CN1257733C - Skin and mueosa tissue disinfectant and its processing method - Google Patents
Skin and mueosa tissue disinfectant and its processing method Download PDFInfo
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- CN1257733C CN1257733C CN200410028177.9A CN200410028177A CN1257733C CN 1257733 C CN1257733 C CN 1257733C CN 200410028177 A CN200410028177 A CN 200410028177A CN 1257733 C CN1257733 C CN 1257733C
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Abstract
The present invention provides a Chinese herbal medicine disinfectant, particularly a skin and mueosa tissue disinfectant and a processing method thereof, which is characterized in that the disinfectant is composed of 2.5 grams of iodine, 50 grams of flavescent sophora root, 40 grams of fructus, 50 grams of phellodendron bark, 20 grams of kufan, 30 grams of alkyl alcohol ether and 30 grams of phosphoric acid. The preparing method of the disinfectant comprises the steps that the flavescent sophora roots, the fructus and the kufan are respectively put into a distilling tank; water with the weight seven times more than that of the mixture of the flavescent sophora roots, the fructus and the kufan is added to the distilling tank and heated to 110 DEG C, and the temperature is kept for two hours; filtered medicine liquid is concentrated to 1: 1, and then ethanol is added to the liquid for precipitation for 24 hours; the filtrate is kept for spare use; the alkyl alcohol ether is added to a reaction tank, and then a stirrer is started; the iodine is orderly added to the rotating alkyl alcohol ether, and the mixture is heated, mixed and emulsified for 90 hours at constant temperature so as to form brown bright cream emulsion iodine for spare use; the Chinese medicine filtrate and the cream emulsion iodine which are kept for spare use are added to the diluting tank, and then are mixed for four hours; the phosphoric acid is slowly added to the diluting tank, and the pH value is adjusted till the content of effective iodine and the Chinese medicines is detected; when the content reaches to the trade standard content, the final mixture is packed to form finished products. The present invention has the functions of high efficiency, quick efficiency, long efficiency, broad spectrum, insect disinfestation, itch relieving, hemostasis, pain alleviating, convergence, surface disease treating, muscle recovery, etc. The present invention can permeate into skin and mueosa tissues by.
Description
Technical field
The present invention relates to Chinese medicine preparation, especially a kind of mucocutaneous tissue disinfection agent and processing method thereof.
Background technology
According to inquiry about market information, commercially available disinfectant is various in style, and its technical quality and Disinfection Effect are very different.Accomplish that really efficient, wide spectrum, long-acting, quick-acting, safety non-toxic, product non-stimulated, free from environmental pollution are careful for it few.Present more widely used chloride class disinfectant, though peroxide disinfectant etc. can reach efficiently, the broad-spectrum disinfectant effect, but abnormal smells from the patient is too big, zest is strong, can only can not be directly used in the sterilization of human body skin, mucosal tissue as hospital environment, ground, body surface, patient's medicated clothing, quilt and the vehicle sterilization of transporting patient.And side effect is big in actual use, and often improper because of depositing, using method is not right, blast occurs, kills and wounds phenomenons such as skin, mucosa.In addition, because iodine is water insoluble, traditional product is helping under the solvent condition, must use just can reach Disinfection Effect when higher content of iodine, and skin, mucosa are had certain zest.In the use as the untimely easy skin ambustion of iodine that takes off.In time take off iodine after must sterilizing in the clinical use, operation and inconvenient.External sterilization of initial stage eighties expert is for solving this difficult problem, and the employing macromolecular compound is a carrier, forms the polyvidone chelated iodine, and available iodine content obviously reduces than iodine tincture, and its bactericidal effect but improves several times.Be widely used in clinical mucocutaneous use.But in using, actual clinical finds that also there are some shortcomings in povidone iodine, viscosity is big, easily form film, penetration power is relatively poor, and soapy feeling is obvious, and abnormal smells from the patient is more unpleasant, exist simultaneously and use professional range narrower, generally be used for hospital operating room medical worker hands sterilization, operative site and injection site sterilization, and the iodine minimum content necessary 〉=deficiencies such as 5000mg/L.
