CN1240141A - Medicinal granule with anti-senility function - Google Patents
Medicinal granule with anti-senility function Download PDFInfo
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Abstract
The Chinese medicine in the form of granules with the health-care functions of raising internal SOD content, removing internal free radicals, reducing the generation of LPO, protecting cell membrane and delaying senility for curing male and female climateric syndrome, including the symptoms of night sweat, sleepless and amnesia, flushed face, listlessness, dysphoria and sexual hypoesthesia, etc. with reliable and obvious effect is prepared from 12 Chinese medicinal materials of cooked rehmannia root, lycium berry, glehnia root, Chinese angelica root, mulberry, turtle shell, cuscuta seed and Chinese yam, etc..
Description
The present invention is made by the natural Chinese medicines material, belongs to pollution-free food medicine category, specifically is meant a kind of anti-aging medicinal granule with anti-senility function that prolongs.
Along with global population aging day by day, particularly China are just entering senescence society, China and foreign countries' medical circle defying age especially defying age Medicines and Health Product as one of great scientific research task of human life's science.According to the relevent statistics, only naturally-aged crowd in China's Mainland also has about 200,000,000 pathologic senilism crowds just up to more than 100,000,000 people.This shows that only with regard to the domestic market, the scientific research of defying age Medicines and Health Product is significant, market application foreground is wide.Modern medicine thinks that the mankind an aged bioprocess will inevitably occur with advancing age, wears out to comprise physiological " aging " and pathologic " senilism " and " aging ".The aging activity usefulness that mainly shows as reduces thinking and hypodynamia, coordination function forfeiture etc.Motherland's medical science thinks that the prosperity and decline of people's growth strong the wait for a long time natural law and essence in kidney is closely related, and pools of traditional Chinese medicine of extensive knowledge and profound scholarship has many treatment senilism and antidotal classic prescriptions, for multiplying and living of the Chinese nation brought into play huge benefit remote.It is anti-aging how doctor trained in Western medicine prolongs in mode oral and that injection is plain, intensifies vigor in the body.But excessive long-term supplementing hormone can destroy total balance of the body, produces drug dependence even can cause some unknowable pathological changes to take place, and should carefully use.More existing health-care products, as TAIYANGSHEN ORAL LIQUID, SOD oral liquid or the like, role is more single-minded, or additional SOD content, or certain internal organs of conditioning human body, lacks aggregate balancing and coordinates effect.
The purpose of this invention is to provide a kind of the kidney invigorating and support kidney, comprehensive coordination balance function of human body improves human body superoxides medicine enzyme SOD content, removes interior free yl, the medicinal granule with anti-senility function of the slow down aging of the generation of minimizing lipid oxide LPO.
Motherland's medical science is thought, senilism or old and feeble various crowds fail gradually owing to kidney qi, essence and blood is not enough day by day, the imbalance of YIN and YANG that causes kidney, and the kidney yin kidney yang that to be each internal organs negative and positive is basic, and then cause the disorderly of each function or degenerate, this just forms the basic condition of pathological changes such as geromorphism and female climacteric syndrome.Because factor affecting such as various old and feeble crowds' body constitution, work and rest, life, environment, spirit, disease, can not self regulate the syndrome that adapts to based on a series of function disorders of suffering from a deficiency of the kidney, thereby form pathologic variations such as senilism, female climacteric syndrome.The adolescence of body senilism, middle age, particularly middle age a series of physiological change can occur to the old transition period.Mainly be the kidney qi degradation, menses day withered, asthenia of essence and blood, dash and appoint decline, imbalance between YIN and YANG.Damage of kidney-YIN, passages through which vital energy circulates lose in moistening foster warm, cause the conscience dysfunction.Special under the influence of deficiency of the kidney yin, deficiency of marrow-reservoir, the card that first god is easily not normal, disarmony between the heart and kidney then appears in the easy fall of gods.Deficiency of kidney yin causes the kidney failing to nourish the liver, causes the hepatic and renal YIN deficiency.Therefore, the main cause of this disease of the hepatic and renal YIN deficiency.The sheet that declines that prolongs of the present invention is that the hepatic and renal YIN deficiency is established, and is monarch drug with Radix Rehmanniae Preparata nourishing YIN and benefiting blood, vital essence replenishing and marrow benifiting in the side, the moon of Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori invigorating the liver and kidney, and the Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG is ministerial drug altogether.The spleen and stomach provide the material basis of the acquired, the source of vital function, so with the gas of Radix Panacis Quinquefolii, Rhizoma Dioscoreae supplementing QI and nourishing YIN tonifying the spleen and stomach, Semen Cuscutae YANG invigorating tonifying YIN, Radix Glehniae, Radix Ophiopogonis nourishing lung and stomach the moon, Chinese angelica blood supplementing; The Semen Platycladi tranquilizing by nourishing the heart is an adjuvant drug; Fructus Mori is returned the warp of Liver and kidney in addition, and the effect of nourishing YIN and supplementing blood is arranged, and also is messenger drug.All medicines share, and play the health care of nourishing the liver and kidney, adjusting negative and positive nourishing blood to tranquillize the mind altogether.
