder and liquid state etc.;
Described panaxoside also is the commercially available prod, comprises the panaxoside extract from genseng root or leaves and stems, can make powdery, also can be liquid extract etc.
Because kudzuvine root isoflavone has blood sugar reducing function fast and effectively, panaxoside has the effect of adjusting blood sugar level and the effect that substitutes part insulin.
Three kinds of compositions synergy can be brought into play its characteristics separately again simultaneously, makes the effect of beverage more perfect, can stablize and reduces effectively or stabilize blood sugar.
Contained three kinds of functional components in the beverage of the present invention: CHAGA water extract, kudzuvine root isoflavone and panaxoside are the integration of drinking and medicinal herbs material of Ministry of Public Health's approval, their security is very high, and beverage of the present invention aspect the amount of drinking without limits, therefore in the production of beverage, the content range of three kinds of compositions does not have strict restriction yet.That is, in the beverage of the present invention arbitrarily content and ratio to add these three kinds of compositions functional.
However, the inventor finds that when content of functional component is too high, can influence the mouthfeel of beverage, if content is low excessively, hypoglycemic effect is not obvious after a large amount of experiments.Therefore the present invention has found proper content range through repetition test and checking:
Contain CHAGA water extract 5ml～400ml/L in the beverage; Preferred content is 40ml～200ml/L; More preferred content is 60ml～120ml/L.
With content is that 40% kudzuvine root isoflavone is an example, and the content range in beverage is 100mg～1600mg/L; Preferred content is 400mg～1200mg/L.
With total saponin content is that 80% the panaxoside from gen-seng haulms is an example, and the content range in beverage is 25～1000mg/L; Preferred content is 50～400mg/L.
Below be the different proportionings of alternative content of functional component in the various products of beverage of the present invention:
| Prescription | CHAGA water extract (ml/L) | Kudzuvine root isoflavone (mg/L) | Panaxoside (mg/L) |
| 1 | 80 | 800 | 200 |
| 2 | 70 | 600 | 240 |
| 3 | 120 | 1600 | 0 |
| 4 | 40 | 100 | 800 |
| 5 | 400 | 0 | 0 |
| 6 | 100 | 1200 | 50 |
| 7 | 250 | 0 | 1000 |
| 8 | 150 | 600 | 150 |
| 9 | 200 | 400 | 400 |
| 10 | 5 | 1400 | 25 |
More than the purity of three kinds of compositions is in the table: every 125g CHAGA raw material obtains the 1L water extract, and kudzuvine root isoflavone content is 40%, and content of ginsenoside is 80%.The example of enumerating these content is to calculate when preparing for convenience.In fact, the raw material of variable concentrations or content all can be used for preparing beverage of the present invention, if calculate in proportion just can, be not so limited.
Beverage of the present invention can be all kinds that those of ordinary skills know in the prior art, the beverage of various tastes, comprises carbonated beverage and noncarbonic acids beverage.
Aspect the preparation of beverage, except that the technology of industry routines such as the color and luster of noting adjusting beverage, mouthfeel, clarity, the difference of preparing with common beverages is not use sucrose as sweetener, both be adapted to hyperglycaemia or the diabetic takes, also can be used for healthy population.For example, can use albumen sugar, xylitol, Aspartame, A_K sugar sweeteners such as (acesulfame potassiums) to substitute sucrose in the beverage.
The preparation method of beverage of the present invention is on the basis of various traditional beverage preparation, adding above-mentioned three kinds of functional components forms, the preparation method of these conventional beverage, to those skilled in the art, the ripe production method that is conventional, standard and can realizes, and the existing corresponding production standard of country.
Through experiment confirm, beverage of the present invention is drunk continuously and can be made fasting blood-glucose descend 20% in 7 days.If (melbine can descend 38% to take the drug dose that also can suitably reduce the treatment diabetes about 30-40 days continuously; Glibenclamide can descend 27%), perhaps under the condition that does not increase dose, can obtain significantly blood sugar reducing function.Drink beverage of the present invention, critical person of hyperglycaemia or diabetic have also obtained rehabilitation and have assisted a ruler in governing a country treatment when drink essential moisture every day, can also reduce and take side effect and the internal organs injury that the treatment diabetes medicament causes in a large number.
Therefore this functionality of drink composition is a food, and any crowd except that the diabetic all can take, and is especially taking pre/after meal, can prevent hyperglycaemia and diabetes, again can antifatigue, the enhancing immunity of organisms, promote healthy.
CHAGA water extract in the beverage of the present invention, kudzuvine root isoflavone and panaxoside good water solubility, constituent structure is stable, and the beverage product of making is reddish brown, clear and bright, the nothing precipitation.Because of CHAGA water extract free from extraneous odour, add various spices, sweetener, acid after, can produce the nectar of different mouthfeels.Both met the production standard of country, and can satisfy people's taste demand again about beverage.
