CN1086713A - Margarita calcium and preparation method - Google Patents
Margarita calcium and preparation method Download PDFInfo
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- CN1086713A CN1086713A CN93117551A CN93117551A CN1086713A CN 1086713 A CN1086713 A CN 1086713A CN 93117551 A CN93117551 A CN 93117551A CN 93117551 A CN93117551 A CN 93117551A CN 1086713 A CN1086713 A CN 1086713A
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A kind of with Margarita and Margarita layer powder is raw material through and organic acid reaction, with the sodium hydroxide neutralization, filter, concentrate, crystallization, drying, be ground into the method for powder preparation Margarita calcium and gained Margarita calcium thereof.This product contains the calcium about 20%wt, and several amino acids, easily is dissolved in water, is easy to absorption of human body, is the desirable calcium source that human body replenishes calcium.
Description
The present invention relates to a kind of method and gained trophosome-Margarita calcium that from Margarita and Margarita layer powder, extracts the high food nutrition body of calcium content soluble in water.
Calcium is the indispensable essential mineral element of human body, and it plays a part to cause the pass in the human life activity important.Calcium is the basis of skeleton and tooth, and calcium is in the condensing of blood of human body, the adjusting of nervous tissue, the control of heart movement, and the adjusting of muscle activity is had the important physical chemical action.Yet the malnutrition and the disease that cause owing to the human body calcium deficiency are very general in worldwide, and therefore, concerning the people, it is very necessary replenishing a certain amount of calcium.
At present, state by market on, the calcium source that replenishes calcium as human body is a lot.Great majority as food additive are inorganic salts of calcium, as precipitated calcium carbonate, calcium hydrogen phosphate, calcium sulfate, calcium chloride etc., except that calcium chloride, other is indissoluble or is slightly soluble in water, and be difficult to be absorbed by the body, the use in the food and medicine industry is fewer and feweri.Another kind of calcium source is an organic calcium salt, output is less, as CSL, five hydration calcium lactate, calcium gluconate etc., all depending on inorganic carbonate calcium or calcium oxide etc. makes with corresponding organic acid reaction, though this class calcium source all is dissolved in water, but its calcium content is all lower, generally between 8-12%wt.Also all there is a common shortcoming in this calcium source of two types, all is synthetic promptly, lacks other nutrition.
The food and medicine industry to the requirement in the calcium source of calcium replenishing is: 1) natural biological organic calcium; 2) nonhazardous, and have certain activity and be easy to absorption of human body; 3) can be water-soluble; 4) calcium content is about 20%, and one of purpose of the present invention provides a kind of calcium source of satisfying above-mentioned requirements, and another object of the present invention provides a kind of method for preparing this calcium source.
Margarita and Margarita layer powder are the Chinese crude drugs of a basket for holding earth, are medical treatment, health care, nutrition and cosmetic good merchantable brand.Margarita and Margarita layer powder contain abundant biological calcium and several amino acids.Traditional method is to grind to form fine powder directly to take, but because it is insoluble in water, so be difficult to be absorbed by the body.The present invention is a raw material with Margarita and Margarita layer powder, produces a kind of soluble in water, calcium content novel calcium replenishing about 20%wt, that contain several amino acids, that be easy to absorption of human body and uses the calcium source.
In order to reach purpose of the present invention, the inventive method comprises the steps:
1) and organic acid reaction
Nacreous layer and Margarita are washed roguing respectively, pulverized 200 mesh sieves, get Margarita layer powder and Margarita powder.Organic acid is heated to 80-100 ℃, injects corrosion resistant enamel or stainless steel reactor, under stirring condition 40-60rpm, the Margarita layer powder that slowly adds water furnishing pasty state maintains the temperature at 80-100 ℃, and reaction was carried out 3-4 hour.As a kind of selection, Margarita layer powder directly under agitation can be added in the reactor.Described organic acid comprises acetic acid, propanoic acid, lactic acid, gluconic acid and levulinic acid, preferably acetic acid.It should be noted that, the organic acid addition is too much, can extract some impurity, influences product quality, the organic acid addition very little, the extraction ratio of active ingredient is low, and therefore, the organic acid addition is suitable, as using acetic acid (95%wt), the weight ratio of Margarita layer powder and acetic acid is 40-60:60-40, during application, acid can be diluted.
