CN1219507C - Combination containing fulvic acid for cleaning skin - Google Patents
Combination containing fulvic acid for cleaning skin Download PDFInfo
- Publication number
- CN1219507C CN1219507C CN 200310103342 CN200310103342A CN1219507C CN 1219507 C CN1219507 C CN 1219507C CN 200310103342 CN200310103342 CN 200310103342 CN 200310103342 A CN200310103342 A CN 200310103342A CN 1219507 C CN1219507 C CN 1219507C
- Authority
- CN
- China
- Prior art keywords
- fulvic acid
- cleansing composition
- skin cleansing
- acid
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PUKLDDOGISCFCP-JSQCKWNTSA-N 21-Deoxycortisone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2=O PUKLDDOGISCFCP-JSQCKWNTSA-N 0.000 title claims abstract description 97
- FCYKAQOGGFGCMD-UHFFFAOYSA-N Fulvic acid Natural products O1C2=CC(O)=C(O)C(C(O)=O)=C2C(=O)C2=C1CC(C)(O)OC2 FCYKAQOGGFGCMD-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 239000002509 fulvic acid Substances 0.000 title claims abstract description 97
- 229940095100 fulvic acid Drugs 0.000 title claims abstract description 97
- 238000004140 cleaning Methods 0.000 title abstract description 18
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 22
- 230000000694 effects Effects 0.000 claims description 22
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Landscapes
- Cosmetics (AREA)
Abstract
The present invention discloses a composition which contains fulvic acid, and is used for cleaning skin. The effective components of the fulvic acid account for 0.5 to 5% of the total weight of the composition, and exit in the mode of fulvic acid liposomes which are the products obtained by taking phosphatidyl choline as a wall material to embed fulvic acid, wherein the weight ratio of the fulvic acid to the phosphatidyl choline is 1:3 to 5. The composition of the present invention can be prepared into various personal hygienic articles, such as bath lotion, solution for washing hands, etc., which have the functions of cleaning, skin care and health care, and have acceptable appearances and colours which are realized by adding the effective addition amount of fulvic acid in the mode of liposomes, and therefore, fulvic acid can be widely used in the industry of products for cleaning skin.
Description
Technical field
The present invention relates to a kind of skin cleansing composition, especially refer to a kind of skin cleansing composition that contains the fulvic acid liposome, has the cleaning and health care skin care effect.
Background technology
Fulvic acid (also claiming yellow humic acid) is the less macromolecular organic compound of humic-acid kind molecular weight, be that the chemical compound by primary structure is formed with the poly-basic aromatic carboxylic acid, contain various active functional group, can be water-soluble, sour, alkali, ethanol and acetone, easily be absorbed by the body, have stronger biological activity, be widely used in the world of medicine at present.
Recorded and narrated the medicine of a kind of being called " coal looses " in the Compendium of Material Medica, be used for the treatment of diseases such as infectiousness ulcer and women are hemorrhage, main functional component wherein is exactly a fulvic acid.Therefore the medicinal research of fulvic acid is existing knows that fulvic acid can be used as topical agent for many years, is a kind of effective antiinflammatory and hemorrhage.When outside be used for the health infection site, can activate superoxide dismutase (containing zinc element and copper) by regulating the concentration level of trace element zinc and copper, disproportionation is also got rid of the free radical that infected position produces, thereby suppress the secretion of inflamed sites enzyme, play the effect that diminishes inflammation; Fulvic acid simultaneously can also blood circulation promoting, and accelerate blood is solidified, and treats many because the disease that the disorder of blood capillary blood circulation causes can be used as coagulant again and plays anastalsis by recovering to improve in the blood capillary blood circulation.Fulvic acid can stimulate the coat of the stomach blood circulation and suppress the secretion of coat of the stomach gastric acid, also can stimulate the secretion of the various parathyrines of protection gastric wall in the stomach, the control gastric ulcer.Fulvic acid also has the immune mechanism of adjusting simultaneously, the secretion of scalable regulate thyroid hormones signi, thus regulate the circulation nucleoside at cellular level.
