CN1265795C - Serial compound iron/calcium nutritious element tonic and preparation method thereof - Google Patents
Serial compound iron/calcium nutritious element tonic and preparation method thereof Download PDFInfo
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- CN1265795C CN1265795C CN 200410011113 CN200410011113A CN1265795C CN 1265795 C CN1265795 C CN 1265795C CN 200410011113 CN200410011113 CN 200410011113 CN 200410011113 A CN200410011113 A CN 200410011113A CN 1265795 C CN1265795 C CN 1265795C
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- salicylic acid
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- calcium hydroxide
- ferrous carbonate
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Abstract
The present invention belongs to a serial compound iron/calcium nutritious element tonic and a preparation method thereof. The preparation method of the serial compound iron/calcium nutritious element tonic comprises the following steps: ferrous carbonate, calcium hydroxide and salicylic acid are calculated and accurately weighed according to the quantity of the nutritious element tonic to be prepared and the chemical constitution of Fe<x>Ca<1-x>L2; the ferrous carbonate and the calcium hydroxide are mixed and added with water to prepare suspension liquid; the weighed salicylic acid is added with water, and the weighed salicylic acid is also heated and stirred so as to prepare salicylic acid water solution; the suspension liquid of the ferrous carbonate and the calcium hydroxide is put on a heating stirrer, and the salicylic acid water solution is dropped under a continuously stirring process; the reaction temperature of preparation is controlled to be from 70 to 80 DEG C, and the reaction time of the preparation is controlled to be from 3.0 to 4.0 hours; after a reaction, excess water as solvent is evaporated, and the mode of the evaporation of the water as solvent can be the mode of the heating evaporation under the temperature of 50 DEG C; after a target product is completely separated out, the serial compound iron/calcium nutritious element tonic as the target product is obtained by a filtering process and a drying process. The mode of the drying process can be a natural drying mode and an infrared lamp roasting mode, and the recovery rate of the target product can reach 92.5 to 94.1%.
Description
Technical Field
The invention belongs to a nutrient element supplement, and particularly relates to a series of composite iron-calcium nutrient element supplements.
The invention also relates to a preparation method of the nutrient element supplement.
Background
Iron is an important nutrient element of human body, and its content is 0.006% of human body weight. Iron is both a prosthetic group of proteins and an essential component of many enzymes. Iron has important functions in the processes of oxygen exchange and transmission in human blood, biocatalysis, electron transfer on the respiratory chain and the like. Iron deficiency has become a common nutrient element deficiency disease for people in China due to dietary structure and the like, wherein infants, teenagers and women of childbearing age are high risk groups. The deficiency of iron can cause a series of pathological changes, such as blood diseases, kidney diseases and liver diseases, and seriously affect the physical health of people in China. Calcium is an important macronutrient element of human bodies, not only is an important constituent element of bones and teeth, but also is widely involved in a series of important life activity processes such as the release and activation of intracellular and extracellular enzymes, the release of synaptic neurotransmitters, the synthesis and secretion of protein hormones, the maintenance of cardiac rhythm, blood coagulation, muscle stress and the like. Calcium deficiency can have serious consequences and can seriously affect health. The calcium deficiency phenomenon exists in different degrees of people of different ages in China. In conclusion, aiming at the dietary and health characteristics of the people in China, it is necessary to develop a high-efficiency iron and calcium nutrient element supplement, which is helpful for improving the health level of the people in China and promoting the prosperity and the defy of the people in China.
At present, nutrient element supplements have attracted much attention, and some nutrient element supplements are commercialized. Iron supplements such as ferrous sulfate, ferric gluconate; calcium supplements such as calcium carbonate and calcium gluconate. Several new nutrient supplement patents are increasing, such as calcium nutrient salt (chinese patent application No. 93110481), calcium gourmet powder (chinese patent application No. 96116582). The iron-calcium supplement plays a certain role in preventing and treating iron and calcium deficiency. However, careful analysis of the iron and calcium supplements currently in use has revealed that these nutritional element supplements have some limitations. First, these nutrient element supplements were only single supplements of iron and calcium. As is known, the human body is a very complex system, and metabolism needs a plurality of nutrient substances to participate together, so that the effect of singly supplementing a certain nutrient element is not ideal, and the effect of simultaneously supplementing a plurality of nutrientelements can achieve a better effect. Secondly, the iron and calcium anion carriers of the iron and calcium nutrient supplement are not ideal. Inorganic acid radicals are used as carriers of iron and calcium nutrient elements, and the inorganic acid radicals are easy to generate certain side effects when entering human bodies. When ethylene diamine tetraacetate is used as a carrier of iron (Chinese patent application No. 98100374), the anion and the iron complex are very stable, which is not beneficial to the absorption of iron by human body. Therefore, carriers of ideal nutrient elements are urgently preferred.
