IL309694A - Treatment of bulging veins with agonists of the mechanosensitive ion channel type PIEZO component 1 (PIEZO1) - Google Patents

Treatment of bulging veins with agonists of the mechanosensitive ion channel type PIEZO component 1 (PIEZO1)

Info

Publication number
IL309694A
IL309694A IL309694A IL30969423A IL309694A IL 309694 A IL309694 A IL 309694A IL 309694 A IL309694 A IL 309694A IL 30969423 A IL30969423 A IL 30969423A IL 309694 A IL309694 A IL 309694A
Authority
IL
Israel
Prior art keywords
piezo1
agonists
treatment
ion channel
channel component
Prior art date
Application number
IL309694A
Other languages
English (en)
Hebrew (he)
Inventor
Manuel Allen Revez Ferreira
Joshua Backman
Alexander Li
Aris Baras
Goncalo Abecasis
Original Assignee
Regeneron Pharma
Manuel Allen Revez Ferreira
Joshua Backman
Alexander Li
Aris Baras
Goncalo Abecasis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Aris Baras, Goncalo Abecasis filed Critical Regeneron Pharma
Publication of IL309694A publication Critical patent/IL309694A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL309694A 2021-07-08 2022-07-05 Treatment of bulging veins with agonists of the mechanosensitive ion channel type PIEZO component 1 (PIEZO1) IL309694A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163219462P 2021-07-08 2021-07-08
PCT/US2022/073441 WO2023283560A1 (en) 2021-07-08 2022-07-05 Treatment of varicose veins with piezo type mechanosensitive ion channel component 1 (piezo1) agonists

Publications (1)

Publication Number Publication Date
IL309694A true IL309694A (en) 2024-02-01

Family

ID=82748409

Family Applications (1)

Application Number Title Priority Date Filing Date
IL309694A IL309694A (en) 2021-07-08 2022-07-05 Treatment of bulging veins with agonists of the mechanosensitive ion channel type PIEZO component 1 (PIEZO1)

Country Status (10)

Country Link
US (1) US20230041060A1 (https=)
EP (1) EP4367266A1 (https=)
JP (1) JP2024524554A (https=)
KR (1) KR20240049797A (https=)
CN (1) CN121175436A (https=)
AU (1) AU2022307546A1 (https=)
CA (1) CA3225855A1 (https=)
IL (1) IL309694A (https=)
MX (1) MX2023015276A (https=)
WO (1) WO2023283560A1 (https=)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK4317456T3 (da) * 2019-02-18 2025-09-08 Regeneron Pharma Varianter af mekanoensitiv ionkanalkomponent 1 af piezotypen (piezo1) og anvendelser deraf

Also Published As

Publication number Publication date
WO2023283560A1 (en) 2023-01-12
CA3225855A1 (en) 2023-01-12
MX2023015276A (es) 2024-04-03
JP2024524554A (ja) 2024-07-05
EP4367266A1 (en) 2024-05-15
AU2022307546A1 (en) 2024-01-04
CN121175436A (zh) 2025-12-19
US20230041060A1 (en) 2023-02-09
KR20240049797A (ko) 2024-04-17

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