Summary of the invention
The objective of the invention is to overcome above deficiency, a kind of have efficient, quick-acting, long-acting, wide spectrum, parasite killing, antipruritic, hemostasis, pain relieving convergence, dispel mucocutaneous tissue disinfection agent and processing method thereof apparent, that repair functions such as flesh are provided.This disinfectant can hypersynchronous skin, mucosal tissue, kills the intralesional pathogen rapidly, and normal skin, mucosal tissue are not had any infringement and stimulation.
The objective of the invention is to be achieved by the following scheme: mucocutaneous tissue disinfection agent prescription is made up of following, iodine 1.5-4.0 gram, Radix Sophorae Flavescentis 25-65 gram, Pericarpium Zanthoxyli 28-60 gram, Cortex Phellodendri 35-68 gram, dried Alumen 8-25 gram, alkyl ethoxylated 21-45 gram, phosphatase 11 0-35 gram.
Mucocutaneous tissue disinfection agent optimum formula is: iodine 2.5 grams, Radix Sophorae Flavescentis 50 grams, Pericarpium Zanthoxyli 40 grams, Cortex Phellodendri 50 grams, dried Alumen 20 grams, alkyl ethoxylated 30 grams, phosphoric acid 30 grams.
The processing method of mucocutaneous tissue disinfection agent is by poly-obtaining of following step:
(1) gets Radix Sophorae Flavescentis 25-65 gram, Pericarpium Zanthoxyli 28-60 gram, Cortex Phellodendri 35-68 gram, dried Alumen 8-25 gram, put into respectively in the alembic, add 7 times of water and begin heating, boil to 110 ℃ of reservations 2 hours, leach medicinal liquid, surplus slag adds 3 times of water boils 1 hour again, the liquid of extractive distillation simultaneously leaches medicinal liquid, merges filtrate then 2 times, begin to be concentrated into 1: 1, add 60-70% ethanol 500ml, precipitate 24 hours, reclaim and filter ethanol, added ethanol precipitation again 24 hours, refilter, reclaim ethanol, filtrate for later use;
(2) getting alkyl ethoxylated 21-45 gram puts in the retort, start agitator, press per minute 80-200 rotating speed, get iodine 1.5-4.0 gram again and put into successively in the alkyl ethoxylated of rotation, begin heating, heat while stirring, keep 80 ℃ of constant temperature, continuous stirring emulsifying 90 hours promptly forms the bright paste of brown essence, be emulsifying iodine, standby;
(3) standby middle drug filtrate and paste emulsion iodine are put in the thinning tank, stirred 4 hours, get phosphatase 11 0-35 gram, slowly put in the thinning tank, transfer pH value 1.18-2.8, detect available iodine content, check Chinese medicine content simultaneously, when all reaching industry standard content, promptly divide to be filled to finished product.
The present invention has the following advantages:
1, the available iodine content of product can reach very strong Disinfection Effect at 40mg/L.Iodine cooperates the quick-acting wide spectrum killing actions that both play iodine with Chinese herbal medicine, the long-acting killing action of Chinese herbal medicine is arranged again.Stock solution got final product 100% killing microorganisms in 2 minutes.After test reached 6 hours, still reach same disinfection effect.And the black bacillus subtilis spore there is strong killing action.
2, owing to iodine is difficult to dissolving, even if dissolving runs into other material such as plant amylum, saccharide muddiness takes place easily, variable color, formation precipitate, and reduce the content of iodine, and bactericidal effect is weakened.Production technology process of the present invention solved iodine with the extraction herb liquid composite after, its disinfectant solution does not have precipitation for the brownish red transparency liquid, its bactericidal effect obviously improves.And the natural fragrance flavor, give the people a kind of pure and fresh sweet sensation.
3, pH value of the present invention is between 1.18-2.8, and under the stronger environment of this acidity, microprotein is solidified the rapid cracking death of thalline, and skin, mucosa are not had any stimulation.By the skin of mosquito bite, antipruritic immediately in the energy of the present invention with the Intradermal toxin, eliminate erythra.
4, the present invention kills the intralesional antibacterial selectively as being coated in skin, mucosa infection position, and the lesion tissue sheet is come off, and simultaneously quick repair tissue forms new granulation.And normal skin, mucosal tissue are not had any detrimental effect.