Based on the above mechanism of action, report is also arranged, and some utilize the topical agent of humic acids (yellow humic acid, fulvic acid sodium) preparation, because this class material includes the phytosterol material, have stronger physiologically active, the microcirculation of skin, the regeneration of body of gland, the metabolism of cell are all improved significantly.This class medicament can be used for treating common skin diseases such as chronic eczema, urticaria, pruritus, seborrheic dermatitis, psoriasis, and it is reported than higher effective percentage.Also have report to develop the sodium fulvate medicinal liquid, have effects such as microcirculation improvement, allaying tiredness, recovery physical ability, muscle strength reinforcing, for the large-area soft tissue injury of athlete and hard training and the fatigue limit that causes, can play tangible regulating action, effectively cure rate reaches more than 94%.Report that also humic acids medically also can be used for diseases such as dipping bath treatment of arthritis and gynaecopathia.
In a word, for many years to fulvic acid the research of treatment and health function and Products Development be confined to medicinally basically, its scope of application also just is confined to the crowd that has been found that condition of illness need be treated.Also relevant for the research report of the skin moistening effect of fulvic acid, all the time there is not corresponding product to be developed out, one of reason is humus and the grizzle that fulvic acid derives from soil, this is as pitchy or black, the fulvic acid color that can be applied to human body of the higher degree that present producer can provide is all darker, crystal comes near to black, even 1% aqueous solution also is color as the soy sauce, as medicament, user is generally not fastidious to its color and luster, even but be used in such as seldom addition in the daily cleaning product such as body lotion and also make us being difficult to accepting; Another reason is that the time of staying at the body surface position in the use is very short for Personal hygiene articles for washing (fancy soap, the agent of bathing, hand lotion etc.), is difficult to the effect of performance fulvic acid under low content like this.
So, how can both guarantee effective additive capacity of fulvic acid, make its color and luster mode of appearance make us being easy to accepting again, be the key point that fulvic acid can be used widely in this series products.
Summary of the invention
The object of the present invention is to provide a kind of skin cleansing composition that contains fulvic acid, utilize said composition to can be made into all kinds of personal hygiene articles, for example bathe agent, handwashing liquid etc., the effect that not only has skin protection, health care, and color and luster is easy to accept, thereby provides a class new product for the market of this series products.
For reaching above-mentioned purpose, the effective content of fulvic acid is the 0.5-5% of compositions gross mass in the skin cleansing composition that contains fulvic acid provided by the present invention, and this fulvic acid exists with fulvic acid liposome form, this liposome is for being that the wall material carries out lipid-encapsulated product to fulvic acid with lecithin, and wherein the mass ratio of fulvic acid and lecithin is 1: 3-1: 5.
Lecithin described here is commercial generalized lecithin, being construed as can be the phospholipid that comprises multiple different chemical structure, generally comprise phosphatidylcholine (Phosphotidyl cholinc, be commonly called as PC), PHOSPHATIDYL ETHANOLAMINE (Phosphotidyl ethanolamine, be commonly called as PE), phosphatidylinositols (Phosphotidyl inostol, PI), Phosphatidylserine (Phosphotidylserine, PS), (Phosphotidyl acid PA) waits phospholipid and lipoids to phosphatidic acid.
Adopt modern liposome embedded technology among the present invention, with lecithin is the wall material, fulvic acid is carried out embedding and obtains the fulvic acid liposome, this liposome is effectively improved the color and luster of fulvic acid, under effective addition (generally 0.5-5% gets final product) of fulvic acid, the appearance luster of said composition goods can be accepted by user.
