CN1239181C - Chinese patent medicine for treating apoplexy - Google Patents

Abstract

The present invention relates to a Chinese patent medicine for treating apoplexy, which is prepared by using raw materials of astragalus root, leech, chuanxiong rhizome, angelica, safflower, peach kernel, paeony, etc. as a basic prescription through a scientific processing according to the principle of pattern identification as the basis for determining treatment of radically reform and simultaneous treatment of the manifestations and the root causes of diseases of China medicine. The Chinese patent medicine has the functions of benefiting qi, promoting blood circulation, dispersing blood clots and dredging the meridians. The Chinese patent medicine is used for treating hemiplegia, limb numbness, facial distortion and stiff tongue, impeded speech and other symptoms caused by apoplexyand in clinics with excellent effects.

Description

A kind of Chinese patent medicine that is used for the treatment of apoplexy

Content of the present invention belongs to the preparing technical field of pharmaceuticals, relates to a kind of Chinese patent medicine that can be used for treating apoplexy (being cerebral hemorrhage, cerebral thrombosis, cerebral embolism of Western medicine diagnose etc.).

The apoplexy of Chinese medicine definition belongs to cerebrovascular disease, how under energy and blood of human body interior-deficiency situation, or, show as unexpected confused servant, hemiplegia, facial hemiparalysis, in silence or symptom such as stuttering puckery, the hemianesthesia of speech because of the overstrain internal injury or because of being worried angry or bringing out because of having a liking for food savoury and tobacco and wine etc.Morbidity is anxious, the state of an illness heavy because apoplexy has, it is fast to change, can repeatedly fall ill and characteristics such as case fatality rate height, particularly old people healthy of human body health in serious harm, bring very white elephant per capita to society, family and patient are individual, thereby this class disease also is the heat subject that medical circle is concentrated concern and research in recent years always.

At present, doctor trained in Western medicine clinical treatment cerebrovascular disease mainly is the therapeutic alliance that relies on multiple medicine, as adopt vasodilation, depressor etc., though curative effect is very fast, but human body all there are the untoward reaction and the side effect of certain degree, and its emphasis is the acute stage at disease, for patient after acute stage recovery and the treatment of sequela also lack safe and effective medicine; And the traditional Chinese medical science is treated the medicine of apoplexy and thoracic obstruction class at present generally based on benefiting QI for activating blood circulation class medicine, as ZHONGFENG HUICHUN WAN etc., but in clinical practice, also still exist medication not comprehensively, problem such as curative effect is unstable and cure rate is low.

The objective of the invention is at the existing defective of state of the art, by excavating the pure Chinese medicinal preparation that is exclusively used in the treatment apoplexy that the abundant Chinese medicine resource of motherland provides a kind of prescription science, curative effect height and human body is had no side effect.

The preparation scheme of medicine of the present invention is that the designer obtains by concentrated summary development to the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs thought of apoplexy and on modern medicine pharmaceutical test basis according to motherland's traditional medicine.Apoplexy often betided after the middle age, mainly was because come to one's autumn, kidney Qi deficiency, and YANG QI deficiency, sun declines then that gas goes, then diseases that suffer stroke more." ancient Chinese medical classics traces back to whirl and concentrates wind to distinguish " said: " the non-external ailment said due to cold or exposure of apoplexy person, be this gas from disease also.Ordinary person over four ten days, when the weakness of QI, or because of melancholy happiness anger, hinders its gas person, and this disease is arranged more." so the blood pertaining to YIN master is quiet, blood can not depend on the promotion of gas voluntarily, and as deficiency of kidney-QI, a little less than the decline of YANG QI, the deficiency of vital energy can not be transported blood, the gas unable to walk, blood can not be flourish, stagnation of QI-blood, venation resistance numbness, muscle arteries and veins muscle loses in moistening to support and hemiplegia, facial hemiparalysis then occur.Blood stagnancy due to deficiency of QI, not smooth through the operation of feeling pulse blood, this mistake of tongue is supported, so speech is stuttering puckery, very then in silence, slobbering.The retardance of deficiency of vital energy damp, brothers' swelling, diarrhea with loose stool.And complexion is white all of a sudden, shortness of breath and fatigue, white and thin fur, dimly pale tongue, purplish tongue, deep-thready pulse etc. are the hold concurrently opinion disease of blood stasis of the deficiency of vital energy.The appearance of comprehensive above-mentioned assertive evidence is owing to the deficiency of vital energy and the hyperamization stasis of blood, and the rule of treatment is when being benefiting QI for activating blood circulation.According to understanding to above-mentioned etiology and pathogenesis, designer of the present invention chooses some drug effects and concentrates and be easy to and prepare patent medicine for the raw material of Chinese medicine prescription that human vas absorbs, medicine in the side is by comprising the Radix Astragali, Hirudo, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Semen Persicae, Radix Paeoniae Rubra, the Radix Aucklandiae, Rhizoma Acori Graminei, Pheretima, Herba Taxilli, Radix Et Caulis Acanthopanacis Senticosi is formed at interior meter 12 herbal medicines, full side has inrigorating qi and promoting blood circulation, the effect of removing blood stasis collateral dredging, aspect the treatment of apoplexy, particularly aspect the treatment of this disease convalescent period and sequela stage, has fabulous effect, the blood stasis due to qi deficiency syndrome is fundamentally improved, thereby significantly reduced or eliminate of the threat of this disease health of people.

