CN1242785C - Medication for treating ulcer of oral cavity and preparation method - Google Patents
Medication for treating ulcer of oral cavity and preparation method Download PDFInfo
- Publication number
- CN1242785C CN1242785C CNB031180523A CN03118052A CN1242785C CN 1242785 C CN1242785 C CN 1242785C CN B031180523 A CNB031180523 A CN B031180523A CN 03118052 A CN03118052 A CN 03118052A CN 1242785 C CN1242785 C CN 1242785C
- Authority
- CN
- China
- Prior art keywords
- medicine
- ethanol
- parts
- cinnabaris
- percolate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine for treating oral ulcer and a preparation method thereof. The medicine is prepared from Chinese gall, natural indigo, camphol, clove, Rhizoma Bletillae, sodium borate and cinnabar. The main method for preparing the medicine is as follows: clean materials are proportionally weighed according to the optimal weight; the Chinese gall, the clove and the Bletillae Rhizoma Pulveratum are pulverized into coarse powder which is then mixed with the natural indigo and the sodium borate; the mixture is moistened with an amount of 60% ethanol, and impregnated with 60% ethanol for 15 days by way of impregnation; the mixture is then percolated slowly, and the percolate is collected for standby; the cinnabar is used as the solvent after being moistened with 60% ethanol by way of percolation, and cinnabar percolate is collected; the camphol is mixed together with the two kinds of percolate after being dissolved in a right amount of 6% ethanol, 60% ethanol is added into the mixed solution to 1000 ml, and the medicine is obtained after the mixed solution is placed statically for 24 hours and filtered. The present invention which is an applying agent and can obviously promote canker healing has the advantages of unique preparation method, obvious analgesia effect, delayed relapse, novel dosage form, convenient preservation, convenient operation and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of oral ulcer, the invention still further relates to the preparation method of this medicine.
Background technology
Though it is various to treat the medicine of oral ulcer in the market, as " watermelon crystal spray ", various " ulcer films ", " cydiodine ", " meaning can be pasted ", " healthy and free from worry " etc., but the effect of its treatment oral ulcer is all not too satisfied, and the shelf-life is short, and is not too convenient during use.Consult Chinese patent literature, the correlation technique of treatment oral ulcer has: application number 93111391 treatment oral ulcer medications one Margarita Hylotelephium erythrostictum (Miq.) H.Ohba looses and application number 93110244 KOUKUILING and preparation method thereof, have only four Chinese medicine identical with the present invention respectively with three flavor medicines, and all be powder, difference is clearly.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of oral ulcer, another object of the present invention provides the preparation method of this medicine.
Solution of the present invention is to be the Therapeutic Principle according to the theory about the treatment oral ulcer in " all sick time opinion dispute skin ulcers are waited ", " danxi's experiential therapy ", " secretly handing down key to Diagnosis and Treatment ", " the practical traditional Chinese medical science stomatology ", screens through clinical trial repeatedly to form.By the varnish dosage form that following traditional Chinese medicines material weight proportion is made, trade name: doubly blue or green oral ulcer liquid.
Medicine of the present invention is made by following traditional Chinese medicines material weight proportion:
Galla Chinensis 80-250 part Indigo Naturalis 100-250 part Borneolum Syntheticum 50-250 part Flos Caryophylli 0-250 part
Pseudobulbus Bletillae (Rhizoma Bletillae) 0-200 part Borax 80-200 part Cinnabaris 30-80 part
Each Chinese medicine preparation preferred weight ratio range of medicine of the present invention:
Galla Chinensis 120-220 part Indigo Naturalis 140-220 part Borneolum Syntheticum 100-210 part Flos Caryophylli 0-170 part
Pseudobulbus Bletillae (Rhizoma Bletillae) 0-170 part Borax 100-180 part Cinnabaris 30-60 part
Each Chinese medicine preparation optimum weight proportioning of medicine of the present invention:
150 parts of 180 portions of Flos Caryophyllis of 180 parts of Borneolum Syntheticums of 180 parts of Indigo Naturaliss of Galla Chinensis
60 parts in 150 parts of Cinnabaris of 150 parts of Boraxs of Pseudobulbus Bletillae (Rhizoma Bletillae)
The preparation method that above-mentioned each Chinese medicine is made medicine of the present invention is:
1, take by weighing clean material by the optimum weight proportioning, every part is unit with the gram.
