CN105232942A - Traditional Chinese medicine compound treating generalized dystonia - Google Patents
Traditional Chinese medicine compound treating generalized dystonia Download PDFInfo
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- CN105232942A CN105232942A CN201510821520.3A CN201510821520A CN105232942A CN 105232942 A CN105232942 A CN 105232942A CN 201510821520 A CN201510821520 A CN 201510821520A CN 105232942 A CN105232942 A CN 105232942A
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Abstract
The invention provides a traditional Chinese medicine compound treating generalized dystonia. The compound is prepared from, by weight, 10-15 parts of astragalus, 6-12 parts of radix codonopsis, 4-8 parts of cinnamon, 6-9 parts of radix rehmanniae preparata, 3-9 parts of dogwood fruit pulp, 6-9 parts of radix ophiopogonis, 3-8 parts of wolfberries, 3-6 parts of fructus schizandrae, 5-10 parts of dried tangerine peel, 5-10 parts of angelica sinensis, 5-10 parts of rhizoma chuanxiong, 5-10 parts of divaricate saposhnikovia roots, 3-9 parts of tortoise plastron glue and 3-9 parts of notopterygium roots. The healing rate is 22%, the effective rate is over 82%, compared with a treatment method used clinically at present, the compound has the advantages of being remarkable in treatment effect, free of side effects and high in safety, the use effect is more outstanding on patients in the early stage of diseases, and the aims of attenuating symptoms, reducing lesions and achieving complete healing can be achieved after the compound is taken for a long time.
Description
Technical field
The invention belongs to tcm field, especially relate to one and treat the dystonic Chinese medicine composition of general.
Background technology
Myodystonia is a kind of disease pedigree covering numerous disease, and be the third-largest dyskinetic disorder be positioned at after parkinson disease, essential tremor, inherited genetic factors is played an important role in the generation of this disease.At present, combining closely of basic and clinic studies makes dystonic diagnosis bring up to genetics and molecular level.But it is worthy of note, for clinicist, first should based on the symptomatology of disease, from symptomatology set off in search diagnosis break-through point, this is only the key of myodystonia Clinics and Practices.
Dystonic syndrome (dystonicsyndrome) is called for short myodystonia (dystonia), that agonist and Antagonistic muscle shrink inharmonious or excess shrinkage, the dyskinetic syndrome that to cause with dystonia action and posture be feature, has not autonomy and persistence feature.The change of muscular tension is not noticeable, and interestingly abnormal position posture and involuntary conversion action.Myodystonia can affect the proper motion amplitude of affected limbs, scope, speed and flesh meat toughness etc.
A kind of extrapyramidal system illness that myodystonia is unique or mainly the involuntary movement of slow with the near-end muscle of neck, trunk and extremity, lasting, strong torsion sample is performance.Myodystonia can be divided into general, focal or segmental.Doctor trained in Western medicine controls except with except medicine dystonic symptom at present, can also install divergence type brain pacemaker, but be all control disease from symptom, does not fundamentally eliminate morbidity stove.
The traditional Chinese medical science thinks that myodystonia is: deficiency of both QI and blood, attacks outside cold-evil; Depending on attacking the difference at muscle arteries and veins position outside its cold-evil, can occur that stiffness of the neck, opisthotonus, arm foot is tetanic, refer to toe flexing, spasm of the limbs joint stuffiness etc.Thermal burn essence and blood, muscle arteries and veins loses and moistens: occur limbs contracture after calentura, person's back opisthotonos, joint stuffiness, very then moving difficulty, and body is won thin.Hemorrhagic disorder and consumption of essence, muscle arteries and veins loses supports: natural endowment is not enough, and Liver and kidney essence and blood element loses, and light red tongue tongue is few, thready and weak pulse.The traditional Chinese medical science, on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adds differential diagnosis of diseases medication, has certain curative effect for mitigation symptoms.Treatment disease for dystonic syndrome invades people's sun passages through which vital energy circulates by the heresy of wind and cold, does not relax through gas, and retardance body fluid runs, caused by the mistake of muscle arteries and veins is supported.Control should expelling wind and cold, expelling pathogenic factors from muscles is eliminating evil, promote the production of body fluid Shu Mai, side's GEGEN TANG (including peony and licorice decoction), strengthens the dosage of Radix Puerariae, the Radix Paeoniae Alba, Radix Glycyrrhizae, therefore named heavy prescription GEGEN TANG in former side.With Ramulus Cinnamomi, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae harmonizing yingfen and weifen in side; Herba Ephedrae giving diaphoresis to expel pathogen; Take Radix Puerariae as principal agent with its " sweet in the mouth is pungent coolly can be played cloudy gas and rise body fluid, grows muscle arteries and veins and its traction of relaxing "
Still comparatively common with Western medicine for the treatment of this disease at present, but side effect is comparatively large, and patient compliance is poor, and Chinese medicine takes effect slowly, and the cycle of taking is long.
