CN1205880C - Health-care food with immune-regulating and face-beautifying function and its preparation method - Google Patents
Health-care food with immune-regulating and face-beautifying function and its preparation method Download PDFInfo
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- CN1205880C CN1205880C CNB031334741A CN03133474A CN1205880C CN 1205880 C CN1205880 C CN 1205880C CN B031334741 A CNB031334741 A CN B031334741A CN 03133474 A CN03133474 A CN 03133474A CN 1205880 C CN1205880 C CN 1205880C
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Abstract
The present invention relates to a health-care food with the functions of immunological regulation and facial beautification and a preparation method thereof. The health-care food of the present invention is prepared from grape seed extract, wheat germ oil, rice bran oil, pearl, soybean isoflavone, etc. The health-care food has the characteristics of reasonable formula, scientific technology, high bioavailability, unique preparation, easy absorption by human bodies, obvious and exact function, no toxic or side effect, low administration dose, quick absorption, etc. The health-care food which integrates the functions of immunological regulation, facial beautification(chloasma removal) and skin care can be eaten for a long time.
Description
Technical field
The present invention relates to a kind of oral dosage form composition, is a kind of oral dosage form composition with immunomodulating, cosmetology function and preparation method thereof specifically.
Background technology
Along with the progress of society, people's lives rhythm is accelerated gradually, and many womans' operating pressure also strengthens gradually, and regular meeting causes immunocompetence to descend, the endocrine disturbance, and chloasma can appear in face, brings many adverse influences for work and life.But have at present immunomodulating, beauty treatment (functions of removing chloasma) function for oral dosage form composition all over the body in various degree exist deficiencies such as taking dose is big, effect is imprecise.
Summary of the invention
The purpose of this invention is to provide a kind of oral dosage form composition and preparation method thereof with immunomodulating, beauty treatment (yellowish-brown class dispels) function.
Oral dosage form composition of the present invention is a kind of health food, by pure natural raw material Semen Vitis viniferae extract, Semen Tritici aestivi germ oil, Testa oryzae oil, Margarita, soybean isoflavone etc., and forms through scientific composition is refining with reference to the modern pharmacological research achievement.
Semen Vitis viniferae extract contains the multiple compositions that belong to polyphenol compound such as procyanidin, anthocyanin, have multiple biological activitys such as edible safety, antioxidation, developed country's approved is used for fields such as medicine, foods and cosmetics, and China also allows to be used for oral dosage form composition.A lot of research both domestic and external shows that all Semen Vitis viniferae extract is powerful antioxidant and free radical scavenger.Enjoy the good reputation of " skin vitamin ", " oral cosmetics " at national Semen Vitis viniferae extracts such as America and Europes, can impel the appropriately crosslinked of collagen protein, effectively remove free radical, thereby keep skin submissive, smooth, and the activity of interior tryrosinase capable of inhibiting cell, obviously reduce the cell melanin content.
Contain abundant unsaturated fatty acid in the Semen Tritici aestivi germ oil, reach 80% of fatty acid total amount, its main fatty acid is linoleic acid, oleic acid, gamma-Linolenic acid.Semen Tritici aestivi germ oil also contains abundant vitamin E; the protection polyunsaturated fatty acid is not oxidized; the restraint of liberty radical reaction; by improving hormone secretion, avoid the generation of lipid peroxide, can moisten glabrous skin; the wrinkle removing stricture of vagina is anti-aging; alleviate or eliminate pigmentation, reduce the appearance of black speck, strengthen skin elasticity.A certain amount of octacosanol still can improve exercise tolerance, has the obvious anti-fatigue effect.The vitamin E of Semen Tritici aestivi germ oil still can play certain anti-Oxidation of Fat and Oils effect in this product.
Contain unsaturated fatty acids such as oleic acid, linoleic acid in the Testa oryzae oil, and contain many kinds of biological active substanceies such as abundant oryzanol, Squalene, tocopherol, sterol, be described as " healthy oils " by nutritionist, have lipidemia, lipid oxidation and inhibition effect from the body synthetic cholesterol.Its contained oryzanol is a kind of neuroregulator, and contained Squalene has blood fat reducing, physiologically actives such as cholesterol reducing.Its contained ferulic acid has the absorption action of ultraviolet radiation, has very strong oxidation resistance, can reduce the tryrosinase that pigmentation and inhibition generate chloasma, to suppress skin aging, improves whiteness.