2, get Galla Chinensis, Flos Caryophylli, Rhizoma Bletillae powder and be broken into coarse powder and mix with Indigo Naturalis, Borax, moistening with an amount of 60% ethanol, by infusion process with 60% alcohol dipping 15 days, percolation slowly, the collection percolate is standby.
3, get Cinnabaris and make solvent with 60% ethanol, collect the Cinnabaris percolate by percolation.
4, get Borneolum Syntheticum with an amount of ethanol (60%) dissolving, mix, add 60% ethanol to 1000ml with above-mentioned two percolates, quiet to filtration in 24 hours promptly.
The present invention shows that by clinical test results for many years following advantage and curative effect are arranged:
1, tangible analgesic effect is arranged.Can play the analgesic effect of getting instant result behind each coating, also faster than anesthetics, the analgesic time is longer, can keep 2-2.5 hour.
2, promote that the effect of ulcer healing is obvious, and the effect that delays ulcer recurrence is arranged.
3, dosage form novelty is convenient to preserve, and long shelf-life uses very simple and convenient.
4, this pharmaceutical formulation is reasonable, preparation technology advanced person, and steady quality has comfortable mouthfeel, and is without any side effects.
5, the clinical research of defending school Affiliated Hospital and Shaoyang City First People's Hospital, refined two department of stomatology, Hospital in Hunan by Hunan Province's Shaoyang City proves, to recurrent ulcer, illness such as herpetic stomatitis, cheilitis, traumatic ulcer, migratory glossitis, anaphylaxis lip inflammation, burning tongue have unique curative effect.Total effective rate is all more than 98.8.Pay a return visit 100 routine patients, mostly this medicine analogy is " refreshing medicine ".
The 370 routine oral ulcer patients that the present invention is defended school Affiliated Hospital at the Hunan Province's Shaoyang City result that carries out clinical research, observation is reported as follows below:
1, general clinical data
Treat oral ulcer 185 examples with the present invention, with " watermelon crystal " contrast treatment oral ulcer patient 185 examples, male 162 people in 370 examples, women 208 people, the age is between 8 months to 78 years old.
Recurrent aphtha 298 people, traumatic ulcer 40 people, herpetic aphtha 32 people.
2, alternative: discontented 48 hours persons take place in ulcer.
3, get rid of object:
3.1, antibiotic for oral administration and aphtha curative in the recent period; 3.2, take immunosuppressant and medicament for immunity enhancement in March; 3.3, acute infectious disease, autoimmune disease, tumor patient.
4, medication: experimental group is coated with ulcer surface, every day 3-4 time with blue or green ulcer liquid doubly; Matched group sprays the affected part with watermelon crystal spray, every day 3-4 time.
5, observational technique and therapeutic evaluation standard:
Carry out with reference to the oral ulcer topical therapeutic criterion of therapeutical effect that in December, 2000 China first Professional Committee's plenary session for the third time of stomatology meeting diseases of oral mucosa passed through, observe the burst healing time of soup and the average healing stage of ulcer, adopt vision analogy scale (VAS method) the record pain relief degree of every day ulcer phase, eliminate fully until pain, ulcer healing was observed 9 days.
Produce effects: pain elimination in two days after the medication, ulcer disappears in three days.
Effectively: pain elimination in three days after the medication, ulcer disappears in four days.
Invalid: pain relief in four days after the medication, ulcer healing after five days.
5, result:
5.1, the effect of shortening ulcer healing is obvious: experimental group ulcer phase after medication obviously shortens, healing in most patients' the ulcer four days, part recurrent aphtha patient obviously prolongs (seeing Table one) its gap phase
Table 1 liang group ulcer The average healing comparison (my god)
| Group | The example number | The average healing and standard deviation | Just give preceding sick time and standard deviation |
| Experiment contrast | 185 185 | 3.216 0.856 6.308 1.301 | 1.891 0.372 1.851 0.366 |
| u＝27.00 p＜0.01 u＝1.043 p＞0.05 | |||
5.2, significant analgesic effect is arranged: the analgesic onset time than narcotics is also fast, and it is longer to hold time, and generally can keep 2-2.5 hour.