5, the present invention has hemostasis, pain relieving, antipruritic, damp eliminating concurrently, restrains, repaiies function such as flesh at sterilization, disinfectant simultaneously.Short incrustation of its is lighter time when wound surface recovers, and do not form cicatrix, the non-pigment calmness.
6, the present invention uses its effect highly significant at clinical gynecological, STD Dept., Department of B urn etc., is generally embrocating second day sx, and the 4th day transference cure was almost recovered in ten days.
7, because prescription of the present invention is reasonable, the tight a beautiful gem of the advanced operation of technology does not produce the three wastes in the production, the abnormal smells from the patient that in extraction process, is distributed, and the effect of purifying air is pure environment-friendly product.
In view of above each advantage, this product detects through relevant authoritative institution of country, and stock solution is killed microorganisms such as withered black, golden Portugal, Bai Nian, kills in 2 minutes 100%.Dilute 80 times, act on 3 minutes to pathogenic microorganism killing rates such as golden Portugal, large intestines and reach 99.99%-99.92%, in 2 year effect duration of 54 ℃, 14 days accelerated tests, its bactericidal effect is constant substantially.
Description of drawings
The invention will be further described below in conjunction with the observation on Clinical Application result.
Table one is observation on Clinical Application result's example table of the present invention;
Table two is the present invention and other like product function comparison sheet.
The specific embodiment
The present invention adopts high section biotechnology, select for use and have high infiltration, the high softening strong alkyl ethoxylated of dissolution, medicinal algae essence iodine is formed smart bright paste with envelope form emulsifying dissolving, select for use again have heat clearing away, the multiple rare Chinese medicine of detoxifcation, killing parasites for relieving itching, damp eliminating convergence, anticancer growth, by the microcell technology, extract pure elite, both refining composite having efficient, quick-acting, long-acting, wide spectrum, killing parasites for relieving itching, hemostasis, pain relieving convergence, damp eliminating, repairing disinfecting, the sterilization special product of function such as flesh of forming.
Embodiments of the invention are as follows:
Embodiment 1 Chinese herbal medicine formula is: iodine 1.5-4.0 gram, Radix Sophorae Flavescentis 25-65 gram, Pericarpium Zanthoxyli 28-60 gram, Cortex Phellodendri 35-68 gram, dried Alumen 8-25 gram, alkyl ethoxylated 21-45 gram, phosphatase 11 0-35 gram.
The optimum formula of embodiment 2 Chinese herbal medicine is: iodine 2.5 grams, Radix Sophorae Flavescentis 50 grams, Pericarpium Zanthoxyli 40 grams, Cortex Phellodendri 50 grams, dried Alumen 20 grams, alkyl ethoxylated 30 grams, phosphoric acid 30 grams.
The processing method of Chinese herbal and crude drugs preparations is obtained by following steps:
(1) gets Radix Sophorae Flavescentis 25-65 gram, Pericarpium Zanthoxyli 28-60 gram, Cortex Phellodendri 35-68 gram, dried Alumen 8-25 gram, put into respectively in the alembic, add 7 times of water and begin heating, boil to 110 ℃ of reservations 2 hours, leach medicinal liquid, surplus slag adds 3 times of water boils 1 hour again, the liquid of extractive distillation simultaneously leaches medicinal liquid, merges filtrate then 2 times, begin to be concentrated into 1: 1, add 60-70% ethanol 500ml precipitation 24 hours, reclaim and filter ethanol, added ethanol precipitation again 24 hours, refilter, reclaim ethanol, filtrate for later use.
(2) getting alkyl ethoxylated 21-45 gram puts in the retort, start agitator, press per minute 80-200 rotating speed, get iodine 1.5-4.0 gram again, put into successively in the alkyl ethoxylated of rotation, begin heating, heat while stirring, keep 80 ℃ of constant temperature, continuous stirring emulsifying 90 hours, form the bright paste of brown essence, be emulsifying iodine, standby.
(3) standby middle drug filtrate and paste emulsion iodine are put in the thinning tank, stirred 4 hours, get phosphatase 11 0-35 gram, slowly throw in the thinning tank, transfer pH value 1.18-2.8, detect available iodine content, check Chinese medicine content simultaneously, divide when all reaching industry standard content to be filled to finished product.
