CN1275617C - Externally applied agent for relieving inflammation and antibiosis - Google Patents
Externally applied agent for relieving inflammation and antibiosis Download PDFInfo
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- CN1275617C CN1275617C CN 03117233 CN03117233A CN1275617C CN 1275617 C CN1275617 C CN 1275617C CN 03117233 CN03117233 CN 03117233 CN 03117233 A CN03117233 A CN 03117233A CN 1275617 C CN1275617 C CN 1275617C
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Abstract
The present invention provides an externally applied agent for inflammation diminishing and antibiosis, which is characterized in that the present invention is prepared from raw materials of the following weight proportion: 140 to 200 portions of giant knotweed rhizome, 0.8 to 10 portions of alum, 32 to 40 portions of gypsum and ethanol. The present invention not only can be used for antisepsis and antivirus, but also can be used for corrosion prevention and the promotion of tissue regeneration. The present invention has strong stypticity, quickly and effectively inhibits the inflammatory edema exudation of affected parts, prevents the necrosis progrediens of wound surfaces, and promotes the scab and the healing of injury parts in a short time. The present invention can also be used for effectively treating gynecology inflammation, reduces and eliminates the sore yang disease of skin mucosa, and ' fire toxin ', ' wind evil ' and 'water dampness' caused by the infection of burn and scald wound surfaces, balances ' yin and yang', and regulates ' five phases ' to achieve the aims of the regeneration and repairing of the tissues, so that patients' pain, disability and death are reduced, and patients' economic burdens are lightened.
Description
Technical field
The present invention relates to a kind of medicine for external use, the especially a kind of antiphlogistic antibacterial medicine for external use that can treat burn.
Background technology
Up to now, treatment burn, mucocutaneous skin infection YANG syndrome, traumatic surface infect, except that take or injection of antibiotics, topical agent adopts cream or ointment wrapping more, also electricity consumption is roasting to large-area burn.Though the one side that these conventional methods have its section to emulate the advanced, but from clinical practice, find to still have the deficiency of the following aspects: the one, wound surface uses ointment, cream class medicine, though can preserve moisture, be unfavorable for the dry incrustation of wound surface, easily cause the remaining skin histology necrosis of infective wound surface and the prolongation course of disease.The 2nd, the roasting wound surface of electricity can only take stopgap measures, though can temporarily solve the drying incrustation of wound surface, but very easily produce necrosis progrediens (being to infect under the crust) under the crust, can not suppress inflammatory body fluid owing to electricity is roasting oozes out, more can not erosion prevention and muscle growing, the artificial natural cover for defense is built in the infection that easily be bacterial growth, particularly bacillus pyocyaneus, in making, the patient of severe injury unnecessary permanent disability or dead occurs because of septicemia or dense toxemia etc.The 3rd, the wrapping meeting of changing dressings brings misery to patient, even can cause artificial damage wound surface, can increase the consumption of hygienic material (gauze, absorbent cotton, adhesive plaster) simultaneously.If above-mentioned injured wound surface can not get treating timely and effectively, the wound surface that has perhaps infected can not get control, remaining skin histology will be corroded and even expand as III degree wound surface, can only rely on this moment and cut crust and make skin graft and eliminate wound surface, and this method is except that bringing to the patient secondary damage and the misery, also can produce cicatrix, and the course of disease is long, increases patient's financial burden.Besides in clinical common gynecologic inflammation, as illness such as the pudendal pruritus due to gonococcus property, colpitis mycotica, the cervicitis etc., fulminant leucorrhagia with yellowish discharge, leucorrhoea grow in quantity, though it is a lot of to treat the Pharmaceuticals of this type of disease, single medicinal material is many, but curative effect difference is different, and Fa Zuo phenomenon is outstanding repeatedly.
At present, can be used for the treatment of inflammation of woman genetic system, can be used for the treatment of simultaneously water again, burn and scald, mucocutaneous skin infection YANG syndrome, traumatic surface infect, particularly infection effectively, the inflammatory body fluid that suppresses the injury quickly and effectively oozes out, prevent the wound surface necrosis progrediens, make injured wound surface incrustation healing in a short time, simultaneously again can antiviral formal medicine actually rare.
