CN1775733A - Calcium nervonate and its preparing method and use - Google Patents
Calcium nervonate and its preparing method and use Download PDFInfo
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- CN1775733A CN1775733A CN 200510048654 CN200510048654A CN1775733A CN 1775733 A CN1775733 A CN 1775733A CN 200510048654 CN200510048654 CN 200510048654 CN 200510048654 A CN200510048654 A CN 200510048654A CN 1775733 A CN1775733 A CN 1775733A
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Abstract
The invention a relates to compound nervonic acid calcium salt and its preparing method and application. Its chemical name is z-15-cis-15-tetracosenic acid calcium salt, and its molecular formula is C48H90O4Ca, and its skeleton symbol is [CH3(CH2)7CH= CH(CH2)13COO]2Ca, its molecular weight is 771.3, and its melting point is 133-135 deg.C. The invention makes nervonic acid directly react with calcium oxide, or nervonic acid directly react with calcium oxide and calcium hydroxide, or nervonic acid directly react with calcium oxide, calcium hydroxide and calcium chloride on certain conditions to make it. It can regulate cranial n's system and functions of brain cells to a certain extent, able to strengthen the connective transfer between brain cells, and improve the action of calcium ions. And it can be singly made into health food or act as a nutrition strengthening agent; also act as health and medicinal raw material, made into tablets, capsules, powder and other health calcium
Description
Technical Field
The invention relates to the field of chemistry, in particular to a novel compound calcium nervonate and a preparation method and application thereof.
Background
The problems of brain and calcium supplement always plague people, and how to find effective supplement and strengthening products becomes the focus of attention of researchers and manufacturers. At present, various brain-tonifying health care products sold in the market can be roughly divided into the following categories: supplementing brain nutrition, improving cerebral cortex excitability, promoting cerebral blood circulation, etc. The pharmacological components of the medicine are analyzed, one part has a certain stimulation effect on the nervous system of the brain, and the other part has the functions of calming and soothing and helping to enhance the sleep control or memory function of the brain. Nervonic acid is a neurotrophic factor, is an indispensable component for forming cell membranes in human bodies, plays an important role in various tissues of human bodies, plays an important role in regulating nerve mediators and receptors, and has obvious effects on the development and growth of the cranial nerve system and the connection formation between brain cells. Through the regulation of the function of the brain cell membrane by the nervonic acid, the connection and transmission of information between the brain cells can be enhanced, the effect of calcium ions is improved, and the nervonic acid has important effects on improving the brain and enhancing the memory.
Calcium is the most abundant and essential mineral element in human body, the function of the calcium is taken as the composition component of the skeleton and teeth of the body, and the calcium also participates in various physiological activities, the deficiency of the calcium can cause chondropathy, and the supply amount of the calcium in the national recommended diet is 800-1000 mg/d. In recent years, China has paid high attention to calcium deficiency, but inorganic calcium supplements have great stimulation to gastric mucosa, and are difficult to absorb by human bodies, most calcium ions are discharged out of the bodies without being absorbed, so the calcium supplement effect is poor.
Disclosure of Invention
The invention aims to provide a new compound calcium nervonate, a preparation method thereof and a calcium supplement preparation prepared by the compound, which not only can supplement the brain, but also can supplement the calcium, and has small toxic and side effects and high bioavailability.
The nervonic acid calcium of the invention is obtained by directly reacting nervonic acid with calcium oxide, calcium hydroxide or calcium chloride under certain conditions, and the chemical name of the nervonic acid calcium is as follows: calcium (z) -15-tetracosenoic acid, molecular formula: c48H90O4Ca, molecular weight: 771.3, melting point: 133-135 ℃, is white fine powder, is insoluble in water and ethanol, and is decomposed into nervonic acid and corresponding calcium salt when meeting acid. The reaction formula is as follows:
the preparation method of the calcium nervonate comprises the following steps:
is prepared by reacting nervonic acid with calcium oxide, calcium hydroxide or calcium chloride under the following conditions: the reaction temperature is 45-85 ℃, the reaction time is 30-180 min, the mass ratio of the reactant liquid to the solid is 1: 1-10: 1, and the ratio of the quantity (mole number) of the reactant raw material substances is 2: 1-1: 4. Under magnetic stirring, firstly preparing measured calcium oxide and distilled water into lime milk, slowly adding an ethanol solution of nervonic acid at the temperature of 45-85 ℃, stirring and reacting for 30-180 min to generate a white solid in a reaction solution, carrying out suction filtration while the solution is hot, enabling the pH of a filtrate to be 6.0, washing a filter cake twice by using ethanol and water respectively, draining, and drying in a constant-temperature drying oven at the temperature of 80 ℃ for 2-3 hours to obtain a finished product.
