CN1212125C

CN1212125C - Strontium-calcium composite tonic series and its preparation

Info

Publication number: CN1212125C
Application number: CN 200310115831
Authority: CN
Inventors: 牛春吉; 牛盈赞; 孙艳红; 王众
Original assignee: Changchun Institute of Applied Chemistry of CAS
Current assignee: Changchun Institute of Applied Chemistry of CAS
Priority date: 2003-11-27
Filing date: 2003-11-27
Publication date: 2005-07-27
Anticipated expiration: 2023-11-27
Also published as: CN1543984A

Abstract

The present invention relates to a strontium-calcium compound series nutrient element supplement and a preparation method thereof, and the nutrient element supplement has the following chemical formula: Sr<x>Ca(1-x)L2, wherein x is at least 0.1 and at most 0.3, and L is an ascorbic acid radical and has the following chemical formula: C6 H7O6. The preparation method of the strontium-calcium compound series nutrient element supplement comprises the following steps: (a) strontium carbonate, calcium carbonate and vitamin C are respectively weighed and made into suspension liquid and water solution; (b) the suspension liquid of the strontium carbonate and the calcium carbonate is mixed and is also stirred under the temperature of 30 DEG C to 40 DEG C; (c) the water solution of the vitamin C is dripped into the mixed suspension liquid obtained by the step (b) in a stirring process, and a reaction lasts for 2.5 to 3.5 hours; (d) water content is evaporated under the temperature of 30 DEG C to 40 DEG C until the target product is completely separated out, a filtering process is carried out, and then the final product is obtained by a natural drying process or an infrared lamp drying process under room temperature.

Description

Series composite strontium-calcium nutrient element tonic and its preparation method

Technical Field

The invention belongs to a nutrient element supplement, and particularly relates to a series of composite strontium-calcium nutrient element supplements.

The invention also relates to a preparation method of the nutrient element supplement.

Background

Calcium is a well-known nutrient element essential to the human body. It is an important element of human bone marrow and teeth. It has many important physiological functions, and plays a pivotal role in the physiological processes of muscle stress, nerve impulse transmission, cardiac rhythm maintenance, blood coagulation, cell function, synthesis and secretion of protein hormones, release and activation of intracellular and extracellular enzymes, and release of synaptic neurotransmitters. The lack of calcium leads to various malfunctions in the life process and thus to pathological changes. For example, rickets seriously affect the growth and development of infants, and if the infants cannot be effectively treated in time, disabilities of different degrees are accompanied with the infants for a long time. As another example, osteoporosis has become a significant public health problem and threats to human health are ongoing. Because of the insufficient calcium intake of our country, the calcium supplement has been generally concerned by people for a long time.

At present, dazzling calcium supplement advertisements flood various publicity media in China, and some brand calcium supplements are popular in the market and are utilized by people. And new calcium supplements are emerging (chinese patent application No. 96116582, 93110481). However, there are two major chemical components of calcium supplements currently in use: (1) calcium supplements in inorganic form, such as calcium carbonate. (2) An organic form of calcium supplement, such as calcium gluconate. The calcium supplement can supplement calcium required by human body, and has effects in preventing and treating calcium deficiency. However, after careful study of the above calcium supplements, they have been found to have a common limitation of supplying calcium alone as a nutrient. Research results continuously reveal that people need a plurality of nutrient elements (including macro elements and trace elements), and particularly, the synergistic effect among the nutrient elements is considered to be important, so that the application of the compound nutrient element supplement achieves the effect of getting twice the result with half the effort. Strontium is not only an essential element for calcification of human bone marrow and teeth, but also has a special function of promoting calcification of bone marrow. However, the research on dietary intake and nutrition hygiene indicates that the intake of strontium is obviously insufficient for people in China. Based on the analysis, the series of composite strontium calcium nutrient element supplements break through the serious limitation of a single calcium supplement and become a precursor of a new generation of calcium supplements.

Disclosure of Invention

The invention aims to provide a series of composite strontium calcium nutrient element supplements.

The invention also aims to provide a preparation method of the nutrient element supplement.

The invention is based on the following principle: (1) scientifically utilizes the complementary effect between strontium and calcium. Calcium is the major component of bone and teeth. Bone calcium is in dynamic equilibrium with what is known as the pool of miscible calcium, i.e., calcium in bone is constantly released from osteoclasts into the pool of miscible calcium, which is constantly deposited in osteoblasts. Strontium is a bone-friendly element and is mainly concentrated in places with vigorous calcification. Although strontium only accounts for 0.12% of bones, the special function of strontium is to promote calcification of bones, and the lack of strontium damages the calcification of bones and slows down the growth. The complementary effect of the strontium and the calcium is skillfully utilized, so that the calcium supplement has obvious effect. (2) The biological molecular vitamin C (ascorbic acid) is used as two metal ion carriers of strontium and calcium so as to improve the human body absorption rate of the strontium and the calcium. The vitamin C is an important biomolecule in the human body, and the vitamin C complex of the nutrient elements exists in the human body and directly participates in the metabolic process in the human body, so the vitamin C complex is easy to be absorbed and utilized by the human body, and the physical energy is saved. On the other hand, the composite strontium calcium nutrient element supplement does not introduce other useless or harmful anions into the human body. (3) The principle of simultaneous supplement of multiple nutrients. The composite strontium-calcium nutrient element supplement can simultaneously supplement calcium, strontium and important nutrient component vitamin C required by human body. Based on the principle, the invention creates a series of composite strontium calcium nutrient element supplements for the first time.

