CN1239178C - Method for preparing qingkailing granules - Google Patents
Method for preparing qingkailing granules Download PDFInfo
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- CN1239178C CN1239178C CNB031269869A CN03126986A CN1239178C CN 1239178 C CN1239178 C CN 1239178C CN B031269869 A CNB031269869 A CN B031269869A CN 03126986 A CN03126986 A CN 03126986A CN 1239178 C CN1239178 C CN 1239178C
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- powder
- granules
- baicalin
- qingkailing
- taurine
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Abstract
The present invention relates to a new method for preparing qingkailing granules, particularly to a method for preparing granules by using traditional Chinese medicinal materials as main raw materials. The method comprises: adding the water extract of honeysuckle flower, cape jasmine fruit and isatis root, the hydrolysate of buffalo horn powder and nacre powder, taurocholic acid, hyodeoxycholic acid and baicalin to starch water solution with a temperature of 60 to 90 DEG C, uniformly stirring and homogenizing the mixed solution to obtain emulsion, spray-drying the emulsion to obtain dry powder, adding a proper quantity of auxiliary materials to the dry powder and preparing granules by a conventional method. The obtained granules have the advantages of good mouth feel, high stability and long shelf life. Besides, the granules are free from sugar, and are suitable for patients with diabetes to use.
Description
Technical field
The present invention relates to a kind of is the method for preparing granule of primary raw material with the Chinese crude drug.
Background technology
The Qingkailing granule agent be a kind of be the Chinese patent medicine of primary raw material with the Chinese crude drug.This product has the effect of heat-clearing and toxic substances removing, tranquillizing and allaying excitement, cure mainly diseases such as flu, fever, this product is classified as essential drugs by ministry of Health of China, the propagation of the global severe acute respiratory syndrome that caused by coronavirus in 2003, do not find severe acute respiratory syndrome treatment had specific drug in, as the clinical practice of Chinese patent medicine Qingkailing preparation, it is the medicine that certain curative effect is arranged as treatment SARS disease that the relevant administration office of China has issued Qingkailing preparation.
As some medical materials in the main active in the Qingkailing granule agent, as baicalin,, taurine, Hyodeoxycholic Acid be extremely bitter medicine waiting, some animal cream are again the medicines that is difficult to inlet, in a word, QINGKAILING is the prepared product of preparation technology of Chinese patent medical granule routinely, mouthfeel is very poor, and the patient can not accept.In the patent disclosure of CN1288724 and CN1247078 a kind of preparation method of Qingkailing granule agent, but, what adopt in CN1288724 is cholic acid and animal cream usefulness-cyclodextrin embedding, its embedding process trouble, and embedding rate is low, and the extract of Chinese crude drug Flos Lonicerae, Radix Isatidis, Fructus Gardeniae is again to adopt spray-dired method, so total complicated process of preparation, the production cost height, and taste of medicine is still by regulating with the adjuvant Icing Sugar; There is sensory issues equally in the CN1288724 patent, also is will be with a large amount of Icing Sugar.Such product just can not be used for diabetics, and for this reason, we are necessary to solve sensory issues from preparation method.
Summary of the invention
The present invention seeks to produce the Qingkailing granule agent with a kind of better simply preparation method, do not contain sugar, make the mouthfeel of product good, product is stable, long shelf-life.
For implementing purpose of the present invention, the technical scheme that is adopted: by the Chinese crude drug Flos Lonicerae, Fructus Gardeniae, the water extract of Radix Isatidis and Cornu Bubali powder, the hydrolysate of Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin is that to add adjuvant be with Flos Lonicerae with the method improvement of conventional preparation granule to active component, Fructus Gardeniae, the water extract and the Cornu Bubali powder of Radix Isatidis, the hydrolyzed solution of Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin is added in 60～90 ℃ the N-LOK modified starch aqueous solution, the homogenizing that stirs becomes emulsion, carry out spray drying, the xeraphium of gained is made granule according to a conventional method.The concentration of amidin is preferably 30～60% with the total solid content that adds behind the raw material of Chinese medicine, the starch consumption is the dry substance of hydrolysate of the water extract of Chinese crude drug Flos Lonicerae, Fructus Gardeniae, Radix Isatidis and Cornu Bubali powder, Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin total amount 2～5 times, and best starch consumption is the dry substance of hydrolysate of the water extract of Chinese crude drug Flos Lonicerae, Fructus Gardeniae, Radix Isatidis and Cornu Bubali powder, Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin total amount 3.5～4 times.