Disclosure of Invention
The invention aims to provide a series of composite iron-calcium nutrient element supplements;
the invention also aims to provide a preparation method of the series of composite iron-calcium nutrient element supplements.
The invention is based on the following principle: (1) the principle of balanced intake of various nutrients. The human body is a very complex organism, and needs a plurality of nutrients to be taken in simultaneously to exert respective biological functions, thereby ensuring the normal performance of life activities. Although the effect can be achieved by singly supplementing a certain nutrient element, the action effect is difficult to achieve the best effect. And the reasonable matching of two or more nutrient elements and simultaneous supplementation can achieve better effect. (2) The biological molecules are used as carriers of nutrient elements to improve the efficacy of the nutrient element supplement. The biological molecules have important biological functions, directly participate in the life activity process of human bodies and play an important role. The nutrient elements are often involved in metabolic processes in the form of complexes with biomolecules. Thus, the absorption and efficacy of the nutrient elements in the human body can be obviously improved by taking the biological molecules as the nutrient element carriers. And meanwhile, the body energy is saved, and other unnecessary inorganic anions are prevented from being introduced into the body. Based on the scientific principle, the invention takes salicylic acid as a carrier to prepare a series of composite iron-calcium nutrient element supplements. The development of the nutrient element supplement breaks through the limitation of single nutrient element supplements and makes beneficial work for promoting the development of the nutrient element supplement to step from single type to higher-level compound type.
The chemical formula of the series of composite iron-calcium nutrient element supplements provided by the invention is as follows:
FexCa1-xL2
wherein X is more than 0.1 and less than 0.4, and L is salicylate (HOC)6H4COO). The following raw materials were used: ferrous carbonate, chemically pure; calcium hydroxide, chemically pure; salicylic acid, biochemical reagents.
The development of the nutrient element supplement breaks through the limitation of a single nutrient element supplement and has a plurality of remarkable characteristics. (1) The nutritional element supplement can simultaneously supplement two essential elements of ferrum and calcium. The method has special significance for high-risk people who are susceptible to iron deficiency and calcium deficiency, such as infants and the like. (2) The nutritional element supplement takes biomolecule salicylic acid as carrier, has high absorption rate for human body, good action effect, and can save physical energy, and simultaneously avoid introducing inorganic anions with different side effects on human body. (3) The nutrient supplement is formulated with a metal complex, which is convenient for storage, transport and use. (4) The series of composite iron-calcium nutrient element supplements provided by the invention can be prepared into nutrient element supplements with different contents of iron and calcium, and can meet the requirements of different healthy people and individuals.
The nutrient element supplement of the present invention is prepared as follows. According to the amount of the nutrient supplement to be prepared, Fe is chemically composedxCa1-xL2Calculating and accurately weighing ferrous carbonate, calcium hydroxide,Salicylic acid. Ferrous carbonate and calcium hydroxide are mixed and water is added to make a suspension. Adding water to the weighed salicylic acid, and heating and stirring to prepare salicylic acid waterAnd (3) solution. Putting the suspension of ferrous carbonate and calcium hydroxide on a heating stirrer, and dripping the salicylic acid aqueous solution under continuous stirring. The preparation reaction temperature is controlled at 70-80 ℃. Salicylic acid reacts with ferrous carbonate and calcium hydroxide according to the following formula:
with the addition of salicylic acid, ferrous carbonate and calcium hydroxide are continuously converted into a complex with salicylic acid, and carbon dioxide bubbles escape while the reaction is carried out. When the evolution of carbon dioxide bubbles ceased, the preparation reaction was essentially complete. The reaction is continued until the target product is quantitatively generated, and the reaction time is controlled to be 3.0 to 4.0 hours. After the reaction is finished, evaporating excessive solvent water, wherein the solvent water can be evaporated by heating at 50 ℃. After the target product is completely separated out, filtering and drying to obtain a series of compound iron-calcium nutrient element supplements of the target product. The drying mode includes natural drying and infrared lamp baking. The recovery rate of the target product can reach 92.5-94.1%.
The preparation process of the series of the composite iron-calcium nutrient element supplements has outstanding characteristics. The target product can be prepared by one-step reaction, and the method is simple to operate and easy to control. The preparation process does not need large-scale instruments and equipment, and only needs general simple chemical production equipment. The preparation reaction has no side reaction, and the reaction product has no other compound needing to be separated (only water is generated and carbon dioxide escapes), so that the purity and the yield of the target product are high, and no separation operation is needed to be added. The preparation process is easy to industrialize, low in investment and quick in effect.
