CN107375206A - A kind of high biocidal property pearl eyesight improvement drops - Google Patents
A kind of high biocidal property pearl eyesight improvement drops Download PDFInfo
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- CN107375206A CN107375206A CN201710644389.7A CN201710644389A CN107375206A CN 107375206 A CN107375206 A CN 107375206A CN 201710644389 A CN201710644389 A CN 201710644389A CN 107375206 A CN107375206 A CN 107375206A
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- pearl powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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Abstract
The present invention relates to a kind of high biocidal property pearl eyesight improvement drops, its composition of raw materials includes the component of following parts by weight：100 parts of water；10 ~ 15 parts of pearl powder；1 ~ 2 part of borneol；2 ~ 5 parts of Sodium Hyaluronate；1 ~ 5 part of ethyl hydroxy benzoate；The preparation method of the pearl powder comprises the following steps：（a）Pearl powder by crushing pearl into granularity for 100 ~ 200 mesh；（b）Water for injection and food grade lactic acid are added into the pearl powder, is reacted 5 ~ 15 hours at 30 ~ 40 DEG C, filtering, condensing crystallizing, low-temperature negative-pressure are dried；（c）To step（b）The obtained pearl powder is crushed, and is then screened using the screen cloth of 100 ~ 200 mesh.Coordinated by using specific pearl powder and Sodium Hyaluronate, ethyl hydroxy benzoate etc., the stabilizing dissolved to pearl powder can be realized, and there is bacteria resistance function and extend its storage time.
Description
Technical field
The invention belongs to the field of putting drops in one's eyes, and is related to a kind of pearl liquor, and in particular to a kind of high biocidal property pearl eyesight eye drip
Liquid.
Background technology
Cataract particularly cataract of old people is a kind of common disease, frequently-occurring disease, and operative treatment is due to complication cause being present
The problems such as blind.Chronic conjunctivitis is ophthalmology common disease, frequently-occurring disease.Chronic conjunctivitis is that have many reasons to cause, main to include carefully
Bacterium infection, the stimulation of poor environment, the influence of illness in eye, bad habits and customs etc., clinical characters are ophthalmic uncomfortable sense, white bubble
Foam shape secretion, papebral conjunctiva mild hyperaemia are congested unobvious.Visual fatigue is ophthalmology common disease, frequently-occurring disease.Asthenopia is general
Refer to the syndrome of the subjective symptom caused by eye works.The symptom of patient is varied, common are near work not
Can persistently, go out to lose face and eye socket around pain, blurred vision, eyes are dry and astringent, shed tears；Severe patient's headache, nausea, dizziness.
At present, there is the generation of increasing visual fatigue crowd, also increasing crowd pays close attention to and paid attention to regarding for oneself
Power health.Thus research safety, the preventing and treating cataract of comfort type, chronic conjunctivitis, visual fatigue disease drug turn into an important class
Topic.Pearl powder is ophthalmology common medicine, and the function for the screen that disappears with improving eyesight, for a long time, the successive dynasties traditional Chinese medical science is all by pearl treated powder ophthalmology
Disease,《Sheng Nong's herbal classic》、《Thunder God processes haigoushen》、《Compendium of Materia Medica》It is on the books etc. in many ancient medicine monographs.It is precious
Pearl liquid is that it contains ten several amino acids and 20 various trace elements obtained by its extracted effective ingredient of pearl powder, wherein
Glutamic acid, glycine, the content of cystine and element zinc are all higher.Modern study shows, more than ten kinds of amino is contained in pearl liquor
Acid plays an important role to human body, and the amino acid of eyeball tissue is very abundant, wherein such as glutamic acid, cystine and glycine, spy
It is not higher in crystalline lens, cornea and ciliary ligament content, if muddiness will be occurred by reducing or lacking.Due to senile white interior
The variation of the reason for barrier, research find that the Microamount of Elements in Crystalline Lens zinc, copper, iron of muddiness significantly reduce.Existing eye drops exists
Easy breed bacteria during storage so that eye drops fails, it is difficult to ensure the security of continuous use product.
The content of the invention
A kind of high biocidal property pearl eyesight improvement drops are provided the invention aims to overcome the deficiencies in the prior art.