The calcium nervonate of the invention has certain regulation effect on the functions of the brain nervous system and the brain cell membrane, can enhance the connection and transmission of information among brain cells, improves the effect of calcium ions, and has important effects on improving the brain, enhancing memory, promoting intelligence and increasing bone density.
The calcium nervonate can be independently used to prepare health-care food or be used as a nutrition enhancer according to the national dietary nutrition recommended amount; can also be used as raw material for health promotion and medicine, and can be made into health promotion calcium supplement preparation such as tablet, capsule, powder, etc.
Detailed Description
Example 1: adding 0.153g (2.73 mmol) of calcium oxide (CaO) and 1.5mL of distilled water into a 50mL round-bottom flask, preparing lime milk under magnetic stirring, slowly adding a nervonic acid ethanol solution prepared from 2.0g (5.46 mmol) of nervonic acid and 20mL of absolute ethanol under the condition of a 65 ℃ water bath, and reacting for 150min under magnetic stirring; after hot pumping filtration, washing twice with ethanol and water respectively, pumping to obtain white powdery solid, and drying in a constant temperature drying oven at 80 ℃ for 2-3 hours to obtain the finished product of calcium nervonate, which weighs 1.95g and has the yield of 92.8%. The product is in accordance with theoretical value through element analysis, infrared spectrum analysis and calcium content measurement.
Example 2: adding 3.06g (54.64 mmol) of calcium oxide (CaO) and 15mL of distilled water into a 500mL round-bottom flask, preparing lime milk under magnetic stirring, slowly adding a nervonic acid ethanol solution prepared from 20g (54.64 mmol) of nervonic acid and 200mL of 95% ethanol under the condition of 65 ℃ water bath, and reacting for 180min under magnetic stirring; after hot pumping filtration, washing twice with ethanol and water respectively, pumping to obtain white powdery solid, and drying in a constant temperature drying oven at 80 ℃ for 2-3 hours to obtain the finished product of calcium nervonate, which weighs 20.6g and has the yield of 98.1%. The product is in accordance with theoretical value through element analysis, infrared spectrum analysis and calcium content measurement.
Example 3: adding 1.0g (2.73 mmol) of nervonicacid into a 100mL round-bottom flask, adding 50mL of ethanol, fully stirring to dissolve the nervonic acid, slowly adding 65mL of sodium hydroxide solution with the concentration of C being 0.0426mol/L until the pH value is 7-8, heating in a water bath to 75 ℃, adding 76mg (1.37 mmol) of calcium oxide under magnetic stirring, reacting for 150min to generate a white precipitate in the reaction process, changing the reaction system from transparent to white suspension, performing suction filtration while hot, washing the obtained solid twice with ethanol and water respectively, draining, and placing in a constant-temperature drying oven at 80 ℃ for drying for 2-3 hours to obtain the finished product of calcium nervonate, wherein the yield is 78%.
Example 4: a small 100mL round bottom flask was charged with 30mL distilled water, magnetically stirred, and charged with 2g (5.46 mmol) nervonic acid, 0.22g sodium hydroxide, and 0.30g (2.73 mmol) calcium chloride in a water bath at 50 ℃. And (3) after reaction for 30min, cooling and filtering, washing the obtained crude product twice with water, draining, and drying in a constant-temperature drying oven at 80 ℃ for 2-3 hours to obtain the finished product of calcium nervonate with the yield of 92%.
The calcium nervonate prepared in the examples 1 to 4 is prepared into health food or used as a nutrition enhancer according to the national dietary nutrition recommended amount; can also be used as raw material for health promotion and medicine, and can be made into health promotion calcium supplement preparation such as tablet, capsule, powder, etc.
Claims (6)
1. A compound calcium neuraminic acid, characterized in that: chemical name: calcium z-15-tetracosenoic acid, molecular formula: c48H90O4Ca, structural formula: [ CH]3(CH2)7CH＝CH(CH2)13COO]2Ca, molecular weight: 771.3, melting point; 133 ℃ and 135 ℃.