Summary of the invention
The object of the present invention is to provide and a kind ofly can treat burn, scald, can treat the antiphlogistic antibacterial medicine for external use of gynecological, oral ulcer simultaneously again.
Antiphlogistic antibacterial medicine for external use provided by the invention is made by the raw material of following weight portion:
Rhizoma Polygoni Cuspidati 140-200 part,
Alumen 0.8-10 part,
Gypsum Fibrosum 32-40 part,
Surplus is an ethanol.
Described ethanol is that concentration reaches 55% medical ethanol.
Wherein, main with Rhizoma Polygoni Cuspidati (Polygonum Cuspidatum Sieb.et Zucc), its bitter in the mouth, sweet, put down, be slightly cold, can dispel the wind, dampness removing, removing blood stasis with potent drugs, collateral dredging, astringing to arrest bleeding, degraded pyretic toxicity, promoting blood circulation and stopping pain, main stranguria with turbid discharge leukorrhagia, five types of stranguria nebulousurine, carbuncle furuncle and phyma poison, malignant boil tinea disease, eczema rots lower limb, gynecological inflammation, lochiostasis, dark and damp malignant boil, amenorrhea, water, burning hot wound etc., can dispel the ailment said due to cold or exposure of crossing Sheng in the body, calm down the fire-toxin of Sheng, reach the effect of diuretic evacuation of pus, toxin expelling, parasite killing.Assistant is with nature and flavor suffering, sweet, cold Gypsum Fibrosum (Cypsum), with expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, and Gypsum Fibrosum master high fever does not move back, hyperactivity of toxic heat, can treat ulcer sores, aphtha of the mouth and tongue, water, burn, the incised wound feverish skin is burst and not to be closed up etc., can also assist Rhizoma Polygoni Cuspidati heat-clearing and toxic substances removing, parasite killing convergence, reach the effect of erosion prevention and muscle growing.Be aided with acid, puckery and cold Alumen (Alunite) again, being used to suppress edema oozes out, the stream Huang drops down mashed, it is wet to receive its unnecessary water, make that " water " stays and not general in the body, injured skin is done and is not split, profit and being stale-proof, remove the rotten and let fresh grow, can strengthen the merit of Rhizoma Polygoni Cuspidati, Gypsum Fibrosum parasite killing, toxin expelling, evacuation of pus, detumescence, dispeiling pathogenic wind and removing dampness.Three medicines share, and can let out the gas of burning hot poison heresy clearly, with solid body water blood, are used for correcting " negative and positive " imbalance by medicine direct, and it is normal to reach " five elements ", subsidizes operation and amounts to and deposit, the therapeutic purposes that the phase JIDE is pacified.To treatment men and women inflammation of reproductive system, having one's hair waved, burn, mucocutaneous skin infection YANG syndrome, traumatic surface infection etc. has definite curative effect.
Medicine for external use provided by the invention is made by following existing method: raw material fragmentation → 55% soak with ethanol → extraction → filtration → sterilization → packing.
The present invention has following advantage and effect: can be antibiotic by the medicine for external use that above-mentioned prescription is made, antiviral, again can erosion prevention and muscle growing, and astriction is strong, can effectively suppress the affected part inflammatory edema rapidly oozes out, stop the wound surface necrosis progrediens, using the soak exposure method replaces electric roasting, the bandaging strapping of changing dressings, promote the injury healing of forming a scab in a short time, gynecological inflammation is obtained the effective treatment, and can also reduce and eliminate mucocutaneous skin infection YANG syndrome, " fire-toxin " due to empyrosis wound surface infects, " ailment said due to cold or exposure " reaches " water is wet ", balance " negative and positive ", live in peace with each other " five elements ", reach the purpose of tissue regeneration and reparation, reduce patient's misery with this, wounded or disabled, death and financial burden.
The present invention has carried out clinical observation to 100 routine burn and scald patients, and its result is reported as follows:
One, diagnostic criteria and method
By " new drug approval regulation compilation " 509-510 page or leaf, three degree level Four classification method in surgery of Chinese medicine disease (burn due to hot liquid or fire) the diagnosis criterion of therapeutical effect, record burn and scald degree and percentage ratio.Press the modified rule of Nine record burn and scald gross area.