The present invention is by forming approximately in 12 flavors, and white sugar accounts for 7.1% in the per unit medicinal granule with anti-senility function, and Pulvis Talci accounts for 2.0% and contain trace and eat paraffin and pigment, it is characterized in that its formulation ratio is as follows in the described medicinal granule with anti-senility function of per unit:
Radix Rehmanniae Preparata 15.3% Fructus Lycii 8.1%
Radix Glehniae 8.1% Semen Platycladi 6.1%
8.1% Radix Ophiopogonis 6.1% of Radix Angelicae Sinensis
Fructus Mori 8.0% Fructus Ligustri Lucidi 6.1%
Carapax Trionycis 7.6% Radix Panacis Quinquefolii 2.2%
Semen Cuscutae 7.6% Rhizoma Dioscoreae 7.6%
Medicinal granule with anti-senility function: be according to the Traditional health care theory, make with raw materials such as Radix Glehniae, Radix Rehmanniae Preparata, Carapax Trionycis, Rhizoma Dioscoreae, Fructus Lycii, Fructus Mori, Fructus Ligustri Lucidi, Semen Cuscutae, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, Semen Platycladi, Radix Ophiopogonis.Described can the raise content of superoxide dismutase SOD in the body of the sheet that declines that prolongs is removed interior free yl, reduces the generation of lipid peroxide LPO, and the protection cell membrane slows down the body aging process.Prove that through function test the present invention has the health-care effect of slow down aging; Clinical observation treatment 240 examples, HUAHONG PIAN matched group 90 examples, total effective rate is respectively 84.5%, 82.2%, and through the Riddit statistical analysis, two groups of curative effects do not have significant difference.Wherein to YIN-deficiency type climacteric syndrome best results, to hot night sweat, insomnia forgetfulness, flushed face, to warm remissions such as sweating, lethargy, fidgety irritability, hyposexuality, many nightmares of sleeping, dry pharynx dryness of the tongue remarkable, has no adverse reaction after taking medicine.This product is used for the treatment of senilism, female climacteric syndrome has effect convenient and reliable, certain satisfaction.
Accompanying drawing 1 is a process chart of the present invention.
The embodiment that makes tablet is undertaken by following prescription:
Radix Rehmanniae Preparata 15.3% white sugar 7.1%
Fructus Lycii 8.1% Semen Platycladi 6.1%
8.1% Radix Ophiopogonis 6.1% of Radix Glehniae
Radix Angelicae Sinensis 8.1% Fructus Ligustri Lucidi 6.1%
Fructus Mori 8.0% Radix Panacis Quinquefolii 2.2%
Carapax Trionycis 7.6% Pulvis Talci 2.0%
Rhizoma Dioscoreae 7.6% edible paraffin 0.01 ‰
Semen Cuscutae 7.6% food coloring 0.04 ‰
Below be to support various laboratory reports of the present invention, comprising: health care appraisal report, toxicological assessment report, product stability test report and hygiology examining report etc.
One, toxicological assessment report:
Sample source: being tried thing is provided by Wuhan Hong Sheng health products Co., Ltd.Green tablet.
Sample treatment: tried thing and after grinding, be added in the base material, make bulk and be for experiment by 1%, 5%, 10% different proportion.
1, acute toxicity testing:
Animal: Kunming mouse 18-20g, male and female half and half.