Skin cleansing composition provided by the invention generally, for reach cleaning purpose, the auxiliary agent that wherein also should contain the surfactant of total composition 10-30% and/or soap, convention amount, promptly, make undemanding division according to the kind of substrate, compositions of the present invention can be a kind of surfactant system, perhaps soap base system or a kind of mixed system.The general knowledge that the selection of said here surfactant or soap and auxiliary agent and use amount thereof are this area has no particular limits in the present invention basically, perhaps can directly use the base material of producing skin-protection soap or existing skin-cleaning articles.Used surfactant is a surfactant commonly used in the articles for washing industry, comprises a kind of in anion surfactant, amphoteric ionic surfactant, the non-ionic surface active agent or two or more combination wherein.Wherein, anion surfactant is preferably the fatty alcohol-polyoxyethylene ether salt, comprises polyoxyethylenated alcohol sodium sulfate (AES) and AESA (AESA) etc.; Zwitterionic surfactant is preferably betaines, for example empgen BB (BS-12), cocamidopropyl betaine (CAB) and hydroxy sulfo lycine (CHS-35) etc.; Non-ionic surface active agent is preferably alkyl androstanediol class (APG), APG2000 for example, alkanolamide class such as cocoyl diglycollic amide (6501) etc.
For above-mentioned surfactant, can singlely use, also can select one or more mixing wherein to use, the principle of selecting is to help composition system to keep good stable and transparency at normal temperatures, preferably adopt the combination of above-mentioned anion surfactant and amphoteric ionic surfactant, or adopt the surfactant of same type.In compositions, the content of surfactant is preferably at 10-30%, and this content is interpreted as its total working substance content.
Compositions of the present invention can also be a kind of soap base system or mixed system, because the main component of the soap base composite soap afterwards that is fatty acid and alkali, the alkalescence of system is strong (pH value is usually greater than 8), from helping the stable of fulvic acid liposome and the zest of skin being considered, according to the product type needs, can select mixed system by soap and surfactant.
Compositions of the present invention can be used as the cleaning skincare product, and for example fancy soap, bath foam, handwashing liquid, clean agent etc. also can be used as simple conditioning liquid, for example skin care liquid, foot-soaking liquid etc.When using as the liquid of bathing, but shower use, but also dipping bath or do foam bath and use, effect is better.The bathing series products that utilizes said composition to make, under the situation of not adding any pigment, be pale brown color clear liquid, color and luster is vivid, cleaning is not hindered skin, and because the wherein interpolation of fulvic acid liposome, have in the use and preserve moisture, nutrition, anti-inflammatory anti-itch, unsting, regulate metabolism, improve effects such as immune system function and fatigue alleviating.
The used auxiliary agent of the present invention also is type commonly used in this area, antioxidant for example, viscosity modifier, the chela mediating recipe, the pH value regulator, essence, pigment etc., for obtaining better cleaning skin effect, characteristics according to specific product can also be added some the auxotype additive that comprises active skull cap components or natural plants essences by selectivity, for example, (it mainly contains aloin to have the Aloe extraction solution of moisture-keeping bacterium-restraining effect, the Aloe saponin component has sterilization, moisture-keeping function), (its main functional component has the Cacumen Platycladi extracting solution: fenchone, Camphora, borneol acetate, terpene alcohol; And contain juniperic acid, Quercetin, poplar luteoxanthin, kaempferol, hinokiflavone etc.) or the like.In a word, each auxiliary agent can be optionally, and the selection of its use amount and type also is the known technology of this area.For example, be benchmark with the total composition, the use amount of viscosity modifier is that 0.1-5% (mass percent), antioxidant are that 0.02-0.2%, essence are that 0.2-2%, pH value regulator are 0.02-0.5% etc., certainly, also comprises the water of surplus in the said composition.The main purpose of wherein adding antioxidant is the oxidation deterioration that prevents lecithin wall material, product such as the vitamin C that can select BHT for use or have same effect; Viscosity modifier can be selected according to the requirement of final products, for example can select salts such as NaCl for use, also can be macromole such as hydroxyethyl-cellulose; The pH regulator agent can be selected inorganic or organic acid for use, and for example phosphoric acid, citric acid, malic acid, ascorbic acid etc. make the pH value of compositions remain on neutrality substantially, help liposome and keep stable at normal temperatures, preferably adopt citric acid; As for selecting for use of essence, pigment then is according to the needs of different flavor or in order to satisfy the hobby of different consumers.These material major parts obtain easily, and price is lower, and add conveniently, and other raw materials with same function are also selected to use, and among the present invention its type and specification are not had strict requirement.
