CA3225855A1 - Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists - Google Patents

Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists Download PDF

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Publication number
CA3225855A1
CA3225855A1 CA3225855A CA3225855A CA3225855A1 CA 3225855 A1 CA3225855 A1 CA 3225855A1 CA 3225855 A CA3225855 A CA 3225855A CA 3225855 A CA3225855 A CA 3225855A CA 3225855 A1 CA3225855 A1 CA 3225855A1
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CA
Canada
Prior art keywords
seq
complement
position corresponding
piez01
uracil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3225855A
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English (en)
French (fr)
Inventor
Manuel Allen Revez FERREIRA
Joshua Backman
Alexander LI
Aris BARAS
Goncalo Abecasis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CA3225855A1 publication Critical patent/CA3225855A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3225855A 2021-07-08 2022-07-05 Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists Pending CA3225855A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163219462P 2021-07-08 2021-07-08
US63/219,462 2021-07-08
PCT/US2022/073441 WO2023283560A1 (en) 2021-07-08 2022-07-05 Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists

Publications (1)

Publication Number Publication Date
CA3225855A1 true CA3225855A1 (en) 2023-01-12

Family

ID=82748409

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3225855A Pending CA3225855A1 (en) 2021-07-08 2022-07-05 Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists

Country Status (10)

Country Link
US (1) US20230041060A1 (https=)
EP (1) EP4367266A1 (https=)
JP (1) JP2024524554A (https=)
KR (1) KR20240049797A (https=)
CN (1) CN121175436A (https=)
AU (1) AU2022307546A1 (https=)
CA (1) CA3225855A1 (https=)
IL (1) IL309694A (https=)
MX (1) MX2023015276A (https=)
WO (1) WO2023283560A1 (https=)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK4317456T3 (da) * 2019-02-18 2025-09-08 Regeneron Pharma Varianter af mekanoensitiv ionkanalkomponent 1 af piezotypen (piezo1) og anvendelser deraf

Also Published As

Publication number Publication date
WO2023283560A1 (en) 2023-01-12
MX2023015276A (es) 2024-04-03
JP2024524554A (ja) 2024-07-05
EP4367266A1 (en) 2024-05-15
AU2022307546A1 (en) 2024-01-04
IL309694A (en) 2024-02-01
CN121175436A (zh) 2025-12-19
US20230041060A1 (en) 2023-02-09
KR20240049797A (ko) 2024-04-17

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