Give approach: tried thing and join in the feedstuff in 10% ratio and give
Method: take by weighing by 20% of body weight and to be tried thing+base material mixed fodder for animal edible, remember one day 24 hours in animal take in total amount, the preceding fasting 12h of test does not cut off the water supply.Observe a week, and record animal poisoning symptom and death condition.The results are shown in Table 1: table 1 pair acute toxicity test in mice number of animals dead animal is as a result counted in the body weight 24 hours intake and is tried the thing intake, (only), (only), (g) forage volume, (g) tried the thing amount, (g), (every kg body weight) 10 0 18.5 ± 1.0 2.4 ± 0.2 0.24 ± 0.02 12.8 ± 1.110 0 19.5 ± 1.0 2.8 ± 0.2 0.28 ± 0.02 14.2 ± 1.5
In 24 hours animal to take in and to be tried the thing total amount be 12.8-14.2g/kg, animal does not see obvious poisoning symptom and dead the generation in the week.Press the acute toxicity classification, this is tried the nontoxic level in the true border of thing.
2, micronucleus test:
Animal: Kunming mouse, 23-25g, male and female have concurrently.
Dosage grouping: be provided with and tried 1%, 5%, 10% 3 dosage group of thing and blank group and positive controls.
Experimental technique: quantitatively take by weighing by body weight 20% and to be tried the thing feedstuff, after allowing it freely take in 30 hours, put to death animal, get the bone marrow of sternum smear, every animal oil mirror is observed 1000 down and had a liking for and incarnadine cell, and the result is as follows: table 2 couple mouse microkernel test result is tried agent amount number of animals observation of cell number and micronucleus cell occurs and count the micronucleus formation rate
(%) (only) (individual) (individual) (‰) negative control group 0 10 10 * 1,000 22 2.2 experimental group 1.0 10 10 * 1,000 28 2.8
5.0 10 10×1000 25 2.5
10 10 10 * 1,000 24 2.4CP organize (mg/kg) 60 10 10 * 1,000 386 38.6
Conclusion: each experimental group and negative control group result compare, and difference does not have the apparent life of flying; It is negative to show that this is tried thing bone marrow micronucleus test result.
3, mouse sperm deformity test:
Animal: Male Kunming strain mice, 23-25g.
Experimental technique: the dosage same micronucleus test that divides into groups.Degree of being subjected to thing feedstuff continues to feed 30 days basic feedstuffs after five days more continuously, puts to death animal, gets both sides epididymis smear for microscopic examination.The results are shown in Table 3: table 3 pair mouse sperm deformity result of the test is tried agent amount number of animals observation sperm count teratospermia and is counted rate of teratosperm
(%) (only) (individual) (individual) (‰) negative control group 0 10 10 * 1,000 151 1.51 experimental group 1.0 10 10 * 1,000 178 1.78
5.0 10 10×1000 183 1.83
10 10 10 * 1,000 175 1.75CP organize (mg/kg) 60 10 10 * 1,000 424 4.24
Conclusion: each experimental group and negative control group result compare, and difference does not have significance, and it is negative to show that this is tried thing sperm malformation test result.
4, Salmonella reversion test:
Employing is tested through Salmonella typhimurium histidine defect type TA97, TA98, TA100, TA102 four strain bacterial strains that authenticator closes biological requirement; Adopt the inductive rat liver homogenate of Polychlorinated biphenyls (PCB) as external activation system (+S
9).Tried thing and be divided into three dosage groups, solid sample is diluted to variable concentrations after dissolving, and the every ware in sterilization back adds 0.5ml, and concentration is respectively 0.2,200,5000 μ g/ wares.Adopt flat board to mix three multiple parallel sample results of method record.
Table 4 Salmonella reversion test result
Return change clump count (individual) and tried the agent amount
(μ g/ ware)-S
9+ S
9
TA97 TA98 TA100 TA102 TA97TA98 TA100 TA102 is tried thing 0.2 121 36 183 205 135 36 173 235 from beaming back change 0 108 25 162 240 119 28 156 246
200?189 29 195 258 163 35 198 283
Annotate 5,000 163 32 198 256 145 43 183 256 positive control＞5000＞5,000 358 26 1660＞5000＞3,000 256 :-S
9Positive controls is 2,4,7-TNF
972, addition is 0.3 μ g/ ware
+ S
9Positive control is 2-AF, and addition is 10 μ g/ wares
5 30 days feeding trials:
5.1 animal: adopt 3 months aged Wistar rats, totally 80, male and female half and half, body weight 160-180 gram.Animal is provided by Hubei Province's medical experiment animal center.