For example, gross mass with skin cleansing composition of the present invention is a benchmark, can comprise the essence of BHT, 0.2-2% of NaCl, 0.02-0.2% of BS-12,0.1-5% of AES, 5-10% of 5-10% and/or the citric acid of 0.02-0.5% in the prescription that is bathed agent, add the fulvic acid liposome according to concrete needs again, making the fulvic acid effective content is the 0.5-5% of compositions gross mass, surplus is a water, operate through routine, can obtain the bath agent of sundown, clear, have the cleaning skin protection, moisten antipruritic, lessen fatigue, improve health-care effect such as sleep.
In above-mentioned prescription, surfactant A ES, BS-12 constitute to bathe the substrate of agent, can certainly bathe the substrate of agent with soap etc. as the soap base type; BHT is an antioxidant, is mainly used in to prevent lecithin generation oxidation deterioration, can certainly select other suitable antioxidants; The effect of citric acid is to regulate the pH value of compositions neutral basically, and sodium chloride is to be used for the viscosity that the reconciliation statement surface-active agent is bathed the agent system.The front is addressed, and those of ordinary skill in the art can do suitable adjustment to above-mentioned prescription.And key of the present invention just is to have added the fulvic acid composition with clean skin, skin-care effect, and the form by liposome realizes that appearance luster can be accepted by user under effective addition of fulvic acid.
The front is mentioned, and involved relevant constituent content is all based on the content of its active substance, for commodity purchased definite ratio that in use need be converted according to the content of its active substance in the present composition.
For the fulvic acid that solves effective dose in the prior art directly adds in the compositions color and luster dark of being brought, unacceptable problem to, the used fulvic acid of the present invention is a fulvic acid liposome form, it is to adopt modern liposome embedded technology, with lecithin is the wall material, fulvic acid is carried out embedding obtain.Concrete preparation method can comprise: 1. use dissolve with ethanol lecithin, remove insoluble matter, it is standby to get supernatant; 2. with the phosphate buffered solution of pH7.4 fulvic acid is dissolved, add glycerol, it is transparent to be stirred to solution; 3. above-mentioned phospholipid alcoholic solution is injected in the fulvic acid glycerol mixed solution fast, stirs; 4. ultrasonic Treatment.
In the preparation process of above-mentioned fulvic acid liposome, should select the high as far as possible product of fulvic acid content for use as the fulvic acid of raw material, obtain higher biological activity, for example select the more shallow food stage fulvic acid of color for use, avoid the adding of harmful composition, and the higher fulvic acid content (effective content) of biological activity can reach more than 70%.The wall material lecithin of selecting for use is commercial generalized lecithin, can directly be purchased, can select higher best certainly of purity, but cost also can so can select common product for use, clean the partial impurities of removing wherein with acetone before using than higher, the color of lecithin is shoaled to white or little yellow, the consumption and the wash number of acetone are not limit, and are principle with the economical and effective, generally need wash two-three times.Above-mentioned the phospholipid alcoholic solution is injected into way in the fulvic acid glycerol mixed solution fast, can selects syringe for use, and can reach mix homogeneously by stirring rod or mechanical agitation.Supersound process can adopt ultrasonic washing unit, pours suitable quantity of water in its tank, and the beaker that fills above-mentioned mixed solution is placed in the water, and the addition of water does not float with beaker and is as the criterion, and the ultrasonication certain hour takes out and gets final product.