The present invention shows according to the clinical operating position of hospital of a few family at home, to colpitis mycotica, and bacterial vaginitis, diseases such as cervical erosion, condyloma acuminatum, eczema, dermatitis, tinea corporis, its sterilization effect highly significant, action time is of short duration, without any side effects, the patient does not have sense of discomfort.Especially cervical erosion does not have good Therapeutic Method at present, can soften erosion rapidly behind use the present invention, and the degeneration tissue comes off it, very fast formation new organization, and can effectively prevent cervical cancer to take place.
The scope of application of the present invention is extensive, is divided into specifications such as operating room special use, gynecological's special use, Dermatology ﹠ STD Dept. special use, Department of B urn special use according to the clinical practice needs, and each specification is furnished with special implement.In actual applications, directly embrocate, soak, clean, dry and comfortable naturally need not the washing.
Observation on Clinical Application result's example table (table 1)
| Patient's ordinary circumstance | Clinical diagnosis | Using method | Effect observation | |||
| The 1st day | The 2nd day | The 3rd day | 4-10 days | |||
| Woman 36 years old | Colpitis mycotica, severe symptoms | Gauze soaks into medicinal liquid fills in intravaginal | Pruritus vulvae alleviates | Pruritus disappearance secretions reduces | Secretions disappears | The satisfied nothing of effect is uncomfortable. |
| Woman 27 years old | Mycotic road inflammation | Soak into gauze and directly put into vagina | Itch and alleviate | Secretions reduces | Secretions disappears | Itched in 5th and the satisfied nothing discomfort of secretions disappearance effect. |
| Man 40 years old | Behind the condyloma acuminatum water laser operation | One times of washout of medicinal liquid dilution | Wound surface is little itches | The wound surface cleaning | The wound surface cleaning | The 7th day, wound healing, the satisfied nothing of effect is uncomfortable. |
| Woman 42 years old | Condyloma acuminatum companion bacterial vaginitis | Soak into gauze and put into intravaginal | State of an illness no change | Secretions reduces stink and alleviates | Sx | The 4th day secretions is normal, stink disappears, effect satisfied do not have uncomfortable. |
| Man 44 years old | Behind the crissum condyloma acuminatum laser operation | Stock solution is wiped outward | Do not have uncomfortable | Wound surface takes a turn for the better | The wound surface cleaning | Wound surface healing on the 10th does not have uncomfortable. |
| Woman 31 years old | Bacterial vaginitis | Soak into gauze and put into vagina | No change | Secretions reduces to itch and alleviates | Secretions reduces | Secretions was normally tasteless on 1, and effect is satisfied |
| Woman 43 years old | Bacterial vaginitis | The stock solution washout | The local comfort sense | Secretions reduces | Secretions obviously reduces | Effect is satisfied |
| Man 30 years old | Vulval eczema | Stock solution is wiped outward | Ulceration place pain | Alleviation of pain is light | Gargalesthesia disappearance erythra alleviates | The recovery from illness effect was satisfied on 1 |
| Man 26 years old | The left lower extremity contact dermatitis | The stock solution washout | Red, swell, itching alleviates | Red, swollen disappear to itch alleviate | Recovery from illness | Effect is satisfied |
| Woman 50 years old | The diagnostic curettage postoperative | The stock solution washout | Comfort, courageous and upright secretions reduces | Secretions reduces | Secretions obviously reduces | Effect is satisfied |
Above case is that 40 examples are done in the test of strong palace hospital altogether in Beijing, wherein selects 10 examples to publish
With other like product function comparison sheet (table 2)
| Title | Prescription (content %) | PH value | Sterilizing time (min) | Killing effect (%) | Transparency | Extension rate | Zest | Abnormal smells from the patient |
| The present invention | Chinese medicine and iodine 0.25 | 1.18 | 2 | 100 | Brownish red is transparent | 80 | Do not have | Natural fragrance |