2) neutralization reaction liquid
After reaction finishes, add the NaOH aqueous solution, pH value is transferred to neutrality, can add activated carbon decolorizing in case of necessity and purify, follow filtered while hot, the elimination solid impurity.
3) concentrated filtrate
Filtrate is heated to boiling, and evaporation section moisture content is to approximate saturated.
4) crystallization
Filtrate with after concentrating is cooled to below 20 ℃, makes it crystallization.
5) fractional crystallization
Crystallized stock is filtered or centrifugalize, and drying under reduced pressure heats up in the dry run in proper order again, and temperature in order to be suitable for using, can be pulverized dried product between 40-150 ℃, makes it by 120 mesh sieves.
Above-described is that Margarita layer powder is prepared into crystalline product, is referred to as product A, and Margarita powder also can get crystalline product through same step, is referred to as product B.
6) be mixed, magnetize
Described product A and product B are mixed evenly, in principle during being mixed of A and B, the consumption of B is The more the better, but consider economic factor, the consumption of product B is the 0.5-2% of product A, and mixed product is magnetized processing in force-magnetized machine, makes products molecule increase polarity, arrange in order, help dissolving and absorption.The product that obtains by above six step process is exactly a Margarita calcium of the present invention.
Be appreciated that equally, Margarita layer powder and Margarita powder being pressed the weight ratio of 100:0.5-2 mixes, the step of 1-6 by the above makes crystalline product C, and save being mixed in the step 6, with the products C magnetization, the magnetization finished product of gained is basically identical with magnetized finished product that product A, B are mixed again on composition and function like this.It shall yet further be noted that magnetization is a kind of selection of the present invention, product can not magnetized yet.
Can further specify the present invention by the following examples:
The 1Kg Margarita layer powder is added 0.1Kg water furnishing pasty state, the acetic acid of 1Kg95%wt is added water 5Kg, the acetic acid after releasing is heated to 80 ℃, be injected in the enamel reactor, under the mixing speed of 50rpm, add the pasty state Margarita layer powder lentamente, maintain the temperature at 80-100 ℃, reacted 4 hours.Add the NaOH aqueous solution again, PH transferred cause neutrality, add activated carbon decolorizing, filtration, concentrate, crystallisation by cooling, separation, drying, the lily crystalline product A of 1.1Kg.
By same step, can get white crystalline product B, two kinds of products of A, B are pulverized, being mixed promptly gets Margarita calcium.
By analysis, calcic 20.0%wt in the product Margarita calcium (A:B=100:1), water dissolution pass the test, the pH value of its saturated aqueous solution is 6-8, arsenic content (in As) is less than 0.0003%wt, and content of beary metal (in Pb) meets the GB5749-58 standard less than 0.0002%wt.Wherein also contain aspartic acid, threonine, serine, glutamic acid, glycine, alanine, leucine, isoleucine, histidine, lysine, arginine.
This product has following advantage, and it is the calcium replenishing calcium source of All Pure Nature, the calcium content height, and about 20%wt, water-soluble is good, is easy to absorption of human body. Can be used as food additives, also can make various electuaries, tablet or oral liquid, be suitable for directly taking. Technology, the equipment of producing this product are simple, and operation is convenient, and raw material sources are abundant, and cost is lower.
Claims (10)
1, a kind of is the method for raw material production Margarita calcium with Margarita powder and Margarita layer powder, comprises
1) Margarita powder and/or Margarita layer powder and organic acid are pressed 40-60: the 60-40 weight ratio is 80-100 ℃ of reaction 3-4 hour down;
2) add sodium hydrate aqueous solution, pH value is transferred to neutrality; Filtered while hot is removed solid impurity;
3) heating boils off part moisture content concentrated filtrate;
4) cooling concentration liquid makes it crystallization;
5) filter out crystallization, dry, be ground into powder.
2, method according to claim 1 is characterized in that Margarita powder and Margarita layer powder are mixed by the weight ratio of 0.5-2:100.