In order to improve the embedding rate of fulvic acid in liposome, preferred heartwood (fulvic acid) is 1 with the ratio of wall material (lecithin): 3-1: 5, most preferably about 1: 4; The ratio of fulvic acid and glycerol is 1: 6-1: 10, most preferably about 1: 8; Ultrasonic treatment time is 10-60 minute, can use about general 20min.The ethanol that can vapor away wherein obtains the liposome form of needs, if ethanol is all evaporated, can get fulvic acid liposome dry powder.
At preparation skin cleansing composition of the present invention and when preparing various clean skin goods, only need according to the ordinary skill in the art, surfactant or soap and each auxiliary agent are mixed, add the fulvic acid liposome of requirement again, mixing gets final product.Also can earlier the fulvic acid liposome be added in the surfactant, or add simultaneously with each auxiliary agent.Certainly, if use soap to prepare soap base system product, need to regulate earlier its pH value to neutral substantially (the pH value meta-alkalescence of soap base usually), also there is no particular limitation for processing technology subsequently and condition, just for avoiding liposome instability at high temperature to occur, requiring usually is to operate at normal temperatures.
In sum, key of the present invention is to adopt modern liposome embedded technology, (similar with lecithin to the lipid conformation in the skin, be easy to Transdermal absorption) be the wall material, fulvic acid is carried out embedding and obtains the fulvic acid liposome, this liposome is effectively improved the color and luster of fulvic acid, join in the skin cleansing composition, the product of making is highly stable " transparent " system at normal temperatures, can reduce its zest in the use, improve color and luster, improve its tack and percutaneous absorbability at skin surface, increase its penetrating power, improve its health-care effect.Be the wall material with lecithin simultaneously, also can increase the effect of moisture retention and slow release, improve resistance to water, strengthen the function of skin protection and skin and complexion improving.In a word, skin cleansing composition of the present invention has realized that by the form of liposome the appearance luster of product under effective addition (generally 0.5-5% gets final product) of fulvic acid can be accepted by user, thereby fulvic acid can be used widely, in the skin-cleaning articles industry for the market of this series products provides new kind.
The specific embodiment
Have effect below in conjunction with specific embodiment detailed description the solution of the present invention and institute, but can not constitute any qualification the scope of the present invention.
The preparation of embodiment 1 fulvic acid liposome
1, the preparation of phosphate buffered solution
1.1, the preparation of 0.2mol/l sodium dihydrogen phosphate stock solution
Take by weighing 27.6g sodium dihydrogen phosphate (NaH
2PO
4H
2O), use deionized water dissolving, and it is standby to be settled to 1000ml.
1.2, the preparation of 0.2mol/l sodium hydrogen phosphate stock solution
Take by weighing 71.7g sodium hydrogen phosphate (Na
2HPO
412H
2O), with deionized water dissolving and to be settled to 1000ml standby.
1.3, get 19.0ml sodium dihydrogen phosphate stock solution and mix with 81.0ml sodium hydrogen phosphate stock solution, adding 100ml deionized water mixing, promptly get pH value be 7.4 phosphate buffered solution, places the wide mouthed bottle storage standby.
2, the preparation of liposome
2.1, get 10g lecithin (available from Beijing biological engineering group that stands out from one's fellows) in beaker, add the about 50ml of acetone, roll cleaning repeatedly with little spoon, remove partial impurities wherein, it is white or little yellow that the color of lecithin is shoaled, it is inferior generally need to give a baby a bath on the third day after its birth.
2.2, with 50ml ethanol above-mentioned lecithin is all dissolved, remove insoluble matter, it is standby to get supernatant.
2.3, fulvic acid 2.5 gram (food stage, biological activity are about 80%, available from Baoding ten thousand state biochemistry corporation,Ltd.s), with the above-mentioned phosphate buffered solution dissolving of 20ml, add glycerol 20g, it is transparent to be stirred to solution with Glass rod.
2.4, be injected into fast in the above-mentioned fulvic acid glycerol mixed solution with the alcoholic solution of syringe above-mentioned phospholipid, and stir.
