CN101940784B - Novel ointment for treating microorganism infection skin disease and preparation process thereof - Google Patents
Novel ointment for treating microorganism infection skin disease and preparation process thereof Download PDFInfo
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- CN101940784B CN101940784B CN201010266092XA CN201010266092A CN101940784B CN 101940784 B CN101940784 B CN 101940784B CN 201010266092X A CN201010266092X A CN 201010266092XA CN 201010266092 A CN201010266092 A CN 201010266092A CN 101940784 B CN101940784 B CN 101940784B
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Abstract
The invention relates to a ointment and a preparation process thereof. The novel ointment for treating the microorganism infection skin disease consists of the following materials in part by mass: 0.1 to 0.3 part of trivalent silver ion compound, 0.2 to 0.4 part of keratinase, 0.5 to 5 parts of water-soluble keratin, 2 to 3 parts of composite vitamin and 94.3 to 98.7 parts of white petroleum jelly. The preparation process particularly comprises the following steps of: grinding 0.1 to 0.3 part of trivalent silver ion compound, 0.2 to 0.4 part of keratinase, 0.5 to 5 parts of water-soluble keratin and 2 to 3 parts of composite vitamin into powder; and adding 94.3 to 98.7 parts of white petroleum jelly into the powder and uniformly mixing the mixture. The ointment has the effects of rapidly sterilizing and relieving itching, expelling toxin and removing rot, and repairing skin. The ointment is suitable for treating and protecting a local skin disease caused by microorganism infection, such as fugal infection of hand and foot, tinea corporis, tinea cruris and onychomycosis (ringworm of the nails) caused by fungi, erysipelas and leprosy caused by bacteria, chicken pox, flat wart and herpes caused by virus and the like.
Description
Technical field:
The present invention relates to dermopathic novel ointment of a kind of treatment infected by microbes and preparation method thereof.
Background technology:
Medically, dermatosis is the disease of relevant skin, is one of the commonly encountered diseases that has a strong impact on people ' s health, frequently-occurring disease, like leprosy, scabies, mycosis, bacterial skin infections etc.Dermatosis is that skin receives (comprising hair and first) (microbial infection) after the influence of internal and external factor, and its form, 26S Proteasome Structure and Function all change, and produce pathological process, and produce various clinical priorities performances accordingly.How low weight dermopathic sickness rate is very high,, often not unhealthful, but minority is heavier even can threat to life.
Existing market treatment infected by microbes causes in the dermopathic medicament, is main with unguentum.Existing medicament is high to disease produce effects speed, and to exceed rate low but control, easy relapse, this mainly be because in the existing medicine mainly to add the antibiotic antibacterial, the hormonal stimulation body is antibiotic to be main.These medicines show to be exactly that effect is rapid clinically, but follow-up weak, are difficult to lasting expression effect, and antibiotic use simultaneously can engender dermopathic Drug resistance.
Summary of the invention:
The objective of the invention is in order a kind of antibiotic and hormone of not containing to be provided, instant effect, dermopathic novel ointment of treatment infected by microbes that cure rate is high and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is: the dermopathic novel ointment of a kind of treatment infected by microbes, specifically form by following substances quality proportioning:
Trivalent silver iron compound 0.1-0.3 part,
Keratinase 0.2-0.4 part,
Water-soluble keratin 0.5-5 part,
Compound vitamin 2-3 part,
White vaseline 94.3-98.7 part.
Said trivalent silver iron compound is a silver sesquioxide.
Said compound vitamin comprises vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K.
Simultaneously; The present invention also provides the method for preparing of the dermopathic novel ointment of this treatment infected by microbes, and is specific as follows: respectively get trivalent silver iron compound 0.1-0.3 part, keratinase 0.2-0.4 part; Water-soluble keratin 0.5-5 part; Compound vitamin 2-3 part, pulverize adds the blending of white vaseline 94.3-98.7 part evenly then.
It is antipruritic that the present invention has quick sterilization, and toxin expellingization is rotten, repairs the skin effect.This unguentum is applicable to the sick treatment and the protection of local skin of infected by microbes, like fungus-caused trick tinea, tinea corporis and cruris and tinea unguium (tinea unguium); Bacterial erysipelas and leprosy; The chickenpox that virus causes, verruca plana and herpes.
The specific embodiment:
For this patent better is described; Below in conjunction with case study on implementation, the present invention is elaborated, should be noted that simultaneously; Following embodiment just explains effectively that to several kinds of situation of patent working of the present invention other any accommodation based on content of the present invention all belongs to the protection category of this patent of invention.
Embodiment 1:
Trivalent silver iron compound 0.1g, keratinase 0.2g, water-soluble keratin 0.5g, 2 of compound vitamines, white vaseline 94.3g.Get compositions such as trivalent silver iron compound, multivitamin, keratinase, keratin according to the above ratio, pulverize adds the white vaseline blending evenly, promptly gets this finished product ointment.