Two, efficacy evaluation
1, recovery from illness:
1.1, shallow two the degree wound surface heal fully.
1.2, dark two degree wound surface heal substantially, residual wound is only as changing dressings processing.
1.3,3-degree wound heals substantially, residual wound need not made skin graft.
2, take a turn for the better:
2.1, the healing fully of two degree wound surface, but do not have General Symptoms.
2.2, the most of healing of 3-degree wound, the residual wound skin-grafting of still needing.
3, invalid:
3.1, General Symptoms do not improve, traumatic infection can not be controlled.
Three, clinical trial data
(1), physical data: 100 examples are organized in treatment, maximum 65 years old age, minimum 5 years old, 38.5 years old mean age; Male's 62 examples wherein, women's 38 examples; Flame burn (ethanol, gasoline, kerosene, other burn) 61 examples: scald (boiling water, pitch, vegetable oil, vaseline, steam etc.) 39 examples.Matched group 30 examples, maximum 61 years old age, 9 years old minimum age, 32.6 years old mean age: male's 21 examples wherein, women's 9 examples; Flame burn patient 13 examples, scalded patient's 17 examples.Two groups of burn and scald degree of depth see Table 1.
(2), Therapeutic Method:
1, treatment group:
1.1, the burn and scald area hinders the patient at the shallow II degree below 10%, only does debridement, exposes wound surface,
1.2, put the present invention on the skin outward, need not any antibiotic.
1.3, the burn and scald area is 30% following person (comprising dark II degree patient), with use debridement, exposure method is directly treated with this medicine, need not any antibiotic for the patient who does not have shock.Slight shock patients is arranged, when doing above-mentioned treatment, give shock and handle, quiet crystalloid fluid, colloidal solution and other Energy mixture are to replenish body fluid or energy, in order to rehabilitation.This class patient looks individual variation, does the treatment of suiting the medicine to the illness.
1.4, the burn and scald area is 31% above person, when treating, replenish body fluid and add antibiotic and Energy mixture etc. with the present invention.Such patient very easily infects, so with antibiotics medicine partner treatment, the patient is shortened the course of treatment.
1.5; debridement method: use earlier hydrogen peroxide; the thorough debridement of normal saline; the dead bark of broken wrinkle is thoroughly removed; Po vesicle not; needle vesicle in the top of protruding with syringe needle or shears behind the cleaning and sterilizing; be degree in order to flowing to end transudate; the reuse normal saline cleans one time, blots wound surface liquid with absorbent cotton, keeps dead bark; on dead bark, put " the three Yang Pi Dai Nationality " on the skin; stir dead bark gently while put on the skin; allow the dead bark duct of medicinal liquid through needling flow to wound surface, after the debridement, medicine-feeding in every 10-15 minute once; change into after continuous 1 hour and adding medicine to 4-6 time every day; do not wrap up, utilize dead bark to make wound surface " protecting film ", use until wound surface ooze out stop till.
2, matched group:
2.1, shallow II degree burn and scald area is 10% following person, after the debridement, exposes wound surface external " rehabilitation is new " (production of Kunming rehabilitation pharmaceutical factory) and puts on the skin in wound face, need not any antibiotic.
2.2, the burn and scald area is 30% following person (comprising dark II degree patient), for shock person's not wound face with the treatment of (2.1) method; Slight shock person is arranged, replenish body fluid, Energy mixture and shock treatment, in order to fast track rehabilitation.
2.3, because of matched group does not have the burn and scald area 31% above person (severe patient), so slightly.
Two groups of observed results see Table 2, table 3.
Four, discussion and brief summary
The present invention shows through clinical observation result, it has antiphlogistic antibacterial and astriction preferably, the energy heat-clearing and toxic substances removing, the pathogenic fire reducing detumescence, fixing of soil and conservation of water, the inhibition of sintering scald wound evacuation of pus of oozing out, invigorate blood circulation at short notice reduces purulent secretion, promote regeneration and restoration, the course of treatment is shorter than other conventional therapies.The Total Test case is in process of the test, and the total white blood cells that 9 routine burn and scald patients are arranged is at 10000/mm
3More than, neutrality rises to more than the 65-70%, descends gradually after the week, do not find hepatic and renal function injure, do not find the toxicity phenomenon, do not find yet medicine to mucocutaneous have stimulate and the anaphylaxis phenomenon, be to treat comparatively ideal preparation in the empyrosis medicine for external use at present.