2.5, in the tank of ultrasonic washing unit, pour suitable quantity of water into, the beaker that fills above-mentioned mixed solution is placed in the water, the addition of water is that beaker does not float and is as the criterion, take out behind the ultrasonication 20min, with vaporized alcohol, fulvic acid liposome dry powder is standby.
Embodiment 2: the dipping bath formula for a product (with 100 the gram products is benchmark, below identical)
AES(70％)：15 BS-12(25％)：10
NaCl:2 essence: 1.5
Fulvic acid liposome: 5 BHT:0.02
Water: surplus
Embodiment 3: the foam bath agent prescription
AES(70％)：30 BS-12(25％)：20
NaCl:2.5 citric acid: 0.5
Essence: 0.25 fulvic acid liposome: 10
BHT:0.1 water: surplus
Using method: get an amount of this product and stir out sufficient foam in 30-45 ℃ of warm water, whole body immerses, and it is better to be aided with massage effect.
Embodiment 4: clean condensation prescription
AESA：15 6501：2
APG-2000：5 CAB-30：5
Carbopol 2020:0.5 fulvic acid liposome: 3
Ve:0.2 water: surplus
This product is faint yellow transparent gel-form, has abundant foam.Use clean of this product, deep clean, lasting moistening has comfortable skin sense, and be not tight.
Embodiment 5: the hand-cleaning liquid prescription
AES：18 CAB：8
Cocos nucifera oil acyl monoethanolamine: 2 citric acids: 0.5
DP-300 (3-chlorine dihydroxy diphenyl ether): 0.3
Fulvic acid liposome: 2.5 Aloe extraction solution (being purchased) 0.5
Essence: an amount of
Water: surplus
This product has stronger bactericidal function, can thoroughly wash one's hands.
Embodiment 6: the soap base type is bathed agent prescription
Dodecoic acid: 12 tetradecylic acids: 6
KOH:4.84 hydroxyethyl-cellulose: 1.0
APG2000:2 BS-12 (betanin): 5
Fulvic acid liposome: 20 BHT:0.1
Water: surplus
The result of use experiment:
Method: select 150 volunteers to participate in the free trial activity, be divided into three groups at random, 50 people are one group, investigate respectively do not add fulvic acid, directly add fulvic acid, to fulvic acid carry out embedding become the bath agent added behind the liposome to antiinflammatory, antipruritic, lessen fatigue and improve the influence of several aspects such as sleep, regularly do information feedback.
In the trial product that every group provides, except that fulvic acid, all the other compositions are identical, and in two groups of trial products of direct adding fulvic acid that provides and adding fulvic acid liposome, fulvic acid content also is identical (about 2%).
Require each group all be shower every day once, use according to conventional method and to bathe agent.
The result: after 20 days, use the volunteer of common bath agent almost not have what sensation, bathe agent and only play cleaning action, minority feels that after bath some loosens; Use the volunteer who directly adds the bath agent of fulvic acid, do not adhere to having 20 people to feel that itching-relieving action is arranged the use except that 6 people feel disagreeable to its color, 18 people feel that sleep state improves; And use the volunteer of the bath agent added the fulvic acid liposome, and there are 43 people to feel to wash the back body and mind and loosened simultaneously, sleep is good, and 48 people feel and significantly moisten and the itching relieving effect.
Conclusion: utilize the prepared bath agent of fulvic acid liposome of the present invention to have the cleaning and health care skin care effect, and color and luster is beautiful, makes us taking like a shot.Fulvic acid liposome of the present invention helps the popularization of fulvic acid in various skin-cleaning articles and cosmetics.
Claims (9)
1, a kind of skin cleansing composition that contains fulvic acid, wherein the effective content of fulvic acid is the 0.5-5% of compositions gross mass, and this fulvic acid composition exists with fulvic acid liposome form, this liposome is for being that the wall material carries out lipid-encapsulated product to fulvic acid with lecithin, and wherein the mass ratio of fulvic acid and lecithin is 1: 3～1: 5;
The surface activity profit and/or soap, the auxiliary agent of convention amount and the water of surplus that also contain compositions gross mass 10-30% in the described skin cleansing composition.
