CN1281224C

CN1281224C - Cinese medicine increasing leucocyte and preparation thereof

Info

Publication number: CN1281224C
Application number: CN 01127787
Authority: CN
Inventors: 成碧春; 成海荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-08-28
Filing date: 2001-08-28
Publication date: 2006-10-25
Anticipated expiration: 2021-08-28
Also published as: CN1406602A

Abstract

The present invention relates to a traditional Chinese medicine capable of increasing leucocyte and a preparation method thereof. The traditional Chinese medicine is prepared from the components of the following parts by weight: 1 to 5 parts of ginseng, 2 to 6 parts of atractylodes rhizome, 3 to 7 parts of rice vineger and 8 to 12 parts of melanterite. The preparation method comprises: firstly, purifying the ginseng and the atractylodes rhizome, drying and pulverizing the ginseng and the atractylodes rhizome into granules of below 120 meshes; then, mixing the melanterite and the rice vineger, calcining and pulverizing the mixture into granules of below 120 meshes; finally, mixing the granules, and uniformly stirring to obtain the traditional Chinese medicine. The traditional Chinese medicine has the advantages of convenience to take, conspicuous curative effect and no toxic or side effect, and is suitable for treating leukopenia of patients with malignant tumors because of chemotherapy and radiotherapy.

Description

A kind of short leukogenic Chinese medicine and manufacture method

Technical field

This invention belongs to the Chinese medicine class, relates in particular to the leukopenia that treatment causes by radiotherapy, chemotherapy and the Chinese medicine (the white spirit of ginseng) of agranulocytosis) and manufacture method.

Background technology

Radiotherapy, chemotherapy are generally acknowledged by medical circle already as one of main method for the treatment of malignant tumor.But the serious toxic and side effects of bringing after radiotherapy, the chemotherapy, as nausea and vomiting, anorexia, oral cavity and esophageal ulcer etc., make the patient be difficult to stand and adhere to, the leukopenia and the agranulocytosis that cause of particularly radiotherapy, chemotherapy wherein, this serious toxic and side effects, so far still fail to solve, the patient often is forced to end to put, chemotherapy treatment, has therefore influenced curative effect and patient's life span greatly.How to urge to give birth to leukocyte, become a very important problem finishing radiotherapy, chemotherapy regimen for the patient.

The leukopenia that radiotherapy, chemotherapy cause, can cause severe infections, even cause death, to this serious consequence, use CSF (gene recombinaton granulocyte colony-stimulating factor) to impel hemopoietic granulocyte differentiation and proliferation clinically usually, stimulating granulocyte to grow up discharges, the granulocyte of blood prevents severe infections around increasing, and causes the reduction mortality rate to reach, use its curative effect of CSF reliable, but following shortcoming is arranged: 1) to M ³Type leukaemic can not use; 2) certain side effect is arranged, can not use as allergy sufferers; 3) be injection-type in the use, can bring misery to the patient; 4) most scholars think leukemia not the effector should not use promote the growth effect because CSF juvenile white cell to Leukemia Patients equally also has, can cause leukemia relapse or increase the weight of the state of an illness.

Summary of the invention

Purpose of the present invention is exactly in order to address the above problem, and a kind of short leukogenic Chinese medicine and manufacture method are provided.

A kind of short leukogenic Chinese medicine is characterized in that: by weight, made by Radix Ginseng 1-5 part, Rhizoma Atractylodis 2-6 part, rice vinegar 3-7 part, ferrosisuifas crudus 8-12 part.

The manufacture method of above-mentioned Chinese medicine is characterized in that: by proportioning, get Radix Ginseng, Rhizoma Atractylodis earlier, after the purification, dry, be ground into the following granule of 120 orders; Ferrosisuifas crudus is mixed with rice vinegar, after the calcination, be ground into the following granule of 120 orders, mix with aforementioned particles again and mix thoroughly.

Produced according to the method described above Chinese medicine (the white spirit of ginseng) has the recovery of the marrow function of promotion and strengthens hemopoietic function, has the short rapidly leukocytic effect that rises, to better curative effect being arranged because of the concurrent severe infections of leukopenia, heating, also can control rapidly and cure infection, make body temperature recover normal naturally.To because of the bone marrow depression of putting, chemotherapy causes, cause erythrocyte to reduce and thrombocytopenia, the patient who presents serious anemia and bleeding clinically, have curative effect equally, can make erythrocyte, hemoglobin, platelet increase sharply, anemia and bleeding are eliminated, increase the oxygen content of blood, the patient is had rosy cheeks, breathe freely suitablely, muscle power strengthens.

