CN121358758A - 一种新型双特异性融合蛋白及其用途 - Google Patents

一种新型双特异性融合蛋白及其用途

Info

Publication number
CN121358758A
CN121358758A CN202480041232.3A CN202480041232A CN121358758A CN 121358758 A CN121358758 A CN 121358758A CN 202480041232 A CN202480041232 A CN 202480041232A CN 121358758 A CN121358758 A CN 121358758A
Authority
CN
China
Prior art keywords
glp
fusion protein
bispecific fusion
diabetes
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202480041232.3A
Other languages
English (en)
Chinese (zh)
Inventor
成永哲
杨尚仁
卢在一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Slbigen Inc
Original Assignee
Slbigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slbigen Inc filed Critical Slbigen Inc
Publication of CN121358758A publication Critical patent/CN121358758A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN202480041232.3A 2023-06-22 2024-06-21 一种新型双特异性融合蛋白及其用途 Pending CN121358758A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR2023008718 2023-06-22
KRPCT/KR2023/008718 2023-06-22
PCT/KR2024/008655 WO2024263005A1 (ko) 2023-06-22 2024-06-21 신규 이중 특이성 융합단백질 및 그의 용도

Publications (1)

Publication Number Publication Date
CN121358758A true CN121358758A (zh) 2026-01-16

Family

ID=93935935

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202480041232.3A Pending CN121358758A (zh) 2023-06-22 2024-06-21 一种新型双特异性融合蛋白及其用途

Country Status (5)

Country Link
EP (1) EP4733314A1 (https=)
JP (1) JP2026507086A (https=)
CN (1) CN121358758A (https=)
AU (1) AU2024313859A1 (https=)
WO (1) WO2024263005A1 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070115947A (ko) * 2005-02-11 2007-12-06 아밀린 파마슈티칼스, 인크. 선택가능한 특성들을 가지는 ｇｉｐ 유사체 및 하이브리드폴리펩타이드
ES2623925T3 (es) 2007-05-30 2017-07-12 Postech Academy-Industry- Foundation Proteínas de fusión de inmunoglobulina
KR101442254B1 (ko) 2008-02-22 2014-09-24 포항공과대학교 산학협력단 최적의 진핵 세포 발현 벡터의 개발
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
KR101825048B1 (ko) * 2014-12-31 2018-02-05 주식회사 제넥신 GLP 및 면역글로불린 하이브리드 Fc 융합 폴리펩타이드 및 이의 용도
KR102349717B1 (ko) * 2020-03-12 2022-01-11 주식회사 에스엘메타젠 신규 대사증후군 및 그와 관련된 질환 치료용 약학 조성물
US20240368239A1 (en) * 2020-03-12 2024-11-07 Sl Metagen Novel bispecific protein and use thereof

Also Published As

Publication number Publication date
WO2024263005A1 (ko) 2024-12-26
JP2026507086A (ja) 2026-02-27
AU2024313859A1 (en) 2026-01-15
EP4733314A1 (en) 2026-04-29

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