CN1278715C - Medication for treating diabetes - Google Patents

Abstract

The present invention relates to a medicine for treating diabetes, which is characterized in that the medicine for treating diabetes is orderly and respectively prepared from 10 to 14 shares of bitter melon nut, 10 to 14 shares of lychee seed, 7.5 to 11 shares of mulberry twig, 7.5 to 11 shares of astragalus root, 5 to 9 shares of red sage root, 7.5 to 11 shares of mongolian snakegourd root, 5 to 9 shares of hemlock parsley, 15 to 19 shares of radix notoginseng, 5 to 9 shares of safflower, 5 to 9 shares of epimedium herb and 3 to 6 shares of scorpion by weight range proportion. The medicine of the present invention can be prepared into three preparations, comprising pancreas recovery capsules, pancreas recovery umbilical plaster and blood sugar reducing stype. The medicine of the present invention can make diabetic patients obtain long-term stable goals; insulin resistance is relieved or eliminated; islet functions are protected and repaired; the blood sugar regulating function is gradually recovered; immunity is reinforced; blood circulation is promoted; fat is regulated, and the blood sugar metabolism of the diabetic patients returns to normal. The blood sugar is smoothly controlled, and complications caused by pathologic change are prevented and treated.

Description

A kind of medicine for the treatment of diabetes

Technical field

The present invention relates to a kind of medicine by three kinds of route of administration treatment diabetes.

Background technology

The medicine of treatment diabetes mainly contains oral sulphanylureas, biguanides, α-glycosides enzyme inhibitor or subcutaneous injection insulin at present; The traditional Chinese medical science adopts dialectical Orally-administered decoction of three types of diabetes or Chinese Traditional Medicines (as diabetes pill) more, and effect has a big chunk diabetics not have typical case's " three-many-one-little " symptom slowly and now.To stubbornly high blood sugar or the bigger patient of blood glucose fluctuation, especially be combined the cardiovascular and cerebrovascular complication patient, real no better good medicine.Western medicine is by stimulating pancreas emiocytosis insulin, of a specified duration makes the impaired depletion of β cell; Or by direct supplementation with insulin, not only be difficult to control requirement, also may cause hypoglycemia, and can produce problems such as insulin dependency and secondary failure, cause the diabetes patient not only blood sugar level be difficult to reach for a long time target stably, and progressively cause vascular lesion to cause various complication.

Summary of the invention

The purpose of this invention is to provide a kind of pure Chinese medicinal preparation, can treat diabetes, can overcome the above-mentioned shortcoming of prior art by three kinds of route of administration of for oral administration, external application and pin and medicine.

A kind of medicine for the treatment of diabetes, it is characterized in that containing bitter gourd core, Semen Litchi, Ramulus Mori, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Herba Epimedii, Scorpio, their weight range ratio respectively is 10-14,10-14,7.5-11,7.5-11,5-9,7.5-11,5-9,15-19,5-9,5-9 and 3-6.

The preparation method of the capsule-type medicine of above-mentioned treatment diabetes, it is characterized in that taking by weighing bitter gourd core, Semen Litchi, Ramulus Mori, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Herba Epimedii, Scorpio, extract with decocting earlier and leach precipitation repeatedly, merging filtrate is condensed into cream, this cream is mixed with alcoholic solution, staticly settle after stirring evenly, get supernatant concentration and become precipitate with ethanol cream, add the adjuvant dextrin to the latter and make dried particles, sterilization incapsulates.

The preparation method of above-mentioned treatment diabetes umbilicus subsides type medicine, it is characterized in that taking by weighing earlier Ramulus Mori, Flos Carthami, Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Epimedii, Rhizoma Chuanxiong, Radix Trichosanthis, the water decoction filtering repeatedly, merging filtrate, staticly settle and be condensed into cream, this cream and ethanol are mixed with alcoholic solution, staticly settle after stirring evenly, get supernatant concentration and become precipitate with ethanol cream, take by weighing bitter gourd core more in addition, Semen Litchi, Radix Notoginseng, Scorpio is made fine powder after the oven dry, fine powder and above-mentioned precipitate with ethanol cream are merged, other adds Mentholum, Oleum menthae, Borneolum Syntheticum or Oleum Caryophylli are made equal cream, should be fixed on bone-strengthening musk plaster film central authorities by equal cream.