Summary of the invention
For the defect of prior art, the object of this invention is to provide a kind ofly to fill blood, essence and blood of living, strong Liver and kidney can treat the dystonic Chinese medicine composition of general, long-term taking can reach mitigation symptoms, reduces the curative effect of focus.
Specifically, technical scheme of the present invention is:
One treats the dystonic Chinese medicine composition of general, and the active component contained has the Radix Astragali, Radix Codonopsis, Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Corni, Radix Ophiopogonis, Fructus Lycii, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Rhizoma Et Radix Notopterygii.
Invention further provides one and treat the dystonic Chinese medicine composition of general, comprise by weight composition:
Radix Astragali 10-15 part, Radix Codonopsis 6-12 part, Cortex Cinnamomi 4-8 part, Radix Rehmanniae Preparata 6-9 part, Fructus Corni 3-9 part, Radix Ophiopogonis 6-9 part, Fructus Lycii 3-8 part, Fructus Schisandrae Chinensis 3-6 part, Pericarpium Citri Reticulatae 5-10 part, Radix Angelicae Sinensis 5-10 part, Rhizoma Chuanxiong 5-10 part, Radix Saposhnikoviae 5-10 part, Colla Plastri Testudinis 3-9 part, Rhizoma Et Radix Notopterygii 3-9 part.
Preferably, the weight ratio of above each composition is:
The Radix Astragali 12 parts, Radix Codonopsis 6 parts, Cortex Cinnamomi 6 parts, 8 parts, Radix Rehmanniae Preparata, Fructus Corni 6 parts, Radix Ophiopogonis 8 parts, Fructus Lycii 6 parts, Fructus Schisandrae Chinensis 5 parts, Pericarpium Citri Reticulatae 6 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Chuanxiong 6 parts, Radix Saposhnikoviae 6 parts, Colla Plastri Testudinis 6 parts, Rhizoma Et Radix Notopterygii 5 parts.
A kind of dystonic Chinese medicine composition of general for the treatment of of the present invention is preparing the application in treatment general dystonic syndrome medicine, and raw material above-mentioned during application all selects conventional medicine selection.
One of the present invention is treated the dystonic Chinese medicine composition of general and is being prepared into decoction, granule, and other pharmaceutically acceptable dosage forms.Be preferably decoction.
One treats the dystonic Chinese medicine composition of general, prepares the method for decoction:
(1) be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 3-4cm, soaked 1-2 hour;
(2) big fire decocts to after boiling, and slow fire decocts 40-60 minute, collecting by filtration medicinal liquid;
(3) adding distil water is to not having powder 3-4cm again, and big fire is to after boiling, and slow fire decocts 20-40 clock, collecting by filtration medicine;
(4) merged by the medicinal liquid of twice collection, be divided into two parts, every day respectively takes portion sooner or later.
Carry out preferably above-mentioned preparation method, result is as follows:
(1) be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 4.5cm, soaked 1.5 hours;
(2) big fire decocts to after boiling, and slow fire decocts 50 minutes, collecting by filtration medicinal liquid;
(3) adding distil water is to not having powder 3.5cm again, and big fire is to after boiling, and slow fire decocts 30 minutes, collecting by filtration medicinal liquid
(4) merged by the medicinal liquid of twice collection, be divided into two parts, every day respectively takes portion sooner or later.
