CN1211090C - 聚丙烯酸钠作为制备动静脉血管出血的止血剂的应用 - Google Patents
聚丙烯酸钠作为制备动静脉血管出血的止血剂的应用 Download PDFInfo
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- CN1211090C CN1211090C CN 03153260 CN03153260A CN1211090C CN 1211090 C CN1211090 C CN 1211090C CN 03153260 CN03153260 CN 03153260 CN 03153260 A CN03153260 A CN 03153260A CN 1211090 C CN1211090 C CN 1211090C
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- Prior art keywords
- polyacrylic acid
- sodium polyacrylate
- carboxymethyl cellulose
- hemorrhage
- hemostatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 238000002360 preparation method Methods 0.000 title claims abstract description 8
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- 239000001768 carboxy methyl cellulose Substances 0.000 title abstract description 36
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- 239000008112 carboxymethyl-cellulose Substances 0.000 title abstract description 36
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- 229920002134 Carboxymethyl cellulose Polymers 0.000 title abstract description 26
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 239000002874 hemostatic agent Substances 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 43
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 39
- 208000032843 Hemorrhage Diseases 0.000 claims abstract description 35
- 210000001367 artery Anatomy 0.000 claims abstract description 9
- 210000003462 vein Anatomy 0.000 claims abstract description 7
- 230000002792 vascular Effects 0.000 claims description 6
- 230000023597 hemostasis Effects 0.000 abstract description 12
- 230000002439 hemostatic effect Effects 0.000 abstract description 11
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract description 10
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract description 10
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract description 10
- 210000004204 blood vessel Anatomy 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 4
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- 230000000694 effects Effects 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 238000012856 packing Methods 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 abstract 3
- 208000027418 Wounds and injury Diseases 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 238000010521 absorption reaction Methods 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
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- 238000004659 sterilization and disinfection Methods 0.000 description 6
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
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- 241001465754 Metazoa Species 0.000 description 4
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- 229910052649 zeolite group Inorganic materials 0.000 description 4
- 230000002745 absorbent Effects 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 238000001266 bandaging Methods 0.000 description 3
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- 239000004745 nonwoven fabric Substances 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000010413 gardening Methods 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical class [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 止血时间(秒) | 失血量(毫升) | 180分钟死亡率(%) |
空白对照组 | 48.9 | 100 | |
加压包扎组 | 1570.0 | 53.6 | 80 |
加压包扎+云南白药组 | 1500.0 | 40.1 | 100 |
沸石组 | 26.76 | 18.1 | 40 |
Quickclot组 | 32.4 | 23.5 | 40 |
聚丙烯酸钠组 | 30.0 | 21.0 | 0 |
羧甲基纤维素接枝聚丙烯酸组 | 25.0 | 18.5 | 0 |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03153260 CN1211090C (zh) | 2003-08-12 | 2003-08-12 | 聚丙烯酸钠作为制备动静脉血管出血的止血剂的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 03153260 CN1211090C (zh) | 2003-08-12 | 2003-08-12 | 聚丙烯酸钠作为制备动静脉血管出血的止血剂的应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410096825 Division CN1292755C (zh) | 2003-08-12 | 2003-08-12 | 羧甲基纤维素接枝聚丙烯酸的应用及止血材料 |
Publications (2)
Publication Number | Publication Date |
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CN1481811A CN1481811A (zh) | 2004-03-17 |
CN1211090C true CN1211090C (zh) | 2005-07-20 |
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CN 03153260 Expired - Lifetime CN1211090C (zh) | 2003-08-12 | 2003-08-12 | 聚丙烯酸钠作为制备动静脉血管出血的止血剂的应用 |
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CN (1) | CN1211090C (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107847635A (zh) * | 2015-05-06 | 2018-03-27 | 捷锐士阿希迈公司(以奥林巴斯美国外科技术名义) | 羧甲基壳聚糖海绵制剂 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102008742B (zh) * | 2010-12-15 | 2013-08-07 | 常云峰 | 一种止血剂及含有该止血剂的外伤敷料 |
CN103027925B (zh) * | 2013-01-09 | 2014-06-04 | 中国人民解放军第二军医大学 | 一种兼具止血和杀菌活性的聚合物 |
CN103287146B (zh) * | 2013-05-03 | 2015-07-15 | 戚裕 | 一种快干热升华转印介质 |
CN108904530B (zh) * | 2018-08-03 | 2021-04-23 | 安徽省银锂子生物科技发展有限公司 | 一种纳米银杀菌止血组合物 |
-
2003
- 2003-08-12 CN CN 03153260 patent/CN1211090C/zh not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107847635A (zh) * | 2015-05-06 | 2018-03-27 | 捷锐士阿希迈公司(以奥林巴斯美国外科技术名义) | 羧甲基壳聚糖海绵制剂 |
CN107847635B (zh) * | 2015-05-06 | 2021-08-27 | 捷锐士阿希迈公司(以奥林巴斯美国外科技术名义) | 羧甲基壳聚糖海绵制剂 |
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Publication number | Publication date |
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CN1481811A (zh) | 2004-03-17 |
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Owner name: SHENZHEN HONGHUA INVESTMENT CO., LTD. Free format text: FORMER OWNER: FEILD FLOOD TRANSFUSION INST., ACADEMY OF MILITARY MEDICINE SCIENCES, PLA Effective date: 20050916 |
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Address after: Shenzhen City, Futian District province Guangdong North Road 7003, China Building 9 floor Patentee after: SHENZHEN HONGHUA PHARMACEUTICAL Co.,Ltd. Address before: Shenzhen City, Futian District province Guangdong North Road 7003, China Building 9 floor Patentee before: SHENZHEN HONGHUA INVESTMENT Co.,Ltd. |
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Granted publication date: 20050720 Termination date: 20100812 |
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Owner name: SHENZHEN SHENGGONG TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHENZHEN HONGHUA PHARMACEUTICAL CO., LTD. Effective date: 20130830 |
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Effective date of registration: 20130830 Address after: 518000 people's building, Shennan Avenue, Shenzhen, Guangdong 511, Futian District Patentee after: SHENZHEN SHENGGONG TECHNOLOGY Co.,Ltd. Address before: Shenzhen City, Guangdong province Futian District 518034 North Road 7003, China Building 9 floor Patentee before: SHENZHEN HONGHUA PHARMACEUTICAL Co.,Ltd. |
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Owner name: TIANJIN TAIMING JIAYE TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHENZHEN SHENGGONG TECHNOLOGY CO., LTD. Effective date: 20131203 |
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Effective date of registration: 20131203 Address after: 300401 Tianjin city Beichen District Tianjin medicine and medical equipment Industrial Park and Shinco Valley Park 25-1 Patentee after: Tianjin Taiming Jiaye Technology Co.,Ltd. Address before: 518000 people's building, Shennan Avenue, Shenzhen, Guangdong 511, Futian District Patentee before: SHENZHEN SHENGGONG TECHNOLOGY Co.,Ltd. |
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