2. The method for preparing calcium nervonate according to claim 1, wherein the compound is obtained by directly reacting nervonic acid with calcium oxide or calcium oxide, calcium hydroxide or nervonic acid with calcium oxide, calcium hydroxide and calcium chloride under certain conditions, the reaction temperature is 45-85 ℃, the reaction time is 30-180 min, the ratio of the quantity of the reaction raw materials is nervonic acid to calcium hydroxide is 2: 1-1: 4, and the content of the calcium nervonate as a reaction product is 5.18-5.22% by weight.
3. The method for preparing calcium nervonate according to claim 2, which comprises the following steps: adding calcium oxide and distilled water into a flask, preparing lime milk under magnetic stirring, slowly adding a nervonic acid ethanol solution prepared from nervonic acid and absolute ethyl alcohol under the condition of 65 ℃ water bath, reacting for 150min under magnetic stirring, carrying out suction filtration while hot, washing twice with ethanol and water respectively, carrying out suction drying to obtain a white powdery solid, and drying in a constant-temperature drying oven at 80 ℃ for 2-3 hours to obtain the finished product of calcium nervonate.
4. The method for preparing calcium nervonate according to claim 2, which comprises the following steps: adding nervonic acid into a flask, adding ethanol, fully stirring to dissolve the nervonic acid, slowly adding a sodium hydroxide solution until the pH value is 7-8, heating in a water bath to 75 ℃, adding calcium oxide under magnetic stirring, reacting for 150min to generate a white precipitate in the reaction process, changing the reaction system from transparent to a white suspension, carrying out suction filtration while the reaction system is hot, washing the obtained solid twice with ethanol and water respectively, draining, and drying in a constant-temperature drying box at 80 ℃ for 2-3 hours to obtain the finished product of calcium nervonate.
5. The method for preparing calcium nervonate according to claim 2, which comprises the following steps: adding distilled water into a flask, magnetically stirring, adding nervonic acid, sodium hydroxide and calcium chloride under the condition of 50 ℃ water bath, reacting for 30min, cooling, filtering, washing the obtained crude product twice with water, draining, and drying in a constant-temperature drying oven at 80 ℃ for 2-3 h to obtain the finished product of calcium nervonate.
6. The use of the calcium nervonate according to claim 1, wherein the calcium nervonate is used alone to prepare health food or used as nutrition enhancer or used as medicine raw material to prepare health calcium supplement preparations such as tablet, capsule, powder and the like according to the national dietary nutrition recommended amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510048654 CN1775733A (en) | 2005-11-29 | 2005-11-29 | Calcium nervonate and its preparing method and use |
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| CN 200510048654 CN1775733A (en) | 2005-11-29 | 2005-11-29 | Calcium nervonate and its preparing method and use |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101861893A (en) * | 2010-03-04 | 2010-10-20 | 云南大学 | Application of nervonic acid zinc to baby humanized formula milk |
| CN114773150A (en) * | 2022-04-27 | 2022-07-22 | 云南华年生物科技有限公司 | Method for extracting nervonic acid from allium sativum seed kernel oil by water extraction, alcohol precipitation and calcification and application of nervonic acid |
| CN115350322A (en) * | 2022-09-14 | 2022-11-18 | 山东大学 | Preparation method of calcium nervonate nanoparticles and application of calcium nervonate nanoparticles in preparation of bone defect repair material |
-
2005
- 2005-11-29 CN CN 200510048654 patent/CN1775733A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101861893A (en) * | 2010-03-04 | 2010-10-20 | 云南大学 | Application of nervonic acid zinc to baby humanized formula milk |
| CN114773150A (en) * | 2022-04-27 | 2022-07-22 | 云南华年生物科技有限公司 | Method for extracting nervonic acid from allium sativum seed kernel oil by water extraction, alcohol precipitation and calcification and application of nervonic acid |
| CN115350322A (en) * | 2022-09-14 | 2022-11-18 | 山东大学 | Preparation method of calcium nervonate nanoparticles and application of calcium nervonate nanoparticles in preparation of bone defect repair material |
| CN115350322B (en) * | 2022-09-14 | 2023-03-07 | 山东大学 | Preparation method of calcium nervonate nanoparticles and application of calcium nervonate nanoparticles in preparation of bone defect repair material |
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