5.2 neat amount and grouping: establish three neat amount groups and a matched group, every group of 20 animals, each 10 of male and female.Recommend 1111 times of daily intaking amount promptly 10% as high dose group by the crowd, divide into 5%, 1% be in, low dose group.Fed one month, and measured relevant index by test requirements document.
5.3 observation index
5.3.1 clinical examination: comprise general performance, behavior, poisoning and death condition.Food-intake and food utilization weekly.
5.3.2 blood test: measure haemachrome (Hb), red blood cell count(RBC), numeration of leukocyte and classification during off-test.
5.3.3 blood biochemistry checking: comprise glutamate pyruvate transaminase (ALT), serum urea ammonia (BUN).
5.3.4 internal organs are weighed and organ coefficient
5.3.5 histopathologic examination: all animals are carried out the gross anatomy inspection, and main organs such as the heart, liver,spleen,kidney, lung are carried out pathological examination.
5.4 result of the test:
5.4.1 clinical examination: in the test, animal is not found any poisoning symptom, and appetite, hair color are all normal.Body weight and food utilization the results are shown in Table 5: as seen from the table, various rat body weights and food utilization result difference do not have significance.Table 5 pair rat body weight and food utilization as a result the moving weight of dosage (g, food utilization (%) thing (only) of M ± SD) (%)
♀ matched group 10 162.4 ± 12.6 245.8 ± 26.6 83.4 13.7 ± 0.6 of increasing weight around the number initial weight the
1 10 157.9±21.1 239.3±23.6 81.4 13.4±0.8
5 10 160.1 ± 13.9 233.0 ± 27.8 72.9 13.2 ± 0.1 10 10 165.6 ± 10.1 241.0 ± 23.6 75.4 13.6 ± 0.3 ♂ control groups 10 168.6 ± 14.7 271.8 ± 34.8 113.2 18.4 ± 0.3 1 10 164.5 ± 13.7 284.5 ± 26.4 120.0 18.4 ± 0.2 5 10 162.4 ± 12.6 278.7 ± 35.1 116.3 17.8 ± 0.3 10 10 168.6 ± 14.7 271.8 ± 31.3 103.2 17.4 ± 0.2
There is not significance with the matched group comparing difference
5.4.2 hematological examination:Hb measures, RBC counts, the WBC count results sees Table 6:through check, Hb content, RBC counting, each group difference of WBC count results do not have significance. table 6 pair rat Hb content, the RBC counting, WBC counting affect (g/L) (* 1012/L) (* 109/L) control group 10 130.2 ± 3.8 7.16 ± 0.34 14.8 ± 1.60 1 10 136.5 ± 4.5 7.65 ± 0.46 16.4 ± 1.53 5 10 127.8 ± 5.6 6.90 ± 0.57 18.3 ± 1.4810 10 135.9 ± 3.8 7.59 ± 0.63 16.9 ± 1.08 of dosage number of animals Hb content RBC counting WBC counting (%) (only)
5.4.3 blood biochemistry checking: serum BUN, GPT assay see Table 7, do not have significance through checking each group difference.Table 7 couple rat BUN, ALT, AST influences dosage (%) number of animals (only) BUN (g/L) ALT (U/L) AST (U/L) matched group 10 19.6 ± 1.35 61.8 ± 5.3 226.8 ± 35.0 1% 10 18.3 ± 0.98 54.6 ± 11.8 234.6 ± 18.3 5% 10 21.9 ± 1.08 62.3 ± 9.5 215.6 ± 43.2 10% 10 20.8 ± 1.56 58.3 ± 4.8 223.6 ± 41.8
5.4.4 organ weights and coefficient: organ weights and coefficients such as liver,kidney,spleen the results are shown in Table 8; With matched group relatively, organ weights such as each dosage group rat liver,kidney,spleen and difference of coefficients do not have significance.Organ weights and moving liver kidney spleen (%) things (only) of coefficient results dosage such as table 8 pair rat liver,kidney,spleen
Number weight (g) coefficient (%) weight (g) coefficient (%) weight (g) coefficient (%) ♀ matched group 10 8.35 ± 1.08 3.4 ± 0.19 1.54 ± 0.29 0.62 ± 0.01 1.18 ± 0.11 0.48 ± 0.02
1 10 8.11±1.35 3.4±0.20 1.50±0.03 0.63±0.03 1.03±0.02 0.43±0.03
5 10 8.08 ± 0.95 3.5 ± 0.18 1.51 ± 0.08 0.65 ± 0.01 1.05 ± 0.05 0.45 ± 0.01 10 10 8.28 ± 1.18 3.4 ± 0.23 1.52 ± 1.03 0.63 ± 0.04 1.08 ± 0.03 0.45 ± 0.02 ♀ matched groups 10 11.8 ± 1.45 4.2 ± 0.08 1.89 ± 0.08 0.67 ± 0.03 1.31 ± 0.04 0.46 ± 0.01
1 10 12.1±1.13 4.3±0.18 1.96±0.09 0.69±0.05 1.35±0.02 0.47±0.01
5 10 11.3±1.15 4.1±0.13 1.83±0.05 0.64±0.03 1.29±0.03 0.46±0.02 10 10 10.9±1.63 3.9±0.12 1.80±0.03 0.66±0.02 1.28±0.02 0.47±0.01
Compare * P＜0.05 with matched group
