CN1235640C - 用于药物滥用治疗的半抗原载体轭合物及其制备方法 - Google Patents

用于药物滥用治疗的半抗原载体轭合物及其制备方法 Download PDF

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Publication number
CN1235640C
CN1235640C CNB971993637A CN97199363A CN1235640C CN 1235640 C CN1235640 C CN 1235640C CN B971993637 A CNB971993637 A CN B971993637A CN 97199363 A CN97199363 A CN 97199363A CN 1235640 C CN1235640 C CN 1235640C
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Prior art keywords
side chain
carrier
hapten
conjugates
nicotine
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Expired - Fee Related
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CNB971993637A
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English (en)
Chinese (zh)
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CN1244130A (zh
Inventor
P·A·斯温
J·L·格林斯泰恩
M·A·艾克丝雷
B·S·福克斯
S·P·帕沃斯
M·L·格夫特
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Immulogic Pharmaceutical Corp
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Immulogic Pharmaceutical Corp
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Publication of CN1244130A publication Critical patent/CN1244130A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNB971993637A 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法 Expired - Fee Related CN1235640C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/720,487 1996-09-30
US08/720,487 US5876727A (en) 1995-03-31 1996-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2005100228305A Division CN1814301B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN200610099904XA Division CN1951502B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法

Publications (2)

Publication Number Publication Date
CN1244130A CN1244130A (zh) 2000-02-09
CN1235640C true CN1235640C (zh) 2006-01-11

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ID=24894184

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB971993637A Expired - Fee Related CN1235640C (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN2005100228305A Expired - Fee Related CN1814301B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN200610099904XA Expired - Fee Related CN1951502B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法

Family Applications After (2)

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CN2005100228305A Expired - Fee Related CN1814301B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN200610099904XA Expired - Fee Related CN1951502B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法

Country Status (13)

Country Link
US (1) US5876727A (enExample)
EP (2) EP1024834B1 (enExample)
JP (2) JP2001501933A (enExample)
CN (3) CN1235640C (enExample)
AT (1) ATE372786T1 (enExample)
AU (1) AU733980B2 (enExample)
BR (1) BR9711580A (enExample)
CA (2) CA2267456C (enExample)
DE (1) DE69738140T2 (enExample)
DK (1) DK1024834T3 (enExample)
ES (1) ES2293664T3 (enExample)
PT (1) PT1024834E (enExample)
WO (1) WO1998014216A2 (enExample)

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HK1027293A1 (en) 2001-01-12
CN1814301B (zh) 2010-05-26
CN1814301A (zh) 2006-08-09
DK1024834T3 (da) 2008-01-21
ES2293664T3 (es) 2008-03-16
EP1024834A2 (en) 2000-08-09
HK1106140A1 (en) 2008-03-07
CA2267456C (en) 2009-03-24
BR9711580A (pt) 2004-03-30
CA2574049A1 (en) 1998-04-09
AU6483498A (en) 1998-04-24
CN1951502B (zh) 2010-09-15
DE69738140T2 (de) 2008-06-12
CA2267456A1 (en) 1998-04-09
ATE372786T1 (de) 2007-09-15
PT1024834E (pt) 2007-12-18
EP1024834B1 (en) 2007-09-12
JP2001501933A (ja) 2001-02-13
WO1998014216A2 (en) 1998-04-09
EP1857121A2 (en) 2007-11-21
DE69738140D1 (de) 2007-10-25
CN1244130A (zh) 2000-02-09
CN1951502A (zh) 2007-04-25
JP2009280599A (ja) 2009-12-03
US5876727A (en) 1999-03-02
EP1857121A3 (en) 2011-03-09
AU733980B2 (en) 2001-05-31
WO1998014216A3 (en) 1998-12-10

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