The proportioning value that constitutes each raw material components of Chinese patent medicine of the present invention is: 40～1000 unit of weights of the Radix Astragali, 10～500 unit of weights of Hirudo, 10～450 unit of weights of Rhizoma Chuanxiong, 9～500 unit of weights of Radix Angelicae Sinensis, 45～400 unit of weights of Flos Carthami, 20～600 unit of weights of Semen Persicae, 50～300 unit of weights of Radix Paeoniae Rubra, 30～300 unit of weights of the Radix Aucklandiae, 20～400 unit of weights of Rhizoma Acori Graminei, 10～600 unit of weights of Pheretima, 20～500 unit of weights of Herba Taxilli, 7～500 unit of weights of Radix Et Caulis Acanthopanacis Senticosi extractum.

The prescription of making according to above-mentioned raw materials has demonstrated fully the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of motherland's medical science about " radicallying reform ", " treating both the principal and the secondary aspects of a disease at the same time ".Be monarch drug with the Radix Astragali, Hirudo in the side, Radix Astragali sweet in the mouth tepor wherein, kind can tonifying Qi and lifting yang, " Japan hanako materia medica " more says " Radix Astragali helps the gas strengthening bone and muscle, puts on flesh and enriches blood "." herbal classic is met former " claims it again, and " though the property temperature compensation and can be led to blood circulation regulating, popular meridians stagnate also can hinder in stopping up." make healthy energy vigorous, then limbs are able to replenishing vital QI with drugs of warm nature, and its motion is from can be strong, and the primary disease deficiency of vital energy be this, and blood stasis is for marking, so reuse the Radix Astragali with invigorating primordial QI; Hirudo is distinguished the flavor of into cold in nature, is good at dissipating blood stasis to promote menstruationg, the Shennong's Herbal cloud: " the Hirudo master by stagnant blood, blood stasis, month close, the removing blood stasis abdominal mass gathers loss of fecundity, dredging water passages." " book on Chinese herbal medicine through kind of a record " meaning again: " and Hirudo is liked anthropophagy's blood most, and property slow be apt to into, slow then hemopoietic is not hindered, and is apt to into then hard long-pending easily broken, borrows its power to stagnate so that merit is long-pending for a long time, from strong and harmless also." above the two compatibility, Radix Astragali QI invigorating is to effect a permanent cure, and the Hirudo removing blood stasis can be received the merit for the treatment of both the principal and the secondary aspects of a disease at the same time to take stopgap measures.