The pharmacological action of Chinese medicine involved in the present invention:
The Radix Astragali has the effect of strengthening QI of middle-JIAO, treatment the deficiency of vital energy weak, there is no the cureless diseases such as appetite, spontaneous sweating, hemiplegia, Radix Codonopsis, nature and flavor are sweet, flat, spleen reinforcing lung qi, enrich blood, and promote the production of body fluid, and the invigorating the spleen and replenishing QI function of the Radix Astragali strengthened by Radix Codonopsis.Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Radix Rehmanniae Preparata, sweet, tepor, yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Fructus Corni, liver and kidney tonifying, essence astringing and desertion stemming.Radix Ophiopogonis, Fructus Lycii nourishing the liver and kidney, replenishing essence is nourished blood.Fructus Schisandrae Chinensis tranquilizing by nourishing the heart, reinforcing the kindey to control nocturnal emission.Colla Plastri Testudinis nourishing YIN for benefiting the kidney, reinforcing the heart of nourishing blood.Radix Angelicae Sinensis, sweet, acrid, warm, blood regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.Rhizoma Chuanxiong, blood circulation promoting and enriching.Radix Saposhnikoviae, pungent, sweet, micro-Warm, expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Rhizoma Et Radix Notopterygii, dispeiling pathogenic wind and removing dampness, dispels the wind syndrome caused by deficiency of Liver and kidney.Under Pericarpium Citri Reticulatae in controlled atmosphere.
The advantage that the present invention has and good effect are:
Due to Therapeutic Method dialectical in Chinese medicine, word is with filling blood and the medicine of strong Liver and kidney, and combined therapy, is applicable to because of deficiency of both QI and blood, attacks, the general myodystonia that Liver and kidney blood and essence asthenia causes outside cold-evil.
Cure rate of the present invention is 22%, and effective percentage reaches more than 82%, and have evident in efficacy with clinical Therapeutic Method ratio of locking at present, have no side effect, the advantage that safety is high, patient's result of use at ill initial stage is more outstanding.Long-term taking can reach mitigation symptoms, reduces the curative effect of focus.
Detailed description of the invention
Embodiment 1
One treats the dystonic Chinese medicine composition of general, comprises by weight composition:
Radix Astragali 15g, Radix Codonopsis 12g, Cortex Cinnamomi 8g, Radix Rehmanniae Preparata 9g, Fructus Corni 9g, Radix Ophiopogonis 9g, Fructus Lycii 8g, Fructus Schisandrae Chinensis 6g, Pericarpium Citri Reticulatae 10g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Radix Saposhnikoviae 10g, Colla Plastri Testudinis 9g, Rhizoma Et Radix Notopterygii 9g.
One treats the dystonic Chinese medicine composition of general, prepares the method for decoction:
According to the preparation method of decoction in summary of the invention, be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 5cm, soaked 2 hours; Big fire decocts to after boiling, and slow fire decocts 60 minutes, collecting by filtration medicinal liquid; Adding distil water is to not having powder 4cm again, and big fire is to after boiling, and slow fire decocts 40 clocks.Collecting by filtration medicinal liquid, merges the medicinal liquid of twice collection, is divided into two parts.
Embodiment 2
One treats the dystonic Chinese medicine composition of general, comprises by weight composition:
Radix Astragali 10g, Radix Codonopsis 6g, Cortex Cinnamomi 4g, Radix Rehmanniae Preparata 6g, Fructus Corni 3g, Radix Ophiopogonis 6g, Fructus Lycii 3g, Fructus Schisandrae Chinensis 3g, Pericarpium Citri Reticulatae 5g, Radix Angelicae Sinensis 5g, Rhizoma Chuanxiong 5g, Radix Saposhnikoviae 5g, Colla Plastri Testudinis 3g, Rhizoma Et Radix Notopterygii 3g.
One treats the dystonic Chinese medicine composition of general, prepares the method for decoction:
According to the preparation method of decoction in summary of the invention, be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 4cm, soaked 1 hour; Big fire decocts to after boiling, and slow fire decocts 40 minutes, collecting by filtration medicinal liquid; Adding distil water is to not having powder 3cm again, and big fire is to after boiling, and slow fire decocts 20 clocks, collecting by filtration medicinal liquid, is merged by the medicinal liquid of twice collection, is divided into two parts.