The chemical formula of the series composite strontium-calcium nutrient element supplement provided by the invention is as follows:

Sr_xCa_(1-x)L₂wherein x is more than or equal to 0.1 and less than or equal to 0.3; l is ascorbate, which has the chemical formula C₆H₇O₆。

The raw materials used were as follows: strontium carbonate (SrCO)₃) Chemically pure; calcium carbonate (CaCO)₃) Chemically pure; vitamin C (C)₆H₈O₆Ascorbic acid), biochemical reagents.

The series of composite strontium calcium nutrient element supplements break through the limitation of the traditional single calcium supplement and become a precursor of a new generation of composite calcium supplements. The nutrient element supplement has the following remarkable advantages: (1) scientifically utilizes the complementary functions of strontium and calcium, and has very outstanding calcium supplementing effect. Compared with single calcium supplement, the calcium supplement can achieve the effect of twice the result with half the effort. (2) Strontium is a component of human bone marrow, and is also an indispensable element for tooth calcification, and can promote calcification of exposed areas of teeth. And the strontium intake of Chinese people is far lower than the international standard. The series composite strontium-calcium nutrient element supplement can simultaneously provide calcium, strontium and important nutrient component vitamin C required by human body. (3) The strontium and calcium contents in the series of composite strontium calcium nutrient element supplements can be changed, so that a series of strontium calcium nutrient element supplements can be formed, and the requirements of people in different health states can be met.

The preparation process of the series of composite strontium calcium nutrient element supplements is simple and easy to implement. Preparing chemical composition of series composite strontium calcium nutrient element supplements (Sr)_xCa_(1-x)L₂) Strontium carbonate, calcium carbonate and vitamin C are accurately weighed respectively. Adding water, and stirring to make the strontium carbonate into suspension. A suspension of calcium carbonate was also prepared. Dissolving vitamin C in water to obtain water solution. The suspensions of strontium carbonate and calcium carbonate were mixed and placed on a heated stirrer. Dropwise adding the vitamin C aqueous solution into the mixed suspension of strontium carbonate and calcium carbonate under the condition of continuous stirring. The preparation reaction temperature is controlled to be 30-40 ℃. The vitamin C, strontium carbonate and calcium carbonate are subjected to chemical reaction according to the following formula:

the vitamin C dripped into the carbonate suspension reacts with a large amount of excessive carbonate, the carbonate is continuously dissolved, and carbon dioxide bubbles escape. The reaction vessel is water except the generated target product. When the carbon dioxide bubbles stop escaping, the reactant carbonate is almost completely dissolved, and the reaction is continued until the reaction is quantitatively finished. The reaction time is controlled to be 2.5-3.5 hours. After completion of the reaction, the excess solvent water was evaporated to precipitate the target product. The solvent water can be evaporated slowly at 40 deg.C or evaporated under reduced pressure at 30 deg.C. After the target product is completely separated out, filtering and drying to obtain the target product Sr which is the series composite strontium calcium nutrient element supplementof the invention_xCa_(1-x)L₂Wherein x is more than or equal to 0.1 and less than or equal to 0.3; l ═ C₆H₇O₆Or ascorbate). The drying method can be natural drying at room temperature or infrared lamp drying. The recovery rate of the target product is 90.1-93.4%.

The preparation process of the series composite strontium calcium nutrient element supplement has the following advantages: (1) the preparation of the target product requires only one inorganic reaction. The preparation process is simple and easy to operate, easy to master and easy to industrialize. (2) The preparation of the target product does not need large and complex instruments and equipment, and only uses the simplest and most common equipment in general chemical preparation. Therefore, the industrialization is convenient, the investment is low and the effect is quick. (3) The preparation reaction of the target product is single, and no side reaction occurs. Besides the target product, only escaped carbon dioxide and water exist in the reaction product, so that the purity and yield of the obtained product are high, and no separation operation is needed.