5.4.5 the result of histopathologic examination: to respectively tried thing group and matched group partly the internal organs such as the heart, liver, lung, spleen, kidney of animal carried out histopathologic slide's observation, no abnormality seen pathology pathological changes.
6, tertogenicity test
6.1 animal: adopt the Wistar rat, female Mus 250-270 gram, male Mus 300 grams, each 48.Animal is provided by Hubei Province's medical experiment animal center.
6.2 dosage grouping: the blank group is set and is tried basic, normal, high three the dosage groups of thing; Tried the basic, normal, high dosage group of thing and join nutrition purposes, especially for feeding animals in the base material with 1%, 5%, 10% the thing that tried respectively, the blank group is fed normal diet.
2.3 method: animal with the cage copulation, is found sperm as become pregnant zero day to find cloudy bolt or vaginal smear with male and female 1: 1.Obtain 38 of pregnant Mus, 9 of matched groups; Basic, normal, high dosage group is respectively 9,10,11.Began to be tried thing at the 1st day that becomes pregnant, when being checked through pregnant Mus vagina on the 20th day courageous and upright secretions being arranged, sacrificed by decapitation animal immediately, check pregnant Mus and tire Mus situation, record: uterus weight, corpus luteum number, absorb tire, stillborn fetus number, the tire number of living; Tire Mus body weight, health, tail are long; And check that one by one the tire Mus has or not deformity, if any anencephaly bulging, exencephalia, microcephaly, microtia, ommatidium, chapped lip, manomelia and limb, many limbs, no limb; It is unusual to check skeleton at last every nest 1/2 tire Mus to be made bone specimen, 1/2 puts and fixedly makes the internal organs pathologic finding in the Bouins liquid in addition.
6.4 result: see Table 9,10,11
With matched group relatively, tried that thing is respectively organized pregnancy rate, average tire Mus is counted indifference; Tire Mus outward appearance is not seen deformity; Tried thing and respectively organize tire Mus body weight, height, tail length and matched group relatively, difference does not have significance; Compare with matched group, the sagittal suture of each experimental group and the width of bregma all belong to normally, all no abnormal discovery of skull, breastbone, rib, spinal column and internal organs inspection.According to the above: each experimental group does not exert an influence no teratogenesis to the tire Mus growth promoter of rat.The pregnant Mus of dosage copulation number that influences of table 9 pair rat breeding is counted the average tire number of pregnancy rate tire Mus number stillborn fetus number and absorbs (%) (only) (/) (only) (only) matched group 12 9 75 51 5.63 03 of tire (%) (only) (only)
1 12 9 75 53 5.89 0 0
5 12 10 83 68 6.8 0 1 10 12 10 83 64 6.4 0 4： 10 （ M±SD ） （ ％ ） （ ） （ g ） （ cm ） （ cm ） 51 2.948±0.236 3.108±0.238 1.436±0.108 1 53 2.983±0.315 3.068±0.235 1.445±0.115 5 68 2.846±0.513 3.042±0.432 1.421±0.110 10 64 3.056±0.315 3.084±0.364 1.400±0.10311 （ ％ ） （ ／ ） （ ， ） 5／20 0.24。
1 7/25 0.23
5 7,/30 0.21 10 9,/35 0.22 annotate: the sagittal suture width is all belonging to normal result and judgement (Results and Evaluation) below 1.0 millimeters
Medicinal granule with anti-senility function takes in to 24 hours per os of the Kunming mouse of two kinds of sexes that to be tried the thing total amount be 12.8-14.2g/kg, does not find poisoning symptom and death condition, press the acute toxicity classification, and this is tried the nontoxic grade of class material in the true border of thing.The result is all negative for three mutagenicity tests (PCEMNR micronucleus test, mouse sperm deformity experiment, Salmonella reversion test).Feeding trial showed in 30 days: this is tried thing 1%, 5%, 10% dosage, and rat blood, biochemistry, internal organs histopathology are not had obvious influence.Tertogenicity test is the result show: this is tried thing does not have teratogenesis to rat.