It is about 92% that Margarita contains calcium carbonate, and Organic substance is about 5%, comprises trace element such as 18 seed amino acids, carotenoid and ferrum, magnesium, lithium, titanium.Having improves looks brightens, spot-removing function.Also have effects such as immunomodulating, slow down aging, raising vision.Margarita powder also can be used as the calcium source, improves the middle-aged and elderly people osteoporosis.
Soybean isoflavone goes out from the Semen sojae atricolor separation and Extraction, has the main active of flavone compound structure.Studies show that it can promote the immunity of organism allelotaxis, have a liking for the effect that cell has the hypertrophy of inducing, enhanced activity huge.In addition, soybean isoflavone also has weak estrogen action, can prevent and alleviate climacteric syndrome.
The reasonable combination of each raw material makes oral dosage form composition of the present invention can have excellent immunomodulating and beauty treatment (functions of removing chloasma) function.
Oral dosage form composition of the present invention is to be made by the raw material of following weight parts:
Semen Vitis viniferae extract 0.5-5 part
Semen Tritici aestivi germ oil 1-10 part
Testa oryzae oil 0.5-5 part
Margarita powder 0.05-2 part
Soybean isoflavone 0.1-5 part.
Oral dosage form composition of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.
The preparation method that above-mentioned each component is made oral dosage form composition of the present invention is:
(1) chooses satisfactory Semen Vitis viniferae extract, Semen Tritici aestivi germ oil, Testa oryzae oil, Margarita and soybean isoflavone, and test, after meeting the requirements, leave and take standby according to respective standard;
(2) with crushing pearl to 400 order fine powder, standby behind the dry heat sterilization;
(3) with Semen Vitis viniferae extract, Semen Tritici aestivi germ oil, Testa oryzae oil, Margarita powder and the soybean isoflavone mix homogeneously of described weight proportion.
Required various conventional adjuvant was made any peroral dosage form commonly used when oral dosage form composition of the present invention can add the preparation different dosage form, as soft capsule, hard capsule, granule, tablet, oral liquid etc.
Oral dosage form composition of the present invention shows through functional experiment, toxicological security experiment and stability experiment, remarkable, definite, nontoxic, the good stability of its effect, taking confirmation through majority, is the health food that has strong immunomodulating and beauty treatment (functions of removing chloasma) function and can eat for a long time.Has reasonable recipe, craft science, bioavailability height; Prescription is unique, easily is absorbed by the body, and function is remarkable, has no side effect; Taking dose is little, absorbs characteristics such as rapid.
The specific embodiment
Below in conjunction with embodiments of the invention the present invention is further described, but the present invention is not limited to embodiment, those of ordinary skills do some modification, still in protection domain of the present invention.
Embodiment 1-5: oral dosage form composition preparation of soft capsule of the present invention, the weight proportion of each raw material sees the following form.
Preparing the used adjuvant of oral dosage form composition soft capsule of the present invention is the raw material of following weight parts:
Cera Flava 0.05-3 part
The weight proportion of the used capsule material of preparation soft capsule is: gelatin: glycerol: water=1: (0.2 0.6): (0.6-1).
| Embodiment number | Semen Vitis viniferae extract (kg) | Semen Tritici aestivi germ oil (kg) | Testa oryzae oil (kg) | Margarita powder (kg) | Soybean isoflavone (kg) | Cera Flava (kg) |
| 1 | 0.5 | 1.0 | 0.5 | 0.05 | 0.1 | 0.05 |
| 2 | 1.0 | 2.3 | 1.0 | 0.2 | 0.5 | 0.08 |
| 3 | 2.0 | 6.0 | 1.5 | 0.5 | 1.0 | 1.0 |
| 4 | 3.0 | 8.0 | 3.0 | 1.0 | 3.0 | 2.0 |
| 5 | 5.0 | 10.0 | 5.0 | 2.0 | 5.0 | 3.0 |
The source of each raw material and quality standard are as follows in the present embodiment:
1, Semen Vitis viniferae extract
Source: Tianjin spike natural product research and development company limited, Guilin Lay mattress biotech firm, grand ginseng industry company limited of a specified duration.
