CN103083349A - Compound fluconazole gel for pets and preparation process thereof - Google Patents
Compound fluconazole gel for pets and preparation process thereof Download PDFInfo
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- CN103083349A CN103083349A CN 201110342856 CN201110342856A CN103083349A CN 103083349 A CN103083349 A CN 103083349A CN 201110342856 CN201110342856 CN 201110342856 CN 201110342856 A CN201110342856 A CN 201110342856A CN 103083349 A CN103083349 A CN 103083349A
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- fluconazole
- compound fluconazole
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Abstract
The invention belongs to the technological field of veterinary medicines. Specifically, the invention mainly relates to a prescription of a compound fluconazole gel treating mixed infection of bacteria, fungi and mites in pets and a preparation process thereof. The invention provides an externally applied gel preparation with good breathability and transdermal absorption, small irritation as well as good curative effects, i.e. the compound fluconazole gel. The compound fluconazole gel prepared according to the prescription and process provided in the invention overcomes the disadvantages of high oil content and poor breathability in existing veterinary compound fluconazole ointments, fills the blank of the veterinary drug market, and has the characteristics of good curative effects and good breathability.
Description
Technical field
The invention discloses a kind of house pet with compound fluconazole gel and preparation technology thereof, belong to the veterinary drug preparation technical field.
Background technology
The sick abnormal refractory of present pet skin, and mixed infection is serious, the medicine of existing treatment pet skin disease adopts people's medicine more, because man and animal skin is widely different, therefore medicine is difficult to the due effect of performance, and people's medicine is for animals and China's veterinary drug rules are contrary, so the related drugs dosage form of the treatment skin of house pet urgent clinical needs house pet special use.
The gel good permeability, be particularly suitable for the underdeveloped sweat gland of pet skin, be conducive to the self-recovery of skin, and gel is with an organic solvent few, zest is little, and is safe, even licked can be not busy yet for house pet, therefore gel is relatively to be fit to the clinical use of house pet, there is not yet at present treatment house pet Related Skin Diseases gel dosage form both at home and abroad and occurs.
The mixed emotion condition of current dermatosis is extremely serious, and the single medicine composition has been difficult to play the effect that As the medicine took effect, the symptoms lessened, and the compound medicines that therefore draws by drug regimen becomes one of direction of house pet medicine research and development.
Summary of the invention
The object of the invention is to fill up the blank in house pet medicine market, a kind of compound fluconazole gel and preparation technology of effective treatment pet skin disease is provided.
For reaching above purpose, the technical solution used in the present invention is: a kind of house pet is with a kind of compound fluconazole gel, it is characterized in that the hydrotrope take Acritamer 940 is as substrate, take fluconazol, woods Mycosporin, Borneolum Syntheticum, indomethacin, lignocaine as principal agent, take the hydroxy benzoic acid esters as antiseptic, take ethanol or azone as transdermal enhancer, take triethanolamine, diethanolamine or sodium hydroxide as acid-base modifier.By weight, wherein the concentration of the Acritamer 940 hydrotrope is 1%-3%; The concentration of fluconazol, lincomycin, Borneolum Syntheticum, indomethacin, lignocaine is respectively 1-3%, 2-4%, 1-3%, 0.5-1%, 0.5%-2%, and the concentration of hydroxy benzoic acid esters antiseptic is 0.5%-1%; The consumption of transdermal enhancer is 0.5%-1%; The acid-base modifier consumption is 8%-15%; Other is water.
A kind of preparation technology of compound fluconazole gel is characterized in that getting Acritamer 940, antiseptic adds the pure water swelling to spend the night; Next day, get fluconazol, lincomycin, Borneolum Syntheticum, indomethacin, lignocaine and add water and grind, add respectively in carbomer, stir, make mix homogeneously there is no a large amount of bubbles.Add pH adjusting agent, transdermal agent adds water quantitative; Continue to stir, to complete mix homogeneously, get the compound fluconazole gel.
The invention has the advantages that, prepared gel homogeneity is good, good permeability, good absorbing, nonirritant, is particularly suitable for the clinical use of house pet.