Detailed Description
Example 1
Accurately weighing 0.080mole of salicylic acid, 0.004mole of ferrous carbonate and 0.036mole of ferrous carbonate respectivelyCalcium hydroxide. Ferrous carbonate and calcium hydroxide are mixed and water is added to make a suspension. Adding water into the weighed salicylic acid, and heating and stirring to prepare the salicylic acid aqueous solution. Placing the suspension of ferrous carbonate and calcium hydroxide on a heating stirrerThe salicylic acid aqueous solution is dropped into the solution under continuous stirring. The preparation reaction temperature is controlled at 70 ℃. With the addition of salicylic acid, ferrous carbonate and calcium hydroxide are continuously converted into a complex with salicylic acid, and carbon dioxide bubbles escape while the reaction is carried out. When the evolution of carbon dioxide bubbles ceased, the preparation reaction was essentially complete. The reaction is continued until the target product is quantitatively generated, and the reaction time is controlled to be 3.0 hours. After the reaction is finished, evaporating excessive solvent water, wherein the solvent water can be evaporated by heating at 50 ℃. After the target product is completely separated out, filtering and naturally drying at room temperature to obtain a series of compound iron-calcium nutrient element supplements of the target product. The chemical formula of the target product is Fe0.1Ca0.9L2(wherein L is salicylate) and the recovery rate of the target product is 93.4%.
Example 2
Accurately weighing 0.160mole of salicylic acid, 0.008mole of ferrous carbonate and 0.072mole of calcium hydroxide respectively. The reaction temperature was controlled at 75 ℃ and the rest of the procedure was the same as in example 1. The chemical formula of the obtained target product is Fe0.1Ca0.9L2The recovery of the target product was 92.8%.
Example 3
Accurately weighing 0.200mole of salicylic acid, 0.010mole of ferrous carbonate and 0.090mole of calcium hydroxide respectively. The reaction temperature was controlled to 80 ℃ and the other operations were carried out in the same manner as in example 1. The chemical formula of the prepared target product is Fe0.1Ca0.9L2The recovery of the target product was 94.1%.
Example 4
Accurately weighing 0.080mole of salicylic acid, 0.004mole of ferrous carbonate and 0.036mole of calcium hydroxide respectively. The reaction time was controlled at 3.5h and the rest of the procedure was as in example 1. Prepared target productThe chemical formula of the compound is Fe0.1Ca0.9L2The recovery of the target product was 93.7%.
Example 5
Accurately weighing 0.160mole of salicylic acid, 0.008mole of ferrous carbonate and 0.072mole of calcium hydroxide respectively. The reaction time was controlled at 4.0h and the rest of the procedure was as in example 1. The prepared target productHas a chemical formula of Fe0.1Ca0.9L2The recovery of the target product was 93.3%.
Example 6
Accurately weighing 0.200mole of salicylic acid, 0.010mole of ferrous carbonate and 0.090mole of calcium hydroxide respectively. The desired product was dried with an infrared lamp and the procedure was otherwise as in example 1. The chemical formula of the prepared target product is Fe0.1Ca0.9L2The recovery rate of the target product is 93.9%.
Example 7
Accurately weighing 0.160mole of salicylic acid, 0.016mole of ferrous carbonate and 0.064mole of calcium hydroxide respectively. The reaction temperature was controlled at 75 ℃ and the rest of the procedure was the same as in example 1. The chemical formula of the prepared target product is Fe0.2Ca0.8L2The recovery of the target product was 93.1%.
Example 8
Accurately weighing 0.160mole of salicylic acid, 0.032mole of ferrous carbonate and 0.048mole of calcium hydroxide respectively. The reaction temperature was controlled at 80 ℃ and the rest of the procedure was the same as in example 1. The chemical formula of the prepared target product is Fe0.4Ca0.6L2The recovery of the target product was 92.5%.
Claims (2)
1. A series of composite iron-calcium nutrient element supplements has a chemical formula as follows:
FexCa1-xL2wherein X is more than 0.1 and less than 0.4, L is salicylate radical, and the following raw materials are used: chemically pure ferrous carbonate; chemically pure calcium hydroxide; the biochemical reagent is salicylic acid.
2. A method for preparing the series of composite iron calcium nutrient supplements of claim 1, comprising mixing ferrous carbonate and calcium hydroxide, adding water to form a suspension, adding water to the weighed salicylic acid, heating and stirring to form an aqueous salicylic acid solution, placing the suspension of ferrous carbonate and calcium hydroxide on a heating stirrer, dripping the aqueous salicylic acid solution under continuous stirring, controlling the reaction temperature to be 70-80 ℃, and reacting the salicylic acid with the ferrous carbonate and calcium hydroxide according to the following formula:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410011113 CN1265795C (en) | 2004-10-08 | 2004-10-08 | Serial compound iron/calcium nutritious element tonic and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410011113 CN1265795C (en) | 2004-10-08 | 2004-10-08 | Serial compound iron/calcium nutritious element tonic and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1628672A CN1628672A (en) | 2005-06-22 |
| CN1265795C true CN1265795C (en) | 2006-07-26 |
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| CN 200410011113 Expired - Fee Related CN1265795C (en) | 2004-10-08 | 2004-10-08 | Serial compound iron/calcium nutritious element tonic and preparation method thereof |
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