Embodiment 3
One treats the dystonic Chinese medicine composition of general, comprises by weight composition:
The Radix Astragali 12 grams, Radix Codonopsis 6 grams, Cortex Cinnamomi 6 grams, 8 grams, Radix Rehmanniae Preparata, Fructus Corni 6 grams, Radix Ophiopogonis 8 grams, Fructus Lycii 6 grams, Fructus Schisandrae Chinensis 5 grams, Pericarpium Citri Reticulatae 6 grams, Radix Angelicae Sinensis 8 grams, Rhizoma Chuanxiong 6 grams, Radix Saposhnikoviae 6 grams, Colla Plastri Testudinis 6 grams, Rhizoma Et Radix Notopterygii 5 grams.
One treats the dystonic Chinese medicine composition of general, prepares the method for decoction:
According to the preparation method of decoction in summary of the invention, be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 3.5cm, soaked 1.5 hours; Big fire decocts to after boiling, and slow fire decocts 50 minutes, collecting by filtration medicinal liquid; Adding distil water is to not having powder 3.5cm again, and big fire is to after boiling, and slow fire decocts 30 minutes, collecting by filtration medicinal liquid, is merged by the medicinal liquid of twice collection, is divided into two parts.
Embodiment 4: clinical observation
4.1 analysis of clinical
Accept for medical treatment and confirm as the dystonic patient of general 50 clinically, age 2-28 year, in-2 years January of the course of disease, Therapeutic Method is the decoction in content of the present invention, and it is 3 years that treatment adds the cycle of following up a case by regular visits to.
4.2 therapeutic scheme
To be the decoction in the present invention in treatment, be a course for the treatment of with 4 weeks, further consultation after the course for the treatment of; Report situations according to patient, in the scope of summary of the invention, take the circumstances into consideration the dose adding and subtracting each taste.
4.3 curative effect determinate standard
Cure: after the treatment of 6 courses for the treatment of, malaise symptoms disappears completely or substantially;
Effective: after the treatment of 6 courses for the treatment of, malaise symptoms major part point is alleviated, and nothing is obvious or have slight dysfunction, state of an illness held stationary.
Effective: after the treatment of 6 courses for the treatment of, symptom partial rcsponse, leaves over dysfunction in various degree.
Invalid: after the treatment of 6 courses for the treatment of, symptom is not improved; Or unstable condition, or be slowly in progress.
Clinical test results in 4.4 the present embodiment
Cure rate: healing/diseased individuals
Effective percentage: (cure+effective+effectively)/diseased individuals
The research method adopted and clinical test results as follows:
Experimental result: in the dystonic patient of 50 routine general, according to above criterion, through identifying that 11 examples are cured, 17 examples are effective, and effectively, invalid be 9 examples to 13 examples, and cure rate is 22%, and effective percentage is 82%.
Conclusion: decoction therapeutic effect of the present invention is remarkable, cure rate is higher, general dystonic syndrome this, the medicine that there is no specially good effect at present is clinically treated, use Chinese medicine composition of the present invention, cure rate reach 22% and effective percentage reach 82% and belonged to treatment primary disease aspect medicine evident in efficacy, be adapted at further genralrlization application clinically.
4.5 model cases,
Case 1, Wang, man, 15 years old, people from Qingdao, recent appearance is not easily swallowed, aphasis, the symptoms such as the degree of lip-rounding is abnormal, from discomfort by medical 1 month, carry out my institute's treatment and take the decoction provided in the embodiment of the present invention 1, after treating 1 course for the treatment of, symptom alleviates to some extent, swallowing act recovers, 6 courses for the treatment of of continual cure, and mouth recovers normal, language is enunciated clear, finally cures.Within 3 months, Effect of follow-up visit by telephone does not recur.
Case 2, Lee, female, 8 years old, people from Qingdao, not easy to-move head is there is, the symptoms such as muscle rigidity, especially muscle of back when my institute checks over 2014, limitation of activity, symptom occurs more than 1 year, once several hospitalizes, DeGrain, after treating 1 course for the treatment of, malaise symptoms has alleviation, can easily rotary head, muscle rigidity phenomenon is alleviated to some extent, 6 courses for the treatment of of continual cure, muscle of back, activity freely, is finally cured.
Above specific embodiments of the invention have been described in detail, but described content being only preferred embodiment of the present invention, can not being considered to for limiting practical range of the present invention.All equalizations done according to the present patent application scope change and improve, and all should still belong within patent covering scope of the present invention.
