CN121175436A - 用压电式机械敏感离子通道组分1(piezo1)激动剂治疗静脉曲张 - Google Patents

用压电式机械敏感离子通道组分1(piezo1)激动剂治疗静脉曲张

Info

Publication number
CN121175436A
CN121175436A CN202280060862.6A CN202280060862A CN121175436A CN 121175436 A CN121175436 A CN 121175436A CN 202280060862 A CN202280060862 A CN 202280060862A CN 121175436 A CN121175436 A CN 121175436A
Authority
CN
China
Prior art keywords
seq
complement
thymine
uracil
piezo1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280060862.6A
Other languages
English (en)
Chinese (zh)
Inventor
M·A·R·费雷拉
J·巴克曼
A·李
A·巴拉斯
G·阿贝卡西斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CN121175436A publication Critical patent/CN121175436A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280060862.6A 2021-07-08 2022-07-05 用压电式机械敏感离子通道组分1(piezo1)激动剂治疗静脉曲张 Pending CN121175436A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163219462P 2021-07-08 2021-07-08
US63/219,462 2021-07-08
PCT/US2022/073441 WO2023283560A1 (en) 2021-07-08 2022-07-05 Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists

Publications (1)

Publication Number Publication Date
CN121175436A true CN121175436A (zh) 2025-12-19

Family

ID=82748409

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280060862.6A Pending CN121175436A (zh) 2021-07-08 2022-07-05 用压电式机械敏感离子通道组分1(piezo1)激动剂治疗静脉曲张

Country Status (10)

Country Link
US (1) US20230041060A1 (https=)
EP (1) EP4367266A1 (https=)
JP (1) JP2024524554A (https=)
KR (1) KR20240049797A (https=)
CN (1) CN121175436A (https=)
AU (1) AU2022307546A1 (https=)
CA (1) CA3225855A1 (https=)
IL (1) IL309694A (https=)
MX (1) MX2023015276A (https=)
WO (1) WO2023283560A1 (https=)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK4317456T3 (da) * 2019-02-18 2025-09-08 Regeneron Pharma Varianter af mekanoensitiv ionkanalkomponent 1 af piezotypen (piezo1) og anvendelser deraf

Also Published As

Publication number Publication date
WO2023283560A1 (en) 2023-01-12
CA3225855A1 (en) 2023-01-12
MX2023015276A (es) 2024-04-03
JP2024524554A (ja) 2024-07-05
EP4367266A1 (en) 2024-05-15
AU2022307546A1 (en) 2024-01-04
IL309694A (en) 2024-02-01
US20230041060A1 (en) 2023-02-09
KR20240049797A (ko) 2024-04-17

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