The preparation method of the stype type medicine of above-mentioned treatment diabetes, it is characterized in that taking by weighing bitter gourd core, Semen Litchi, Ramulus Mori, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Herba Epimedii, Scorpio, extract with decocting earlier and leach precipitation repeatedly, merging filtrate is condensed into cream; This cream is mixed with alcoholic solution, staticly settles after stirring evenly, get supernatant concentration and become cream, chromium system medical catgut is put into this cream soak, take out back room temperature airing in the sterile preparation chamber, will soak medicated line and be cut into the stype line segment, the sterilization vacuum seal is standby.

Medicine of the present invention can make the diabetes patient reach for a long time target stably; alleviate or eliminate insulin resistant; protection and repair islet function, self blood glucose regulation function are progressively recovered, enhance immunity, improving blood circulation and reducing fat, realize that diabetes patient's blood glucose metabolism recovers normal.Blood glucose is steadily controlled, the complication due to the treatment of vascular pathological changes.

The specific embodiment

Medicine of the present invention can be made three kinds of dosage forms, i.e. pancreas recovery capsule, the multiple health umbilicus subsides of pancreas, blood sugar lowering stype.

1. the method for making of pancreas recovery capsule of the present invention: take by weighing bitter gourd core, Semen Litchi, Ramulus Mori, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Herba Epimedii, Scorpio, their weight kilogram number respectively is 12,12,8,8,6,8,7,18,8,8,5, extract with decocting earlier, decocted 2 hours for the first time, leach precipitation, decocted 1 hour for the second time, leach precipitation, merge 2 times filtrate, be condensed into cream, in the time of 70 ℃, the relative density of this cream is 1.28.Ethanol more than 95% is mixed with the alcoholic solution of spirituosity degree 60-70 with cream and purity, staticly settles after stirring evenly, and gets supernatant concentration and becomes cream, adds 5-15 kilogram adjuvant dextrin and makes dried particles, and sterilization incapsulates (enteric solubility) and gets final product.Every capsules explosive payload is 0.3 gram.This capsule can make effective ingredient not by stomach acids destroy, absorbs in intestinal, to keep its activity, improves curative effect.

2. the multiple health umbilicus of pancreas pastes method for making: take by weighing Ramulus Mori, Flos Carthami, Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Epimedii, Rhizoma Chuanxiong, Radix Trichosanthis earlier, their weight kilogram number respectively is 12,12,9,9,5,8,7, water decoction filtering 2 times, 2 hours for the first time, 1 hour for the second time, merging filtrate staticly settled and is condensed into cream, in the time of 70 ℃, the relative density of this cream is 1.28.Ethanol more than 95% is mixed with the alcoholic solution of spirituosity degree 60-70 with cream and purity, staticly settles after stirring evenly, and gets supernatant concentration and becomes precipitate with ethanol cream standby.Take by weighing bitter gourd core, Semen Litchi, Radix Notoginseng, Scorpio again, their weight kilogram number respectively is 17,9,8,5, make 120 order fine powders after the oven dry, fine powder and precipitate with ethanol cream are merged, other adds the Mentholum of 0.05-0.25 kilogram and makes equal cream, become the pill of 1 centimetre of diameter with hand rubbing, be fixed in bone-strengthening musk plaster film central authorities with plastic sheeting.This umbilicus pastes and can make the efficacy of a drug have strong permeability, characteristics such as long action time.Described Mentholum can be used Oleum menthae, Borneolum Syntheticum or Oleum Caryophylli instead and substitute.

3. pancreas is answered health blood sugar lowering stype method for making, get pancreas recovery capsule semi-finished product precipitate with ethanol cream, 0 and No. 1 chromium system medical catgut is put into cream to be soaked 25-35 days, take out back room temperature airing in the sterile preparation chamber, to soak the stype line segment that medicated line is cut into 1.5 centimetres, 2 centimetres, 3 centimetres different length, the sterilization vacuum seal is standby.This stype can slowly absorbed by tissue fully, thereby duration of efficacy be long in subcutaneous long-term heeling-in.The weight of described precipitate with ethanol cream is 2.5-3.5 with the weight ratio of soaking medicated line: 1.