To reach above-mentioned purpose, the technical solution adopted in the present invention is：A kind of high biocidal property pearl eyesight improvement drops, it
Composition of raw materials include the components of following parts by weight：
The preparation method of the pearl powder comprises the following steps：
(a) pearl powder by crushing pearl into granularity for 100~200 mesh；
(b) water for injection and food grade lactic acid are added into the pearl powder, is reacted 5~15 hours at 30~40 DEG C, mistake
Filter, condensing crystallizing, low-temperature negative-pressure are dried；The mass ratio of the pearl powder, water for injection and food grade lactic acid is 1：3~5：2~
3；
(c) pearl powder obtained to step (b) crushes, and is then screened using the screen cloth of 100~200 mesh
.
Optimally, in step (b), chaotropic agent is additionally added into the pearl powder；The chemical structural formula of the chaotropic agent isIts addition is the 1~5% of the pearl powder addition.
Because above-mentioned technical proposal is used, the present invention has following advantages compared with prior art：The high biocidal property of the present invention
Pearl eyesight improvement drops, coordinated by using specific pearl powder and Sodium Hyaluronate, ethyl hydroxy benzoate etc., can be realized pair
The stabilizing dissolved of pearl powder, and there is bacteria resistance function and extend its storage time.
Embodiment
The high biocidal property pearl eyesight improvement drops of the present invention, its composition of raw materials include the component of following parts by weight：Water 100
Part；10~15 parts of pearl powder；1~2 part of borneol；2~5 parts of Sodium Hyaluronate；1~5 part of ethyl hydroxy benzoate；The preparation of the pearl powder
Method comprises the following steps：(a) pearl powder by crushing pearl into granularity for 100~200 mesh；(b) add into the pearl powder
Enter water for injection and food grade lactic acid, reacted 5~15 hours at 30~40 DEG C, filtering, condensing crystallizing, low-temperature negative-pressure are dried；Institute
The mass ratio for stating pearl powder, water for injection and food grade lactic acid is 1：3~5：2~3；(c) pearl obtained to step (b)
Powder is crushed, and is then screened using the screen cloth of 100~200 mesh.By using specific pearl powder and hyalomitome
Sour sodium, ethyl hydroxy benzoate etc. are coordinated, and can realize the stabilizing dissolved to pearl powder, and are had bacteria resistance function and extended its storage
Time.
In step (b), chaotropic agent is additionally added into the pearl powder；The chemical structural formula of the chaotropic agent isIts addition is the 1~5% of the pearl powder addition, the dissolution of this spline structure
Agent has stronger water imbibition and adsorbs the ability of calcium ion, so as to further promote the absorption of calcium, it is often more important that, its own
With certain sterilization effect, it can be coordinated with above-mentioned material and improve fungistatic effect.In step (b), preferably it is concentrated into
Primary crystal is produced, then standing 20~50 hours crystallizes.In step (b), the condition that the low-temperature negative-pressure is dried is preferably in temperature
50~80 DEG C, dry 30~50 hours under the conditions of 0.10~0.50pa of negative pressure.
The present invention is further described below in conjunction with embodiment.
Embodiment 1
The present embodiment provides a kind of high biocidal property pearl eyesight improvement drops, and its composition of raw materials includes following parts by weight
Component：
Above-mentioned pearl powder is prepared and (can prepared during preparation, then take 10g more) according to following steps：
(a) pearl powder by crushing pearl into granularity for 120 mesh；
(b) 10g pearl powders are taken, are separately added into 30g waters for injection, 20g food grade lactic acids and 0.1g chaotropic agents thereto,
30 DEG C are reacted 15 hours, filtering；Heating, which is concentrated into, produces primary crystal (being concentrated into micro- produce to crystallize), and standing carries out abundant for 20 hours
Crystallization；Dried 50 hours under the conditions of 50 DEG C, negative pressure 0.10pa and carry out abundant negative pressure drying；Chaotropic agent is(chaotropic agent is by corresponding imidazole salts and the organic ion containing the anion
Compound carries out ion exchange and is made)；
(c) pearl powder obtained to step (b) crushes, and is then screened using the screen cloth of 100 mesh.