Table 2 liang group pain is eliminated time and number
| The elimination time (my god) | Experimental group is eliminated number | Matched group is eliminated number |
| 1 | 16 | 2 |
| 2 | 128 | 9 |
| 3 | 39 | 25 |
| 4 | 2 | 32 |
| 5 | 0 | 31 |
| 6 | 0 | 37 |
| 7 | 0 | 24 |
| 8 | 0 | 17 |
| 9 | 0 | 10 |
| Add up to | 185 | 185 |
5.3, significant curative effect (seeing Table 3) arranged
Table 3 liang group curative effect is (%) relatively
| Experimental group | Matched group | |
| Produce effects | 73.6 | 0.5 |
| Effectively | 26.2 | 16.8 |
| Invalid | 0.2 | 82.7 |
| Add up to | 100 | 100 |
| x 2＝576.77 p＜0.01 | ||
Above result of the test shows that this medical instrument has analgesic effect rapidly, lastingly, and the ulcer healing phase effect of shortening obviously, easy to use, comfortable taste, long shelf-life, advantage such as without any side effects, thereby, be worth extensive use and popularization for new approach has been opened up in the treatment of oral ulcer.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Embodiment one, takes by weighing clean material by following weight proportion:
Galla Chinensis 180g Indigo Naturalis 180g Borneolum Syntheticum 180g Flos Caryophylli 150g
Pseudobulbus Bletillae (Rhizoma Bletillae) 150g Borax 150g Cinnabaris 60g
Preparation technology is as shown in Figure 1:
Get Galla Chinensis, Flos Caryophylli, Rhizoma Bletillae powder and be broken into coarse powder, mix with Indigo Naturalis, Borax, moistening with an amount of 60% ethanol, add 8000 milliliters of dippings of 60% ethanol 15 days by infusion process, percolation slowly, it is standby to collect percolate; Get Cinnabaris and make solvent by percolation for 100 milliliters with 60% ethanol, it is standby to collect the Cinnabaris percolate; With Borneolum Syntheticum with an amount of 150 milliliters of dissolvings of 60% ethanol after, with above-mentioned two percolate mix homogeneously, add 60% ethanol to 1000ml, leave standstill and filtered in 24 hours promptly.
Embodiment two, and each Chinese medicine weight proportion of distinguishing the flavor of is with embodiment 1.Preparation technology is as follows: gets Galla Chinensis, Flos Caryophylli, Rhizoma Bletillae powder and is broken into coarse powder, mix with Borneolum Syntheticum, Cinnabaris, Indigo Naturalis, Borax, and moistening with an amount of 60% ethanol, add 1200 milliliters of dippings of 60% ethanol 15 days by infusion process, slow percolation is collected percolate, quietly filters promptly to 24 hours.
Medicine of the present invention is a varnish, is dark-brown supernatant liquid, feeble QI perfume (or spice), mildly bitter flavor is puckery hot cool.
Claims (5)
1. medicine for the treatment of oral ulcer, it is characterized in that: it is made by the following weight proportion raw material:
100250 parts of Borneolum Syntheticum 50-250 of Galla Chinensis 80-250 part Indigo Naturalis part Flos Caryophylli 0-250 part
80200 parts of Cinnabaris 30-80 of Pseudobulbus Bletillae (Rhizoma Bletillae) 0-200 part Borax part
2. the medicine of treatment oral ulcer according to claim 1, wherein each raw material and weight proportion thereof are:
Galla Chinensis 120-220 part Indigo Naturalis 140-220 part Borneolum Syntheticum 100-210 part Flos Caryophylli 0-170 part
Pseudobulbus Bletillae (Rhizoma Bletillae) 0-170 part Borax 100-180 part Cinnabaris 30-60 part
3. medicine according to claim 2, wherein each raw material and weight proportion thereof are:
150 parts of 180 portions of Flos Caryophyllis of 180 parts of Borneolum Syntheticums of 180 parts of Indigo Naturaliss of Galla Chinensis
60 parts in 150 parts of Cinnabaris of 150 parts of Boraxs of Pseudobulbus Bletillae (Rhizoma Bletillae)
4. the medicine of treatment oral ulcer according to claim 1 and 2 is characterized in that described this medicine is a varnish.