The specific embodiment:
The preparation of embodiment 1 CHAGA extract
(1) with CHAGA broken or cutting into about 1cm
3Bulk adds pure water in 1 to 8 ratio in container, temperature remains on about 5-20 ℃, and sealing is soaked after 72 hours and got supernatant;
(2) add pure water in 1 to 8 ratio again, temperature remains on about 5-15 ℃, and sealing is soaked after 96 hours and got supernatant.
(3) add pure water in 1 to 5 ratio again, temperature remains on about 5-15 ℃, and sealing is soaked after 72 hours and got supernatant.
(4) 3 supernatants are mixed, 180 eye mesh screens filter; To filter back liquid concentrates with vacuum concentration pot;
(5) per 10 kilograms of CHAGA raw materials are answered 80 liters of concentrates of output (125 gram CHAGAs/liter).Behind the illumination-based disinfection, collect standby.
Embodiment 2 calcareous type hypoglycemic drinks
One, prescription:
Press the CHAGA water extract 400L (every liter of usefulness 125 gram CHAGA raw materials extract) of embodiment 1 method preparation
The two woods prepared slices of Chinese crude drugs Co., Ltds in kudzuvine root isoflavone (content is 40%) 4kg Ningbo produce
Panaxoside (extract from gen-seng haulms, total saponin content is 80%) 1kg Jilin ginseng and pilose antler firm produces
Albumen sugar 5kg saccharin sodium 0.4kg edible phosphoric acid (85%) 2.25L
Citric acid 5kg caramel colorant 4L cola essence 5.5L
Softening pure water 600L
Above-mentioned prescription can about 1000L syrup, in 1: 4 ratio, use filling apparatus pour into again in the syrup 4000L carbonated water common 5000L (500000ml) beverage, but packing 10000 bottles (500 milliliters/bottle) is standby.
Two, the technological process of production:
1. will filter behind albumen sugar, the saccharin sodium Wen Rong;
2. add acid, essence and pigment etc.;
3. will add behind the kudzuvine root isoflavone Wen Rong;
4. will add behind the panaxoside Wen Rong;
5. add CHAGA water extract;
6. all batch mixes are stirred, then illumination-based disinfection.Get supernatant and filtration after leaving standstill;
7. obtain finished product after grouting, filling carbonated water, gland, the check.
Three, reduce the clinical observation of diabetic's fasting blood-glucose
1. experimental subjects:
Recruit the diabetes B patient of voluntary participation test, all meet WHO diagnostic criteria in 1985.Get rid of infection, allergy, high blood pressure, heart failure, tumour and other diseases.Selected 32 examples, male 18 examples, women 14 examples; Age 30-66 is between year, average 58 years old; Diabetic duration 3-10, average 8.5 years; 32 examples are divided into two groups sequentially at random, beverage group 16 examples, control group 16 examples.
2. experimental technique
The beverage instructions of taking: every day the 2-3 bottle, every bottle of 300ml took 7 days continuously.
Detection method: fasting blood-glucose adopts Luo Shi (Hong Kong) blood glucose meter to measure.
Statistical method: significant difference adopts the t check between self and group.
3. clinical observation result: this beverage is taken continuously and can be made fasting blood-glucose descend 20% in 7 days, and expression beverage group self has significant difference before and after taking.Taking beverage group and control group after the beverage more also has the difference of conspicuousness, and concrete data see the following form:
Take the influence to diabetic's fasting blood-glucose after seven days of this beverage
| Group | The example number | Before drinking (mmol/L) | Drink back (mmol/L) | Rate of descent % | The P value |
| Control group | 16 | 8.98 | 9.03 | 0 | |
| The beverage group | 16 | 8.77 | 7.06* | 20 | ＜0.05 |
* compare before and after representing self to take or with control group significant difference is all arranged.
4. conclusion: this beverage can effectively reduce diabetic's fasting blood-glucose.
Four, this beverage reduces the clinical research of treatment diabetes medicament consumption
1. experimental subjects:
Recruit the diabetes B patient of voluntary participation test, all case is a diabetes B by WHO diabetes diagnosis standard diagnostics, gets rid of severe complication (DKA, stupor).The male sex's 35 examples wherein, women's 25 examples.Age 45-69 year, 58.6 years old mean age; Course of disease 2-20, average 8.6 years; Companion's chronic liver injury 7 examples, high fat of blood 12 examples, coronary heart disease 16 examples, cataract 2 examples.All case is divided into 4 groups at random by selected order.
2. experimental technique
The beverage instructions of taking: every day the 2-3 bottle, every bottle of 300ml took 40 days continuously.