The present invention is according to the dialectical deficiency of both QI and YIN of the Chinese medicine of diabetes, hold concurrently folder blood stasis, the scorching pathogenic characteristic of the deficiency of YIN, with supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, moisturize to promote the production of body fluid and be a cube principle, overcome traditional dialectical limitation of diabetes three types of diabetes, the traditional Chinese medical science disease standard that meets " the clinical research guidelines of new Chinese medicine treatment diabetes (diabetes) ", and, design according to a tree name as we in conjunction with the modern medicine scientific achievement.Bitter gourd core, Semen Litchi, Radix Trichosanthis, the Radix Astragali, Herba Epimedii have effects such as supplementing QI and nourishing YIN, sweet cold beneficial blood, blood enriching and dryness moistening, promoting the production of body fluid to quench thirst in the Chinese medicine of the present invention, from this treatment is monarch drug altogether, blood sugar lowering is promoted the production of body fluid, invigorated blood circulation to Flos Carthami, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Scorpio, meridians dredging, blood stasis dispelling altogether for ministerial drug; Reuse the pseudo-ginseng blood-circulation-invigovating blood stasis dispelling, it is active to promote blood circulation, and the Ramulus Mori nourishing the liver and kidney that nourishes blood is that diabetes are in harmonious proportion key medicine, gets its relaxing muscles and tendons and activating QI and blood in the collateral, week row whole body, with the power of the moving all medicines of boosting, and two medicines are associated with mutually, and treating both the principal and secondary aspects of a disease makes for assistant altogether.Modern pharmacological research shows, contains the plant hypoglycemic polypeptide protein in the bitter gourd core, is similar to the polypeptide (Polypetide-k) of " human insulin " function; Semen Litchi contains blood sugar lowering composition L-a-methylene-cyclopropylglycine (L-a-methyl-enecyclopropyl-glycine).Blood sugar reducing function is respectively in different link target organs and surrounding tissue.Radix Notoginseng contains Radix Notoginseng total arasaponins can bring out the islet cells secretion, promotes the hepatocyte carbohydrate metabolism, and the contained composition of Ramulus Mori can improve the human lymphocyte conversion ratio, has the adjusting immunization, can improve lassitude, thirst with desire to drink, numb limbs and tense tendons, spontaneous perspiration.The present invention cures mainly all types of diabetes, can select dosage form according to the state of an illness.Be particularly suitable for merging complication such as cardiovascular and cerebrovascular vessel, peripheral nerve and take medicine cureless middle and elderly diabetic rehabilitation of patients treatment for a long time.

Because the present invention comes blood sugar lowering by the amount that increases insulin artificially, therefore can not increase the islets of langerhans burden, do not influence the homergy of diabetes patient's body and the absorption of the necessary nutrition of body yet, can not bring any damage and side effect in the time of blood sugar lowering to human body, and treating diabetes in the past is to rely on the powerful β of stimulation of exogenous medicine cell uelralante to come blood sugar lowering, but being difficult to bear for a long time such over loading, islets of langerhans stimulates, the not enough problem of while insulin active also obtains the essence solution, also can increase the weight of Liver and kidney metabolism burden, therefore at present nearly all hypoglycemic medicine all indicates " careful usefulness of hepatic renal dysfunction person or forbidding ".The present invention is by repairing impaired islet cells and a large amount of increment, activate insulin active, improve the quality of insulin, enhancing body and surrounding tissue are adjusted immunity to the utilization rate of glucose, improving blood circulation and reducing fat, anticoagulant and thrombolytic, blood circulation promoting recovers the function equilibrium of pathological state, and comprehensive adjustment is steadily controlled the diabetes blood glucose, effect is lasting, the generation of control and elimination complication.