Detailed Description

The invention is further illustrated by the following examples:

example 1

Accurately weigh 0.01 moles of strontium carbonate, 0.09 moles of calcium carbonate and 0.20 moles of vitamin C, respectively.Calcium carbonate suspensions were also prepared by adding water and stirring to suspend strontium carbonate. Adding water to prepare the vitamin C aqueous solution. Mixing strontium carbonate and calcium carbonateThe suspension is placed on a heating stirrer, and the vitamin C aqueous solution is dropwise added into the strontium carbonate and calcium carbonate mixed suspension under the condition of continuous stirring. The preparation reaction temperature is controlled at 30 ℃. The vitamin C added dropwise to the carbonate suspension reacts with a large amount of carbonate, which is constantly dissolved with the escape of carbon dioxide bubbles. When the carbon dioxide bubbles stop escaping, the reactant carbonate is almost completely dissolved, and the reaction is continued until the reaction is quantitatively finished. The reaction time was controlled at 2.5 h. After completion of the reaction, the excess solvent water was evaporated to precipitate the target product. The solvent water can be evaporated slowly at 40 ℃. After the target product is completely separated out, filtering and drying to obtain the target product Sr which is the series composite strontium calcium nutrient element supplement of the invention_0.1Ca_0..9L₂，L^-＝C₆H₇O₆(ascorbate). The drying method can be natural drying at room temperature. The recovery of the target product was 92.8%.

Example 2

Accurately weigh 0.05 moles of strontium carbonate, 0.45 moles of calcium carbonate and 1.00 moles of vitamin C, respectively. Calcium carbonate suspensions were also prepared by adding water and stirring to suspend strontium carbonate. Adding water to prepare the vitamin C aqueous solution. The mixed suspension of strontium carbonate and calcium carbonate was placed on a heated stirrer, and the aqueous solution of vitamin C was added dropwise to the mixed suspension of strontium carbonate and calcium carbonate. The preparation reaction temperature is controlled at 35 ℃. The rest of the procedure was the same as in example 1. The target product Sr of the series composite strontium-calcium nutrient element supplement of the invention is obtained_0.1Ca_0..9L₂The recovery rate was 93.1%.

Example 3

Accurately weighed 0.10 moles of strontium carbonate, 0.90 moles of calcium carbonate and 2.00 moles of vitamin C, respectively. The preparation reaction temperature is controlled at 40 ℃. The rest of the procedure was the same as in example 1. The target product is Sr_0.1Ca_0..9L₂The recovery rate was 90.7%.

Example 4

Accurately weigh 0.05 moles of strontium carbonate, 0.45 moles of calcium carbonate and 1.00 moles of vitamin C, respectively. The reaction time was 3.0 h. The rest of the procedure was the same as in example 1. The target product is Sr_0.1Ca_0..9L₂The recovery rate was 90.1%.

Example 5

Accurately weighed 0.10 moles of strontium carbonate, 0.90 moles of calcium carbonate and 2.00 moles of vitamin C, respectively. The reaction time was 3.5 h. The rest of the procedure was the same as in example 1. The target product is Sr_0.1Ca_0..9L₂The recovery rate was 91.5%.

Example 6

Excess water was evaporated at 30 ℃ under reduced pressure. The rest of the procedure was the same as in example 1. The target product is Sr_0.1Ca_0..9L₂The recovery rate was 93.4%.

Example 7

After filtration, the product was dried under an infrared lamp. The rest of the procedure was the same as in example 1. The target product is Sr_0.1Ca_0..9L₂The recovery rate was 90.6%.

Example 8

Accurately weigh 0.02 moles of strontium carbonate, 0.08 moles of calcium carbonate and 0.20 moles of vitamin C, respectively. The rest of the procedure was the same as in example 1. The target product is Sr_0.2Ca_0..8L₂The recovery rate was 91.4%.

Example 9

Accurately weigh 0.03 moles of strontium carbonate, 0.07 moles of calcium carbonate and 0.20 moles of vitamin C, respectively. The rest of the procedure was the same as in example 1. The target product is Sr_0..3Ca_0..7L₂The recovery rate was 92.6%.

Claims

1. A series of composite strontium calcium nutrient element supplements with chemical formula of

Sr_xCa_(1-x)L₂

In the formula: x is more than or equal to 0.1 and less than or equal to 0.3; l is ascorbate, which has the chemical formula C₆H₇O₆。

2. A method of preparing the nutritional supplement of claim 1, comprising the main steps of:

a) respectively weighing strontium carbonate, calcium carbonate and vitamin C, and respectively preparing suspension and aqueous solution;

b) mixing the suspension of strontium carbonate and calcium carbonate, and stirring at 30-40 ℃;

c) c, dropwise adding the vitamin C aqueous solution into the mixed solution obtained in the step b under stirring, and reacting for 2.5-3.5 hours;

d) evaporating water at 30-40 deg.C until the target product is completely separated out, filtering, and drying to obtain the final product.

3. The method of claim 2, wherein the drying is natural drying at room temperature.

4. The method of claim 2, wherein the drying is infrared lamp drying.