The microcapsule powder that contains active component after the spray drying adds an amount of adjuvant, prepares granule with conventional method.Preferably water and/or 95% ethanol are granulated after making soft material as wetting agent, can be packed behind dry, the granulate.
Carry out stability test with prepared Qingkailing granule agent:
Adopt stable accelerated test research method, Qingkailing granule and wrapped granule place 60 ℃, 85 ℃ calorstat respectively, 85 ℃ sample is per hour observed and by the quality standard working sample, observe and press the quality standard working sample sample every day of 60 ℃, result: packing is arranged and under 60 ℃ of conditions, do not place 2 months with the sample of packing, its particulate outward appearance is constant, meets quality standard.Qingkailing granule and wrapped granule place 40 ℃ respectively, observe in every month under relative humidity 75% condition and press quality standard working sample, result: have the sample of packing to place 3 months, its particulate outward appearance is constant, meets quality standard.Illustrate that this product is stable, the shelf-life can be assert and is equivalent to 3 years.
Adopted a kind of starch among the present invention; owing in the microgranule of starch itself space is arranged; so it is a kind of good embedding medium; and embedding rate can be up to more than 95%; it has been widely used in embedding spice, fat and vitamin; and; the viscosity of this starch is low; emulsion that can compounding high concentration goes spray drying; the emulsion emulsion stability and the film property of gained are fine, and the loss in the time of can making spray drying reduces to minimum, and the product that spraying is come out can keep stable for a long time; active component is finely protected, makes not to be subjected to oxidation.So adopted the said method for preparing the Qingkailing granule agent of the present invention, because Chinese crude drug is basically by starch embedding, become a kind of microcapsule of starch after the spray drying, so the granule product mouthfeel of last gained is good, good stability, long shelf-life, prove through stability test, our shelf life of products can assert and be equivalent to 3 years, and do not contain sugar in the product, and product is fit to diabetics to be used.
Below in conjunction with embodiment technical scheme of the present invention is described.
The specific embodiment
The preparation method of Qingkailing granule agent:
(1) take by weighing raw material taurine 13g, Hyodeoxycholic Acid 15g, Concha Margaritifera powder 200g, Cornu Bubali powder 100g, baicalin 20g, Fructus Gardeniae 100g, Radix Isatidis 800g, Flos Lonicerae extract 20g are stand-by.
(2) preparation of Concha Margaritifera powder and Cornu Bubali powder hydrolysate: the water intaking horn powder is got filtrate for later use with the 4mol/l barium hydroxide heating hydrolysis of 8 times of amounts after 6～7 hours; Get Concha Margaritifera powder with the 4mol/l sulfuric acid solution heating hydrolysis of 8 times of amounts 6～7 hours, put the cold filtrate of getting, be added in the Cornu Bubali hydrolysate, transfer PH to 4 with barium hydroxide, get and use ethanol precipitation after filtrate concentrates, get filtrate recycling ethanol, it is standby that accent PH to 7 rear filtrate is condensed into extractum.
(3) preparation of Flos Lonicerae, Fructus Gardeniae and Radix Isatidis water extract: get Fructus Gardeniae and Radix Isatidis and put in the extraction pot, the water that adds 8 times of amounts, boiled 2 hours, get filtrate, with the water of 6 times of amounts, boiled 1 hour for the second time, merge 2 times filtrate, Flos Lonicerae is added in the filtrate, and it is standby to be concentrated into suitable density and to be 1.05～1.1 extractum.
(4) preparation of taurine, Hyodeoxycholic Acid solution: get 75% alcoholic solution that taurine, Hyodeoxycholic Acid place 2 times of amounts, the sodium hydroxide with 20% is transferred PH to 9, make dissolve fully standby.