2, the described skin cleansing composition of claim 1, wherein, described surface activity profit is anion surfactant, amphoteric ionic surfactant, non-ionic surface active agent or two or more combination wherein.
3, the described skin cleansing composition of claim 2, wherein, described anion surfactant is the fatty alcohol-polyoxyethylene ether salt; Described zwitterionic surfactant is a betaines; Described non-ionic surface active agent is alkyl androstanediol class or alkanolamide class.
4, the described skin cleansing composition of claim 2, wherein, described surfactant is the combination of anion surfactant and amphoteric ionic surfactant.
5, the described skin cleansing composition of claim 1, wherein, described auxiliary agent alternative comprises the viscosity modifier of 0.1-5%, the antioxidant of 0.02-0.2%, the essence of 0.2-2% and the pH value regulator of 0-1%.
6, the described skin cleansing composition of claim 5, wherein, described viscosity modifier comprises NaCl, and described antioxidant comprises BHT, and described pH value regulator comprises citric acid.
7, each described skin cleansing composition that contains fulvic acid of claim 1-6, wherein, gross mass with compositions is a benchmark, contains the fulvic acid, essence and the citric acid of 0.02-0.5% and the water of surplus of 0.2-2% of BHT, 0.5-5% of NaCl, 0.02-0.2% of empgen BB, the 0.1-5% of polyoxyethylenated alcohol sodium sulfate, the 5-10% of 5-10%.
8, the described skin cleansing composition of claim 1, wherein, described fulvic acid liposome prepares in accordance with the following methods: 1. use dissolve with ethanol lecithin, remove insoluble matter, it is standby to get supernatant; 2. with the phosphate buffered solution of pH 7.4 fulvic acid is dissolved, add glycerol, it is transparent to be stirred to solution; 3. above-mentioned phospholipid alcoholic solution is injected in the fulvic acid glycerol mixed solution fast, stirs; 4. ultrasonic Treatment.
9, the described skin cleansing composition of claim 1 is used to make the purposes of fancy soap, clean agent, hand lotion, bath shampoo or foot bath agent.
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| CN102178630A (en) * | 2011-04-26 | 2011-09-14 | 李雪萍 | Cosmetic application method of biological acid and cosmetic preparation of biological acid |
| CN104224564A (en) * | 2013-06-24 | 2014-12-24 | 天津市安颐实业有限公司 | Anti-aging fulvic acid smoothing toner and preparation method thereof |
| CN103834512B (en) * | 2014-03-11 | 2016-10-26 | 昆明理工大学 | A kind of montanin wax laundry soap and preparation method thereof |
| JP6586268B2 (en) * | 2014-10-07 | 2019-10-02 | 辻製油株式会社 | Method for inhibiting heat coloring of lecithin |
| CN104306587B (en) * | 2014-10-11 | 2017-12-22 | 昆明理工大学 | A kind of blister antipruritic liquid that disappears for bite by mosquitos |
| EP3432903A4 (en) * | 2016-03-26 | 2020-04-08 | Sirbal Ltd. | Herbal nanoformulations for treating psoriasis and other skin conditions |
| WO2018005308A1 (en) * | 2016-06-29 | 2018-01-04 | Sirbal Ltd. | Prognostic and diagnostic methods and herbal therapies for treating dermatoses, autoimmune diseases and inflammatory ailments |
| CN107595752A (en) * | 2017-09-19 | 2018-01-19 | 常州诺丁精密机械制造有限公司 | A kind of preparation method of toner |
| CN107805557A (en) * | 2017-11-10 | 2018-03-16 | 北京泰克美高新技术有限公司 | A kind of handmade soap and preparation method thereof |
| RU2710362C1 (en) * | 2019-03-26 | 2019-12-26 | Валерий Иванович Федосеев | Toilet soap |
-
2003
- 2003-10-29 CN CN 200310103342 patent/CN1219507C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1539404A (en) | 2004-10-27 |
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