Embodiment 2
The present embodiment provides a kind of high biocidal property pearl eyesight improvement drops, and it is different with basically identical in embodiment 1
It is that its composition of raw materials includes the component of following parts by weight：
Embodiment 3
The present embodiment provides a kind of high biocidal property pearl eyesight improvement drops, and it is different with basically identical in embodiment 1
It is that its composition of raw materials includes the component of following parts by weight：
Embodiment 4
The present embodiment provides a kind of high biocidal property pearl eyesight improvement drops, and it is different with basically identical in embodiment 1
It is in step (b), to be also added into 0.5g chaotropic agents before the reaction
Embodiment 5
The present embodiment provides a kind of high biocidal property pearl eyesight improvement drops, and it is basically identical with the step in embodiment 1, no
Be：In step (b), 0.3g chaotropic agents are also added into before the reaction
Comparative example 1
The present embodiment provides a kind of eye drops for improving eyesight, unlike：It does not contain borneol, Sodium Hyaluronate and oxybenzene second
Ester.
By embodiment 1-5 and comparative example 1 interrupt eye drops cavy is carried out cataract experiment (by phacoscotasmus degree from
It is normal to be divided into the expression of 0,0.5,1,2,3 numerical value in various degree to serious, from phacoscotasmus degree close to (be about 1.5 ±
0.80) cavy is tested), phacoscotasmus makes moderate progress after 3 months, but still close.Example 1-5 and contrast
Example 1 interrupts eye drops as in culture dish, and OD=0.1 Candida albicans bacterium solution is added dropwise respectively, it is small to carry out culture 4 at room temperature
When after coated plate, counted after being further cultured for 24 hours, colony counts are followed successively by comparative example 1, embodiment 1, embodiment 2, real from more to less
Apply example 3, embodiment 5 and embodiment 4.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
Scholar can understand present disclosure and implement according to this, and it is not intended to limit the scope of the present invention.It is all according to the present invention
The equivalent change or modification that Spirit Essence is made, it should all be included within the scope of the present invention.
Claims (2)
1. a kind of high biocidal property pearl eyesight improvement drops, it is characterised in that its composition of raw materials includes the group of following parts by weight
Point：
The preparation method of the pearl powder comprises the following steps：
(a) pearl powder by crushing pearl into granularity for 100~200 mesh；
(b) water for injection and food grade lactic acid are added into the pearl powder, is reacted 5~15 hours at 30~40 DEG C, filters, is dense
Sheepshank is brilliant, low-temperature negative-pressure is dried；The mass ratio of the pearl powder, water for injection and food grade lactic acid is 1：3~5：2~3；
(c) pearl powder obtained to step (b) crushes, and is then screened i.e. using the screen cloth of 100~200 mesh
Can.
2. high biocidal property pearl eyesight improvement drops according to claim 1, it is characterised in that：In step (b), to the treasure
Chaotropic agent is additionally added in pearl powder；The chemical structural formula of the chaotropic agent isIt is added
Measure as the 1~5% of the pearl powder addition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710644389.7A CN107375206A (en) | 2017-08-01 | 2017-08-01 | A kind of high biocidal property pearl eyesight improvement drops |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710644389.7A CN107375206A (en) | 2017-08-01 | 2017-08-01 | A kind of high biocidal property pearl eyesight improvement drops |
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| Publication Number | Publication Date |
|---|---|
| CN107375206A true CN107375206A (en) | 2017-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710644389.7A Pending CN107375206A (en) | 2017-08-01 | 2017-08-01 | A kind of high biocidal property pearl eyesight improvement drops |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113925828A (en) * | 2021-09-23 | 2022-01-14 | 重庆视健眼健康产业有限公司 | Borneol eye lotion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086713A (en) * | 1993-09-18 | 1994-05-18 | 邵阳市宝庆营养制剂厂 | Margarita calcium and preparation method |
| CN105769920A (en) * | 2014-12-25 | 2016-07-20 | 苏州太湖美药业有限公司 | Pearl clear-sighted eye drops and preparation method |
-
2017
- 2017-08-01 CN CN201710644389.7A patent/CN107375206A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086713A (en) * | 1993-09-18 | 1994-05-18 | 邵阳市宝庆营养制剂厂 | Margarita calcium and preparation method |
| CN105769920A (en) * | 2014-12-25 | 2016-07-20 | 苏州太湖美药业有限公司 | Pearl clear-sighted eye drops and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 巩玲: "《眼科学基础实训教程》", 31 August 2016, 西安交通大学出版社 * |
| 邱澄宇: "《水产品加工新技术与营销》", 30 September 2011, 金盾出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113925828A (en) * | 2021-09-23 | 2022-01-14 | 重庆视健眼健康产业有限公司 | Borneol eye lotion |
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Application publication date: 20171124 |