CN121695288A - Setd2抑制剂和相关方法和用途，包括组合疗法 - Google Patents

Setd2抑制剂和相关方法和用途，包括组合疗法

Info

Publication number
CN121695288A
CN121695288A CN202511995231.5A CN202511995231A CN121695288A CN 121695288 A CN121695288 A CN 121695288A CN 202511995231 A CN202511995231 A CN 202511995231A CN 121695288 A CN121695288 A CN 121695288A
Authority
CN
China
Prior art keywords
alkyl
cycloalkyl
optionally substituted
amino
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202511995231.5A
Other languages
English (en)
Chinese (zh)
Inventor
M·A·雷蒙迪
J·A·托特曼
V·莫特瓦尼
K·L·科斯莫普洛斯
J·兰珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epizyme Inc
Original Assignee
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc filed Critical Epizyme Inc
Publication of CN121695288A publication Critical patent/CN121695288A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202511995231.5A 2020-02-19 2021-02-19 Setd2抑制剂和相关方法和用途，包括组合疗法 Pending CN121695288A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062978692P 2020-02-19 2020-02-19
US62/978,692 2020-02-19
PCT/US2021/018863 WO2021168313A1 (en) 2020-02-19 2021-02-19 Setd2 inhibitors and related methods and uses, including combination therapies
CN202180028429.XA CN115380033B (zh) 2020-02-19 2021-02-19 Setd2抑制剂和相关方法和用途，包括组合疗法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202180028429.XA Division CN115380033B (zh) 2020-02-19 2021-02-19 Setd2抑制剂和相关方法和用途，包括组合疗法

Publications (1)

Publication Number Publication Date
CN121695288A true CN121695288A (zh) 2026-03-20

Family

ID=77391740

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202511995231.5A Pending CN121695288A (zh) 2020-02-19 2021-02-19 Setd2抑制剂和相关方法和用途，包括组合疗法
CN202180028429.XA Active CN115380033B (zh) 2020-02-19 2021-02-19 Setd2抑制剂和相关方法和用途，包括组合疗法

Family Applications After (1)

Application Number Title Priority Date Filing Date
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Country Status (11)

Country Link
US (1) US12691111B2 (enExample)
EP (1) EP4107157A4 (enExample)
JP (1) JP2023514280A (enExample)
KR (1) KR20220143116A (enExample)
CN (2) CN121695288A (enExample)
AU (1) AU2021224855A1 (enExample)
BR (1) BR112022016573A2 (enExample)
CA (1) CA3168069A1 (enExample)
IL (1) IL295654A (enExample)
MX (1) MX2022010171A (enExample)
WO (1) WO2021168313A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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IL272379B2 (en) 2017-08-14 2025-11-01 Epizyme Inc Methods of treating cancer by inhibiting setd2
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CN121695288A (zh) 2020-02-19 2026-03-20 Epizyme股份有限公司 Setd2抑制剂和相关方法和用途，包括组合疗法
EP4351552A4 (en) * 2021-06-09 2025-06-18 Epizyme, Inc. COMBINATION THERAPIES WITH SETD2 INHIBITORS
CN117956995A (zh) * 2021-08-30 2024-04-30 江苏恒瑞医药股份有限公司 一种ezh2抑制剂用于制备治疗t细胞淋巴瘤的药物的用途
AU2022377650A1 (en) * 2021-11-01 2024-05-16 Epizyme, Inc. Crystalline forms of n-((1r,3s)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1h-indole-2-carboxamide
CN117486779A (zh) * 2023-09-26 2024-02-02 青岛海洋生物医药研究院股份有限公司 一种3-羟基-2-氧化吲哚类化合物及其在制备抗肿瘤药物中的应用

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Publication number Publication date
CN115380033A (zh) 2022-11-22
CA3168069A1 (en) 2021-08-26
KR20220143116A (ko) 2022-10-24
AU2021224855A1 (en) 2022-09-08
US20230133671A1 (en) 2023-05-04
BR112022016573A2 (pt) 2022-11-08
EP4107157A1 (en) 2022-12-28
MX2022010171A (es) 2022-12-06
JP2023514280A (ja) 2023-04-05
CN115380033B (zh) 2026-01-09
WO2021168313A1 (en) 2021-08-26
US12691111B2 (en) 2026-07-28
EP4107157A4 (en) 2024-03-13
IL295654A (en) 2022-10-01

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