Embodiment 2:
Trivalent silver iron compound 0.2g, keratinase 0.3g, water-soluble keratin 2.5g, 3 of compound vitamines, white vaseline 96.5g.Get compositions such as trivalent silver iron compound, multivitamin, keratinase, keratin according to the above ratio, pulverize adds the white vaseline blending evenly, promptly gets this finished product ointment.
Embodiment 3:
Trivalent silver iron compound 0.3g, keratinase 0.4g, water-soluble keratin 5g, 3 of compound vitamines, white vaseline 98.7g.Get compositions such as trivalent silver iron compound, multivitamin, keratinase, keratin according to the above ratio, pulverize adds the white vaseline blending evenly, promptly gets this finished product ointment.
Above-mentioned trivalent silver iron compound can be prepared from through following method: sodium hydroxide (potassium) 0.1-0.3 part, Tetrasilver tetroxide 1-2 part, sodium peroxydisulfate (potassium) 1-3 part; The abundant grinding mixes evenly, and fineness of the particles is the 100-200 order, goes up mixture adding 3～5 parts of deionized waters (w/v) for per 10 parts; The furnishing semi-fluid condition; Behind 50～80 ℃ of insulation 1～2h, filter, and with distilled water flushing at least three times; With the unreacted sodium peroxydisulfate of flush away (potassium) and sodium hydroxide (potassium) and product sodium sulfate (potassium) impurity, promptly obtain the nanometer trivalent silver iron compound.Said trivalent silver iron compound can be silver sesquioxide, specifically can be: silver sesquioxide.This trivalent silver iron compound is nontoxic, and is non-stimulated, and bactericidal effect can't develop immunity to drugs well, tackles the key component of dermatosis microorganism as this novel ointment.
Said compound vitamin comprises vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K.
Vitamin is the necessary material of human homergy's function, removes indivedual vitamin, outside can being synthesized by human body oneself like vitamin D, generally all needs by external supply.Various common vitamin are clinical all can be helpful to the skin normal growth, all can cause skin injury or microbial infection and lack these vitamin accordingly:
(1) vitamin A: growth, vision and reproductive function to human body are all very important, and nervous system and endocrine are had regulating action, and growth, hypertrophy and the differentiation to epithelial tissue simultaneously has important regulating action, can improve hyperkeratosis.Can be used for treating vitamin A deficiency, pityriasis rubra pilaris, lichen pilaris, ichthyosis, children's's psoriasis, squamous follicular keratosis, carrying out property symmetry erythroderma, pigment property lichen planus, acne conglobata etc.
(2) vitamin B1: with nervous system and hormonal system substantial connection is arranged, the involved in sugar metabolism, and can suppress the activity of acetylcholine esterase, alleviate scytitis.Can be used for treating eczema, dermatitis, pyoderma, candidiasis, light sensation dermatoses, post-herpetic neuralgia, polyneuritis etc.
(3) vitamin B2: the metabolism of involved in sugar, protein and fat, increase ultraviolet toleration, have the antihistaminic effect simultaneously.Can be used for treating seborrheic dermatitis, seborrheic alopecia, acne vulgaris, rosacea, Sycosis vulgaris, mouthful all eczema, solar dermatitis etc.
(4) vitamin B6: suppress histamine, reduce the activity of blood capillary and hyaluronidase, and participate in all amino acid whose synthetic and decomposition.Can be used for treating seborrheic dermatitis, seborrheic alopecia, acne vulgaris, rosacea, eczema, exudative psoriasis, neurodermatitis, prurigo gestationis, alopecia areata, cheilitis etc.
(5) vitamin B12: be essential coenzyme in the multiple metabolic process in the body; Participate in the synthetic of nucleoprotein; The conversion of methyl and the metabolism of fat and sugar can be used for treating chronic urticaria, contact dermatitis, early stage psoriasis, verruca plana, chickenpox, herpes zoster, lichen planus, seborrheic dermatitis, light sensation dermatoses etc.
(6) vitamin C: strengthen the density of capillary wall, lower its permeability and fragility, prevent the diffusion of inflammatory disorders, promote granulation tissue growth and wound healing.Can be used for treating purpuric dermatosis, eczema, urticaria, chloasma, melanosis, the special property sent out speckle shape pigmentation, early stage psoriasis, arsenical dermatitis etc.
(7) vitamin D: with calcium, phosphorus metabolism and autonomic nervous system, endocrine and vascular system substantial connection is arranged, histamine and acetylcholine esterase are had antagonism, have the effect of corticosteroid hormone appearance.Can be used for treating atoipc dermatitis, lupus erythematosus, alopecia areata, acne conglobata, generalized pustular psoriasis etc.
(8) vitamin E: strengthen the capillary of skin resistance; Keep the normal permeability of blood capillary; Improve the capable defense reaction that reaches cold of blood and strengthen, can be used for treating chilblain, erythema multiforme, erythema nodosum, simple purpura, Pigmentary Purpuric Delmatosis, acrocyanasis disease etc.
(9) vitamin K: promote synthetic thrombinogen of liver and blood plasma factor, synergism is arranged, can regulate autonomic nervous dysfunction with corticosteroid hormone.Can be used for treating purpura, chronic urticaria, lymphoma companion skin pruritus etc.
