CN1212852C

CN1212852C - Medicine for curing cervical spondylopathy

Info

Publication number: CN1212852C
Application number: CNB011372036A
Authority: CN
Inventors: 薛志祥
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-10-20
Filing date: 2001-10-20
Publication date: 2005-08-03
Anticipated expiration: 2021-10-20
Also published as: CN1428155A

Abstract

The present invention relates to a pure Chinese medicinal preparation for curing cervical spondylosis, which is a cervical spondylosis curing medicine prepared from 10 kinds of Chinese herbal medicines (preferred parts by weight): 100 parts of long-noded pit viper, 100 parts of cibot rhizome, 30 parts of succinum, 30 parts of cassia branch, 30 parts of red sage root, 30 parts of Chinese clematis, 30 parts of kudzuvine root, 30 parts of rhizoma drynariae, 30 parts of centipede and 30 parts of stir-frying nux vomica according to a special technology. The present invention has the efficiency of activating blood circulation to dissipate blood stasis and dredging channels and particularly has a significant curative effect on nervus root type cervical spondylosis, vertebral artery type cervical spondylosis, sympathetic type cervical spondylosis and mixed type cervical spondylosis.

Description

A kind of medicine for the treatment of cervical spondylosis

Cervical spondylosis claims cervical vertebra syndrome again, is because the cervical intervertebral disk degenerative changes caused a series of symptom, and clinical manifestation is dizzy and symptomes complices such as neck, shoulder, arm, hands pain, numbness.

This is a kind of commonly encountered diseases, frequently-occurring disease, the multiple age is in 30-50 year, a young and middle-aged in recent years patient also is an ascendant trend, but in the treatment patient, 9 years old～13 years old juvenile student is also arranged, thereby they cause cervical spondylosis owing to quarrelling and fighting noisily to cause injury, person between twenty and fifty are again because of bending over one's desk working for a long time, as accounting, editor's etc. about 30 years old woman, their sickness rate is more than 95%.

The cause of disease of cervical spondylosis: endogenous cause of ill is a 1. 2. caused by liver and kidney deficiency of congenital malformation; Exopathogenic factor is because of acute cervical spinal injury, chronic strain, and the acute inflammation around the wind-cold damp pathogen, neck all can cause the generation of primary disease.