Two, health care appraisal report:
1, sample treatment: medicinal granule with anti-senility function is crossed 80 mesh sieves after grinding, fruit offerings fly survival assay is used.During zoopery, tried thing and joined in the base material, made block nutrition purposes, especially for feeding animals in different ratios.
2, drosophila survival experiment:
Laboratory animal: Drosophila melanogaster (drosophila melanogaster).
Method for breeding: adopt flat cultivation vial to cultivate, 25 of every pipes are put 25 ℃, and relative humidity is in 65% the dark incubator, change a subculture in four days.The basal medium prescription is as follows:
Component corn part brown sugar agar benzoic acid dried yeast powder hydration meter content (%) 10 13.5 1.5 0.15 1 73.85 100
Dosage: establish 1 blank group and tried thing 0.2%, 1%, 5%3 dosage groups.
Experimental technique: collect the virgin fly that hatches in the 10h, with the grouping of weighing behind the etherization, male and female are divided and are supported, and each 100 of every group of female male drosophilas mix the basal medium that is tried thing, and every 24h adds up survival number and the death toll of fruit bat, until whole death.
The result: see Table 1, as seen from Table 1,0.2%, 1.0%, 5.0% dosage group can obviously prolong the average life of female fruit bat, and 1.0%, 5.0%, the dosage group can obviously prolong the average life of male fruit bat; 0.2% dosage group can obviously prolong the maximum life span of male fruit bat, and 5.0% dosage group can obviously prolong the maximum life span of male fruit bat, with the matched group comparing difference significance (P＜0.05) is arranged.What table 1 pair fruit was restricted survival assay influences group sample number average weight (ug) T
50(d) average life (d) maximum life span (d) ♀ contrasts 100 883 45 47.6 ± 13.6 74.5 ± 3.1
0.2％ 100 892 61 62.9±11.4* 78.6±5.34*
1.0％ 100 846 60 60.6±9.26* 74.5±2.88
5.0% 100 873 65 53.4 ± 9.53*, 69.7 ± 5.03 ♂ contrast 100 736 49 50.8 ± 12.9 74.5 ± 13.4
0.2％ 100 724 50 52.2±10.8 70.1±5.1
1.0％ 100 732 60 61.3±11.5* 80.2±3.6
5.0% 100 740 65 65.2 ± 12.7*, 84.3 ± 1.42** represents relatively to annotate P＜0.05 with matched group: T
50The expression half death time
3, biochemical indicator detects
Animal: 16 monthly age Kunming mouses, totally 40,3 the monthly age 10 of mices.
Hubei Province's medical experiment animal center provides.
Grouping: the human body that provides according to manufacturer is recommended daily intaking amount 0.09/kg.d, enlarges 10,20,30 times respectively, promptly 0.9,1.8,2.7g/kg.d, and as being tried the basic, normal, high dosage group of thing dosage.Tried thing and join in the feedstuff for animal edible, the animal food-intake is calculated by 10% of body weight, other establish aged matched group and few age matched group, replace with normal diet; Tried thing continuously one month; Take a blood sample, put to death animal then and make the mensuration of serum, liver lipid peroxide (LPO) content and liver superoxide dismutase (SOD) vigor.