In the side with Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Chuanxiong, when being classified as ministerial drug, this five medicine is all the product of blood circulation promoting and blood stasis dispelling, to help the power of Hirudo eliminating blood stasis and inducing menstruation.Wherein, Semen Persicae sweet-bitter flavor slightly warm in nature can promoting blood circulation and breaking stagnation and moisturize " medicine justice " cloud: Semen Persicae " main broken blood-retention, water month by month, and just body pain, extremity wood numbness, left hemiplegia "; The Flos Carthami acrid in the mouth is warm in nature, energy promoting blood circulation to restore menstrual flow eliminating stagnation, and " book on Chinese herbal medicine is dredged warp " cloud: " Flos Carthami is the key medicine of promoting the circulation of blood ... go into the heart and go into liver, makes stagnant blood descending." Radix Paeoniae Rubra bitter in the mouth slightly warm in nature, can eliminating stasis to stop pain, the removing heat from blood detumescence, " Mingyi Bielu " cloud its " clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder intestine and small intestine "; Rhizoma Chuanxiong acrid in the mouth tepor for gas medicine in the blood, is not only invigorated blood circulation, but and circulation of qi promoting, " book on Chinese herbal medicine is just " cloud: " its property of Rhizoma Chuanxiong is kind looses, and walks Liver Channel again ... removing blood stasis with potent drugs holds, promoting blood circulation, separate stagnation of QI, by pain, arrange dense detumescence, by the blood dysmenorrhea." the hot slightly warm in nature of Radix Angelicae Sinensis sweet in the mouth, can enrich blood invigorate blood circulation, menstruction regulating and pain relieving, " book on Chinese herbal medicine just " claim its " invigorating middle warmer has, in the row benefit is arranged, the sincere gas medicine in the blood, also the panacea in the blood is also." this product and drug for invigorating blood circulation and eliminating stasis mutually 5, can invigorate blood circulation and blood trouble not, share with the benefiting qi and nourishing blood medicine, can enrich blood and do not stay the stasis of blood, and the wonderful of promoting tissue regeneration by removing blood stasis arranged.

Fang Zhongzuo gets its invigorating the liver and kidney, strengthening bone and muscle with Radix Et Caulis Acanthopanacis Senticosi, Herba Taxilli, and is soft to control the muscles and bones flaccidity." book on Chinese herbal medicine is looked for the truth " cloud: " Herba Taxilli is that kidney tonifying and enriching blood is wanted agent, and the edge kidney governing bones sends out blood main, and hardship is gone into kidney, and kidney must mend that then muscles and bones is strong, unlikely flaccidity syndrome and arthralgia syndrome and ache "." Mingyi Bielu " claims slender acanthopanax can control " a little less than the bipod arthralgia aggravated by cold wind, five slow void are won, and the invigorating middle warmer benefit is smart, hard muscles and bones, Qiang Zhiyi ".Help again with Rhizoma Acori Graminei, get its eliminating turbid pathogen with aromatics and have one's ideas straightened out, to control that stiff tongue is felt embarrassed to mention or forgetful in a trance, " Chongqing hall random notes " cloud: " the comfortable gas of Rhizoma Acori Graminei, the smooth mind, happy mood, beneficial will, panacea also.Removing summer-heat medicinal it, so as to a surname's knot of thought and being proficient in the law of natural movement." help again with Pheretima with dredge the meridian passage, the Radix Aucklandiae is with regulating the flow of QI to alleviate depression, this two all can help blood circulation promoting medicine to stagnate with promoting the circulation of blood.

All medicines share in the full side, can play the merit of inrigorating qi and promoting blood circulation, removing blood stasis collateral dredging altogether, are applicable to diseases such as hemiplegia due to the blood stasis due to qi deficiency, facial hemiparalysis, aphasia.

Actual product of the present invention is the various form of Chinese drug made from the conventional preparation technology of Chinese medicine that comprise capsule, tablet, granule etc.

Clinical observation and curative effect

In development process of the present invention, for this medicine of objective evaluation to the clinical efficacy of apoplexy and to the safety of human body, the applicant once according to Ministry of Public Health bureau of drug policy ﹠ administration defend nineteen ninety-five medicine examine in No. 060 official written reply spirit of word carry out the II clinical trial phase, during clinical treatment and observe case 300 examples altogether.