Chinese medicine thinks that the skeleton of suffering from a deficiency of the kidney loses supports, gas, blood, expectorant, arthralgia due to blood stasis resistance passages through which vital energy circulates.The skeleton of suffering from a deficiency of the kidney then loses in moistening foster, gives birth in the hyperosteogeny, causes injury of tendon and muscle flesh and decreases, and of a specified duration is blood-stasis internal-depression; Second blood operation in Tianjin is unable, and stopping coacervation is phlegm-turbidity and blood stasis blood, the obstruction of meridian circulation, and dignified with the passing of time hyperosteogeny is living.Primary disease is levying of deficiency in origin and excess in superficiality, die and consolidate it with the kidney invigorating, control its mark with blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, and as the principles of formulating prescriptions, formed " a kind of medicine for the treatment of cervical spondylosis ", clinical observation shows that this medicine is all effective to each myelopathy, and is more outstanding to spondylotic radiculopathy, vertebral artery type, adrenergic type, mixed type curative effect especially.Rhizoma Cibotii bitter in the mouth, sweet, warm is returned the Liver and kidney warp in the side." book on Chinese herbal medicine justice ": " can the replenishing vital QI with drugs of warm nature Liver and kidney, logical hundred arteries and veins of transferring, strong waist knee joint, hard spine, sharp joint, and drive the numbness work; it is useless to play flaccidity again can astringency inducing dash and stagnate, and strong superintending and directing appointed, and effect is very grand, really the product used of weak old and feeble perseverance; and temperature and not dry, walks and does not let out, and particularly has every advantage and not a single disadvantage, not to attach most importance to, very unfortunately also." book on Chinese herbal medicine through vegetables ": " Rhizoma Cibotii, bitter can dampness, the beneficial blood of sweet energy, temperature can be fostered the spirit of nobility, be mend and the medicine that can walk also.Suffering from a deficiency of the kidney, then the back is strong, and there is the disease of emergency in office, the nourishing kidney replenishing QI and blood, and then the back is not strong, the trouble of the no emergency of office.So I in the treating cervical spondylosis prescription, reuse Rhizoma Cibotii with dispelling wind and relieving pain, mending the strong waist of bone is principal agent.Agkistrodon sweet in the mouth, salty, warm in the side, the poisonous Liver Channel of returning.This moral character is apt to away scurry, in walk internal organs, infuse fur outward, nowhere less than, can search ailment said due to cold or exposure, saturating joint is used for wind chill blockage more, limbs pain, joint is unfavorable, the stupid numb disease of muscle is equipped with Semen Strychni (processed), the Scolopendra channels sootheing and network vessel quickening is principal agent in the side again.Be equipped with the Ramulus Cinnamomi qi and blood circulation promotion in the side, the meridian dredging; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling: Radix Puerariae is with controlling stiff nape and back: " medicine justice ": " Radix Clematidis: property is fierce, and lid is walked and do not kept, the logical twelve channels and collaterals of a surname; cure mainly wind, wet, expectorant is stopped up in the meridians that stagnate, and causes into the gout migratory arthralgia caused by wind, and arthralgia is swollen or numb; because of its power violent, also can cartilage.Rhizoma Drynariae: the continuous muscle of the kidney invigorating pain relieving is cured the wound.Full side's compatibility, also invigorating the liver and kidney is consolidated it, and the meridian dredging blood circulation promoting and blood stasis dispelling that relaxes is again controlled its mark, so the treatment cervical spondylosis is had significant curative effect.

Therefore, medicine of the present invention is to be the Chinese patent medicine that feedstock production forms with following pharmaceutical composition.

Agkistrodon 100-200 gram, Rhizoma Cibotii 100-200 gram, succinum 30-50 gram, Ramulus Cinnamomi 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Radix Clematidis 30-50 gram, Radix Puerariae 30-50 gram, Rhizoma Drynariae 30-50 gram, Wu pine 30-50 gram, Semen Strychni (processed) 30-50 restrain (weight portion).

The preferred weight proportioning of pharmaceutical composition of the present invention is:

Agkistrodon 100, Rhizoma Cibotii 100, succinum 30, Ramulus Cinnamomi 30, Radix Salviae Miltiorrhizae 30, Radix Clematidis 30, Radix Puerariae 30, Rhizoma Drynariae 30, Scolopendra 30, Semen Strychni (processed) 30 (weight portion)

Pharmaceutical composition of the present invention can be prepared into any pharmaceutical preparation that is suitable for using clinically according to conventional formulation technology.For example: pill, tablet, powder, capsule, granule any.

Pharmaceutical composition of the present invention can directly prepare patent medicine, also can extract respectively each group of compositions, prepares patent medicine then, and these are all within protection scope of the present invention.

Process for preparing medicine of the present invention is:

1, selected crude drug: selected high-quality Chinese crude drug, remove impurity, differentiate and the run-of-the-mill check that by pharmacopeia regulation of poor quality, rotten, worm post, defective medical material such as go mouldy must not use.

2; polish: with Agkistrodon; Rhizoma Cibotii; Ramulus Cinnamomi; Radix Salviae Miltiorrhizae; Radix Clematidis; Radix Puerariae; Rhizoma Drynariae; Scolopendra; Semen Strychni (processed) adds 8 times of water loggings or does not have powder 2-3cm; heating decocts 2 hours after-filtration; medicinal residues add 4 times of amounts of water; heating for the second time decocts and filtered in 1 hour again; the merging filtrate low-temperature evaporation; be concentrated into half amount of original volume; adding 95% ethanol equivalent mixing spends the night and makes sedimentation; the supernatant that inclines steams to slip and reclaims ethanol, and revaporization concentrates; putting cold place filtered precipitation in 24 hours fully; the filtrate low-temperature evaporation is to flute honey shape (water content 20%), and succinum is ground into powder and is blended into, and adds an amount of excipient mixing; make soft material with 70% ethanol; move to granulation machine 12 orders and granulate, put in the baking oven dry again under the low temperature, encapsulated standby (per 1 gram contains crude drug 2 grams).