3, method according to claim 1, it is characterized in that Margarita powder and Margarita layer powder are prepared into powder through the 1-5 of described step respectively, with two kinds of powder by being mixed from Margarita powder gained powder (B) with from the weight ratio of Margarita layer powder gained powder (A) with 0.5-2:100.
4, by the described method of claim 1, wherein said organic acid is acetic acid or propanoic acid or lactic acid or gluconic acid or levulinic acid.
5,, it is characterized in that described powder is magnetized in magnetizer according to the method for claim 1 or 3.
6, a kind of Margarita calcium is characterized in that it is is that raw material is prepared from through following steps with Margarita powder and Margarita layer powder:
1) weight ratio of Margarita powder and/or Margarita layer powder and organic acid being pressed 40-60:60-40 is 80-100 ℃ of reaction 3-4 hour down;
2) add sodium hydrate aqueous solution and regulate pH value to neutral; Filter, remove solid impurity;
3) heating boils off part moisture content, concentrated filtrate;
4) cooling concentration filtrate makes it crystallization;
5) crystallization of filtration, the drying and crushing powdered.
7, Margarita calcium according to claim 6 is characterized in that Margarita powder and Margarita layer powder are mixed by the weight ratio of 0.5-2:100.
8, Margarita calcium according to claim 6, it is characterized in that Margarita powder and Margarita layer powder make powder through described step 1-5 respectively, with two kinds of powder of gained by from Margarita powder gained powder (B) be mixed from the weight ratio of Margarita layer powder gained powder (A) with 0.5-2:100.
9, Margarita calcium according to claim 6, the organic acid of stating wherein are acetic acid or propanoic acid or lactic acid or gluconic acid or levulinic acid.
10,, it is characterized in that the process magnetization in magnetizer of described powder according to claim 6 or 8 described Margarita calciums.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93117551A CN1086713A (en) | 1993-09-18 | 1993-09-18 | Margarita calcium and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93117551A CN1086713A (en) | 1993-09-18 | 1993-09-18 | Margarita calcium and preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1086713A true CN1086713A (en) | 1994-05-18 |
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| CN93117551A Pending CN1086713A (en) | 1993-09-18 | 1993-09-18 | Margarita calcium and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020348A (en) * | 2010-10-25 | 2011-04-20 | 深圳市百宝堂生物科技有限公司 | Water rich in pearl calcium ions and preparation method thereof |
| CN104906141A (en) * | 2014-03-14 | 2015-09-16 | 浙江欧诗漫生物股份有限公司 | Method for separation of soluble edible calcium from pearls |
| EP3108873A4 (en) * | 2014-03-14 | 2016-12-28 | Osmun Biological Co Ltd | Method for separating and preparing pearl extract from pearls |
| CN107375206A (en) * | 2017-08-01 | 2017-11-24 | 苏州太湖美药业有限公司 | A kind of high biocidal property pearl eyesight improvement drops |
| CN107495336A (en) * | 2017-08-01 | 2017-12-22 | 苏州太湖美药业有限公司 | A kind of preparation method of soluble pearl powder |
-
1993
- 1993-09-18 CN CN93117551A patent/CN1086713A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020348A (en) * | 2010-10-25 | 2011-04-20 | 深圳市百宝堂生物科技有限公司 | Water rich in pearl calcium ions and preparation method thereof |
| CN104906141A (en) * | 2014-03-14 | 2015-09-16 | 浙江欧诗漫生物股份有限公司 | Method for separation of soluble edible calcium from pearls |
| EP3108873A4 (en) * | 2014-03-14 | 2016-12-28 | Osmun Biological Co Ltd | Method for separating and preparing pearl extract from pearls |
| CN104906141B (en) * | 2014-03-14 | 2019-05-21 | 欧诗漫生物股份有限公司 | A method of the isolated solvable edible calcium from pearl |
| CN107375206A (en) * | 2017-08-01 | 2017-11-24 | 苏州太湖美药业有限公司 | A kind of high biocidal property pearl eyesight improvement drops |
| CN107495336A (en) * | 2017-08-01 | 2017-12-22 | 苏州太湖美药业有限公司 | A kind of preparation method of soluble pearl powder |
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