(5) take by weighing starch by (Starch ﹠amp; Chemical (Asia) Pte Ltd) starch that provides, model is that the starch 650g of N-LOK is dissolved in the water of 1800g, be heated to 80 ℃, stir half an hour down at 80 ℃, make starch fully dissolve the back stirring and add baicalin and the above-mentioned Concha Margaritifera powder that makes and Cornu Bubali powder hydrolysate extractum, taurine, Hyodeoxycholic Acid solution and Flos Lonicerae, Fructus Gardeniae and Radix Isatidis the water extracted immersing paste down successively.After having fed in raw material, continue to stir a moment, stop heating, put cold with feed liquid through the homogenizer emulsifying, then with the emulsion spray drying, spray drying condition: 160～185 ℃ of inlet temperature, 85～95 ℃ of leaving air temps, charging rate 30～33L/Hr, collected spray powder is 870g, this spray powder is added the stevioside mixing of dextrin 120g and 5g after, make soft material with 95% ethanol, granulation, dry, packing, every bag of 1g.
Claims (3)
1, a kind of preparation method of Qingkailing granule agent, be by the Chinese crude drug Flos Lonicerae, Fructus Gardeniae, the water extract of Radix Isatidis and Cornu Bubali powder, the hydrolysate of Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin is that active component adds the method that prepare granule of adjuvant with routine, it is characterized in that: with Flos Lonicerae, Fructus Gardeniae, the water extract and the Cornu Bubali powder of Radix Isatidis, the hydrolyzed solution of Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin is added in 60～90 ℃ the aqueous solution of N-LOK modified starch, after the homogenizing that stirs becomes emulsion, carry out spray drying, the xeraphium of gained adds an amount of adjuvant, makes granule according to a conventional method.
2, according to the preparation method of the said Qingkailing granule agent of claim 1, it is characterized in that: the concentration in the amidin is 30～60% with the total solid content that adds behind the raw material of Chinese medicine, and the starch consumption is the dry substance of hydrolysate of the water extract of Chinese crude drug Flos Lonicerae, Fructus Gardeniae, Radix Isatidis and Cornu Bubali powder, Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin total amount 2～5 times.
3,, it is characterized in that the starch consumption is the dry substance of hydrolysate of the water extract of Chinese crude drug Flos Lonicerae, Fructus Gardeniae, Radix Isatidis and Cornu Bubali powder, Concha Margaritifera powder and taurine, Hyodeoxycholic Acid, baicalin total amount 3.5～4 times according to the preparation method of the said Qingkailing granule agent of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031269869A CN1239178C (en) | 2003-06-25 | 2003-06-25 | Method for preparing qingkailing granules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031269869A CN1239178C (en) | 2003-06-25 | 2003-06-25 | Method for preparing qingkailing granules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1513505A CN1513505A (en) | 2004-07-21 |
| CN1239178C true CN1239178C (en) | 2006-02-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031269869A Expired - Fee Related CN1239178C (en) | 2003-06-25 | 2003-06-25 | Method for preparing qingkailing granules |
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| Country | Link |
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| CN (1) | CN1239178C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299717C (en) * | 2004-08-06 | 2007-02-14 | 北京中医药大学 | Pharmaceutical composition for treating cerebral apoplexy and its preparation method |
| CN100376260C (en) * | 2005-08-29 | 2008-03-26 | 贵州益佰制药股份有限公司 | Method for preparing Qingkailing preparation |
| WO2007059649A1 (en) * | 2005-11-25 | 2007-05-31 | Zhiquan Zhao | Chinese pharmaceutical compositions for treating upper respiratory tract infection and processes for preparation thereof |
| CN107913317A (en) * | 2017-11-28 | 2018-04-17 | 广州白云山明兴制药有限公司 | A kind of preparation method of Chinese medicinal granule |
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2003
- 2003-06-25 CN CNB031269869A patent/CN1239178C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1513505A (en) | 2004-07-21 |
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