5. the preparation method of the described treatment stomatocace medicine of claim 1, it is characterized in that: a. takes by weighing clean material by weight ratio; B. get Galla Chinensis, Flos Caryophylli, Rhizoma Bletillae powder and be broken into coarse powder, mix with Indigo Naturalis, Borax, moistening with an amount of 60% ethanol, add 60% alcohol dipping 15 days by infusion process, percolation slowly, it is standby to collect percolate; C. get Cinnabaris and make solvent with 60% ethanol, collect the Cinnabaris percolate by percolation.D. get Borneolum Syntheticum 60% dissolve with ethanol, mix, add 60% ethanol, leave standstill and filtered promptly in 24 hours to 100ml with above-mentioned two percolates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031180523A CN1242785C (en) | 2003-01-24 | 2003-01-24 | Medication for treating ulcer of oral cavity and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031180523A CN1242785C (en) | 2003-01-24 | 2003-01-24 | Medication for treating ulcer of oral cavity and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1519009A CN1519009A (en) | 2004-08-11 |
| CN1242785C true CN1242785C (en) | 2006-02-22 |
Family
ID=34284802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031180523A Expired - Fee Related CN1242785C (en) | 2003-01-24 | 2003-01-24 | Medication for treating ulcer of oral cavity and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1242785C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579764B (en) * | 2012-03-13 | 2013-12-11 | 常熟华港制药有限公司 | Traditional Chinese medicine for preventing and curing recurrent aphthae and preparing method thereof |
| CN102525871B (en) * | 2012-03-13 | 2013-04-10 | 常熟华港制药有限公司 | Toothpaste for preventing and treating recurrent aphtha and preparation method |
| CN115844993A (en) * | 2022-12-13 | 2023-03-28 | 湖南倍青生物科技有限公司 | A Chinese medicinal disinfectant for oral cavity and skin, and its preparation method |
-
2003
- 2003-01-24 CN CNB031180523A patent/CN1242785C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1519009A (en) | 2004-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1923234A (en) | Traditional Chinese medicinal formulation for treating osteoarthropathy | |
| WO2013071727A1 (en) | Anti-tumor traditional chinese medical composition | |
| CN114306206A (en) | External traditional Chinese medicine composition for treating thyroid nodule and preparation method and application of external traditional Chinese medicine gel plaster | |
| CN1876163A (en) | Navel-adhibitting medicine for vomit-stopping in chemotherapy | |
| CN1242785C (en) | Medication for treating ulcer of oral cavity and preparation method | |
| JP2000512270A (en) | Compositions and methods for the treatment of herpes simplex | |
| CN101385774B (en) | Medicine composition for treating recurrent oral ulcer and its preparation method | |
| CN101049485A (en) | Mulberry - ginger soft capsule for treating common cold, and preparation method | |
| CN1895593A (en) | Medicine for treating acne and its preparation | |
| CN107501435A (en) | The extracting method of pachymaran and its application | |
| CN101829193B (en) | Medicine composite for treating cervical erosion and preparation method thereof | |
| CN1057928C (en) | Medicine for ulcer and its preparation | |
| CN1178890C (en) | Method for extracting hypericin from Hypericum perforatum and medicine made up using hypericin as main composition | |
| CN1094264A (en) | Tobacco agent health article | |
| CN1120007C (en) | Medicine for treating mastopathy | |
| CN1061256C (en) | Hypertension ointment for external use | |
| CN101829253B (en) | Medicine composite for treating cervical erosion and preparation method thereof | |
| CN101829167B (en) | Medicine composite for treating cervical erosion and preparation method thereof | |
| CN102552440A (en) | Anti-asthmatic and anti-inflammatory medicament and preparation method and application thereof | |
| CN1141098C (en) | New application of benzene ring pelargonate hydrochloride | |
| CN101618157B (en) | Medicine composition for treating autumn-dryness cold and preparation method thereof | |
| CN107362296B (en) | Medicine for treating benign tumor of skin and preparation method thereof | |
| CN1954879A (en) | Granule of zhamusa-four-does and its preparation method | |
| CN1259974C (en) | Drug giving-up medicine made-up by non-thebaica medicines | |
| CN113181340A (en) | Qingbing powder formula for treating recurrent oral ulcer and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Caifeng Document name: Notification of Termination of Patent Right |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060222 Termination date: 20120124 |