Radiotherapy, chemotherapy take simultaneously Chinese medicine provided by the invention can make put, patients undergoing chemotherapy finishes chemotherapy regimen smoothly, thereby improve curative effect, to Leukemia Patients particularly remarkable because of leukopenia and the agranulocytosis that chemotherapy causes.

Chinese medicine provided by the invention has the effect of human body immunity improving power.

Chinese medicine provided by the invention has no side effect, and is oral capsule in the use, and determined curative effect is reliable, and no pain can replace the use of CSF.

The specific embodiment

By weight, get Radix Ginseng 100 grams, Rhizoma Atractylodis 500 grams, rice vinegar 500 grams, ferrosisuifas crudus 900 grams purify Radix Ginseng, Rhizoma Atractylodis earlier, dry, are ground into the following granule of 120 orders; Again ferrosisuifas crudus is mixed with rice vinegar, after the calcination, be ground into the following granule of 120 orders, mix to mix thoroughly with aforementioned particles then and make.

The above-mentioned Chinese medicine of making is made honeyed pill or tablet or capsule, make every honeyed pill or tablet or capsule contain 525 milligrams in above-mentioned medicated powder, packing gets final product.

The zoopery of doing through Hong Kong Chinese University: give mice feed every day " the white spirit of ginseng " 5mg, after three days, measure the expression character of different mouse spleen cell mRNA (information nucleic acid), found that: the interleukin-11-α of experimental mouse (1L-1 alpha) exceeds four times than matched group, interleukin-11 3 (1L-13) exceeds three times than matched group, and stem cell factor (SCF) exceeds twice than matched group.

The biologic activity of interleukin-11 (1L-1): 1) promote thymocyte cell, T cell activation propagation and differentiation; 2) enhanced CT L (cytotoxic T lymphocyte) and NK's (natural killer cell) is lethal; 3) collaborative 1L-4 stimulates B cell proliferation, the generation of differentiation and immune globulin (1g); 4) collaborative CSF promotes hemopoietic function; 5) stimulate stem cell to produce stem cell factor (S.C.F).

The biologic activity of interleukin-11 3 (1L-13): 1) stimulate B cell proliferation and CD23 to express, induce the B cell produce immunoglobulin (lgM, lgG, lgE); 2) induce large granular lymphocyte (L.G L) to produce interferon r (IFN-r); 3) suppressing monokaryon---the struvite cytokine of macrophage produces.

From above-mentioned zoopery, confirm the effect that " the white spirit of ginseng " has human body immunity improving power really.Put, chemotherapy takes " ginseng white spirit " clinical observation finding simultaneously:

1) can obviously alleviate gastrointestinal reaction, eliminate nausea and vomiting, appetite strengthening makes weight increase, and body constitution strengthens.

2) generation of control oral cavity and esophageal ulcer, the original oral ulcer of patient also can heal rapidly.

3) significantly reduce the incidence rate of alopecia.

Clearly, put, the chemotherapy patients proves in the clinical observation of taking " ginseng white spirit ", because immunocompetence improves, resistance strengthens, and puts, the toxic and side effects of chemotherapy just greatly reduces, and health status is significantly improved, the life quality obviously improves, and helps further putting, the enforcement of chemotherapy regimen.

Claims

1, a kind of short leukogenic Chinese medicine is characterized in that: by weight, by Radix Ginseng 1-5 part, Rhizoma Atractylodis 2-6 part, rice vinegar 3-7 part, ferrosisuifas crudus 8-12 part is made.

2, the manufacture method of Chinese medicine according to claim 1 is characterized in that: by the described proportioning of claim 1, get Radix Ginseng, Rhizoma Atractylodis earlier, after the purification, dry, be ground into the following granule of 120 orders; Ferrosisuifas crudus is mixed with rice vinegar, after the calcination, be ground into the following granule of 120 orders, mix with aforementioned particles again and mix thoroughly.