Claims (8)
1. treat the dystonic Chinese medicine composition of general, it is characterized in that: the composition contained is: the Radix Astragali, Radix Codonopsis, Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Corni, Radix Ophiopogonis, Fructus Lycii, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Rhizoma Et Radix Notopterygii.
2. one according to claim 1 treats the dystonic Chinese medicine composition of general, it is characterized in that: comprise by weight composition: Radix Astragali 10-15 part, Radix Codonopsis 6-12 part, Cortex Cinnamomi 4-8 part, Radix Rehmanniae Preparata 6-9 part, Fructus Corni 3-9 part, Radix Ophiopogonis 6-9 part, Fructus Lycii 3-8 part, Fructus Schisandrae Chinensis 3-6 part, Pericarpium Citri Reticulatae 5-10 part, Radix Angelicae Sinensis 5-10 part, Rhizoma Chuanxiong 5-10 part, Radix Saposhnikoviae 5-10 part, Colla Plastri Testudinis 3-9 part, Rhizoma Et Radix Notopterygii 3-9 part.
3. one according to claim 1 treats the dystonic Chinese medicine composition of general, it is characterized in that: the weight ratio of above each composition is for being the Radix Astragali 12 parts, Radix Codonopsis 6 parts, Cortex Cinnamomi 6 parts, 8 parts, Radix Rehmanniae Preparata, Fructus Corni 6 parts, Radix Ophiopogonis 8 parts, Fructus Lycii 6 parts, Fructus Schisandrae Chinensis 5 parts, Pericarpium Citri Reticulatae 6 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Chuanxiong 6 parts, Radix Saposhnikoviae 6 parts, Colla Plastri Testudinis 6 parts, Rhizoma Et Radix Notopterygii 5 parts.
4. one according to claim 1 and 2 treats the dystonic Chinese medicine composition of general, it is characterized in that: described Chinese medicine composition is prepared into decoction, granule or other pharmaceutically acceptable dosage form.
5. one according to claim 4 treats the dystonic Chinese medicine composition of general, it is characterized in that: described Chinese medicine composition is prepared into decoction.
6. prepare a kind of method for the treatment of the dystonic Chinese medicine composition of general according to claim 1, it is characterized in that: the method preparing decoction:
1) be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 3-4cm, soaked 1-2 hour;
2) big fire decocts to after boiling, and slow fire decocts 40-60 minute, collecting by filtration medicinal liquid;
3) adding distil water is to not having powder 3-4cm again, and big fire is to after boiling, and slow fire decocts 20-40 minute, collecting by filtration medicinal liquid
4) merged by the medicinal liquid of twice collection, be divided into two parts, every day respectively takes portion sooner or later.
7. a kind of method for the treatment of the dystonic Chinese medicine composition of general according to claim 6, is characterized in that, prepare the method for decoction:
1) be immersed in pure water by the above prepared slices of Chinese crude drugs, the water surface did not have powder 4.5cm, soaked 1.5 hours;
2) big fire decocts to after boiling, and slow fire decocts 50 minutes, collecting by filtration medicinal liquid;
3) adding distil water is to not having powder 3.5cm again, and big fire is to after boiling, and slow fire decocts 30 minutes, collecting by filtration medicinal liquid
4) merged by the medicinal liquid of twice collection, be divided into two parts, every day respectively takes portion sooner or later.
8. one according to claim 1 and 2 treats the dystonic Chinese medicine composition of general, it is characterized in that: the application of this Chinese medicine composition in preparation treatment general myodystonia medicine.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106474371A (en) * | 2016-10-24 | 2017-03-08 | 刘亮 | One kind treats dystonic Chinese medicine |
| CN111658732A (en) * | 2020-07-31 | 2020-09-15 | 潍坊医学院 | Traditional Chinese medicine composition, preparation method and application thereof |
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| CN103566201A (en) * | 2013-11-11 | 2014-02-12 | 韩培海 | Traditional Chinese medicine decoction for treating post-stroke hypermyotonia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474371A (en) * | 2016-10-24 | 2017-03-08 | 刘亮 | One kind treats dystonic Chinese medicine |
| CN111658732A (en) * | 2020-07-31 | 2020-09-15 | 潍坊医学院 | Traditional Chinese medicine composition, preparation method and application thereof |
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