The present invention treats female reproductive system inflammation 69 routine clinical observation result:
One, diagnostic criteria
1, tcm diagnosis standard: " TCM Gynecology " four editions, five editions teaching materials of the national traditional Chinese medical science of reference universities and colleges unified editing.Clinical being divided into " pudendal pruritus, leukorrhagia, dysmenorrhea, mass in the abdomen " etc.
2, Western medicine diagnose standard
2.1, symptom: pruritus vulvae, causalgia or with irritations such as urgent micturition, dysurea, Niao Frequency.
2.2, gynecologial examination: secretions is unusual, and trichomonal vaginitis secretions is yellow cystose; Colpitis mycotica secretions is the bean dregs sample; Senile vaginitis secretions is that pus sample or yellow fluid sample or vaginal mucosa have the petechia.
2.3, laboratory examination: trichomonal vaginitis, microscopically can find infusorian in vaginal secretions; Can find mycete in the colpitis mycotica secretions.
3, test case standard
3.1, include the case standard in: meet pudendal pruritus, leukorrhagia, dysmenorrhea, causalgia, with urgent micturition, dysurea, Niao Frequency, mass in the abdomen; The unusual person of gynecologial examination secretions can include the test case in.
3.2, get rid of case
3.2.1, person more than 70 years old
3.2.2, menstrual phase, pregnancy women.
3.2.3, medication in accordance with regulations, can't judge curative effect or data not umbra ring the observation of curative effect person.4、
4, standards of grading
4.1, found infusorian 10 minutes in the leucorrhea
4.2, found syphilis 10 minutes in the leucorrhea
4.3, the postmenopausal women suffered from vaginitis 10 minutes
4.4, pruritus vulvae, causalgia 5 minutes
4.5, leucorrhoea grow in quantity 2 minutes
4.6, vaginal mucosa had the petechia 1 minute
4.7, sexual anhedonia 1 minute
4.8, Niao Frequency urgent micturition dysurea 1 minute
5, calibration
Severe: accumulative total is divided at the 16-20 branch
Moderate: accumulative total is divided at the 11-15 branch
Slightly: accumulative total is divided at the 5-10 branch
6, curative effect determinate standard
Recovery from illness: laboratory examination is normal, and the vagina itching of vulva disappears bitterly, and secretions transfers to normally, and scoring is 0.Three months menstruation cycles of drug withdrawal do not have recurrence, and every inspection is normal.
Produce effects: laboratory examination is normal, and vagina itching of vulva pain obviously alleviates, and treatment back integration reduces below 2/3 than before treating.
Take a turn for the better: laboratory examination is normal, and other symptom exists, or other sx and laboratory check unusually, and treatment back integration reduces below 1/3 before than treatment.
Invalid: inspection of treatment back and symptom are with before treating.
7, observational technique
7.1, adopt random method to carry out, observe 69 examples altogether.
7.2, administrated method and consumption
7.2.1, solution 10ml of the present invention, medicinal liquid is pushed vagina, raise buttocks and kept every day 2 times 15 minutes.
7.2.2, the course of treatment: 10 days
8, matched group
Matched group 30 examples are treated with JIEERYIN (production of Chengdu En Wei group).
9, statistical method:
Total effective rate (%)=cure rate (%)+produce effects and improvement rate (%)
Two, Therapeutic Method
Liniment of the present invention got abandon former bottle cap, it is tight that other gets standby intubate lid, slowly inserts intravaginal, pushes medicine liquid washing, every day 2 times, logotype 1-2 course of treatment.