| Hundred richnesses | PVP iodine 5 | 5.6～6 | 5-10 | 99.99 | Sepia is opaque | 10-20 | Do not have | Pungent chemical odor |
| FUKANG disappears | Chinese medicine+iodine is an amount of | 5 | Uncertain | Antibacterial uncertain | The bright amount precipitation of grey black | 5 | Slightly | Pungent taste of Chinese medicine |
| SHUJIE | Chinese medicine+antibiotic numerous amount is uncertain | 7.0 | Uncertain | Antibacterial uncertain | The bright amount precipitation of grey black color | 5-10 | Slightly | Slight Chinese medicine and western medicine |
| FUYINJIE | Chinese medicine and western medicine | 4.5 | Uncertain | Uncertain | Faint yellow muddiness | 10-20 | Slightly | Slight sour Rhizoma Zingiberis Recens flavor |
| SHENBAI XIYE | Pure Chinese medicine | 4.0 | Uncertain | Uncertain | The turbid precipitation of grey black color contamination | 10 | Slightly | Pure taste of Chinese medicine |
Claims (3)
1, a kind of mucocutaneous tissue disinfection agent, it is characterized in that: the disinfectant prescription is made up of following: iodine 1.5-4.0 gram, Radix Sophorae Flavescentis 25-65 gram, Pericarpium Zanthoxyli 28-60 gram, Cortex Phellodendri 35-68 gram, dried Alumen 8-25 gram, alkyl ethoxylated 21-45 gram, phosphatase 11 0-35 gram.
2, mucocutaneous tissue disinfection agent according to claim 1, it is characterized in that: the prescription of disinfectant is made up of following: iodine 2.5 grams, Radix Sophorae Flavescentis 50 grams, Pericarpium Zanthoxyli 40 grams, Cortex Phellodendri 50 grams, dried Alumen 20 grams, alkyl ethoxylated 30 grams, phosphoric acid 30 grams.
3, the processing method of the described mucocutaneous tissue disinfection agent of claim 1: it is characterized in that being obtained by following steps: (1) gets Radix Sophorae Flavescentis 25-65 gram, Pericarpium Zanthoxyli 28-60 gram, Cortex Phellodendri 35-68 gram, dried Alumen 8-25 gram, put in the alembic respectively, add 7 times of water and begin heating, boil to 110 ℃ of reservations 2 hours, leach medicinal liquid, surplus slag adds 3 times of water boils 1 hour again, the liquid of extractive distillation simultaneously, leach medicinal liquid, merge filtrate then 2 times, began to be concentrated to 1: 1, add 60-70% ethanol 500ml, precipitate 24 hours, reclaim and filter ethanol, added ethanol precipitation again 24 hours, refilter, reclaim ethanol, filtrate for later use;
(2) getting alkyl ethoxylated 21-45 gram puts in the retort, start agitator, press per minute 80-200 rotating speed, get iodine 1.5-4.0 gram again, put into successively in the alkyl ethoxylated of rotation, begin heating, heat while stirring, keep 80 ℃ of constant temperature, continuous stirring emulsifying 90 hours, promptly form the bright paste of brown essence, be emulsifying iodine, standby;
(3) standby middle drug filtrate and paste emulsion iodine are put in the thinning tank, stirred 4 hours, get phosphatase 11 0-35 gram, slowly put in the thinning tank, transfer pH value 1.18-2.8, detect available iodine content, check Chinese medicine content simultaneously, divide when all reaching industry standard content to be filled to finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410028177.9A CN1257733C (en) | 2004-07-22 | 2004-07-22 | Skin and mueosa tissue disinfectant and its processing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410028177.9A CN1257733C (en) | 2004-07-22 | 2004-07-22 | Skin and mueosa tissue disinfectant and its processing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1596946A CN1596946A (en) | 2005-03-23 |
| CN1257733C true CN1257733C (en) | 2006-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200410028177.9A Expired - Fee Related CN1257733C (en) | 2004-07-22 | 2004-07-22 | Skin and mueosa tissue disinfectant and its processing method |
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| CN (1) | CN1257733C (en) |
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|---|---|---|---|---|
| CN107281473A (en) * | 2017-05-08 | 2017-10-24 | 阮伟 | A kind of composition of maintenance uterine cavity mucous membrane and preparation method thereof |
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