Pharmaceutical composition of the present invention has liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, the effect of the meridian dredging that relaxes.Especially comparatively outstanding to spondylotic radiculopathy, vertebral artery type, adrenergic type, mixed type cervical spondylosis curative effect.

Clinical research:

1, physical data: 100 examples are organized in treatment, matched group 100 examples.Sex and age treatment group: male's 60 examples, schoolgirl's 40 examples.10 examples below 40 years old, 40-50 year 50 examples, 50-60 year 30 examples, 60-70 year 10 examples, the course of disease is the longest 20 years, the shortest person 3 months.Pathology typing: spondylotic radiculopathy 50 examples, vertebral artery type 30 examples, adrenergic type 10 examples, mixed type 10 examples.Tcm syndrome differentiation and typing: wind and cold wet type 30 examples, qi stagnation and blood stasis type 20 examples, phlegm-damp resistance network type 10 examples, deficiency of the liver and kindey type 20 examples, deficiency of qi and blood type 20 examples.

Matched group: 100 examples, male 60 examples, women 40 examples.9 examples below 40 years old, 45-50 year 50 examples, 50-60 year 25 examples, 60-70 year 16 examples.The course of disease is the longest 18 years, and is the shortest 5 months.Pathology typing: spondylotic radiculopathy 20 examples, vertebral artery type 20 examples, adrenergic type 50 examples, mixed type 10 examples, tcm syndrome differentiation and typing: wind and cold wet type 20 examples, qi stagnation and blood stasis type 20 examples, phlegm-damp resistance network type 30 examples, deficiency of the liver and kindey type 30 types.

All case all meets " differential diagnosis in tcm diagnosis criterion of therapeutical effect ":

1, about the diagnostic criteria of cervical spondylosis.

2, Therapeutic Method: the treatment group is taken " a kind of medicine for the treatment of cervical spondylosis ", and each 3, every 0.5 gram, day 3 times.Matched group is taken ZHUANGGU GUANJIE WAN (southern pharmaceutical factory produces), and every day 2 times, each 10 grams are all taken 3 months post-evaluation curative effects for two groups continuously.

3, result:

3.1 criterion of therapeutical effect: formulate with reference to " clinical disease diagnosis is according to curing the improvement standard ".

3.2 therapeutic outcome: the treatment group is cured 40 examples (40%), 50 examples that take a turn for the better (50%), invalid 10 examples (10%), total effective rate 90%.

Matched group is cured 7 examples (7%), 27 examples that take a turn for the better (27%), invalid 66 examples (66%), total effective rate (34%).

Two groups of total effective rates relatively there were significant differences P＜0.01

Two groups of each pathology typings relatively see Table 1

Table 1 liang group different pathological pattern of syndrome curative effect:

Eurymeric	Group	N	Cure	Take a turn for the better	Invalid	Effective percentage (%)
Eurymeric	Group	N	Cure	Take a turn for the better	Invalid	Effective percentage (%)	Spondylotic radiculopathy	The treatment group	50	20	27	3	94％
Matched group	20	3	4	13	35％			The treatment group	50	20	27	3	94％
Matched group	20	3	4	13	35％	Vertebral artery type		The treatment group	30	10	16	4	86.7％
Matched group	20	2	4	14	30％			The treatment group	30	10	16	4	86.7％
Matched group	20	2	4	14	30％		Adrenergic type	The treatment group	10	5	4	1	90％
Matched group	50	1	17	32	36％			The treatment group	10	5	4	1	90％
Matched group	50	1	17	32	36％	Mixed type		The treatment group	10	5	3	2	80％
Matched group	10	1	2	7	30％			The treatment group	10	5	3	2	80％

Annotate: compare ※ P＜0.05 ※ P＜0.01 with matched group

Experimentation:

One, experiment material: get 20 of healthy rabbits, behind the labelling of weighing, be divided into treatment group and matched group at random, every group of 10 white rabbits.