Said keratinase is one type of enzyme with keratin hydrolysing activity of microorganisms, is applied to cosmetics and skincare product at present, helps active factors to see through skin barrier, removes the unnecessary cutin of skin, realizes the deep layer nursing of skin.The cuticular main composition of epiderm skin is a keratin, and it contains more cystine, so disulfide bond content is many especially; In protein peptide chain, play crosslinked action, so chemical property is stable especially, and higher mechanical strength is arranged; Be difficult for dissolving and digestion, contain more cystine (14-15%).Horny layer keratin disulfide bond after physical chemistry or biological method degradation treatment is opened, and can be changed into water-soluble keratin, has the skin keratin of reparation layer function.
Provide below and use the treatment case now with aid illustration:
Method for using: get an amount of ointment, evenly be applied to disease sites, smoothen every day 1-2 time repeatedly.
Result of use:
Hu, the woman, 55 years old, suffer from onychomycosis for many years, the fingernail Lycoperdon polymorphum Vitt, the deck becomes atrophy, and idol has hemorrhage.Use this unguentum to be applied to fingernail, use more than ten day after, the pathological changes fingernail reduces also has new fingernail to form.
Punishment, the woman, 40 years old, intensive needle point big or small pimple, papulovesicle or vesicle took place, conscious itching very much or burn feeling in the skin of back erythema.In all sorts of ways for many years and do not cure, use this ointment to smear five times after, erythema disappears, skin does not have gargalesthesia.
Cao, the man, 69 years old, hand referred to a blister, itched, hospital diagnosis is a virus infected herpes, common hormones ointment is effective on the external market, but recurrence again after the drug withdrawal, use behind this ointment twice and just take effect, once week the back fully recover.
Claims (2)
1. ointment, it is characterized in that: said ointment is made up of following substances quality proportioning:
Silver sesquioxide 0.1-0.3 part,
Keratinase 0.2-0.4 part,
Water-soluble keratin 0.5-5 part,
Compound vitamin 2-3 part,
White vaseline 94.3-98.7 part,
Said compound vitamin comprises vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K.
2. the method for preparing of the described ointment of claim 1; It is characterized in that: said method for preparing is following: respectively get quality than silver sesquioxide 0.1-0.3 part; Keratinase 0.2-0.4 part, water-soluble keratin 0.5-5 part, compound vitamin 2-3 part; Pulverize adds the blending of white vaseline 94.3-98.7 part evenly then.
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| CN201010266092XA CN101940784B (en) | 2010-08-30 | 2010-08-30 | Novel ointment for treating microorganism infection skin disease and preparation process thereof |
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| CN201010266092XA CN101940784B (en) | 2010-08-30 | 2010-08-30 | Novel ointment for treating microorganism infection skin disease and preparation process thereof |
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| CN101940784A CN101940784A (en) | 2011-01-12 |
| CN101940784B true CN101940784B (en) | 2012-04-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4104814A1 (en) * | 2021-06-15 | 2022-12-21 | DSM IP Assets B.V. | Novel use of vitamin b12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586891A (en) * | 2014-12-30 | 2015-05-06 | 谭华陶 | Active polypeptide with effect of treating acne as well as preparation method and application of active polypeptide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1324607A (en) * | 2000-03-27 | 2001-12-05 | 塔罗制药工业有限公司 | Anti-fungus agent for local treatment of fungus infection of finger and its peripheral tissue and controllable releasable system of keratin-dissolving agnt |
| CN101644000A (en) * | 2008-08-04 | 2010-02-10 | 香港纺织及成衣研发中心 | In-situ synthetic method for nanometer multifunctional silver-protein struture |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070292355A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1324607A (en) * | 2000-03-27 | 2001-12-05 | 塔罗制药工业有限公司 | Anti-fungus agent for local treatment of fungus infection of finger and its peripheral tissue and controllable releasable system of keratin-dissolving agnt |
| CN101644000A (en) * | 2008-08-04 | 2010-02-10 | 香港纺织及成衣研发中心 | In-situ synthetic method for nanometer multifunctional silver-protein struture |
Non-Patent Citations (1)
| Title |
|---|
| 杨建强等.角蛋白酶研究进展.《生物技术通讯》.2005,第16卷(第2期),201-203. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4104814A1 (en) * | 2021-06-15 | 2022-12-21 | DSM IP Assets B.V. | Novel use of vitamin b12 |
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| CN101940784A (en) | 2011-01-12 |
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Owner name: SUZHOU TNY SANJIA NANOMETER TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SUZHOU BANGAN NEW MATERIAL SCIENCE AND TECHNOLOGY CO., LTD. Effective date: 20130201 |
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Effective date of registration: 20130201 Address after: 215000 Jiangsu province Suzhou Wuzhong Changqiao Su Li Road No. 62 Patentee after: SUZHOU TNY3+ NANOTECHNOLOGY CO.,LTD. Address before: Double road Suzhou Industrial Park Suzhou city Jiangsu province 215122 No. 2 Patentee before: SUZHOU BANGAN NEW MATERIAL TECHNOLOGY CO.,LTD. |
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