The present invention is with effective components of Chinese medicinal, be formulated as the anti-gastric acid of coating dosage form for oral administration, putty-type and non-specific high density stype, effect in conjunction with the sleeve pipe puncture needle, become the medicine of three kinds of route of administration treatment diabetes of for oral administration, external application, pin and medicine by single treatment means, select to use according to the different state of an illness.Sleeve pipe puncture needle provided by the invention both had been a needling action, again as implanting the medical apparatus and instruments of medicine, non-specific high density stype is brought multiple pharmaceutical compositions effect into as carrier, the Accommodation of stimulation of performance persistency and medicine, the direct therapeutical effect of physical chemistry with acupuncture mechanicalness and medicine fully excites inherent regulative mechanism in the body.In the other visceral nerve treatment of specific vertebra line (spinous process is other opens 1.0-1.5 cun, its deep layer distributing the other sympathetic ganglion of vertebra) reconnaissance, sp 6 point of care on course of disease elder's adapted crural fascia district inner edge.If the earlier whole ridge of spinous process lateral deviation is arranged.The therapentic part routine disinfection, the Pu Dong of sterile working towel.No. 12 sleeve pipe puncture needles getting the sterilization of getting ready withdraw from the part nook closing member, and the stype of getting ready is put into needle tubing, at point of care diagonal quick needle insertion, reach muscular fasciae lower floor after, the inserting needle certain depth.Use certain maneuver (light, in, strong stimulation), when the patient acid, fiber crops are arranged, when expanding sense, the limit advances the stype limit to move back puncture needle with nook closing member, and stype is sent into point of care muscular fasciae lower floor, and stype is leaked outside, and goes out the pinprick of sterilizing behind the pin, pastes adhesive bandage.By the absent-mindedness of sleeve pipe puncture needle, stay and plant stype adjustment internal organs vegetative nerve function, treatment in 30 days is once at interval.3 times is a course of treatment.No pain, have no side effect.

Putty-type blood sugar lowering umbilicus provided by the invention pastes characteristics such as having infiltration is strong, long action time.By umbilical part (SHENJUE acupoint) administration, enter blood circulation through second rich beniol of umbilicus.Without gastrointestinal absorption, directly changed one in the every 2-3 of administration days and paste, convenient, safety, curative effect is reliable, stimulation damage and the side effect of having avoided chemical sugar-lowering that patient is brought effectively.

The clinical data observation of curative effect of the medicine of three kinds of route of administration treatment diabetes of the present invention

Method: the 42 routine patients that receive treatment all meet the diagnostic criteria of WHO type ii diabetes in 1985.The amount of patient's total calorie card every day and carbohydrate remains unchanged, and the activity of every day remains unchanged substantially, without the lipid lowerers anticoagulant.Dropping into medicine is 5 of pancreas recovery capsule dosage of the present invention, and PO, tid 0.5h before the meal take.The blood sugar lowering umbilicus pastes and changes 2-3 time weekly, and be 30 days a course of treatment, and stype is implanted per 30 days 1 time.Carry out related check around the course of treatment.

Criterion of therapeutical effect, fasting glucose (FBG), 2h blood glucose (2hBG after the meal), glycolated hemoglobin (GHB) reduction＞30% after the meal are produce effects; Reducing 10-30% is effectively, and it is invalid reducing＜10%.It is produce effects that T-CHOL (TC) reduces＞20%; Reducing 10-19% is effectively, does not reach effective standard person for invalid.It is produce effects that triglyceride (TG) reduces＞40%, and reducing 20-39% is effectively, does not reach effective standard person for invalid.HDL-C (HDL-C) rising＞20% is a produce effects, and rising 10-19% is effectively, and rising＜10% is invalid, and hemorheology index compares before and after the treatment, sees Table 1,2,3 in detail respectively.All patients that receive treatment all do not find toxic and side effects.