Experiment method:
When experiment finishes, get the tail blood system, measure activity of SOD in serum, LPO content from serum; Put to death animal then, get liver, the liver homogenate of preparation 1% is made the SOD vitality test.SOD measures and adopts nitrite method, LPO to measure the conjugated double bond method (test kit builds up bio-engineering corporation available from Nanjing) that adopts.
The result: see Table 2. with the basic, normal, high dosage group of matched group comparison medicinal granule with anti-senility function can obviously reduce serum and 10% liver homogenate LPO content (P＜0.01); Basic, normal, high dosage group can obviously raise serum and 1% liver homogenate SOD activity (P＜0.01).The influence of table 2. pair aged mouse liver and SOD in serum, LPO
Moving LPO (few age (g/kg) counts the aged contrast of serum 10% LH serum 1% LH 10 41.3 ± 4.7 262.5 ± 37.3 173.6 ± 61.0 259.4 ± 58.8 0.9 10 27.8 ± 4.6*, 154.3 ± 24.2*, 338.8 ± 49.8* 436.5 ± 54.4* 1.8 10 28.3 ± 4.5* 183.4 ± 31.3* 372.5 ± 41.8* 399.3 ± 35.7* 2.7 10 29.6 ± 4.0* 162.7 ± 33.3*, 260.1 ± 53.9 383.3 ± 49.1* and contrasts 10 28.2 ± 4.0 149.3 ± 41.4 364.7 ± 61.0 461.6 ± 50.0 by nmol.MDA/ml SOD (NU/mL) dosage thing (only)
With relatively * P＜0.01 result and the judgement (Results and Evaluation) of aged matched group
The slow down aging result of the test shows: the middle and high dosage group of medicinal granule with anti-senility function (1) can prolong the average life of fruit bat, and low dose group can prolong the maximum life span of female fruit bat, and high dose group can prolong the maximum life span of male fruit bat; (2) recommend 10,20,30 times of daily intaking amount (4.5g/50kg) to be equivalent to human body that manufacturer provides, promptly 0.9,1.8,2.7g/kg, respectively as being tried the basic, normal, high dosage group of thing.Basic, normal, high dosage group can obviously reduce serum and 10% liver homogenate LPO content; Basic, normal, high dosage group can obviously raise serum, 1% liver homogenate SOD vigor.According to delaying senility function assessment process regulation, this is tried thing delaying senility function.
Three, product stability test report:
Four, hygiology examining report: assay:
970,310 970,315 970320 moisture (%), 3.04 3.02 3.02 protein (%), 5.54 5.65 5.55 arsenic (mg/Kg, in As)＜0.3＜0.3＜0.3 lead (mg/Kg, in Pb)＜0.5＜0.5＜0.5 hydrargyrum (mg/Kg is in Hg)＜0.3＜0.3＜0.3 total number of bacteria (individual/g)＜10＜10＜10 coliform (individual/100g)＜30＜30＜30 pathogenic bacterium do not detect mycete (individual/g)＜10＜10＜10 yeast (individual/g)＜10＜10＜10
Claims (1)
- A kind of medicinal granule with anti-senility function is made up of 12 flavor Chinese medicines, and white sugar accounts for 7.1% in the described granule of per unit, and Pulvis Talci accounts for 2.0% and contain micro-food coloring and paraffin, and it is characterized in that: in the described medicinal granule with anti-senility function of per unit, its formulation ratio is as follows:Radix Rehmanniae Preparata 15.3% Fructus Lycii 8.1%Radix Glehniae 8.1% Semen Platycladi 6.1%8.1% Radix Ophiopogonis 6.1% of Radix Angelicae SinensisFructus Mori 8.0% Fructus Ligustri Lucidi 6.1%Carapax Trionycis 7.6% Radix Panacis Quinquefolii 2.2%Semen Cuscutae 7.6% Rhizoma Dioscoreae 7.6%
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| CN1098291A (en) * | 1993-07-31 | 1995-02-08 | 四川省中药研究所 | The anti-senility Chinese patent medicine |
| CN1053352C (en) * | 1994-04-22 | 2000-06-14 | 杜凯 | Marrow oral liquor |
| CN1056985C (en) * | 1994-08-16 | 2000-10-04 | 张一宇 | Health Chinese medicine Massa Medicata fermentata oral liquid and its preparing method |
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