Quality standard: insoluble matter in procyanidin content 〉=95%, the water≤5%, other meets company standard.
2, Semen Tritici aestivi germ oil
Source: Jiangsu Xu Zhou Ai Pu group, pine group of the Jiangsu Six Dynasties, Earthquake of Anyang station in Henan distillation albumen company limited.
Quality standard: color and luster orange yellow, acid value≤1.0mgKOH/g oil, moisture and volatile matter content≤0.1%, vitamin E 〉=1000mg/kg, other meets company standard.
3, rice sugar and oil
Source: Xianju, Zhejiang milky way company, the Jiangxi benefit Development Co., Ltd that makes the science and technology prosperous
Quality standard: have inherent abnormal smells from the patient of edible refine Testa oryzae oil and flavour, acid value (mgKOH/g)≤4.0%, moisture and volatile matter content≤0.20%, peroxide value (meq/kg)≤20, other meets the ZBX14014-89 of People's Republic of China (PRC) professional standard and company standard.
4, Margarita
Meet 2000 editions requirements of Chinese Pharmacopoeia.
5, soybean isoflavone
The source: Taiyuan, Shanxi unit is biochemical industry company, the three-dimensional company in Shandong, Ha Gaoke bean product company limited too.
Quality standard: pale yellow or light brown powder, moisture≤5%, soybean isoflavone effective content 〉=40%, other meets company standard.
Oral dosage form composition preparation of soft capsule method of the present invention is (with embodiment 2 is example, and other embodiment is except that raw material consumption difference, and preparation method is substantially the same manner as Example 2):
(1) chooses raw material
Choose satisfactory Semen Vitis viniferae extract, Semen Tritici aestivi germ oil, Testa oryzae oil, Margarita, soybean isoflavone, and test, after meeting the requirements, leave and take standby according to respective standard.
(2) preparation Margarita powder
Margarita is crushed to 400 orders with ultrafine crusher, standby behind the dry heat sterilization.
(3) preparation soft capsule content
2.3kg Semen Tritici aestivi germ oil, 1.0kg Testa oryzae oil and 0.08kg Cera Flava are placed material-compound tank, after 35 ℃ of mixing of constant temperature are stirred, 0.5kg soybean isoflavone powder, 0.2kg Margarita powder and 1.0kg Semen Vitis viniferae extract are added wherein, continue to stir 20～30 fens kinds, make mixing of materials even, 100 mesh sieves filter.Material after the filtration is squeezed in the degassing tank, is under the 50-100mmHg vacuum at 35 ℃ of constant temperature, pressure, stirs 30～45 minutes at a slow speed with the degassing, and the material after the degassing is squeezed in the heat-preserving container, gets soft capsule content, is incubated in 35 ℃ in order to pelleting.
(4) preparation soft capsule packaging material
Get the soft capsule material batching, and make the soft capsule packaging material.Earlier glycerol and water injection glue pot are warming up to 60-90 ℃, the back that stirs adds gelatin, continues to stir 2～3h until color even under this temperature.Stir the degassing 20～30 minutes when being evacuated down to 50～100mmHg in the jar, squeeze into after the degassing and be incubated in the heat-preserving container, leave standstill 2-3h, in order to giving vent to anger in 60 ℃.
(5) pill
Soft capsule packaging material and capsule 's content with above-mentioned preparation, respectively in two hoppers of suction pelleting, debugging machine is the compacting soft gelatin capsule after the capacity of thickness, the uniformity and every seed lac ball of capsule skin meets the requirements, and the lift-over cooling in the strand cage of the soft gelatin capsule after the compacting is deoiled and fixing about 1-2h.
(6) soft capsule drying
The soft capsule of preparation under 25～31 ℃ of temperature, humidity≤35% condition, dry 48～60h.
(7) after selection, the check, soft capsule is pressed in the In Aluminium Foil Packing plate, reinstalls in the blank carton, seal seal, be finished product, warehouse-in is preserved in the corrugated case of packing into.
The oral dosage form composition soft capsule of making by embodiment 1-5 of the present invention after testing, every net content 0.5g, every contains procyanidin and is no less than 80mg.Eating method is oral, every day 2 times, each 2-4 grain.