Three, therapeutic outcome sees Table 4
Four. discuss
The present invention's liniment has heat-clearing and toxic substances removing, parasite killing, itching-relieving action preferably to female genital disease.Comparatively satisfied to pudendal pruritus, pain, leucorrhoea grow in quantity curative effect due to mycete, the infusorian especially.69 routine vagina inflammation are cured 19 examples, produce effects 25 examples, 11 examples that take a turn for the better, invalid 14 examples, total effective rate 79.71%.14 invalid examples are to fail medication in accordance with regulations or use other medicine midway without authorization instead.Matched group 30 examples are cured 6 examples, produce effects 9 examples, 4 examples that take a turn for the better, invalid 11 examples, 63.33%, two group of total effective rate relatively there were significant differences P＜0.05.
The present invention carries out clinical observation to trauma infection contamination 53 examples, periodontitis and oral ulcer 39 examples, and its result is as follows:
One, diagnostic criteria
By " new drug approval regulation compilation " 509-510 page or leaf, surgery of Chinese medicine disease diagnosis criterion of therapeutical effect is carried out.Because of trauma infection contamination and periodontitis, oral ulcer temporarily non-selected to the similar Chinese medicine of better curative effect is arranged, so do not establish matched group.
Two, Therapeutic Method
(1), wound (epidermis contusion) infects, wound surface is done conventional debridement after, soak the sterile gauze soak with the present invention, it is moist keeping the wound surface gauze, stays the medicine yarn to expose wound surface after 8 hours, but also soak wrapping needn't be used antibiotic.Every day such as method are used, and logotype wound surface on the three is promptly formed a scab.
(2), periodontitis, oral ulcer, dip in medicinal liquid of the present invention with absorbent cotton and spread on the affected part, each 10ml, each 10-15 minute, every day 2-3 time, logotype got final product (course of treatment) on the 5th.
Three, therapeutic outcome see Table 5, table 6
Four, discussion and brief summary
Show through clinical observation result, this medical instrument has good antiphlogistic antibacterial and astriction, its main feature is that heat-clearing and toxic substances removing, reducing swelling and alleviating pain, inhibition traumatic surface ooze out, effectively prevent the wound surface necrosis progrediens, can about 24 hours, stop to ooze out by wound surface after the Most patients medication, edema begins to disappear, the healing of can forming a scab in 4-5 days.
Periodontitis, the general medication of oral ulcer patient (rinsing the mouth) 4-6 time (2 days) healing of can subsiding a swelling gradually, and do not find toxic and side effects.
The present invention treats 53 examples, trauma infection contamination periodontitis and oral ulcer 39 examples, and trauma infection contamination was cured maximum duration 9 days, and is the shortest 7 days; Oral ulcer is cured the longest 7 days, the shortest 5 days, total effective rate difference 96.22% and 94.87%.
The specific embodiment
Embodiment 1
1, following proportion raw material is carried out fragmentation:
Rhizoma Polygoni Cuspidati 140 grams,
Alumen 0.8 gram,
Gypsum Fibrosum 32 grams;
2, in above-mentioned raw materials, add 55% medical ethanol 1000ml, soaked 3-5 hour, after the extraction soak, filter, sterilize, pack, promptly get externally-applied liniment.
Every 1ml liniment total solids content is not less than 0.8-1.2%, and relative density of medicine liquid is not less than 0.8523-0.9923, and emodin is not less than 0.05mg.
Embodiment 2
1, following proportion raw material is carried out fragmentation:
Rhizoma Polygoni Cuspidati 200 grams,
Alumen 8 grams,
Gypsum Fibrosum 40 grams;
2, in above-mentioned raw materials, add 55% medical ethanol 1000ml, soaked 3-5 hour, after the extraction soak, filter, sterilize, pack, promptly get externally-applied liniment.
Embodiment 3
1, following proportion raw material is carried out fragmentation:
Rhizoma Polygoni Cuspidati 170 grams,
Alumen 5 grams,
Gypsum Fibrosum 36 grams;
2, in above-mentioned raw materials, add 55% medical ethanol 1000ml, soaked 3-5 hour, after the extraction soak, filter, sterilize, pack, promptly get externally-applied liniment.