Treatment diabetes medicament instructions of taking: according to the clinical treatment principle of medication medication of diabetes, regularly detect blood sugar level voluntarily, according to blood sugar level and other symptoms, decision suitably reduces dosage.
Statistical method: significant difference adopts the t check between self and group.
3. clinical research result:
Took this beverage continuously 40 days, and can obviously reduce the consumption of melbine, slip is 38%, between own control or group positive effect is arranged more all, is 27% and make the rate of descent of glibenclamide, though there is not the significance difference opposite sex, exists tangible downward trend.Concrete data see the following form:
Take the influence to treatment diabetes medicament consumption (mg/ is per day) after 40 days of this beverage continuously:
| Group | The example number | Before drinking | After drinking | Rate of descent % | The P value |
| Melbine+beverage | 15 | 650 | 403.3* | 38 | ＜0.05 |
| Melbine | 15 | 673.33 | 570 | 15 | ＞0.05 |
| Glibenclamide+beverage | 15 | 9.67 | 7.03 | 27 | ＞0.05 |
| Glibenclamide | 15 | 10.17 | 9.37 | 8 | ＞0.05 |
Remarkable type difference is arranged before and after * representing self to take.
Embodiment 3 non-carbonated beverages
Prescription:
CHAGA water extract 350L
Kudzuvine root isoflavone 3kg
Panaxoside 1.2kg
More than three kinds of functional components quality and source with embodiment 2
Softening pure water 650L
Albumen sugar 5kg saccharin sodium 0.4kg edible phosphoric acid (85%) 2.25L
Citric acid 5kg caramel colorant 4L vanillic aldehyde 0.2kg potassium sorbate 0.2kg
Above-mentioned prescription can about 1000L syrup, in 1: 4 ratio, use filling apparatus pour into again in the syrup 4000L soft water common 5000L (5000000ml) beverage, but packing 10000 bottles (500ml/ bottles) is standby.
The technological process of production of this beverage:
1. will filter behind albumen sugar, the saccharin sodium Wen Rong;
2. add acid, essence and pigment etc.;
3. will add behind the kudzuvine root isoflavone thermosol;
4. will add behind the panaxoside thermosol;
5. add CHAGA water extract;
6. all batch mixes are stirred, get supernatant and filtration after leaving standstill;
7. add demineralized water, carry out high-temperature short-time sterilization after the degassing;
8. filling, seal after sterilization again, obtain finished product after the cooling back check.
Claims (5)
1. one kind is reduced and the beverage of prevention hyperglycaemia, its main component and content are: CHAGA water extract 5ml-400ml/L, kudzu root flavone 100mg-1600mg/L and panaxoside 25mg-240mg/L, described CHAGA water extract are that every 125g CHAGA raw material obtains the 1L water extract.
2. the described beverage of claim 1, the CHAGA water extractable content is 40ml～200ml/L.
3. the described beverage of claim 1, the CHAGA water extractable content is 60ml～120ml/L.
4. the described beverage of claim 1, wherein the content of kudzuvine root isoflavone is 400mg～1200mg/L.
5. the arbitrary described beverage of claim 1-4 is soda or noncarbonated beverage products.
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| CN1284487C true CN1284487C (en) | 2006-11-15 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103652157B (en) * | 2013-10-18 | 2016-03-30 | 梅州广通制药有限公司 | A kind of instant molecular health-care tea |
| CN103828987A (en) * | 2014-03-21 | 2014-06-04 | 哈尔滨贝加尔泰生物工程有限公司 | White birch fungus tea beverage and preparing method thereof |
| CN104940220B (en) * | 2015-07-07 | 2019-03-26 | 广州康臣药物研究有限公司 | The pharmaceutical composition and preparation method thereof for preventing and treating diabetic complication |
| CN105124705A (en) * | 2015-10-14 | 2015-12-09 | 延边丹华食品有限责任公司 | Inonotus obliquus beverage |
| CN105685754A (en) * | 2016-01-20 | 2016-06-22 | 哈尔滨瑞烨环保科技有限公司 | Inonotuso bliquus pilat compound solid beverage as well as preparation method and application thereof |
| CN108185245A (en) * | 2017-05-20 | 2018-06-22 | 郑毅男 | A kind of preparation method of ginseng dish's soy drink |
| CN109043276A (en) * | 2018-07-13 | 2018-12-21 | 吉林省长寿堂保健品有限公司 | A kind of inonotus obliquus solid beverage and the preparation method and application thereof |
| CN111110719A (en) * | 2018-11-01 | 2020-05-08 | 韩连慧 | Chinese medicine with functions of reducing blood sugar, blood pressure and weight and discharging uric acid and production method thereof |
| CN109730228A (en) * | 2019-01-07 | 2019-05-10 | 湖北颐玺阁健康管理有限公司 | A kind of hypoglycemic solid beverage and preparation method thereof |
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