Claims (2)
1, a kind of oral dosage form composition with immunomodulating, cosmetology function is characterized in that it is to be made by the raw material of following weight portion:
Semen Vitis viniferae extract 0.5-5 part
Semen Tritici aestivi germ oil 1-10 part
Testa oryzae oil 0.5-5 part
Margarita powder 0.05-2 part
Soybean isoflavone 0.1-5 part.
2, the preparation method of oral dosage form composition as claimed in claim 1 is characterized in that comprising the following steps:
(1) chooses satisfactory Semen Vitis viniferae extract, Semen Tritici aestivi germ oil, Testa oryzae oil, Margarita and soybean isoflavone, and test, after meeting the requirements, leave and take standby according to respective standard;
(2) with crushing pearl 400 order fine powders, standby behind the dry heat sterilization;
(3) with Semen Vitis viniferae extract, Semen Tritici aestivi germ oil, Testa oryzae oil, Margarita powder and the soybean isoflavone mix homogeneously of described weight proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031334741A CN1205880C (en) | 2003-06-17 | 2003-06-17 | Health-care food with immune-regulating and face-beautifying function and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031334741A CN1205880C (en) | 2003-06-17 | 2003-06-17 | Health-care food with immune-regulating and face-beautifying function and its preparation method |
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| CN1460417A CN1460417A (en) | 2003-12-10 |
| CN1205880C true CN1205880C (en) | 2005-06-15 |
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| CNB031334741A Expired - Fee Related CN1205880C (en) | 2003-06-17 | 2003-06-17 | Health-care food with immune-regulating and face-beautifying function and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI582110B (en) * | 2011-07-01 | 2017-05-11 | Shiseido Co Ltd | Platelet-derived growth factor-BB produces hyperactivity agents, and is associated with leaf-derived stem cell-producing accelerators, stem cell stabilizers, and dermal regenerators |
| US10391137B2 (en) | 2011-07-01 | 2019-08-27 | Shiseido Company, Ltd. | Platelet-derived growth factor-BB production promotor, and mesenchymal stem cell production accelerator, stem cell stabilizer and dermal regenerator comprising the same |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435829C (en) * | 2005-12-24 | 2008-11-26 | 蒋艳群 | Chinese herbal medicine composition of regulating human body endocrine and face beautifying spot eliminating |
| CN100374156C (en) * | 2006-01-10 | 2008-03-12 | 张恩及 | Health products for face care and body care |
| CN100420391C (en) * | 2006-12-18 | 2008-09-24 | 东北虎药业股份有限公司 | Health-care food with anti-oxidation and lowering weight functions |
| CN101112237B (en) * | 2007-08-31 | 2010-12-22 | 北京因科瑞斯医药科技有限公司 | Health products having a function of dispelling chloasma |
| CN101874621B (en) * | 2009-11-05 | 2012-09-05 | 蒋小明 | Deer placenta pearl capsules and preparation method thereof |
| CN103830160B (en) * | 2014-03-20 | 2016-04-27 | 宁波保税区攀峒信息科技有限公司 | A kind of paddy oil pearl skin cream and processing method |
-
2003
- 2003-06-17 CN CNB031334741A patent/CN1205880C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI582110B (en) * | 2011-07-01 | 2017-05-11 | Shiseido Co Ltd | Platelet-derived growth factor-BB produces hyperactivity agents, and is associated with leaf-derived stem cell-producing accelerators, stem cell stabilizers, and dermal regenerators |
| US10391137B2 (en) | 2011-07-01 | 2019-08-27 | Shiseido Company, Ltd. | Platelet-derived growth factor-BB production promotor, and mesenchymal stem cell production accelerator, stem cell stabilizer and dermal regenerator comprising the same |
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| Publication number | Publication date |
|---|---|
| CN1460417A (en) | 2003-12-10 |
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Address after: 132000 Jilin high tech Zone, Jilin Province Road No. three, No. 4 Patentee after: Jilin cloud Health Food Co., Ltd. Address before: 132012 No. two, No. 3, hi tech Zone, Jilin, Jilin Patentee before: Jilin Xinkeqi Health-care Food Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050615 Termination date: 20200617 |
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