One, include the case standard in: meet diagnostic criteria of traditional Chinese medical science apoplexy and the diagnostic criteria of doctor trained in Western medicine cerebral thrombosis, Chinese medical discrimination belongs to apoplex involving the channels and collaterals, blood stasis due to qi deficiency disease, the Western medicine diagnose cerebral thrombosis recovery phase, and patient age is between 40～71 years old.

Two, medicining mode: oral this Chinese patent medicine capsule, every day 3 times, day dose 5～7g is a course of treatment all around.

Three, observation index: apoplexy integration method

1, mind state: conscious 0 minute

Staring spells (drowsy, wake up after can and people's words) 1 minute

The mind mist (drowsiness, exhale answer imprecise) 2 minutes

Coma 3 minutes

Muddle-headed (coma has concurrently simultaneously and takes off disease) 4 minutes

2, language performance: normal 0 minute

General express, name can not 1 minute

Form a complete sentence in a minute and expressed incomplete 2 minutes

Not talkative word, phrase 3 minutes

Language can not or substantially can not 4 minutes

3, upper limb shoulder joint: normal 0 minute

Normal but the muscular strength of last act differed from 1 fen

Last act is put down shoulder or is skipped over shoulder 2 minutes

Last act is less than takeing on 3 fens

Slightly swung 4 fens inactive or front and back

4, upper limb articulations digitorum manus: normal 0 minute

Action is effectively and muscular strength differed from 1 fen respectively for finger

Clench fist to stretch and refer to 2 fens

Count on one's fingers, can not hold fist, can not stretch 3 fens

Can not move 4 fens

5, lower limb hip joint: normal 0 minute

Raised more than 45 ° 1 fen

45 ° of less thaies 2 minutes

Swing energy translation 3 minutes

Inactive 4 minutes

6, lower limb toe joint: normal 0 minute

Stretch and bend freely but weak 1 minute of power

Stretch and bent incomplete 2 minutes

Slightly moving 3 minutes

Inactive 4 minutes

7, integration capability: life can be taken care of oneself, open 0 minute

Live on one's own life, simple work and partial function is arranged incomplete 1 minute

Can walk, partial self-help, auxiliary 2 minutes of the people that still needs

Can stand and take a step, need the people to take care of at any time 3 fens

Liied in bed 4 fens

Four, efficacy assessment standard: full marks are 28 minutes before treating, and starting point is divided minimum being not less than 12 fens, and its efficacy evaluation adopts the nimodipine method:

N 〉=85% is almost recovered;

Produce effects: n 〉=50%;

Effectively: n 〉=20%;

Invalid: n＜20%.

Five, therapeutic outcome: experimental observation group 300 routine cases are after taking this Drug therapy, and total effective rate is 92%, and cure-remarkable-effectiveness rate is 53%, in the process of the test, do not find that this medicine has obvious adverse reaction.

Claims (2)

1, a kind of Chinese patent medicine that is used for the treatment of apoplexy, it is characterized in that: each raw material components and the proportioning value that constitute this medicine are: 40～1000 unit of weights of the Radix Astragali, 10～500 unit of weights of Hirudo, 10～450 unit of weights of Rhizoma Chuanxiong, 9～500 unit of weights of Radix Angelicae Sinensis, 45～400 unit of weights of Flos Carthami, 20～600 unit of weights of Semen Persicae, 50～300 unit of weights of Radix Paeoniae Rubra, 30～300 unit of weights of the Radix Aucklandiae, 20～400 unit of weights of Rhizoma Acori Graminei, 10～600 unit of weights of Pheretima, 20～500 unit of weights of Herba Taxilli, 7～500 unit of weights of Radix Et Caulis Acanthopanacis Senticosi extractum, wherein: the Radix Astragali, Hirudo is a monarch drug, Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Chuanxiong, when being classified as ministerial drug, Radix Et Caulis Acanthopanacis Senticosi extractum, Herba Taxilli, Rhizoma Acori Graminei, Pheretima, the Radix Aucklandiae is an adjuvant drug.

2, the Chinese patent medicine of treatment apoplexy according to claim 1 is characterized in that: described Chinese patent medicine is the various extract oral dosage forms made from the conventional preparation technology of Chinese medicine that comprise capsule, tablet, granule etc.