The specific embodiment
Get Acritamer 940 2g, oxybenzene second fat 0.05g adds water-soluble swollen the spending the night of 20mL.Next day, get fluconazol 1.5g, lincomycin hydrochloride 3g, Borneolum Syntheticum 1.5g, indomethacin 0.5g, lignocaine 1g adds water and grinds, and adds respectively in carbomer, stirs, and makes mix homogeneously there is no a large amount of bubbles.Add the 10mL triethanolamine, the 0.5mL azone.Continue to stir, to complete mix homogeneously.Get the compound fluconazole gel.
Claims (10)
1. compound fluconazole gel is characterized in that the hydrotrope take Acritamer 940 is as substrate, take fluconazol, lincomycin, Borneolum Syntheticum, indomethacin, lignocaine as principal agent, take the hydroxy benzoic acid esters as antiseptic.
2. compound fluconazole gel described according to claims 1, wherein the concentration of the Acritamer 940 hydrotrope is 1%-3%.
3. Compound Ketoconazone Gel described according to claims 1, wherein the concentration of fluconazol, lincomycin, Borneolum Syntheticum, indomethacin, lignocaine is respectively 1-3%; 2-4%; 1-3%; 0.5-1%; 0.5%-2%, other is water.
4. compound fluconazole gel described according to claims 1, wherein hydroxy benzoic acid esters antiseptic can be methyl hydroxybenzoate, ethyl hydroxybenzoate, butyl hydroxybenzoate.
5. compound fluconazole gel described according to claims 4, wherein the concentration of hydroxy benzoic acid esters antiseptic is 0.5%-1%.
6. compound fluconazole gel, the acid-base modifier that it is characterized in that substrate is triethanolamine, diethanolamine or sodium hydroxide.
7. a compound fluconazole gel, is characterized in that its transdermal enhancer is ethanol or azone.
8. compound fluconazole gel described according to claims 6, the acid-base modifier consumption that it is characterized in that substrate is 8%-15%.
9. compound fluconazole gel described according to claims 7, the consumption that it is characterized in that its transdermal enhancer is 0.5%-1%.
10. compound fluconazole gel, it is characterized in that its preparation method for get Acritamer 940, antiseptic adds the pure water swelling to spend the night; Next day, get fluconazol, lincomycin, Borneolum Syntheticum, indole U.S. property, lignocaine adds water and grinds, and adds respectively in carbomer, stirs, and makes mix homogeneously there is no a large amount of bubbles; Add pH adjusting agent, transdermal agent adds water quantitative; Continue to stir, to complete mix homogeneously, get the compound fluconazole gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110342856 CN103083349A (en) | 2011-11-03 | 2011-11-03 | Compound fluconazole gel for pets and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110342856 CN103083349A (en) | 2011-11-03 | 2011-11-03 | Compound fluconazole gel for pets and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103083349A true CN103083349A (en) | 2013-05-08 |
Family
ID=48196830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110342856 Pending CN103083349A (en) | 2011-11-03 | 2011-11-03 | Compound fluconazole gel for pets and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103083349A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108338968A (en) * | 2018-03-14 | 2018-07-31 | 青岛科技大学 | One kind is for pet treating otitis media paste and preparation method thereof |
| CN111358851A (en) * | 2020-04-13 | 2020-07-03 | 长江大学 | Gel for treating pet skin diseases and preparation method thereof |
| CN112220789A (en) * | 2020-11-10 | 2021-01-15 | 马保臣 | Compound lidocaine gel for pets, and preparation method and quality control method thereof |
-
2011
- 2011-11-03 CN CN 201110342856 patent/CN103083349A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108338968A (en) * | 2018-03-14 | 2018-07-31 | 青岛科技大学 | One kind is for pet treating otitis media paste and preparation method thereof |
| CN111358851A (en) * | 2020-04-13 | 2020-07-03 | 长江大学 | Gel for treating pet skin diseases and preparation method thereof |
| CN112220789A (en) * | 2020-11-10 | 2021-01-15 | 马保臣 | Compound lidocaine gel for pets, and preparation method and quality control method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130508 |