Table 1 treatment back FBG, after the meal 2hBG and Blood Lipid (X ± S, n=42)

Project	Before the treatment	After the treatment
			FBG (mmol/L) is 2hBG (mmol/L) GHB (%) TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) after the meal	8.78±3.90 14.34±3.90 6.20±1.70 5.29±0.89 2.12±0.19 1.01±0.04	5.26±3.50 9.96±4.30 5.70±1.40 4.92±0.82 1.82±0.93 1.06±0.07

Annotate: paired t-test: P＜0.01

Table 2 treatment back Clinical Laboratory efficacy evaluation (n=42)

Project	Produce effects	Effectively	Invalid	Effectively total	Effective percentage
						FBG is 2hBG GHB TC TG HDL-C after the meal	27 17 14 16 19 12	12 18 19 18 18 17	3 7 9 8 5 13	39 35 33 34 37 29	92.85 83.33 78.57 80.95 88.09 69.04

The clinical efficacy evaluation shows: the medicine of this treatment diabetes has remarkable blood sugar lowering and lipid-lowering effect.Patient's hypoglycemic effect of wherein carrying out second course of therapy obviously improves, and remains further to be observed.

Hemorheology index comparison before and after table 3 treatment (X ± S, n=42)

Project	Before the treatment	After the treatment
			Height is cut the low Fibrinogen of cutting of plasma viscosity packed cell volume	5.39±1.52 1.68±0.24 32.62±15.23 8.89±2.10 3.38±0.81	4.82±1.50** 1.56±0.25** 27.71±15.23* 8.21±2.27* 2.99±0.87**

Through paired t-test: * P＜0.05 * * P＜0.01 shows that this medicine has the obvious treatment effect unusually to hemorheology.

Model case

Lee, the man, 50 years old, cadre .1996 was diagnosed as type ii diabetes April, took multiple Chinese medicine and western medicine hypoglycemic medicine, and is bad during state of an illness fashion, and disease sees that the dim eyesight order is dark, purple dark, the white and thin fur of words, hesitant pulse hemiplegia.Chemical examination fasting glucose 16.2mmol/L, glucose in urine is qualitative ++ ++, glycolated hemoglobin 6.6%, TC6.24mmol/L, TG2.18mmol/L, HDL-C 1.01mmol/L.Give 5 of pancreas recovery capsules, 3 times on the oral 1st, the blood sugar lowering umbilicus pastes and changes 2-3 time weekly, the other visceral nerve treatment of vertebra line is implanted stype (30 days 1 time at interval), look into fasting glucose 7.6mmol/L after one course of treatment, glucose in urine+, continue this triple therapy after second course of treatment, transference cure is looked into fasting glucose 5.8mmol/L, glucose in urine (-), GHB5.6%, TC4.81mmol/L, TG1.79mmol/L, HDL-C 1.07mmol/L.For consolidating curative effect, interruption is taken medicine, and uses pancreas and gets the subsides of health umbilicus, regularly buries medicine, follows up a case by regular visits to half a year, stable disease, and glycemic control is good.

Grandson, woman, 72 years old, peasant.Diabetic history 8 years, because of eating and drinking without temperance, protracted course of disease, fatigue and asthenia when examining, become thin, the excessive thirst polydipsia, look into fasting glucose 10.6mmol/L, glucose in urine +++, give pancreas and get continuous 1 month of health umbilicus subsides external, the other visceral nerve treatment of vertebra line blood sugar lowering stype is implanted, 3 treatment back blood glucose 6.0mmol/L, glucose in urine (-) is followed up a case by regular visits to and was not had recurrence in 1 year.

Claims (2)

1 one kinds of medicines for the treatment of diabetes, it is characterized in that it is made up of effective ingredient and adjuvant, make that described raw materials of effective components is formed and weight ratio is bitter gourd core 10-14, Semen Litchi 10-14, Ramulus Mori 7.5-11, Radix Astragali 7.5-11, Radix Salviae Miltiorrhizae 5-9, Radix Trichosanthis 7.5-11, Rhizoma Chuanxiong 5-9, Radix Notoginseng 15-19, Flos Carthami 5-9, Herba Epimedii 5-9 and Scorpio 3-6.

The preparation method of the medicine of the described treatment diabetes of 2 claim 1 is characterized in that taking by weighing bitter gourd core, Semen Litchi, Ramulus Mori, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Herba Epimedii, Scorpio by the described weight ratio of claim 1; These 11 kinds of Chinese medicines are extracted twice with decocting, leach precipitation respectively; Merging filtrate is condensed into cream.