Table 1. empyrosis wound surface degree of depth branch
| Group | The I degree is to shallow II degree (%) | Dark II degree (%) | III degree (%) | Add up to |
| Treatment group matched group | 55 examples (55) 19 examples (63.33) | 36 examples (36) 11 examples (36.67) | 9 examples (9) | 100 examples, 30 examples |
Table 3. three Yang Pi Dai Nationality therapeutic outcomes
| Group | Cure (%) | Take a turn for the better (%) | Invalid (%) | Cure vast of heaven number | Cure the shortest natural law | Average curative day | Total obvious effective rate |
| Treatment group matched group | 87 (87) 14 (46.66) | 3 (3) 9 (30) | 10 (10) 7 (23.33) | 11 59 | 4 14 | 8.16 18.94 | 90** 76.66** |
Table 2. liang group is red and swollen, ooze out recoverys, the comparison of inflammation infection regression time
| Sings and symptoms | Three Yang Pi Dai Nationality treatment groups | Matched group | ||
| Alleviate the time | Extinction time | Alleviate the time | Extinction time | |
| Red and swollen wound surface oozes out infection | 2-3 days 30-40 minute 48 hours | 3-4 days 1-2 hour 3-4 days | 5-6 days above 6-8 days weeks | 7-8 days 10 days left and right sides 18-22 days |
Table 4
| The treatment group | The example number | Symptom before the treatment | Treatment back symptom |
| 69 examples | Have all that in various degree pudendal pruritus, menstruation are leading, dysmenorrhea, frequent micturition, urgent micturition, secretions increase, (leucorrhea or fulminant leucorrhagia with yellowish discharge) flavor is smelly, finds mycete, infusorian in the leucorrhea.21 examples have the causalgia sense. | 1, recovery from illness 19 examples, laboratory examination is normal, vagina, itching of vulva disappear bitterly, secretions transfers to normally, stop not seeing recurrence in back three months, every inspection is normal.Account for 27.54%.2, produce effects 25 examples, laboratory examination is normal, and vagina, itching of vulva pain obviously alleviate.Account for 36.23%.3, improvement 11 examples, there are 9 routine laboratory examinations normal, and other symptom slightly exists, have 6 routine laboratory examinations unusual, other symptom takes a turn for the better before the treatment.Account for 15.94%.4, invalid 14 examples, symptom does not have significant change.Account for 20.28%. | |
| Matched group | 30 examples | Ditto | 1, cures 6 examples.Account for 20%.2, produce effects 9 examples.Account for 30%.3, improvement 4 examples.Account for 13.33%.4, invalid 11 examples.Account for 36.66%. |
Table 5
| The treatment group | The example number | Cure (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| 53 examples | 26(49.05) | 21(39.62) | 4(7.54) | 2(3.77) | 51(96.22) |
Table 6
| The treatment group | The example number | Cure (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| 39 examples | 21(53.85) | 8(20.51) | 8(20.51) | 2(5.13) | 37(94.87) |
Claims (2)
1, a kind of antiphlogistic antibacterial medicine for external use is characterized in that it is soaked in 1000ml ethanol by following materials of weight proportions to form:
Rhizoma Polygoni Cuspidati 140-200 gram
Alumen 0.8-10 gram
Gypsum Fibrosum 32-40 gram.
2, antiphlogistic antibacterial medicine for external use according to claim 1 is characterized in that described ethanol is that concentration reaches 55% medical ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117233 CN1275617C (en) | 2003-01-23 | 2003-01-23 | Externally applied agent for relieving inflammation and antibiosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117233 CN1275617C (en) | 2003-01-23 | 2003-01-23 | Externally applied agent for relieving inflammation and antibiosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1519008A CN1519008A (en) | 2004-08-11 |
| CN1275617C true CN1275617C (en) | 2006-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03117233 Expired - Lifetime CN1275617C (en) | 2003-01-23 | 2003-01-23 | Externally applied agent for relieving inflammation and antibiosis |
Country Status (1)
| Country | Link |
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| CN (1) | CN1275617C (en) |
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2003
- 2003-01-23 CN CN 03117233 patent/CN1275617C/en not_active Expired - Lifetime
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Address after: 675000 Lucheng South Road, Yunnan, No. 384, No. Patentee after: YUNNAN LONGFAR PHARMACEUTICAL CO.,LTD. Address before: 675000 Lucheng South Road, Yunnan, No. 384, No. Patentee before: Yunnan Longfa Pharmaceutical Co.,Ltd. |
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Granted publication date: 20060920 |