Two, experimental technique: the rabbit knee joint is carried out 90 degree stretch a formula and fix, stretch and fix 40 days, early stage hyperosteogeny forms and the cartilage degeneration, rabbit model, wherein treatment group gavages 3 with a kind of medicine for the treatment of cervical spondylosis at every turn, every day 3 times, matched group gavages each 10 grams of ZHUANGGU GUANJIE WAN, and day 2 times, two groups was a course of treatment with 3 months all.

Three, experimental result: a kind of medication therapy groups for the treatment of cervical spondylosis: after gavaging 3 months, the clinic control hyperosteogeny disappears softening, and painful fiber crops recover to reach 91%.ZHUANGGU GUANJIE WAN matched group: after gavaging 3 months, face the painful fiber crops of control and reach 80%.A kind of medication therapy groups and matched group for the treatment of cervical spondylosis all can obviously alleviate the control clinical symptoms, but treatment group curative effect is better than matched group, P＜0.05.

Embodiment: Agkistrodon 100, Rhizoma Cibotii 100, Ramulus Cinnamomi 30, succinum 30, Radix Salviae Miltiorrhizae 30, Radix Clematidis 30, Radix Puerariae 30, Rhizoma Drynariae 30, Scolopendra 30, Semen Strychni (processed) 30 (weight portion)

Technology:

Defective medical materials such as 1, selected crude drug: selected high-quality Chinese crude drug is removed impurity, and differentiates and the run-of-the-mill check by the pharmacopeia regulation, and is of poor quality, as to go bad, go mouldy must not use.

2; polish: with Agkistrodon; Rhizoma Cibotii; Ramulus Cinnamomi; Radix Salviae Miltiorrhizae; Radix Clematidis; Radix Puerariae; Rhizoma Drynariae; Scolopendra; Semen Strychni (processed); add 8 times of water loggings or do not have powder 2-3cm; heating decocts 2 hours after-filtration; medicinal residues add 4 times of amounts of water, 1 hour after-filtration of heating decoction for the second time again; the merging filtrate low-temperature evaporation; be concentrated into half amount of original volume; adding 95% ethanol equivalent mixing spends the night and makes sedimentation; the supernatant that inclines steams to slip and reclaims ethanol; revaporization concentrates, and puts cold place and precipitation is filtered fully in 24 hours, and the filtrate low-temperature evaporation is to dense shape (water content 20%); succinum is ground into powder and is blended into; add an amount of excipient mixing, make soft material with 70% ethanol, dislocation granulation machine 12 orders are granulated; put that the drying cartridge capsule is standby again under the low temperature in the baking oven, adorn 0.5 gram (every gram contains crude drug 2 grams) for every.

Claims

1, a kind of medicine for the treatment of cervical spondylosis is characterized in that: with Agkistrodon 100-200 gram, and Rhizoma Cibotii 100-200 gram, succinum 30-50 gram, Ramulus Cinnamomi 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Radix Clematidis 30-50 gram, Radix Puerariae 30-50 gram, Rhizoma Drynariae 30-50 gram, Wu pine 30-50 gram, Semen Strychni (processed) 30-50 restrains.

2, a kind of medicine for the treatment of cervical spondylosis according to claim 1 is characterized in that: with Agkistrodon 100 grams, and Rhizoma Cibotii 100 grams, succinum 30 grams, Ramulus Cinnamomi 30 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Clematidis 30 grams, Radix Puerariae 30 grams, Rhizoma Drynariae 30 grams, Scolopendra 30 grams, Semen Strychni (processed) 30 is made.

3, a kind of medicine for the treatment of cervical spondylosis according to claim 1 and 2 is characterized in that: make any one dosage form in pill, tablet, powder, capsule, the granule.